145 results on '"Go, Alan S"'
Search Results
2. Metabolites Associated With Uremic Symptoms in Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
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Dember, Laura M., Landis, J. Richard, Townsend, Raymond R., Appel, Lawrence, Fink, Jeffrey, Rahman, Mahboob, Horwitz, Edward J., Taliercio, Jonathan J., Rao, Panduranga, Sondheimer, James H., Lash, James P., Chen, Jing, Go, Alan S., Parsa, Afshin, Rankin, Tracy, Wulczyn, Kendra E., Shafi, Tariq, Anderson, Amanda, Rincon-Choles, Hernan, Clish, Clary B., Denburg, Michelle, Feldman, Harold I., He, Jiang, Hsu, Chi-yuan, Kelly, Tanika, Kimmel, Paul L., Mehta, Rupal, Nelson, Robert G., Ramachandran, Vasan, Ricardo, Ana, Shah, Vallabh O., Srivastava, Anand, Xie, Dawei, Rhee, Eugene P., and Kalim, Sahir
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- 2024
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3. Adherence to Plant-Based Diets and Risk of CKD Progression and All-Cause Mortality: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
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Chen, Jing, Cohen, Debbie L., Feldman, Harold I., Go, Alan S., Lash, James P., Nelson, Robert G., Rahman, Mahboob, Rao, Panduranga S., Shah, Vallabh O., Unruh, Mark L., Amir, Saira, Kim, Hyunju, Hu, Emily A., Ricardo, Ana C., Mills, Katherine T., He, Jiang, Fischer, Michael J., Pradhan, Nishigandha, Tan, Thida C., Navaneethan, Sankar D., Dobre, Mirela, Anderson, Cheryl A.M., Appel, Lawrence J., and Rebholz, Casey M.
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- 2024
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4. Frailty and Cardiovascular Outcomes in Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
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Chen, Jing, Cohen, Debbie L., Feldman, Harold I., Go, Alan S., Nelson, Robert G., Rahman, Mahboob, Rao, Panduranga S., Shah, Vallabh O., Unruh, Mark L., Hannan, Mary, Chen, Jinsong, Hsu, Jesse, Zhang, Xiaoming, Saunders, Milda R., Brown, Julia, McAdams-DeMarco, Mara, Mohanty, Madhumita Jena, Vyas, Rahul, Hajjiri, Zahraa, Carmona-Powell, Eunice, Meza, Natalie, Porter, Anna C., Ricardo, Ana C., and Lash, James P.
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- 2024
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5. Factors Associated With Non-vaccination for Influenza Among Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
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Dember, Laura M., Landis, J. Richard, Townsend, Raymond R., Fink, Jeffrey, Rahman, Mahboob, Horwitz, Edward J., Rao, Panduranga S., Sondheimer, James H., Go, Alan S., Hsu, Chi-yuan, Parsa, Afshin, Rankin, Tracy, Ishigami, Junichi, Jaar, Bernard G., Charleston, Jeanne B., Lash, James P., Brown, Julia, Chen, Jing, Mills, Katherine T., Taliercio, Jonathan J., Kansal, Sheru, Crews, Deidra C., Riekert, Kristin A., Dowdy, David W., Appel, Lawrence J., and Matsushita, Kunihiro
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- 2024
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6. Cardiovascular and Kidney Outcomes of Non-Diabetic CKD by Albuminuria Severity: Findings From the CRIC Study
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Cohen, D., Appel, Lawrence J., Chen, Jing, Feldman, Harold I., Go, Alan S., Lash, James P., Nelson, Robert G., Rahman, Mahboob, Rao, Panduranga S., Shah, Vallabh O., Unruh, Mark L., Shulman, Rachel, Yang, Wei, Cohen, Debbie L., Reese, Peter P., and Cohen, Jordana B.
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- 2024
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7. Association Between Kidney Clearance of Secretory Solutes and Cardiovascular Events: The Chronic Renal Insufficiency Cohort (CRIC) Study
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Chen, Yan, Zelnick, Leila R, Huber, Matthew P, Wang, Ke, Bansal, Nisha, Hoofnagle, Andrew N, Paranji, Rajan K, Heckbert, Susan R, Weiss, Noel S, Go, Alan S, Hsu, Chi-yuan, Feldman, Harold I, Waikar, Sushrut S, Mehta, Rupal C, Srivastava, Anand, Seliger, Stephen L, Lash, James P, Porter, Anna C, Raj, Dominic S, Kestenbaum, Bryan R, Investigators, CRIC Study, Appel, Lawrence J, He, Jiang, Rao, Panduranga S, Rahman, Mahboob, and Townsend, Raymond R
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Kidney Disease ,Clinical Research ,Cardiovascular ,Prevention ,Heart Disease ,Renal and urogenital ,Aged ,Albuminuria ,Chromatography ,Liquid ,Cohort Studies ,Cresols ,Female ,Glomerular Filtration Rate ,Glycine ,Heart Failure ,Humans ,Incidence ,Indican ,Kidney Tubules ,Kynurenic Acid ,Male ,Middle Aged ,Myocardial Infarction ,Organic Anion Transporters ,Proportional Hazards Models ,Prospective Studies ,Pyridoxic Acid ,Renal Insufficiency ,Chronic ,Ribonucleosides ,Stroke ,Sulfuric Acid Esters ,Tandem Mass Spectrometry ,Xanthines ,CRIC Study Investigators ,cardiovascular disease ,chronic kidney disease ,cinnamoylglycine ,glomerular filtration rate ,heart failure ,indoxyl sulfate ,isovalerylglycine ,kynurenic acid ,myocardial infarction ,p-cresol sulfate ,protein-bound ,proximal tubule ,pyridoxic acid ,renal function ,secretory solute clearance ,stroke ,tiglylglycine ,tubular secretion ,tubular secretory clearance ,uremic toxins ,xanthosine ,Clinical Sciences ,Public Health and Health Services ,Urology & Nephrology - Abstract
Rationale & objectiveThe clearance of protein-bound solutes by the proximal tubules is an innate kidney mechanism for removing putative uremic toxins that could exert cardiovascular toxicity in humans. However, potential associations between impaired kidney clearances of secretory solutes and cardiovascular events among patients with chronic kidney disease (CKD) remains uncertain.Study designA multicenter, prospective, cohort study.Setting & participantsWe evaluated 3,407 participants from the Chronic Renal Insufficiency Cohort (CRIC) study.ExposuresBaseline kidney clearances of 8 secretory solutes. We measured concentrations of secretory solutes in plasma and paired 24-hour urine specimens using liquid chromatography-tandem mass spectrometry (LC-MS/MS).OutcomesIncident heart failure, myocardial infarction, and stroke events.Analytical approachWe used Cox regression to evaluate associations of baseline secretory solute clearances with incident study outcomes adjusting for estimated GFR (eGFR) and other confounders.ResultsParticipants had a mean age of 56 years; 45% were women; 41% were Black; and the median estimated glomerular filtration rate (eGFR) was 43 mL/min/1.73 m2. Lower 24-hour kidney clearance of secretory solutes were associated with incident heart failure and myocardial infarction but not incident stroke over long-term follow-up after controlling for demographics and traditional risk factors. However, these associations were attenuated and not statistically significant after adjustment for eGFR.LimitationsExclusion of patients with severely reduced eGFR at baseline; measurement variability in secretory solutes clearances.ConclusionsIn a national cohort study of CKD, no clinically or statistically relevant associations were observed between the kidney clearances of endogenous secretory solutes and incident heart failure, myocardial infarction, or stroke after adjustment for eGFR. These findings suggest that tubular secretory clearance provides little additional information about the development of cardiovascular disease events beyond glomerular measures of GFR and albuminuria among patients with mild-to-moderate CKD.
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- 2021
8. Blood Pressure, Incident Cognitive Impairment, and Severity of CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
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Appel, Lawrence J., Chen, Jing, Cohen, Debbie L., Feldman, Harold I., Go, Alan S., Lash, James P., Nelson, Robert G., Rao, Panduranga S., Shah, Vallabh O., Unruh, Mark L., Babroudi, Seda, Tighiouart, Hocine, Schrauben, Sarah J., Cohen, Jordana B., Fischer, Michael J., Rahman, Mahboob, Hsu, Chi-yuan, Sozio, Stephen M., Weir, Matthew, Sarnak, Mark, Yaffe, Kristine, Kurella Tamura, Manjula, and Drew, David
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- 2023
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9. Integrated Analysis of Blood and Urine Biomarkers to Identify Acute Kidney Injury Subphenotypes and Associations With Long-term Outcomes
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Bhatraju, Pavan K., Prince, David K., Mansour, Sherry, Ikizler, T. Alp, Siew, Edward D., Chinchilli, Vernon M., Garg, Amit X., Go, Alan S., Kaufman, James S., Kimmel, Paul L., Coca, Steve G., Parikh, Chirag R., Wurfel, Mark M., and Himmelfarb, Jonathan
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- 2023
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10. Ultraprocessed Foods and Kidney Disease Progression, Mortality, and Cardiovascular Disease Risk in the CRIC Study
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Cohen, Debbie L., Feldman, Harold I., Go, Alan S., Nelson, Robert G., Rahman, Mahboob, Shah, Vallabh O., Sullivan, Valerie K., Appel, Lawrence J., Anderson, Cheryl A.M., Kim, Hyunju, Unruh, Mark L., Lash, James P., Trego, Marsha, Sondheimer, James, Dobre, Mirela, Pradhan, Nishigandha, Rao, Panduranga S., Chen, Jing, He, Jiang, and Rebholz, Casey M.
