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Start Over Author "Garrett K. Lam" Journal american journal of obstetrics and gynecology
18 results on '"Garrett K. Lam"'

4. 14: Enhanced preterm delivery predictors: verification in a large independent prospective cohort

Author

William A. Grobman, Corina N. Schoen, Dean V. Coonrod, Sarahn M. Wheeler, Amy Crockett, Jason K. Baxter, Kent D. Heyborne, Ashoka D. Polpitiya, George R. Saade, Angela C. Fox, Angela Hawk, Garrett K. Lam, Leonardo Pereira, Tracey C. Fleischer, Carol Major, J. Jay Boniface, Julja Burchard, Emily J. Su, Louise C. Laurent, Greg C. Critchfield, David M. Haas, Kim A. Boggess, Scott Sullivan, Sherri Longo, and Glenn Markenson

Subjects
Pediatrics, medicine.medical_specialty, business.industry, medicine, Obstetrics and Gynecology, Prospective cohort study, business, Preterm delivery
Published
2020
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5. 9: Performance of a proteomic preterm delivery predictor in a large independent prospective cohort

Author

George R. Saade, Emily J. Su, Dean V. Coonrod, Paul Kearney, Angela C. Fox, Glenn Markenson, Angela Hawk, Louise C. Laurent, J. Jay Boniface, Julja Burchard, Amy Crockett, Jason K. Baxter, Garrett K. Lam, Scott Sullivan, Greg C. Critchfield, Kim A. Boggess, Corina N. Schoen, David M. Haas, Carol Major, Kent D. Heyborne, William A. Grobman, Leonardo Pereira, Sherri Longo, Sarahn M. Wheeler, and Tracey C. Fleischer

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Obstetrics and Gynecology, Medicine, business, Prospective cohort study, Preterm delivery
Published
2020
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6. 128: Uncertainty in gestational age dating impacts diagnosis of complications

Author

Dean V. Coonrod, Matthew K. Hoffman, Michael G. Gravett, Kim A. Boggess, Paul Kearney, George R. Saade, Gregory C. Critchfield, Jay D. Iams, Ryan Treacy, J. Jay Boniface, Julja Burchard, M. Sean Esplin, Garrett K. Lam, Scott Sullivan, Angela C. Fox, Max T. Dufford, Leonardo Pereira, Durlin E. Hickok, and Glenn Markenson

Subjects
medicine.medical_specialty, Obstetrics, business.industry, medicine, Obstetrics and Gynecology, Gestational age, business
Published
2018
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7. 658: Prediction of pregnancy outcomes from serum and clinical factors in women receiving 17-alpha hydroxyprogesterone caproate (17-OHPC)

Author

Glenn Markenson, Kim A. Boggess, Garrett K. Lam, Tracy C. Fleischer, Greg C. Critchfield, Durlin E. Hickok, Scott Sullivan, J. Jay Boniface, Julja Burchard, M. Sean Esplin, Tracy A. Manuck, Matthew K. Hoffman, Angela C. Fox, Dean V. Coonrod, George R. Saade, Max T. Dufford, Leonardo Pereira, Todd L. Randolph, Jay D. Iams, and Babak Shahbaba

Subjects
medicine.medical_specialty, 17-alpha-Hydroxyprogesterone, Obstetrics, business.industry, medicine, Obstetrics and Gynecology, business, Pregnancy outcomes
Published
2018
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8. 356: PPROM and PTL phenotypes are characterized by differences in underlying biochemical pathways

Author

ChienTing Hsu, Paul Kearney, Ashoka D. Polpitiya, Annalise Dykes, Durlin E. Hickok, George R. Saade, Glenn Markenson, Scott Sullivan, Larry Cousins, Max T. Dufford, Tracey C. Fleischer, Garrett K. Lam, Amir J. Lueth, Kim A. Boggess, J. Jay Boniface, Matthew K. Hoffman, M. Sean Esplin, Leonardo Pereira, Angela C. Fox, Jay D. Iams, Todd L. Randolph, and Dean V. Coonrod

Subjects
Genetics, Metabolic pathway, business.industry, Obstetrics and Gynecology, Medicine, business, Phenotype
Published
2017
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9. 337: Use of a second trimester serum-based proteomic risk classifier for prediction of spontaneous and medically-indicated preterm birth

Author

Tracey C. Fleischer, Dean V. Coonrod, Matthew K. Hoffman, Jay D. Iams, J. Jay Boniface, Amir J. Lueth, Max T. Dufford, George R. Saade, Kim A. Boggess, Durlin E. Hickok, Larry Cousins, Scott Sullivan, Ashoka D. Polpitiya, Paul Kearney, Todd L. Randolph, ChienTing Hsu, Angela C. Fox, Leonardo Pereira, M. Sean Esplin, Garrett K. Lam, and Glenn Markenson

