1. Multinodular and Vacuolating Posterior Fossa Lesions of Unknown Significance
- Author
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Antoine Moulignier, C. Vandendries, E. Gerardin, J. Farras, C. Bogey, Thomas Tourdias, Cyrine Drissi, Julien Savatovsky, F. Ducray, M. Rodallec, N. Magne, François Cotton, Sonia Nagi, M. Mejdoubi, Jean-Philippe Cottier, Romain Deschamps, J.A. Garcia, Dragos Catalin Jianu, V. Broquet, B. Carsin, Seyyid Baloglu, Jean-Claude Sadik, Sylvie Grand, Capucine Diard-Detoeuf, Stéphane Kremer, Monique Elmaleh, Natalia Shor, Fabrice Bonneville, Homa Adle-Biassette, P. O. Comby, J. Bailleux, Loïc Duron, M. Ollivier, E. Calvier, and Augustin Lecler
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Supratentorial region ,Posterior fossa ,Infratentorial Neoplasms ,030218 nuclear medicine & medical imaging ,Lesion ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Unknown Significance ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Aged ,business.industry ,Cerebrum ,Adult Brain ,Brain ,Nodule (medicine) ,Middle Aged ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Posterior fossa lesion ,Female ,Neurology (clinical) ,Signal intensity ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Multinodular and vacuolating neuronal tumor of the cerebrum is a rare supratentorial brain tumor described for the first time in 2013. Here, we report 11 cases of infratentorial lesions showing similar striking imaging features consisting of a cluster of low T1-weighted imaging and high T2-FLAIR signal intensity nodules, which we referred to as multinodular and vacuolating posterior fossa lesions of unknown significance. No relationship was found between the location of the lesion and clinical symptoms. A T2-FLAIR hypointense central dot sign was present in images of 9/11 (82%) patients. Cortical involvement was present in 2/11 (18%) of patients. Only 1 nodule of 1 multinodular and vacuolating posterior fossa lesion of unknown significance showed enhancement on postcontrast T1WI. DWI, SWI, MRS, and PWI showed no malignant pattern. Lesions did not change in size or signal during a median follow-up of 3 years, suggesting that multinodular and vacuolating posterior fossa lesions of unknown significance are benign malformative lesions that do not require surgical intervention or removal.
- Published
- 2019
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