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- 2023
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11. Cardiac Structure and Function and Subsequent Kidney Disease Progression in Adults With CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study
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Cohen, Debbie L., Feldman, Harold I., Lash, James P., Nelson, Robert G., Rao, Panduranga S., Shah, Vallabh O., Unruh, Mark L., Ishigami, Junichi, Kansal, Mayank, Mehta, Rupal, Srivastava, Anand, Rahman, Mahboob, Dobre, Mirela, Al-Kindi, Sadeer G., Go, Alan S., Navaneethan, Sankar D., Chen, Jing, He, Jiang, Bhat, Zeenat Yousuf, Jaar, Bernard G., Appel, Lawrence J., and Matsushita, Kunihiro
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- 2023
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12. Serial Fibroblast Growth Factor 23 Measurements and Risk of Requirement for Kidney Replacement Therapy: The CRIC (Chronic Renal Insufficiency Cohort) Study
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Mehta, Rupal, Cai, Xuan, Lee, Jungwha, Xie, Dawei, Wang, Xue, Scialla, Julia, Anderson, Amanda H, Taliercio, Jon, Dobre, Mirela, Chen, Jing, Fischer, Michael, Leonard, Mary, Lash, James, Hsu, Chi-yuan, de Boer, Ian H, Feldman, Harold I, Wolf, Myles, Isakova, Tamara, Investigators, CRIC Study, Appel, Lawrence J, Go, Alan S, He, Jiang, Rao, Panduranga S, Rahman, Mahboob, and Townsend, Raymond R
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Biomedical and Clinical Sciences ,Clinical Sciences ,Prevention ,Kidney Disease ,Clinical Research ,Renal and urogenital ,Biomarkers ,Cohort Studies ,Disease Progression ,Female ,Fibroblast Growth Factor-23 ,Fibroblast Growth Factors ,Humans ,Kaplan-Meier Estimate ,Kidney Failure ,Chronic ,Kidney Transplantation ,Male ,Middle Aged ,Proportional Hazards Models ,Renal Insufficiency ,Chronic ,Renal Replacement Therapy ,Risk Assessment ,Risk Factors ,United States ,CRIC Study Investigators ,CKD progression ,Chronic kidney disease ,biomarker ,dialysis ,disease trajectory ,end-stage renal disease ,fibroblast growth factor 23 ,kidney failure ,kidney function decline ,renal replacement therapy ,transplant ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
Rationale & objectiveStudies using a single measurement of fibroblast growth factor 23 (FGF-23) suggest that elevated FGF-23 levels are associated with increased risk for requirement for kidney replacement therapy (KRT) in patients with chronic kidney disease. However, the data do not account for changes in FGF-23 levels as kidney disease progresses.Study designCase-cohort study.Setting & participantsTo evaluate the association between serial FGF-23 levels and risk for requiring KRT, our primary analysis included 1,597 individuals in the Chronic Renal Insufficiency Cohort Study who had up to 5 annual measurements of carboxy-terminal FGF-23. There were 1,135 randomly selected individuals, of whom 266 initiated KRT, and 462 individuals who initiated KRT outside the random subcohort.ExposureSerial FGF-23 measurements and FGF-23 trajectory group membership.OutcomesIncident KRT.Analytical approachTo handle time-dependent confounding, our primary analysis of time-updated FGF-23 levels used time-varying inverse probability weighting in a discrete time failure model. To compare our results with prior data, we used baseline and time-updated FGF-23 values in weighted Cox regression models. To examine the association of FGF-23 trajectory subgroups with risk for incident KRT, we used weighted Cox models with FGF-23 trajectory groups derived from group-based trajectory modeling as the exposure.ResultsIn our primary analysis, the HR for the KRT outcome per 1 SD increase in the mean of natural log-transformed (ln)FGF-23 in the past was 1.94 (95% CI, 1.51-2.49). In weighted Cox models using baseline and time-updated values, elevated FGF-23 level was associated with increased risk for incident KRT (HRs per 1 SD ln[FGF-23] of 1.18 [95% CI, 1.02-1.37] for baseline and 1.66 [95% CI, 1.49-1.86] for time-updated). Membership in the slowly and rapidly increasing FGF-23 trajectory groups was associated with ∼3- and ∼21-fold higher risk for incident KRT compared to membership in the stable FGF-23 trajectory group.LimitationsResidual confounding and lack of intact FGF-23 values.ConclusionsIncreasing FGF-23 levels are independently associated with increased risk for incident KRT.
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- 2020
13. Race and Mortality in CKD and Dialysis: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
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Ku, Elaine, Yang, Wei, McCulloch, Charles E, Feldman, Harold I, Go, Alan S, Lash, James, Bansal, Nisha, He, Jiang, Horwitz, Ed, Ricardo, Ana C, Shafi, Tariq, Sondheimer, James, Townsend, Raymond R, Waikar, Sushrut S, Hsu, Chi-yuan, Investigators, CRIC Study, Appel, Lawrence J, Kusek, John W, Rao, Panduranga S, and Rahman, Mahboob
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Kidney Disease ,Prevention ,Renal and urogenital ,Good Health and Well Being ,Disease Progression ,Female ,Follow-Up Studies ,Humans ,Male ,Middle Aged ,Prognosis ,Racial Groups ,Renal Dialysis ,Renal Insufficiency ,Chronic ,Retrospective Studies ,Risk Assessment ,Risk Factors ,Survival Rate ,United States ,CRIC Study Investigators ,Chronic Renal Insufficiency Cohort ,Mortality ,cardiovascular disease ,chronic kidney disease ,comorbid conditions ,dialysis ,end-stage renal disease ,non–dialysis-dependent CKD ,race ,racial disparities ,survival analysis ,survival paradox ,transition to dialysis ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
Rationale & objectivesFew studies have investigated racial disparities in survival among dialysis patients in a manner that considers risk factors and mortality during the phase of kidney disease before maintenance dialysis. Our objective was to explore racial variations in survival among dialysis patients and relate them to racial differences in comorbid conditions and rates of death in the setting of kidney disease not yet requiring dialysis therapy.Study designRetrospective cohort study.Settings & participants3,288 black and white participants in the Chronic Renal Insufficiency Cohort (CRIC), none of whom were receiving dialysis at enrollment.ExposureRace.OutcomeMortality.Analytic approachCox proportional hazards regression was used to examine the association between race and mortality starting at: (1) time of dialysis initiation and (2) entry into the CRIC.ResultsDuring 7.1 years of median follow-up, 678 CRIC participants started dialysis. Starting from the time of dialysis initiation, blacks had lower risk for death (unadjusted HR, 0.67; 95% CI, 0.51-0.87) compared with whites. Starting from baseline CRIC enrollment, the strength of the association between some risk factors and dialysis was notably stronger for whites than blacks. For example, the HR for dialysis onset in the presence (vs absence) of heart failure at CRIC enrollment was 1.30 (95% CI, 1.01-1.68) for blacks versus 2.78 (95% CI, 1.90-4.50) for whites, suggesting differential severity of these risk factors by race. When we included deaths occurring both before and after dialysis, risk for death was higher among blacks (vs whites) starting from CRIC enrollment (HR, 1.41; 95% CI, 1.22-1.64), but this finding was attenuated in adjusted models (HR, 1.08; 95% CI, 0.91-1.28).LimitationsResidual confounding.ConclusionsThe apparent survival advantage among blacks over whites treated with dialysis may be attributed to selected transition of a subset of whites with more severe comorbid conditions onto dialysis.
