1. Initial genome-wide scan for linkage with schizophrenia in the Japanese schizophrenia sib-pair linkage group (JSSLG) families
- Author
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Hitoshi Shibuya, Hiroshi Yoneda, K. Kameda, M. Takeichi, Shinichiro Nanko, Tadao Arinami, Kazuo Yara, K. Tanabe, Y. Kitao, Jun Koh, T. Furuno, Takahiro Shinkai, Naoshi Kaneko, Jun Sakai, Nakao Iwata, Tsuyoshi Kitajima, Kiyoshi Yoshitsugu, Yoshihiko Iijima, Takeo Yoshikawa, H. Shimizu, Tomoko Toyota, Y. Fujii, Tsukasa Koyama, Norio Ozaki, Y. Minowa, Sakae Takahashi, M. Mineta, Yasuyuki Fukumaki, Nobutada Tashiro, Toshiyuki Someya, Tsuyuka Ohtsuki, Yasushi Takehisa, Jun Nakamura, Hiroki Ishiguro, K. Ohara, Tatsuyuki Muratake, T. Hashiguchi, Hiroko Hori, Y. Inada, Hiroshi Ujike, Ichiro Kusumi, Eiichi Tanabe, Hiroshi Fukuzako, Takahiro Tsujita, Yoshio Yamanouchi, Takuya Kojima, Yuji Tanaka, Hiroki Shibata, Shoji Tsuji, Takeshi Nishiyama, Kazuo Yamada, Akira Imamura, Kenji Nakata, Y. Suzuki, Osamu Ohmori, Yuji Okazaki, and Toshiya Inada
- Subjects
Linkage (software) ,Genetics ,Genotype ,Genetic Linkage ,Genome, Human ,Siblings ,Schizophrenia (object-oriented programming) ,Chromosome Mapping ,Genome Scan ,Biology ,Genome ,Complete linkage ,Nuclear Family ,Asian People ,Tandem Repeat Sequences ,Genetic linkage ,Schizophrenia ,Humans ,Microsatellite ,Computer Simulation ,Genetic Predisposition to Disease ,Genetic Testing ,Lod Score ,Genotyping ,Genetics (clinical) - Abstract
To determine if there are common genes that contribute to the susceptibility for schizophrenia, first-stage genome-wide scan was carried out by genotyping 417 short-tandem repeat (STR) markers in 338 individuals from 130 families with 148 affected sib-pairs identified at 16 sites nationwide in Japan. Data was from the Japanese Schizophrenia Sib-pair Linkage Group (JSSLG), which is a multi-site collaborative study group established to create a national resource for genetic studies of schizophrenia in Japan. All subjects were Japanese, and the probands and their siblings had schizophrenia. Multipoint non-parametric linkage analysis and exclusion mapping were performed with GENEHUNTER software. Simulation studies suggested that in the absence of linkage we could expect one multipoint maximum LOD score (MLS) of 1.9 per genome scan. An MLS of 3.7 would be expected only once in every 20 genome scans and thus corresponds to a genome-wide significance of 0.05. No loci in the initial screen fulfilled the criteria for significant or suggestive evidence for linkage. Ten chromosomes (1, 2, 3, 4, 5, 8, 9, 14, 17, and 20) had at least one region with a nominal P value
- Published
- 2003