1. Impact of Citharexylum Quadrangular Chloroform Extract and Micronutrient on Praziquantel in Schistosoma Mansoni Infected Mice
- Author
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Ebtehal M. Farrag, Abdel-Razik H. Farrag, Dalia B. Fayed, Shadia M. Kadry, Ahlam H. Mahmoud, and Azza M. Mohamed
- Subjects
biology ,Vitamin E ,medicine.medical_treatment ,Glutathione reductase ,General Medicine ,Glutathione ,Pharmacology ,biology.organism_classification ,Nitric oxide ,Praziquantel ,Lipid peroxidation ,chemistry.chemical_compound ,chemistry ,Catalase ,parasitic diseases ,Immunology ,medicine ,biology.protein ,Schistosoma mansoni ,medicine.drug - Abstract
Praziquantel (PZQ), the drug of choice according to the World Health Organization (WHO), causes some side effects. The appearance of drug resistance against PZQ in Schistosoma mansoni infected species leads to must introduce new effective compounds and/or suppress its side effects. The aim of present work is a trial to solve this problem. Chloroform extract of Citharexylum quadrangular jacq leaves was used as a medicinal plant, which affect the Schistosoma mansoni adults. Prophylactic and therapeutic treatment of Schistosoma mansoni infected mice with the plant extract and/or the antioxidants vitamin E and selenium in combination with PZQ was studied. The study revealed that the combination of the chloroform extract together with vitamin E and selenium improved the efficiency of PZQ. These supplementations are very effective in ameliorating the oxidative insult as well as other parameters: glutathione reductase (GR), thioredoxin reductase (TrxR), catalase (CAT) and reduced glutathione (GSH), nitric oxide (NO) and lipid peroxidation (MDA), hepatic hydroxyproline content, Alanine aminotransferase (ALT), Gamma-glutamyltransferase (γ-GT), tumor necrosis factor-alpha (TNFα), interleukin- 10 (IL-10) and total immunoglobulin E (total IgE) associated with Schistosoma mansoni infection.
- Published
- 2015