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- 2020
14. Serum Calcification Propensity and Coronary Artery Calcification Among Patients With CKD: The CRIC (Chronic Renal Insufficiency Cohort) Study
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Bundy, Joshua D, Cai, Xuan, Scialla, Julia J, Dobre, Mirela A, Chen, Jing, Hsu, Chi-yuan, Leonard, Mary B, Go, Alan S, Rao, Panduranga S, Lash, James P, Townsend, Raymond R, Feldman, Harold I, de Boer, Ian H, Block, Geoffrey A, Wolf, Myles, Smith, Edward R, Pasch, Andreas, Isakova, Tamara, Investigators, CRIC Study, Appel, Lawrence J, He, Jiang, and Rahman, Mahboob
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Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Clinical Research ,Kidney Disease ,Atherosclerosis ,Heart Disease ,Cardiovascular ,Prevention ,Heart Disease - Coronary Heart Disease ,Renal and urogenital ,Good Health and Well Being ,Age Factors ,Aged ,Cohort Studies ,Comorbidity ,Coronary Artery Disease ,Disease Progression ,Female ,Follow-Up Studies ,Glomerular Filtration Rate ,Humans ,Incidence ,Male ,Middle Aged ,Propensity Score ,Prospective Studies ,Renal Insufficiency ,Chronic ,Sex Factors ,Survival Analysis ,Vascular Calcification ,CRIC Study Investigators ,Coronary artery disease ,calcification propensity ,calciprotein particles ,cardiovascular disease ,chronic kidney disease ,coronary artery calcium ,epidemiology ,risk factors ,transformation time (T(50)) ,Clinical Sciences ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
RATIONALE & OBJECTIVE:Coronary artery calcification (CAC) is prevalent among patients with chronic kidney disease (CKD) and increases risks for cardiovascular disease events and mortality. We hypothesized that a novel serum measure of calcification propensity is associated with CAC among patients with CKD stages 2 to 4. STUDY DESIGN:Prospective cohort study. SETTING & PARTICIPANTS:Participants from the Chronic Renal Insufficiency Cohort (CRIC) Study with baseline (n=1,274) and follow-up (n=780) CAC measurements. PREDICTORS:Calcification propensity, quantified as transformation time (T50) from primary to secondary calciprotein particles, with lower T50 corresponding to higher calcification propensity. Covariates included age, sex, race/ethnicity, clinical site, estimated glomerular filtration rate, proteinuria, diabetes, systolic blood pressure, number of antihypertensive medications, current smoking, history of cardiovascular disease, total cholesterol level, and use of statin medications. OUTCOMES:CAC prevalence, severity, incidence, and progression. ANALYTICAL APPROACH:Multivariable-adjusted generalized linear models. RESULTS:At baseline, 824 (65%) participants had prevalent CAC. After multivariable adjustment, T50 was not associated with CAC prevalence but was significantly associated with greater CAC severity among participants with prevalent CAC: 1-SD lower T50 was associated with 21% (95% CI, 6%-38%) greater CAC severity. Among 780 participants followed up an average of 3 years later, 65 (20%) without baseline CAC developed incident CAC, while 89 (19%) with baseline CAC had progression, defined as annual increase≥100 Agatston units. After multivariable adjustment, T50 was not associated with incident CAC but was significantly associated with CAC progression: 1-SD lower T50 was associated with 28% (95% CI, 7%-53%) higher risk for CAC progression. LIMITATIONS:Potential selection bias in follow-up analyses; inability to distinguish intimal from medial calcification. CONCLUSIONS:Among patients with CKD stages 2 to 4, higher serum calcification propensity is associated with more severe CAC and CAC progression.
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- 2019
15. Use of Measures of Inflammation and Kidney Function for Prediction of Atherosclerotic Vascular Disease Events and Death in Patients With CKD: Findings From the CRIC Study
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Amdur, Richard L, Feldman, Harold I, Dominic, Elizabeth A, Anderson, Amanda H, Beddhu, Srinivasan, Rahman, Mahboob, Wolf, Myles, Reilly, Muredach, Ojo, Akinlolu, Townsend, Raymond R, Go, Alan S, He, Jiang, Xie, Dawei, Thompson, Sally, Budoff, Matthew, Kasner, Scott, Kimmel, Paul L, Kusek, John W, Raj, Dominic S, Investigators, CRIC Study, Fink, Jeffrey, Appel, Lawrence J, and Lash, James P
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Biomedical and Clinical Sciences ,Clinical Sciences ,Prevention ,Kidney Disease ,Cardiovascular ,Clinical Research ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Renal and urogenital ,Good Health and Well Being ,Adult ,Aged ,Atherosclerosis ,Biomarkers ,Cohort Studies ,Female ,Humans ,Inflammation ,Kidney Function Tests ,Male ,Middle Aged ,Predictive Value of Tests ,Renal Insufficiency ,Chronic ,Young Adult ,CRIC Study Investigators ,C-reactive protein ,Myocardial infarction ,Pooled Cohort Equation probability ,albuminuria ,atherosclerosis ,atherosclerotic vascular disease ,cardiovascular disease ,chronic kidney function ,cytokines ,estimated glomerular filtration rate ,inflammatory biomarkers ,kidney function ,risk stratification ,stroke ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
RATIONALE & OBJECTIVE:Traditional risk estimates for atherosclerotic vascular disease (ASVD) and death may not perform optimally in the setting of chronic kidney disease (CKD). We sought to determine whether the addition of measures of inflammation and kidney function to traditional estimation tools improves prediction of these events in a diverse cohort of patients with CKD. STUDY DESIGN:Observational cohort study. SETTING & PARTICIPANTS:2,399 Chronic Renal Insufficiency Cohort (CRIC) Study participants without a history of cardiovascular disease at study entry. PREDICTORS:Baseline plasma levels of biomarkers of inflammation (interleukin 1β [IL-1β], IL-1 receptor antagonist, IL-6, tumor necrosis factor α [TNF-α], transforming growth factor β, high-sensitivity C-reactive protein, fibrinogen, and serum albumin), measures of kidney function (estimated glomerular filtration rate [eGFR] and albuminuria), and the Pooled Cohort Equation probability (PCEP) estimate. OUTCOMES:Composite of ASVD events (incident myocardial infarction, peripheral arterial disease, and stroke) and death. ANALYTICAL APPROACH:Cox proportional hazard models adjusted for PCEP estimates, albuminuria, and eGFR. RESULTS:During a median follow-up of 7.3 years, 86, 61, 48, and 323 participants experienced myocardial infarction, peripheral arterial disease, stroke, or death, respectively. The 1-decile greater levels of IL-6 (adjusted HR [aHR], 1.12; 95% CI, 1.08-1.16; P
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- 2019
16. Cognitive Impairment in Non–Dialysis-Dependent CKD and the Transition to Dialysis: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
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Harhay, Meera N, Xie, Dawei, Zhang, Xiaoming, Hsu, Chi-yuan, Vittinghoff, Eric, Go, Alan S, Sozio, Stephen M, Blumenthal, Jacob, Seliger, Stephen, Chen, Jing, Deo, Rajat, Dobre, Mirela, Akkina, Sanjeev, Reese, Peter P, Lash, James P, Yaffe, Kristine, Tamura, Manjula Kurella, Investigators, CRIC Study, Appel, Lawrence J, Feldman, Harold I, He, Jiang, Kusek, John W, Rao, Panduranga, and Rahman, Mahboob
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Clinical Research ,Kidney Disease ,Brain Disorders ,Renal and urogenital ,Good Health and Well Being ,Adult ,Age Factors ,Aged ,Cognitive Behavioral Therapy ,Cognitive Dysfunction ,Cohort Studies ,Disease Progression ,Female ,Humans ,Incidence ,Kidney Failure ,Chronic ,Logistic Models ,Male ,Middle Aged ,Multivariate Analysis ,Neuropsychological Tests ,Predictive Value of Tests ,Prognosis ,Renal Dialysis ,Renal Insufficiency ,Chronic ,Retrospective Studies ,Risk Assessment ,Severity of Illness Index ,Sex Factors ,Transitional Care ,Treatment Outcome ,CRIC Study Investigators ,CKD to ESRD transition ,Chronic kidney diseases ,central venous catheter ,cognitive impairment ,dementia ,dialysis access ,dialysis modality ,end-stage renal disease ,executive function ,incident ESRD ,memory ,peritoneal dialysis ,transplant waitlisting ,Clinical Sciences ,Public Health and Health Services ,Urology & Nephrology - Abstract
BACKGROUND:Advanced chronic kidney disease is associated with elevated risk for cognitive impairment. However, it is not known whether and how cognitive impairment is associated with planning and preparation for end-stage renal disease. STUDY DESIGN:Retrospective observational study. SETTING & PARTICIPANTS:630 adults participating in the CRIC (Chronic Renal Insufficiency Cohort) Study who had cognitive assessments in late-stage CKD, defined as estimated glome-rular filtration rate ≤ 20mL/min/1.73m2, and subsequently initiated maintenance dialysis therapy. PREDICTOR:Predialysis cognitive impairment, defined as a score on the Modified Mini-Mental State Examination lower than previously derived age-based threshold scores. Covariates included age, race/ethnicity, educational attainment, comorbid conditions, and health literacy. OUTCOMES:Peritoneal dialysis (PD) as first dialysis modality, preemptive permanent access placement, venous catheter avoidance at dialysis therapy initiation, and preemptive wait-listing for a kidney transplant. MEASUREMENTS:Multivariable-adjusted logistic regression. RESULTS:Predialysis cognitive impairment was present in 117 (19%) participants. PD was the first dialysis modality among 16% of participants (n=100), 75% had preemptive access placed (n=473), 45% avoided using a venous catheter at dialysis therapy initiation (n=279), and 20% were preemptively wait-listed (n=126). Predialysis cognitive impairment was independently associated with 78% lower odds of PD as the first dialysis modality (adjusted OR [aOR], 0.22; 95% CI, 0.06-0.74; P=0.02) and 42% lower odds of venous catheter avoidance at dialysis therapy initiation (aOR, 0.58; 95% CI, 0.34-0.98; P=0.04). Predialysis cognitive impairment was not independently associated with preemptive permanent access placement or wait-listing. LIMITATIONS:Potential unmeasured confounders; single measure of cognitive function. CONCLUSIONS:Predialysis cognitive impairment is associated with a lower likelihood of PD as a first dialysis modality and of venous catheter avoidance at dialysis therapy initiation. Future studies may consider addressing cognitive function when testing strategies to improve patient transitions to dialysis therapy.
