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Loss of accommodation, transient myopia, or both, were complications following retinal cryotherapy in two eyes and after panretinal photocoagulation in six eyes (seven patients). A 17-year-old young man had these refractive difficulties one week after cryotherapy for retinal holes. His accommodative amplitude measured 1.0 D in the treated eye and 8.0 D in the untreated eye. One week later he received cryotherapy to the previously untreated eye, reducing that accommodative amplitude to 2.5 D. Accommodative paresis and transient myopia resolved without treatment within five weeks. Six other patients (six eyes, seven episodes) with an average age of 33 years demonstrated accommodative loss (40% to 92% decrease, average decrease 64%), transient myopia, or both, after panretinal photocoagulation for proliferative diabetic retinopathy. All patients recovered without treatment within six weeks (average, 22 days). All young patients should be made aware of this transient, but troublesome complication before treatment.

We treated 26 patients with acute toxoplasmic retinochoroiditis with clindamycin between 1974 and 1982. Four patients were treated with clindamycin alone and 17 with clindamycin and prednisolone. Five patients received clindamycin and prednisolone, sulfadiazine, pyrimethamine, or cryocoagulation, or a combination of these. All patients with the acute disease had the characteristic foci and a positive titer on the Sabin-Feldman dye test of at least 1:16. Other causes of retinochoroiditis were excluded. All but two patients, who developed diarrhea after two weeks, received clindamycin for a minimum of three weeks. All patients improved after two weeks of treatment, but two patients with lesions larger than 2 disk diameters required an additional six weeks of treatment to heal completely. During follow-up periods ranging from 18 months to seven years (mean, three years) there have been only two recurrences (7.7%). Complications with clindamycin treatment were limited to gastrointestinal upsets, diarrhea, and skin rash. There were no cases of pseudomembranous colitis, the most serious reported complication of clindamycin use.