1. Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial
- Author
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Miguel Angel Muñoz, José Lapetra, Jordi Salas-Salvadó, Nancy Babio, Miquel Fiol, Francisco J. Tinahones, Andrés Díaz-López, Emilio Sacanella, Albert Goday, Nerea Becerra-Tomás, Carolina Ortega-Azorín, Olga Castañer, Naomi Cano Ibañez, Josep Vidal, Carolina Sorto Sanchez, José V. Sorlí, José A. de Paz, Pilar Matía-Martín, Miquel Gimenez-Gracia, Julia Wärnberg, Laura Torres-Collado, José Manuel Santos-Lozano, Josep A. Tur, Lidia Daimiel, Maria Angeles Zulet, PREDIMED-Plus Investigators, Maria del Mar Bibiloni, Clotilde Vázquez, Estefanía Toledo, Mònica Bulló, Verónica Ruiz, Montse Fitó, Javier Díez-Espino, Manoli Garcia-de-la-Hera, José Carlos Fernández-García, Dolores Corella, Ramon Estruch, Ángel M. Alonso-Gómez, Emilio Ros, Lucas Tojal Sierra, Xavier Pintó, Napoleón Pérez-Farinós, Marga Morey, Miguel Ángel Martínez-González, Jose Lopez-Miranda, Miguel Delgado-Rodríguez, Miguel Ruiz-Canela, Jesús Vioque, Luis Serra-Majem, J. Alfredo Martínez, Dora Romaguera, Almudena Sánchez-Villegas, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, European Research Council, Junta de Andalucía, and Generalitat Valenciana
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Male ,Weight loss ,medicine.medical_specialty ,Mediterranean diet ,PREDIMED-Plus ,Renal function ,Urine ,Overweight ,Kidney ,Kidney Function Tests ,urologic and male genital diseases ,Kidney function ,law.invention ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Humans ,Glomerular filtration rate ,Obesity ,Dietary intervention ,Life Style ,Aged ,business.industry ,Incidence (epidemiology) ,Middle Aged ,medicine.disease ,Nephrology ,Female ,medicine.symptom ,Metabolic syndrome ,business - Abstract
Introduction: Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedDiet) plus increased physical activity (PA) on renal function. Methods: Randomized controlled "PREvención con DIeta MEDiterránea-Plus"(PREDIMED-Plus) trial is conducted in 23 Spanish centers comprising 208 primary care clinics. Overweight/obese (n = 6,719) adults aged 55-75 years with metabolic syndrome were randomly assigned (1:1) to an intensive weight-loss lifestyle intervention with an erMedDiet, PA promotion, and behavioral support (intervention) or usual-care advice to adhere to an energy-unrestricted MedDiet (control) between September 2013 and December 2016. The primary outcome was 1-year change in estimated glomerular filtration rate (EGFR). Secondary outcomes were changes in urine albumin-to-creatinine ratio (UACR), incidence of moderately/severely impaired EGFR (, This work was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is cofunded by the European Regional Development Fund (5 coordinated FIS projects leaded by J.S.-S and J.V., including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926; PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, and PI19/01332); the Especial Action Project entitled Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S.; the European Research Council (Advanced Research Grant 2014–2019; agreement #340918) granted to M.Á.M.-G.; the Recercaixa (No. 2013ACUP00194) grant to J.S.-S.; grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018); the PROMETEO/2017/017 grant from the Generalitat Valenciana; the SEMERGEN grant; funds from the European Regional Development Fund (CB06/03); International Nut & Dried Fruit Council – FESNAD (Long-term effects of an energyrestricted Mediterranean diet on mortality and cardiovascular disease 2014–2015, No. 201302) (PI: M.Á.M.-G.); the AstraZeneca Young Investigators Award in Category of Obesity and T2D 2017 (PI: D.R.); grant of support to research groups No. 35/2011 (Balearic Islands Gov.; FEDER funds) (J.A.T. and C.B.); the JR17/00022 (ISCIII) grant to O.C.; the Boosting young talent call grant program for the development of IISPV research projects 2019–2021 (Ref.: 2019/IISPV/03 grant to A.D.-L.); the Societat Catalana d’Endocrinologia i Nutrició (SCEN) Clinical-Research Grant 2019 (IPs: J.S.-S. and A.D.-L.). Collaborative Nutrition and/or Obesity Project for Young Researchers 2019 supported by CIBEROBN entitled Lifestyle Interventions and Chronic Kidney Disease: Inflammation, Oxidative Stress and Metabolomic Profile (LIKIDI study) grant to A.D.-L.
- Published
- 2021