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- 2018
17. Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD
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Appel, Lawrence J., Feldman, Harold I., Lash, James P., Nelson, Robert G., Rao, Panduranga S., Rahman, Mahboob, Shah, Vallabh O., Townsend, Raymond R., Unruh, Mark L., Bansal, Nisha, Zelnick, Leila R., Ballantyne, Christie M., Chaves, Paulo H.M., Christenson, Robert H., Coresh, Josef, deFilippi, Christopher R., de Lemos, James A., Daniels, Lori B., Go, Alan S., He, Jiang, Hedayati, S. Susan, Matsushita, Kunihiro, Nambi, Vijay, Shlipak, Michael G., Taliercio, Jonathan J., and Seliger, Stephen L.
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- 2022
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18. Evolution of Echocardiographic Measures of Cardiac Disease From CKD to ESRD and Risk of All-Cause Mortality: Findings From the CRIC Study
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Bansal, Nisha, Roy, Jason, Chen, Hsiang-Yu, Deo, Rajat, Dobre, Mirela, Fischer, Michael J, Foster, Elyse, Go, Alan S, He, Jiang, Keane, Martin G, Kusek, John W, Mohler, Emile, Navaneethan, Sankar D, Rahman, Mahboob, Hsu, Chi-yuan, Investigators, CRIC Study, Appel, Lawrence J, Feldman, Harold I, Lash, James P, Ojo, Akinlolu, and Townsend, Raymond R
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Biomedical and Clinical Sciences ,Clinical Sciences ,Prevention ,Clinical Research ,Kidney Disease ,Cardiovascular ,Renal and urogenital ,Good Health and Well Being ,Aged ,Cohort Studies ,Disease Progression ,Echocardiography ,Female ,Heart Diseases ,Humans ,Kidney Failure ,Chronic ,Longitudinal Studies ,Male ,Middle Aged ,Mortality ,Prospective Studies ,Renal Insufficiency ,Chronic ,Risk Factors ,CRIC Study Investigators ,CKD to ESRD transition ,Kidney ,all-cause mortality ,cardiac disease ,cardiovascular disease ,dialysis ,dialysis initiation ,diastolic relaxation ,echocardiogram ,end-stage renal disease ,heart failure ,left atrial volume ,left ventricular ejection fraction ,left ventricular end-diastolic volume ,left ventricular end-systolic volume ,left ventricular mass index ,subclinical CVD ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
Rationale & objectiveAbnormal cardiac structure and function are common in chronic kidney disease (CKD) and end-stage renal disease (ESRD) and linked with mortality and heart failure. We examined changes in echocardiographic measures during the transition from CKD to ESRD and their associations with post-ESRD mortality.Study designProspective study.Setting & participantsWe studied 417 participants with CKD in the Chronic Renal Insufficiency Cohort (CRIC) who had research echocardiograms during CKD and ESRD.PredictorWe measured change in left ventricular mass index, left ventricular ejection fraction (LVEF), diastolic relaxation (normal, mildly abnormal, and moderately/severely abnormal), left ventricular end-systolic (LVESV), end-diastolic (LVEDV) volume, and left atrial volume from CKD to ESRD.OutcomesAll-cause mortality after dialysis therapy initiation.Analytical approachCox proportional hazard models were used to test the association of change in each echocardiographic measure with postdialysis mortality.ResultsOver a mean of 2.9 years between pre- and postdialysis echocardiograms, there was worsening of mean LVEF (52.5% to 48.6%; P
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- 2018
19. Longitudinal Weight Change During CKD Progression and Its Association With Subsequent Mortality
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Ku, Elaine, Kopple, Joel D, Johansen, Kirsten L, McCulloch, Charles E, Go, Alan S, Xie, Dawei, Lin, Feng, Hamm, L Lee, He, Jiang, Kusek, John W, Navaneethan, Sankar D, Ricardo, Ana C, Rincon-Choles, Hernan, Smogorzewski, Miroslaw, Hsu, Chi-yuan, Investigators, CRIC Study, Appel, Lawrence J, Feldman, Harold I, Lash, James P, Ojo, Akinlolu, Rahman, Mahboob, and Townsend, Raymond R
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Kidney Disease ,Prevention ,Renal and urogenital ,Good Health and Well Being ,Adult ,Aged ,Body Mass Index ,Body Weight ,Cause of Death ,Cohort Studies ,Disease Progression ,Female ,Follow-Up Studies ,Humans ,Kidney Failure ,Chronic ,Longitudinal Studies ,Male ,Middle Aged ,Proportional Hazards Models ,Prospective Studies ,Renal Dialysis ,Renal Insufficiency ,Chronic ,Risk Assessment ,Survival Rate ,Weight Loss ,CRIC Study Investigators ,CKD progression ,Weight ,body mass index ,chronic kidney disease ,dialysis initiation ,end-stage renal disease ,mortality ,nutrition ,risk of death ,weight change ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundFew studies have investigated the changes in weight that may occur over time among adults with the progression of chronic kidney disease (CKD). Whether such weight changes are independently associated with death after the onset of end-stage renal disease has also not been rigorously examined.Study designProspective cohort study.Setting & participantsWe studied 3,933 participants of the Chronic Renal Insufficiency Cohort (CRIC) Study, a longitudinal cohort of patients with CKD. We also performed similar analyses among 1,067 participants of the African American Study of Kidney Disease and Hypertension (AASK).PredictorsEstimated glomerular filtration rate (eGFR) and weight change during CKD.OutcomeWeight and all-cause mortality after dialysis therapy initiation.ResultsDuring a median follow-up of 5.7 years in CRIC, weight change was not linear. Weight was stable until cystatin C-based eGFR (eGFRcys) decreased to 5% annualized weight loss after eGFR decreased to
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- 2018
20. Metabolites Associated With Uremic Symptoms in Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
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Wulczyn, Kendra E., primary, Shafi, Tariq, additional, Anderson, Amanda, additional, Rincon-Choles, Hernan, additional, Clish, Clary B., additional, Denburg, Michelle, additional, Feldman, Harold I., additional, He, Jiang, additional, Hsu, Chi-yuan, additional, Kelly, Tanika, additional, Kimmel, Paul L., additional, Mehta, Rupal, additional, Nelson, Robert G., additional, Ramachandran, Vasan, additional, Ricardo, Ana, additional, Shah, Vallabh O., additional, Srivastava, Anand, additional, Xie, Dawei, additional, Rhee, Eugene P., additional, Kalim, Sahir, additional, Dember, Laura M., additional, Landis, J. Richard, additional, Townsend, Raymond R., additional, Appel, Lawrence, additional, Fink, Jeffrey, additional, Rahman, Mahboob, additional, Horwitz, Edward J., additional, Taliercio, Jonathan J., additional, Rao, Panduranga, additional, Sondheimer, James H., additional, Lash, James P., additional, Chen, Jing, additional, Go, Alan S., additional, Parsa, Afshin, additional, and Rankin, Tracy, additional
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- 2024
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21. Risks of Adverse Events in Advanced CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study
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Grams, Morgan E, Yang, Wei, Rebholz, Casey M, Wang, Xue, Porter, Anna C, Inker, Lesley A, Horwitz, Edward, Sondheimer, James H, Hamm, L Lee, He, Jiang, Weir, Matthew R, Jaar, Bernard G, Shafi, Tariq, Appel, Lawrence J, Hsu, Chi-yuan, Investigators, CRIC Study, Feldman, Harold I, Go, Alan S, Kusek, John W, Lash, James P, Ojo, Akinlolu, Rahman, Mahboob, and Townsend, Raymond R
