1. Elevated white blood cell count worsens proteinuria but not estimated glomerular filtration rate: the Kansai Healthcare Study.
- Author
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Sato KK, Hayashi T, Harita N, Koh H, Maeda I, Endo G, Nakamura Y, Kambe H, and Fukuda K
- Subjects
- Adult, Blood Cell Count, Blood Glucose metabolism, Blood Pressure, Body Mass Index, Humans, Japan, Male, Middle Aged, Multivariate Analysis, Proportional Hazards Models, Prospective Studies, Proteinuria metabolism, Treatment Outcome, Glomerular Filtration Rate, Leukocytes cytology, Proteinuria pathology
- Abstract
Background/aims: No prospective studies have estimated the association between white blood cell (WBC) count and the risk of proteinuria. We prospectively examined the relationships of WBC count, as a marker of inflammation, with two outcomes: proteinuria and low estimated glomerular filtration rate (eGFR)., Methods: We enrolled 10,008 Japanese men aged 40-55 years who had neither proteinuria nor low eGFR and were not taking antihypertensive medications at entry. Proteinuria was defined as 1+ or higher on urine dipstick. Low eGFR was defined if eGFR was <60 ml/min/1.73 m(2)., Results: During the 49,644 person-years of follow-up, 1,557 cases of proteinuria were confirmed. After adjusting for age, body mass index, fasting plasma glucose, systolic blood pressure, diastolic blood pressure, antidiabetic medications, alcohol consumption, smoking, regular leisure-time physical activity and eGFR, the highest quintile (≥7.51 × 10(3)/μl) of WBC count was independently associated with an increased risk of incidence of proteinuria [HR: 1.45 (95% CI: 1.23-1.73)] compared with the lowest quintile (≤4.80 × 10(3)/μl). On the other hand, during 52,833 person-years, we confirmed 439 cases of low eGFR. In multivariate models, there was no association between WBC count and low eGFR., Conclusion: Elevated WBC count was independently associated with an increased risk of proteinuria, but not low eGFR., (Copyright © 2011 S. Karger AG, Basel.)
- Published
- 2011
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