Search

Your search keyword '"Lazareth H"' showing total 2 results
Start Over Author "Lazareth H" Journal american journal of kidney diseases the official journal of the national kidney foundation
2 results on '"Lazareth H"'

1. Nephrotoxicity Associated With Niraparib.

Author

Lazareth H, Delanoy N, Cohen R, Boissier E, Ayari H, Combe P, Crespel C, Mercadier-Riaz E, Karras A, Courbebaisse M, Thervet E, and Pallet N

Subjects
Aged, Aged, 80 and over, Dose-Response Relationship, Drug, Female, Humans, Indazoles administration & dosage, Middle Aged, Piperidines administration & dosage, Poly(ADP-ribose) Polymerase Inhibitors administration & dosage, Poly(ADP-ribose) Polymerase Inhibitors adverse effects, Risk Factors, Indazoles adverse effects, Kidney Diseases chemically induced, Ovarian Neoplasms drug therapy, Piperidines adverse effects
Published
2020
Full Text
View/download PDF

2. COVID-19-Related Collapsing Glomerulopathy in a Kidney Transplant Recipient.

Author

Lazareth H, Péré H, Binois Y, Chabannes M, Schurder J, Bruneau T, Karras A, Thervet E, Rabant M, Veyer D, and Pallet N

Subjects
Adult, Allografts, Betacoronavirus, Biopsy, COVID-19, Glomerulonephritis, Membranous diagnosis, Humans, Male, Pandemics, SARS-CoV-2, Coronavirus Infections epidemiology, Glomerulonephritis, Membranous etiology, Kidney pathology, Kidney Transplantation, Pneumonia, Viral epidemiology, Transplant Recipients
Abstract

We report a case of a kidney transplant recipient who presented with acute kidney injury and nephrotic-range proteinuria in a context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Kidney biopsy revealed collapsing glomerulopathy. Droplet-based digital polymerase chain reaction did not detect the presence of SARS-CoV-2 RNA in the biopsy fragment, and the virus was barely detectable in plasma at the time of the biopsy. SARS-CoV-2 RNAemia peaked several days later, followed by a seroconversion despite the absence of circulating CD19-positive lymphocytes at admission due to rituximab-based treatment of antibody-mediated rejection 3 months earlier. Genotyping for the 2 risk alleles of the apolipoprotein L1 (APOL1) gene revealed that the donor carried the low-risk G0/G2 genotype. This case illustrates that coronavirus disease 2019 infection may promote a collapsing glomerulopathy in kidney allografts with a low-risk APOL1 genotype in the absence of detectable SARS-CoV-2 RNA in the kidney and that podocyte injury may precede SARS-CoV-2 RNAemia., (Copyright © 2020 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.)

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results