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Clinical Research ,Patient Safety ,Heart Disease ,Kidney Disease ,Cardiovascular ,Prevention ,Aging ,Renal and urogenital ,Good Health and Well Being ,Adult ,Cardiovascular Diseases ,Clinical Decision-Making ,Cohort Studies ,Disease Progression ,Female ,Glomerular Filtration Rate ,Humans ,Kidney Failure ,Chronic ,Male ,Middle Aged ,Patient-Centered Care ,Prognosis ,Prospective Studies ,Renal Insufficiency ,Chronic ,Risk Assessment ,Risk Factors ,United States ,Chronic kidney disease ,CKD progression ,disease trajectory ,end-stage renal disease ,cardiovascular disease ,mortality ,pre-ESRD death ,incident ESRD ,adverse event ,advanced CKD ,risk factor ,prognosis ,kidney function decline ,CRIC ,CRIC Study Investigators ,Clinical Sciences ,Public Health and Health Services ,Urology & Nephrology - Abstract
BackgroundPeople with advanced chronic kidney disease are at risk for the development of end-stage renal disease (ESRD), but also many other adverse outcomes, including cardiovascular disease (CVD) events and death. Determination of risk factors that explain the variability in prognosis and timing of these adverse outcomes can aid patient counseling and medical decision making.Study designProspective research cohort.Setting & participants1,798 participants with estimated glomerular filtration rates (eGFRs)
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- 2017
22. Abrupt Decline in Kidney Function Before Initiating Hemodialysis and All-Cause Mortality: The Chronic Renal Insufficiency Cohort (CRIC) Study
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Hsu, Raymond K, Chai, Boyang, Roy, Jason A, Anderson, Amanda H, Bansal, Nisha, Feldman, Harold I, Go, Alan S, He, Jiang, Horwitz, Edward J, Kusek, John W, Lash, James P, Ojo, Akinlolu, Sondheimer, James H, Townsend, Raymond R, Zhan, Min, Hsu, Chi-yuan, and Investigators, CRIC Study
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Bioengineering ,Kidney Disease ,Assistive Technology ,Renal and urogenital ,Good Health and Well Being ,Cause of Death ,Cohort Studies ,Disease Progression ,Female ,Humans ,Kidney Failure ,Chronic ,Male ,Middle Aged ,Renal Dialysis ,Renal Insufficiency ,Chronic ,Time Factors ,Kidney function ,disease trajectory ,estimated glomerular filtration rate ,eGFR decline ,hemodialysis ,mortality ,end-stage renal disease ,transition to ESRD ,renal replacement therapy (RRT) initiation ,Chronic Renal Insufficiency Cohort ,CRIC Study Investigators ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundIt is not clear whether the pattern of kidney function decline in patients with chronic kidney disease (CKD) may relate to outcomes after reaching end-stage renal disease (ESRD). We hypothesize that an abrupt decline in kidney function prior to ESRD predicts early death after initiating maintenance hemodialysis therapy.Study designProspective cohort study.Setting & participantsThe Chronic Renal Insufficiency Cohort (CRIC) Study enrolled men and women with mild to moderate CKD. For this study, we studied 661 individuals who developed chronic kidney failure that required hemodialysis therapy initiation.PredictorsThe primary predictor was the presence of an abrupt decline in kidney function prior to ESRD. We incorporated annual estimated glomerular filtration rates (eGFRs) into a mixed-effects model to estimate patient-specific eGFRs at 3 months prior to initiation of hemodialysis therapy. Abrupt decline was defined as having an extrapolated eGFR≥30mL/min/1.73m(2) at that time point.OutcomesAll-cause mortality within 1 year after initiating hemodialysis therapy.MeasurementsMultivariable Cox proportional hazards.ResultsAmong 661 patients with CKD initiating hemodialysis therapy, 56 (8.5%) had an abrupt predialysis decline in kidney function and 69 died within 1 year after initiating hemodialysis therapy. After adjustment for demographics, cardiovascular disease, diabetes, and cancer, abrupt decline in kidney function was associated with a 3-fold higher risk for death within the first year of ESRD (adjusted HR, 3.09; 95% CI, 1.65-5.76).LimitationsRelatively small number of outcomes; infrequent (yearly) eGFR determinations; lack of more granular clinical data.ConclusionsAbrupt decline in kidney function prior to ESRD occurred in a significant minority of incident hemodialysis patients and predicted early death in ESRD.
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- 2016
23. Serum β-Trace Protein and β2-Microglobulin as Predictors of ESRD, Mortality, and Cardiovascular Disease in Adults With CKD in the Chronic Renal Insufficiency Cohort (CRIC) Study
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Foster, Meredith C, Coresh, Josef, Hsu, Chi-yuan, Xie, Dawei, Levey, Andrew S, Nelson, Robert G, Eckfeldt, John H, Vasan, Ramachandran S, Kimmel, Paul L, Schelling, Jeffrey, Simonson, Michael, Sondheimer, James H, Anderson, Amanda Hyre, Akkina, Sanjeev, Feldman, Harold I, Kusek, John W, Ojo, Akinlolu O, Inker, Lesley A, Investigators, CKD Biomarker Consortium and the CRIC Study, Appel, Lawrence J, Go, Alan S, He, Jiang, Lash, James P, Rahman, Mahboob, and Townsend, Raymond R
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Biomedical and Clinical Sciences ,Clinical Sciences ,Prevention ,Clinical Research ,Kidney Disease ,Cardiovascular ,Renal and urogenital ,Good Health and Well Being ,Biomarkers ,Cardiovascular Diseases ,Cohort Studies ,Female ,Humans ,Intramolecular Oxidoreductases ,Kidney Failure ,Chronic ,Lipocalins ,Male ,Middle Aged ,Predictive Value of Tests ,Prospective Studies ,Renal Insufficiency ,Chronic ,beta 2-Microglobulin ,Beta-trace protein ,beta(2)-microglobulin ,CKD Biomarkers Consortium ,filtration markers ,renal function ,estimated glomerular filtration rate ,chronic kidney disease ,end-stage renal disease ,mortality ,cardiovascular events ,Chronic Renal Insufficiency Cohort ,CKD Biomarker Consortium and the CRIC Study Investigators ,β(2)-microglobulin ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundSerum β-trace protein (BTP) and β2-microglobulin (B2M) are independently associated with end-stage renal disease (ESRD) and mortality in the general population and high-risk groups with diabetes or advanced chronic kidney disease (CKD). Less is known about their associations with outcomes and predictive ability in adults with moderate CKD.Study designProspective cohort study.Setting & participants3,613 adults from the CRIC (Chronic Renal Insufficiency Cohort) Study (45% women; mean age, 57.9 years; 41.0% non-Hispanic black; 51.9% with diabetes).PredictorsBTP and B2M levels with a reciprocal transformation to reflect their associations with filtration, creatinine-based estimated glomerular filtration rate (eGFRcr), measured GFR, and a 4-marker composite score combining BTP, B2M, creatinine, and cystatin C levels. Predictors were standardized as z scores for comparisons across filtration markers.OutcomesESRD, all-cause mortality, and new-onset cardiovascular disease.ResultsDuring a 6-year median follow-up, 755 (21%) participants developed ESRD, 653 died, and 292 developed new-onset cardiovascular disease. BTP, B2M, and the 4-marker composite score were independent predictors of ESRD and all-cause mortality, and B2M and the 4-marker composite score of cardiovascular events, after multivariable adjustment. These associations were stronger than those observed for eGFRcr (P vs eGFRcr≤0.02). The 4-marker composite score led to improvements in C statistic and 2.5-year risk reclassification beyond eGFRcr for all outcomes.LimitationsFiltration markers measured at one time point; measured GFR available in subset of cohort.ConclusionsBTP and B2M levels may contribute additional risk information beyond eGFRcr, and the use of multiple markers may improve risk prediction beyond this well-established marker of kidney function among persons with moderate CKD.