Subjects
medicine.medical_specialty, Indicated Preterm Birth, business.industry, Obstetrics, Second trimester, Obstetrics and Gynecology, Medicine, business, Classifier (UML)
Published
2017
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10. 113: Exposure to 17-alpha hydroxyprogesterone caproate (17P) influences expression of maternal serum proteins in progesterone signaling pathways

Author

Tracy A. Manuck, Matthew K. Hoffman, Larry Cousins, Max T. Dufford, Leonardo Pereira, M. Sean Esplin, Dean V. Coonrod, Durlin E. Hickok, Sharon R. Rust, Scott Sullivan, George R. Saade, Paul Kearney, Kim A. Boggess, Garrett K. Lam, Jay D. Iams, Ashoka D. Polpitiya, Tracey C. Fleischer, J. Jay Boniface, ChienTing Hsu, Glenn Markenson, Todd L. Randolph, and Angela C. Fox

Subjects
medicine.medical_specialty, 17-alpha-Hydroxyprogesterone, Endocrinology, business.industry, Internal medicine, Obstetrics and Gynecology, Medicine, Signal transduction, business, Blood proteins
Published
2017
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11. 253: Mechanistic insights from serum proteomic biomarkers predictive of spontaneous preterm birth

Author

Ilia Ichetovkin, Tracey C. Fleischer, Larry Cousins, Ashoka D. Polpitiya, M. Sean Esplin, J. Jay Boniface, Dean V. Coonrod, Trina Pugmire, Chad Bradford, Glenn Markenson, Chien Hsu, Andrew D. Gassman, Max T. Dufford, Leonardo Pereira, Kim A. Boggess, Jeff S. Flick, Scott Sullivan, Jay D. Iams, Rob Severinsen, Angela C. Fox, Garrett K. Lam, Matthew K. Hoffman, George R. Saade, Durlin E. Hickok, and Paul Kearney

Subjects
business.industry, Obstetrics and Gynecology, Medicine, business, Bioinformatics
Published
2016
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12. Minimizing red blood cell contamination while isolating mononuclear cells from whole blood: the next step for the treatment of severe hemolytic disease of the fetus/newborn

Author

Rod Farb, Susan M Orton, Kenneth J. Moise, Lalitha Subramanyam, and Garrett K Lam

Subjects
Hemolytic anemia, Erythrocytes, Rh Isoimmunization, Peripheral blood mononuclear cell, Flow cytometry, Erythroblastosis, Fetal, Pregnancy, Lysis buffer, medicine, Humans, Whole blood, Red Cell, medicine.diagnostic_test, business.industry, Infant, Newborn, Obstetrics and Gynecology, Flow Cytometry, medicine.disease, Red blood cell, medicine.anatomical_structure, Immunology, Blood Component Removal, Erythrocyte Count, Leukocytes, Mononuclear, Female, business, Rh blood group system
Abstract

Objective We examined whether mononuclear cell purification of human blood could be done while minimizing contamination with RhD-positive red blood cells to treat hemolytic disease of the fetus/newborn that was caused by rhesus disease. Study design Whole blood from 16 individuals who tested rhesus positive was diluted and centrifuged over a Ficoll gradient. The cell pellet was incubated with red blood cell lysis buffer, divided into three samples, and analyzed for cell count, mononuclear cell yield, and RhD-positive red cell contamination by flow cytometry. Results Mean RhD-positive red cell contamination was 0.24% (range, 0%-1.9%). The average yield of mononuclear cells was 11.5% (range, 1.8%-23.6%). Through regression analysis, 34 to180 mL of paternal whole blood would be necessary to achieve an antigen load that is sufficient for an HLA antibody response. Conclusion Purification of human blood is possible to produce reasonable mononuclear cell yields with minimal rhesus activity, which makes paternal leukocyte therapy a plausible treatment for severe rhesus alloimmunization.

Published
2003
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13. 193: Verification of a proteomic serum-based classifier to predict spontaneous preterm birth in asymptomatic patients

Author

Ilia Ichetovkin, Tracey C. Fleischer, Durlin E. Hickok, Ashoka D. Polpitiya, Glenn Markenson, M. Sean Esplin, J. Jay Boniface, Scott Sullivan, Matthew K. Hoffman, Jay D. Iams, George R. Saade, Larry Cousins, Kim A. Boggess, Angela C. Fox, Leo Pereira, Garrett K. Lam, Paul Kearney, Chad Bradford, and Dean V. Coonrod

Subjects
medicine.medical_specialty, business.industry, Internal medicine, medicine, Obstetrics and Gynecology, medicine.symptom, business, Asymptomatic, Classifier (UML), Surgery
Published
2016
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14. 17: Clinical validation of a two-protein test for spontaneous preterm birth (sPTB) prediction in a large multicenter prospective study of asymptomatic women

Author

Ilia Ichetovkin, Tracey C. Fleischer, Dean V. Coonrod, Leonardo Pereira, Ashoka D. Polpitiya, Glenn Markenson, Scott Sullivan, J. Jay Boniface, Chad Bradford, George R. Saade, Larry Cousins, Paul Kearney, Angela C. Fox, Garrett K. Lam, Kim A. Boggess, Matthew K. Hoffman, Durlin E. Hickok, Jay D. Iams, and M. Sean Esplin

