1. Choroidal Neovascularization Analyzed on Ultrahigh-Speed Swept-Source Optical Coherence Tomography Angiography Compared to Spectral-Domain Optical Coherence Tomography Angiography
- Author
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Andre J. Witkin, Caio V. Regatieri, Lennart Husvogt, Jay S. Duker, Eric M. Moult, ByungKun Lee, Vijaysekhar Jayaraman, Mehreen Adhi, James G. Fujimoto, Sabin Dang, Joachim Hornegger, Emily Cole, Nadia K. Waheed, Caroline R. Baumal, Ricardo N. Louzada, Eduardo A. Novais, Institute for Medical Engineering and Science, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology. Research Laboratory of Electronics, Adhi, Mehreen, Moult, Eric Michael, Cole, Emily D., Husvogt, Lennart, Lee, ByungKun, and Fujimoto, James G
- Subjects
Male ,Vascular Endothelial Growth Factor A ,0301 basic medicine ,medicine.medical_specialty ,genetic structures ,Mixed type ,Angiogenesis Inhibitors ,Spectral domain ,Article ,03 medical and health sciences ,0302 clinical medicine ,Ophthalmology ,Humans ,Medicine ,Prospective Studies ,Fluorescein Angiography ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,Choroid ,business.industry ,Extramural ,Retinal Vessels ,Optical coherence tomography angiography ,Middle Aged ,Fluorescein angiography ,Choroidal Neovascularization ,eye diseases ,3. Good health ,030104 developmental biology ,Choroidal neovascularization ,medicine.anatomical_structure ,Intravitreal Injections ,Wet Macular Degeneration ,030221 ophthalmology & optometry ,Optometry ,Female ,sense organs ,Tomography ,medicine.symptom ,business ,Tomography, Optical Coherence - Abstract
Purpose To compare visualization of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) using an ultrahigh-speed swept-source (SS) optical coherence tomography angiography (OCTA) prototype vs a spectral-domain (SD) OCTA device. Design Comparative analysis of diagnostic instruments. Methods Patients were prospectively recruited to be imaged on SD OCT and SS OCT devices on the same day. The SD OCT device employed is the RTVue Avanti (Optovue, Inc, Fremont, California, USA), which operates at ∼840 nm wavelength and 70 000 A-scans/second. The SS OCT device used is an ultrahigh-speed long-wavelength prototype that operates at ∼1050 nm wavelength and 400 000 A-scans/second. Two observers independently measured the CNV area on OCTA en face images from the 2 devices. The nonparametric Wilcoxon signed rank test was used to compare area measurements and P values of, National Institutes of Health (U.S.) (R01-EY011289-28), National Institutes of Health (U.S.) (R44-EY022864-03), National Institutes of Health (U.S.) (R01-CA075289-17), United States. Air Force Office of Scientific Research (FA9550-10-1-0551), United States. Air Force Office of Scientific Research (FA9550-12-1-0499)
- Published
- 2016
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