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- 2016
24. Cognitive Impairment and Progression of CKD
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Tamura, Manjula Kurella, Yaffe, Kristine, Hsu, Chi-yuan, Yang, Jingrong, Sozio, Stephen, Fischer, Michael, Chen, Jing, Ojo, Akinlolu, DeLuca, Jennifer, Xie, Dawei, Vittinghoff, Eric, Go, Alan S, Investigators, Chronic Renal Insufficiency Cohort Study, Appel, Lawrence J, Feldman, Harold I, He, Jiang, Kusek, John W, Lash, James P, Rahman, Mahboob, and Townsend, Raymond R
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Biomedical and Clinical Sciences ,Clinical Sciences ,Kidney Disease ,Clinical Research ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Renal and urogenital ,Good Health and Well Being ,Adult ,Aged ,Cognitive Dysfunction ,Disease Progression ,Female ,Humans ,Kidney Failure ,Chronic ,Male ,Middle Aged ,Prospective Studies ,Renal Insufficiency ,Chronic ,Young Adult ,Cognitive impairment ,impaired cognitive function ,chronic kidney disease ,microvascular disease ,Modified Mini-Mental State Exam ,cognitive function testing ,concentration ,attention ,memory ,disease progression ,end-stage renal disease ,renal function ,CRIC ,Chronic Renal Insufficiency Cohort (CRIC) Study Investigators ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundCognitive impairment is common among patients with chronic kidney disease (CKD); however, its prognostic significance is unclear. We assessed the independent association between cognitive impairment and CKD progression in adults with mild to moderate CKD.Study designProspective cohort.Setting & participantsAdults with CKD participating in the CRIC (Chronic Renal Insufficiency Cohort) Study. Mean age of the sample was 57.7±11.0 years and mean estimated glomerular filtration rate (eGFR) was 45.0±16.9mL/min/1.73m(2).PredictorCognitive function was assessed with the Modified Mini-Mental State Examination at study entry. A subset of participants 55 years and older underwent 5 additional cognitive tests assessing different domains. Cognitive impairment was defined as a score > 1 SD below the mean score on each test. Covariates included demographics, kidney function, comorbid conditions, and medications.OutcomesIncident end-stage renal disease (ESRD) and incident ESRD or 50% decline in baseline eGFR.ResultsIn 3,883 CRIC participants, 524 (13.5%) had cognitive impairment at baseline. During a median 6.1 years of follow-up, 813 developed ESRD and 1,062 developed ESRD or a ≥50% reduction in eGFR. There was no significant association between cognitive impairment and risk for ESRD (HR, 1.07; 95% CI, 0.87-1.30) or the composite of ESRD or 50% reduction in eGFR (HR, 1.06; 95% CI, 0.89-1.27). Similarly, there was no association between cognitive impairment and the joint outcome of death, ESRD, or 50% reduction in eGFR (HR, 1.06; 95% CI, 0.91-1.23). Among CRIC participants who underwent additional cognitive testing, we found no consistent association between impairment in specific cognitive domains and risk for CKD progression in adjusted analyses.LimitationsUnmeasured potential confounders, single measure of cognition for younger participants.ConclusionsAmong adults with CKD, cognitive impairment is not associated with excess risk for CKD progression after accounting for traditional risk factors.
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- 2016
25. Serum Fractalkine (CX3CL1) and Cardiovascular Outcomes and Diabetes: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
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Shah, Rachana, Matthews, Gregory J, Shah, Rhia Y, McLaughlin, Catherine, Chen, Jing, Wolman, Melanie, Master, Stephen R, Chai, Boyang, Xie, Dawei, Rader, Daniel J, Raj, Dominic S, Mehta, Nehal N, Budoff, Matthew, Fischer, Michael J, Go, Alan S, Townsend, Raymond R, He, Jiang, Kusek, John W, Feldman, Harold I, Foulkes, Andrea S, Reilly, Muredach P, Investigators, CRIC Study, Appel, Lawrence J, Lash, James P, Ojo, Akinlolu, and Rahman, Mahboob
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Biomedical and Clinical Sciences ,Clinical Sciences ,Kidney Disease ,Clinical Research ,Atherosclerosis ,Prevention ,Diabetes ,Aging ,Heart Disease ,Cardiovascular ,Renal and urogenital ,Metabolic and endocrine ,Good Health and Well Being ,Aged ,Cardiovascular Diseases ,Chemokine CX3CL1 ,Cohort Studies ,Cross-Sectional Studies ,Diabetes Mellitus ,Female ,Humans ,Logistic Models ,Longitudinal Studies ,Male ,Metabolic Syndrome ,Middle Aged ,Mortality ,Myocardial Infarction ,Prognosis ,Proportional Hazards Models ,Prospective Studies ,Renal Insufficiency ,Chronic ,Risk Factors ,CRIC Study Investigators ,Cardiometabolic disease ,Chronic Renal Insufficiency Cohort ,atherosclerosis ,cardiovascular disease ,chronic kidney disease ,diabetes ,fractalkine ,metabolic syndrome ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundCardiometabolic disease is a major cause of morbidity and mortality in persons with chronic kidney disease (CKD). Fractalkine (CX3CL1) is a potential mediator of both atherosclerosis and metabolic disease. Studies of the relationship of CX3CL1 with risk of cardiovascular disease (CVD) events and metabolic traits are lacking, particularly in the high-risk setting of CKD.Study designCross-sectional and longitudinal observational analysis.Setting & participantsAdults with CKD from 7 US sites participating in the Chronic Renal Insufficiency Cohort (CRIC) Study.PredictorQuartiles of plasma CX3CL1 levels at baseline.OutcomesBaseline estimated glomerular filtration rate from a creatinine and cystatin C-based equation, prevalent and incident CVD, diabetes, metabolic syndrome and its criteria, homeostatic model assessment of insulin resistance, hemoglobin A1c level, myocardial infarction, all-cause mortality, and the composite outcome of myocardial infarction/all-cause mortality.ResultsAmong 3,687 participants, baseline CX3CL1 levels were associated positively with several CVD risk factors and metabolic traits, lower estimated glomerular filtration rate, and higher levels of inflammatory cytokines, as well as prevalent CVD (OR, 1.09; 95% CI, 1.01-1.19; P=0.03). Higher CX3CL1 level also was associated with prevalent diabetes (OR, 1.26; 95% CI, 1.16-1.38; P
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- 2015
26. Urine Neutrophil Gelatinase-Associated Lipocalin and Risk of Cardiovascular Disease and Death in CKD: Results From the Chronic Renal Insufficiency Cohort (CRIC) Study
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Liu, Kathleen D, Yang, Wei, Go, Alan S, Anderson, Amanda H, Feldman, Harold I, Fischer, Michael J, He, Jiang, Kallem, Radhakrishna R, Kusek, John W, Master, Stephen R, Miller, Edgar R, Rosas, Sylvia E, Steigerwalt, Susan, Tao, Kaixiang, Weir, Matthew R, Hsu, Chi-yuan, and Investigators, CRIC Study
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Biomedical and Clinical Sciences ,Clinical Sciences ,Cardiovascular ,Atherosclerosis ,Prevention ,Heart Disease ,Clinical Research ,Kidney Disease ,Renal and urogenital ,Good Health and Well Being ,Acute-Phase Proteins ,Adult ,Aged ,Biomarkers ,Cardiovascular Diseases ,Cohort Studies ,Female ,Follow-Up Studies ,Humans ,Lipocalin-2 ,Lipocalins ,Male ,Middle Aged ,Mortality ,Proto-Oncogene Proteins ,Renal Insufficiency ,Chronic ,Risk Factors ,Neutrophil gelatinase-associated lipocalin ,renal tubular injury ,renal tubular dysfunction ,biomarker ,chronic kidney disease ,Chronic Renal Insufficiency Cohort (CRIC) Study ,cardiovascular disease ,ischemic atherosclerotic event ,CRIC Study Investigators ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundChronic kidney disease is common and is associated with increased cardiovascular disease risk. Currently, markers of renal tubular injury are not used routinely to describe kidney health and little is known about the risk of cardiovascular events and death associated with these biomarkers independent of glomerular filtration-based markers (such as serum creatinine or albuminuria).Study designCohort study, CRIC (Chronic Renal Insufficiency Cohort) Study.Setting & participants3,386 participants with estimated glomerular filtration rate of 20 to 70mL/min/1.73m(2) enrolled from June 2003 through August 2008.PredictorUrine neutrophil gelatinase-associated lipocalin (NGAL) concentration.OutcomesAdjudicated heart failure event, ischemic atherosclerotic event (myocardial infarction, ischemic stroke, or peripheral artery disease), and death through March 2011.MeasurementsUrine NGAL measured at baseline with a 2-step assay using chemiluminescent microparticle immunoassay technology on an ARCHITECT i2000SR (Abbott Laboratories).ResultsThere were 428 heart failure events (during 16,383 person-years of follow-up), 361 ischemic atherosclerotic events (during 16,584 person-years of follow-up), and 522 deaths (during 18,214 person-years of follow-up). In Cox regression models adjusted for estimated glomerular filtration rate, albuminuria, demographics, traditional cardiovascular disease risk factors, and cardiac medications, higher urine NGAL levels remained associated independently with ischemic atherosclerotic events (adjusted HR for the highest [>49.5ng/mL] vs lowest [≤6.9ng/mL] quintile, 1.83 [95% CI, 1.20-2.81]; HR per 0.1-unit increase in log urine NGAL, 1.012 [95% CI, 1.001-1.023]), but not heart failure events or deaths.LimitationsUrine NGAL was measured only once.ConclusionsAmong patients with chronic kidney disease, urine levels of NGAL, a marker of renal tubular injury, were associated independently with future ischemic atherosclerotic events, but not with heart failure events or deaths.