Subjects
Pediatrics, medicine.medical_specialty, business.industry, Obstetrics, Obstetrics and Gynecology, Medicine, medicine.symptom, business, Prospective cohort study, Asymptomatic, Test (assessment)
Published
2016
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15. Differential expression of TcR-CD3 zeta as evidence for altered immunoregulation in preeclamptic versus normotensive women

Author

Paul W. Whitecar, Garrett K Lam, Susan M Orton, Douglas D. Taylor, and Kim A. Boggess

Subjects
Adult, medicine.medical_specialty, CD3 Complex, Blotting, Western, Gestational Age, Jurkat cells, Preeclampsia, Flow cytometry, Western blot, Pre-Eclampsia, Pregnancy, Internal medicine, Blood plasma, medicine, Humans, Receptor, biology, medicine.diagnostic_test, business.industry, Obstetrics and Gynecology, Antibodies, Monoclonal, medicine.disease, Flow Cytometry, Endocrinology, Receptor-CD3 Complex, Antigen, T-Cell, Monoclonal, Luminescent Measurements, biology.protein, Female, Antibody, business
Abstract

The study was undertaken to exhibit and quantify the difference in modulation of CD3-zeta protein (an integral component of the T-cell receptor) in preeclamptic and normotensive women.Serum was collected from 10 preeclamptic and 10 normotensive women ator=37 weeks' gestation on admission. Jurkat E-61 cells were incubated with the sera (20% volume to volume) and analyzed with Western immunoblot using mouse monoclonal CD3-zeta antibody. Enhanced chemiluminescence and densitometry were used to qualitatively measure zeta expression of the cells. A de novo flow cytometry assay was developed to quantify the difference in CD3-zeta expression of these cells. Comparisons were performed by t test (P.05 was significant).Preeclamptic patient sera produced a 2.4-fold increase in CD3-zeta expression than normotensive patients on Western blot (P.01). Flow cytometry showed that preeclamptic sera had a 1.4-fold higher expression of CD3-zeta compared with normotensive patients (P.0003).TcR/CD3-zeta expression is normally suppressed in pregnancy. Loss of this suppression occurs in preeclamptic patients, implying increased T-cell function.

Published
2003

16. Digoxin antibody fragment, antigen binding (Fab), treatment of preeclampsia in women with endogenous digitalis-like factor: a secondary analysis of the DEEP Trial

Author

David F. Lewis, Christopher J. Robinson, C. David Adair, George R. Saade, Moana Hopoate-Sitake, Steven W. Graves, Garrett K. Lam, Vardaman M. Buckalew, and Donna D. Johnson

Subjects
Adult, medicine.medical_specialty, Digoxin, Renal function, Placebo, Gastroenterology, Preeclampsia, Immunoglobulin Fab Fragments, Double-Blind Method, Pre-Eclampsia, Pregnancy, Internal medicine, Multicenter trial, medicine, Humans, Antihypertensive Agents, business.industry, Infant, Newborn, Obstetrics and Gynecology, Saponins, medicine.disease, Pulmonary edema, Surgery, Cardenolides, Intraventricular hemorrhage, Creatinine, Gestation, Female, business, medicine.drug
Abstract

Objective Endogenous digitalis-like factors (EDLFs) are elevated in women with preeclampsia, and the use of an anti-digoxin antibody Fab (DIF) in women with preeclampsia who were remote from term reduced maternal blood pressure and preserved renal function. The objective was to determine whether DIF treatment in women with severe preeclampsia in association with positive EDLFs in maternal serum improves maternal-perinatal outcomes. Study Design This was a planned secondary analysis from a randomized, placebo-controlled, double-blind study of DIF in women with severe preeclampsia with positive EDLF status that was managed expectantly between 23 weeks 5 days and 34 weeks' gestation (19 women received placebo, and 17 women received DIF). Primary outcome variables were a change in creatinine clearance and the use of antihypertensives. Secondary outcomes were maternal and perinatal complications. Results Women with positive EDLFs who received DIF had an attenuated decline in creatinine clearance from baseline compared with placebo (–4.5 ± 12.9 vs –53.2 ± 12.6 mL/min; P = .005). In this same group, the use of antihypertensives (the other primary outcome) was lower but not significantly so (41% vs 63%; P = .12). However, women who were treated with DIF had a lower rate of pulmonary edema (1/17 vs 6/19 women; P = .035) and lower rates of neonatal intraventricular hemorrhage (DIF: 0/17 women vs placebo: 5/19 women; P = .015). Conclusion In women with severe preeclampsia who were remote from term who were EDLF positive, the use of DIF was associated with improved maternal and neonatal outcome. These findings suggest the need for a large multicenter trial that would evaluate the benefits of DIF in the treatment of women with severe preeclampsia who are remote from term and with positive EDLF status.

Published
2013
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