1. Role of the M2 haplotype within the annexin A5 gene in the occurrence of pregnancy-related venous thromboembolism
- Author
-
Daniela Pisanelli, Donatella Colaizzo, Elvira Grandone, Giovanni Luca Tiscia, Elena Chinni, Maurizio Margaglione, and Valeria Bafunno
- Subjects
Adult ,medicine.medical_specialty ,Adolescent ,Pregnancy Complications, Cardiovascular ,Polymerase Chain Reaction ,Gastroenterology ,Pregnancy ,Risk Factors ,Internal medicine ,Odds Ratio ,medicine ,Humans ,Annexin A5 ,Risk factor ,Genetic Association Studies ,Aged ,Gynecology ,business.industry ,Haplotype ,Factor V ,Obstetrics and Gynecology ,Venous Thromboembolism ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,Venous thrombosis ,Logistic Models ,Haplotypes ,Gestation ,Female ,business - Abstract
Knowledge about risk factors for venous thromboembolism (VTE) is still limited. A recently found haplotype within the natural anticoagulant protein annexin A5 (ANXA5) exerts an important modulating effect on gene expression.Eighty-three nonanticoagulated patients with a documented pregnancy-related VTE and 195 controls were investigated. The presence of the ANXA5 haplotypes was determined.Twenty-seven patients (32.5%) carried the M2 haplotype. Among them, 17 (63.0%) had a history of VTE in puerperium and 10 (37.0%) during pregnancy. The prevalence of the M2 haplotype was different as compared with that recorded among controls (odds ratio, 2.7; 95% confidence interval, 1.5-4.9, P.001). A logistic regression analysis, correcting for potential confounders (age at which the thrombotic event occurred, factor V Leiden, and factor IIA20210 variants) showed a significant increase (odds ratio, 3.4; 95% confidence interval, 1.7-6.7) of the occurrence of VTE in carriers of the M2 haplotype as compared with noncarriers.The M2 haplotype within the ANXA5 gene may represent a new thrombophilic risk factor for pregnancy-related VTE.
- Published
- 2010
- Full Text
- View/download PDF