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- 2015
27. Adherence to Plant-Based Diets and Risk of CKD Progression and All-Cause Mortality: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
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Amir, Saira, Kim, Hyunju, Hu, Emily A., Ricardo, Ana C., Mills, Katherine T., He, Jiang, Fischer, Michael J., Pradhan, Nishigandha, Tan, Thida C., Navaneethan, Sankar D., Dobre, Mirela, Anderson, Cheryl A.M., Appel, Lawrence J., Rebholz, Casey M., Chen, Jing, Cohen, Debbie L., Feldman, Harold I., Go, Alan S., Lash, James P., Nelson, Robert G., Rahman, Mahboob, Rao, Panduranga S., Shah, Vallabh O., and Unruh, Mark L.
- Abstract
Studies have shown that generally healthy individuals who consume diets rich in plant foods have a lower risk of incident chronic kidney disease (CKD) and cardiovascular disease. This study investigated the prospective associations of plant-based diets with the risk of CKD progression and all-cause mortality in individuals with CKD.
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- 2024
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28. Association of Cardiac Troponin T With Left Ventricular Structure and Function in CKD
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Mishra, Rakesh K, Li, Yongmei, DeFilippi, Christopher, Fischer, Michael J, Yang, Wei, Keane, Martin, Chen, Jing, He, Jiang, Kallem, Radhakrishna, Horwitz, Edward J, Rafey, Mohammad, Raj, Dominic S, Go, Alan S, Shlipak, Michael G, and Investigators, CRIC Study
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Heart Disease ,Kidney Disease ,Prevention ,Cardiovascular ,Detection ,screening and diagnosis ,4.1 Discovery and preclinical testing of markers and technologies ,Renal and urogenital ,Adult ,Aged ,Cross-Sectional Studies ,Disease Progression ,Echocardiography ,Female ,Follow-Up Studies ,Glomerular Filtration Rate ,Heart Ventricles ,Humans ,Male ,Middle Aged ,Predictive Value of Tests ,Prognosis ,Renal Insufficiency ,Chronic ,Retrospective Studies ,Troponin T ,Ventricular Dysfunction ,Left ,Ventricular Function ,Left ,Young Adult ,left ventricular structure ,chronic kidney disease ,CRIC Study Investigators ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundSerum cardiac troponin T (cTnT) is associated with increased risk of heart failure and cardiovascular death in several population settings. We evaluated associations of cTnT levels with cardiac structural and functional abnormalities in a cohort of patients with chronic kidney disease (CKD) without heart failure.Study designCross-sectional.Setting & participantsChronic Renal Insufficiency Cohort (CRIC; N=3,243).PredictorThe primary predictor was cTnT level. Secondary predictors included demographic and clinical characteristics, hemoglobin level, high-sensitivity C-reactive protein level, and estimated glomerular filtration rate using cystatin C.OutcomesEchocardiography was used to determine left ventricular (LV) mass and LV systolic and diastolic function.MeasurementsCirculating cTnT was measured in stored sera using the highly sensitive assay. Logistic and linear regression models were used to examine associations of cTnT level with each echocardiographic outcome.ResultscTnT was detectable in 2,735 (84%) persons; median level was 13.3 (IQR, 7.7-23.8) pg/mL. Compared with undetectable cTnT (
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- 2013
29. Retinopathy and Cognitive Impairment in Adults With CKD
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Yaffe, Kristine, Ackerson, Lynn, Hoang, Tina D, Go, Alan S, Maguire, Maureen G, Ying, Gui-Shuang, Daniel, Ebenezer, Bazzano, Lydia A, Coleman, Martha, Cohen, Debbie L, Kusek, John W, Ojo, Akinlolu, Seliger, Stephen, Xie, Dawei, Grunwald, Juan E, and Investigators, CRIC Study
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Behavioral and Social Science ,Prevention ,Clinical Research ,Aging ,Brain Disorders ,Kidney Disease ,Eye Disease and Disorders of Vision ,Neurosciences ,Eye ,Aged ,Cognition Disorders ,Cross-Sectional Studies ,Female ,Humans ,Male ,Renal Insufficiency ,Chronic ,Retinal Diseases ,Chronic kidney disease ,cognitive impairment ,retinopathy ,CRIC Study Investigators ,Clinical Sciences ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundRetinal microvascular abnormalities have been associated with cognitive impairment, possibly serving as a marker of cerebral small-vessel disease. This relationship has not been evaluated in persons with chronic kidney disease (CKD), a condition associated with increased risk of both retinal pathology and cognitive impairment.Study designCross-sectional study.Setting & participants588 participants 52 years or older with CKD in the Chronic Renal Insufficiency Cohort (CRIC) Study.PredictorRetinopathy graded using the Early Treatment Diabetic Retinopathy Study severity scale and diameters of retinal vessels.OutcomesNeuropsychological battery of 6 cognitive tests.MeasurementsLogistic regression models were used to evaluate the association of retinopathy, individual retinopathy features, and retinal vessel diameters with cognitive impairment (≤1 SD from the mean), and linear regression models were used to compare cognitive test scores across levels of retinopathy, adjusting for age, race, sex, education, and medical comorbid conditions.ResultsThe mean age of the cohort was 65.3±5.6 (SD) years, 51.9% were nonwhite, and 52.6% were men. The prevalence of retinopathy was 30.1%, and the prevalence of cognitive impairment was 14.3%. Compared with those without retinopathy, participants with retinopathy had an increased likelihood of cognitive impairment on executive function (35.1% vs 11.5%; OR, 3.4 [95% CI, 2.0-6.0]), attention (26.7% vs 7.3%; OR, 3.0 [95% CI, 1.8-4.9]), and naming (26.0% vs 10.0%; OR, 2.1 [95% CI, 1.2-3.4]) after multivariable adjustment. Increased level of retinopathy also was associated with lower cognitive performance on executive function and attention. Microaneurysms were associated with cognitive impairment on some domains, but there were no significant associations with other retinal measures after multivariable adjustment.LimitationsUnknown temporal relationship between retinopathy and impairment.ConclusionsIn adults with CKD, retinopathy is associated with poor performance on several cognitive domains, including executive function and attention. Evaluation of retinal microvascular abnormalities may be a promising tool for identifying patients with CKD who are at increased risk of cognitive impairment.
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- 2013
30. Blood Pressure, Incident Cognitive Impairment, and Severity of CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
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Babroudi, Seda, primary, Tighiouart, Hocine, additional, Schrauben, Sarah J., additional, Cohen, Jordana B., additional, Fischer, Michael J., additional, Rahman, Mahboob, additional, Hsu, Chi-yuan, additional, Sozio, Stephen M., additional, Weir, Matthew, additional, Sarnak, Mark, additional, Yaffe, Kristine, additional, Tamura, Manjula Kurella, additional, Drew, David, additional, Appel, Lawrence J., additional, Chen, Jing, additional, Cohen, Debbie L., additional, Feldman, Harold I., additional, Go, Alan S., additional, Lash, James P., additional, Nelson, Robert G., additional, Rao, Panduranga S., additional, Shah, Vallabh O., additional, and Unruh, Mark L., additional
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- 2023
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31. Ultraprocessed Foods and Kidney Disease Progression, Mortality, and Cardiovascular Disease Risk in the CRIC Study
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Sullivan, Valerie K., primary, Appel, Lawrence J., additional, Anderson, Cheryl A.M., additional, Kim, Hyunju, additional, Unruh, Mark L., additional, Lash, James P., additional, Trego, Marsha, additional, Sondheimer, James, additional, Dobre, Mirela, additional, Pradhan, Nishigandha, additional, Rao, Panduranga S., additional, Chen, Jing, additional, He, Jiang, additional, Rebholz, Casey M., additional, Cohen, Debbie L., additional, Feldman, Harold I., additional, Go, Alan S., additional, Nelson, Robert G., additional, Rahman, Mahboob, additional, and Shah, Vallabh O., additional
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- 2023
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32. Non-GFR Determinants of Low-Molecular-Weight Serum Protein Filtration Markers in CKD
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Appel, Lawrence J., Go, Alan S., He, Jiang, Kusek, John W., Lash, James P., Ojo, Akinlolu, Rahman, Mahboob, Liu, Xun, Foster, Meredith C., Tighiouart, Hocine, Anderson, Amanda H., Beck, Gerald J., Contreras, Gabriel, Coresh, Josef, Eckfeldt, John H., Feldman, Harold I., Greene, Tom, Hamm, L. Lee, Horwitz, Edward, Lewis, Julia, Ricardo, Ana C., Shou, Haochang, Townsend, Raymond R., Weir, Matthew R., Inker, Lesley A., and Levey, Andrew S.
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- 2016
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33. Race/Ethnicity and Cardiovascular Outcomes in Adults With CKD: Findings From the CRIC (Chronic Renal Insufficiency Cohort) and Hispanic CRIC Studies
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Appel, Lawrence J., Feldman, Harold I., Go, Alan S., He, Jiang, Kusek, John W., Lash, James P., Ojo, Akinlolu, Rahman, Mahboob, Townsend, Raymond R., Ricardo, Ana C., Roy, Jason, Deo, Rajat, Fischer, Michael, Flack, John, Keane, Martin, Lora, Claudia, Steigerwalt, Susan, Tao, Kaixiang, Wolf, Myles, and Wright, Jackson T., Jr.
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- 2016
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34. Cardiac Structure and Function and Subsequent Kidney Disease Progression in Adults With CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study
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Ishigami, Junichi, primary, Kansal, Mayank, additional, Mehta, Rupal, additional, Srivastava, Anand, additional, Rahman, Mahboob, additional, Dobre, Mirela, additional, Al-Kindi, Sadeer G, additional, Go, Alan S., additional, Navaneethan, Sankar D., additional, Chen, Jing, additional, He, Jiang, additional, Bhat, Zeenat, additional, Jaar, Bernard G., additional, Appel, Lawrence J, additional, Matsushita, Kunihiro, additional, Cohen, Debbie L, additional, Feldman, Harold I., additional, Lash, James P., additional, Nelson, Robert G., additional, Rao, Panduranga S., additional, Shah, Vallabh O., additional, and Unruh, Mark L., additional
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- 2023
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35. Plasma Soluble Tumor Necrosis Factor Receptor Concentrations and Clinical Events After Hospitalization: Findings From the ASSESS-AKI and ARID Studies
- Author
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Coca, Steven G., primary, Vasquez-Rios, George, additional, Mansour, Sherry G., additional, Moledina, Dennis G., additional, Thiessen-Philbrook, Heather, additional, Wurfel, Mark M., additional, Bhatraju, Pavan, additional, Himmelfarb, Jonathan, additional, Siew, Eddie, additional, Garg, Amit X., additional, Hsu, Chi-yuan, additional, Liu, Kathleen D., additional, Kimmel, Paul L., additional, Chinchilli, Vernon M., additional, Kaufman, James S., additional, Wilson, Michelle, additional, Banks, Rosamonde E., additional, Packington, Rebecca, additional, McCole, Eibhlin, additional, Kurth, Mary Jo, additional, Richardson, Ciaran, additional, Go, Alan S., additional, Selby, Nicholas M., additional, and Parikh, Chirag R., additional
- Published
- 2023
- Full Text
- View/download PDF
36. Cognitive Impairment and Progression of CKD
- Author
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Appel, Lawrence J., Feldman, Harold I., Go, Alan S., He, Jiang, Kusek, John W., Lash, James P., Ojo, Akinlolu, Rahman, Mahboob, Townsend, Raymond R., Kurella Tamura, Manjula, Yaffe, Kristine, Hsu, Chi-yuan, Yang, Jingrong, Sozio, Stephen, Fischer, Michael, Chen, Jing, DeLuca, Jennifer, Xie, Dawei, and Vittinghoff, Eric
- Published
- 2016
- Full Text
- View/download PDF
37. Serum β-Trace Protein and β2-Microglobulin as Predictors of ESRD, Mortality, and Cardiovascular Disease in Adults With CKD in the Chronic Renal Insufficiency Cohort (CRIC) Study
- Author
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Appel, Lawrence J., Go, Alan S., He, Jiang, Lash, James P., Rahman, Mahboob, Townsend, Raymond R., Foster, Meredith C., Coresh, Josef, Hsu, Chi-yuan, Xie, Dawei, Levey, Andrew S., Nelson, Robert G., Eckfeldt, John H., Vasan, Ramachandran S., Kimmel, Paul L., Schelling, Jeffrey, Simonson, Michael, Sondheimer, James H., Anderson, Amanda Hyre, Akkina, Sanjeev, Feldman, Harold I., Kusek, John W., Ojo, Akinlolu O., and Inker, Lesley A.
- Published
- 2016
- Full Text
- View/download PDF
38. Serum Fractalkine (CX3CL1) and Cardiovascular Outcomes and Diabetes: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
- Author
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Appel, Lawrence J., Feldman, Harold I., Go, Alan S., He, Jiang, Kusek, John W., Lash, James P., Ojo, Akinlolu, Rahman, Mahboob, Townsend, Raymond R., Shah, Rachana, Matthews, Gregory J., Shah, Rhia Y., McLaughlin, Catherine, Chen, Jing, Wolman, Melanie, Master, Stephen R., Chai, Boyang, Xie, Dawei, Rader, Daniel J., Raj, Dominic S., Mehta, Nehal N., Budoff, Matthew, Fischer, Michael J., Foulkes, Andrea S., and Reilly, Muredach P.
- Published
- 2015
- Full Text
- View/download PDF
39. Healthy Lifestyle and Risk of Kidney Disease Progression, Atherosclerotic Events, and Death in CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
- Author
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Appel, Lawrence J., Feldman, Harold I., Go, Alan S., He, Jiang, Kusek, John W., Lash, James P., Ojo, Akinlolu, Rahman, Mahboob, Townsend, Raymond R., Ricardo, Ana C., Anderson, Cheryl A., Yang, Wei, Zhang, Xiaoming, Fischer, Michael J., Dember, Laura M., Fink, Jeffrey C., Frydrych, Anne, Jensvold, Nancy G., Lustigova, Eva, Nessel, Lisa C., Porter, Anna C., Wright Nunes, Julie A., and Daviglus, Martha L.
- Published
- 2015
- Full Text
- View/download PDF
40. Self-reported Physical Activity and Cardiovascular Events in Adults With CKD: Findings From the CRIC (Chronic Renal Insufficiency Cohort) Study
- Author
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Bruinius, Jacob W., primary, Hannan, Mary, additional, Chen, Jinsong, additional, Brown, Julia, additional, Kansal, Mayank, additional, Meza, Natalie, additional, Saunders, Milda R., additional, He, Jiang, additional, Ricardo, Ana C., additional, Lash, James P., additional, Appel, Lawrence J., additional, Chen, Jing, additional, Cohen, Debbie L., additional, Feldman, Harold I., additional, Go, Alan S., additional, Nelson, Robert G., additional, Rahman, Mahboob, additional, Rao, Panduranga S., additional, Shah, Vallabh O., additional, and Unruh, Mark L., additional
- Published
- 2022
- Full Text
- View/download PDF
41. Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
- Author
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Muiru, Anthony N., primary, Yang, Jingrong, additional, Derebail, Vimal K., additional, Liu, Kathleen D., additional, Feldman, Harold I., additional, Srivastava, Anand, additional, Bhat, Zeenat, additional, Saraf, Santosh L., additional, Chen, Teresa K., additional, He, Jiang, additional, Estrella, Michelle M., additional, Go, Alan S., additional, Hsu, Chi-yuan, additional, Appel, Lawrence J., additional, Chen, Jing, additional, Cohen, Debbie L., additional, Lash, James P., additional, Nelson, Robert G., additional, Rahman, Mahboob, additional, Rao, Panduranga S., additional, Shah, Vallabh O., additional, and Unruh, Mark L., additional
- Published
- 2022
- Full Text
- View/download PDF
42. Heart Failure–Type Symptom Score Trajectories in CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
- Author
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Walther, Carl P., primary, Benoit, Julia S., additional, Bansal, Nisha, additional, Nambi, Vijay, additional, Navaneethan, Sankar D., additional, Feldman, Harold I., additional, Appel, Lawrence J., additional, Chen, Jing, additional, Cohen, Debbie L., additional, Go, Alan S., additional, Lash, James P., additional, Nelson, Robert G., additional, Rahman, Mahboob, additional, Rao, Panduranga S., additional, Shah, Vallabh O., additional, and Unruh, Mark L., additional
- Published
- 2022
- Full Text
- View/download PDF
43. Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD
- Author
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Bansal, Nisha, primary, Zelnick, Leila R., additional, Ballantyne, Christie M., additional, Chaves, Paulo H.M., additional, Christenson, Robert H., additional, Coresh, Josef, additional, deFilippi, Christopher R., additional, de Lemos, James A., additional, Daniels, Lori B., additional, Go, Alan S., additional, He, Jiang, additional, Hedayati, S. Susan, additional, Matsushita, Kunihiro, additional, Nambi, Vijay, additional, Shlipak, Michael G., additional, Taliercio, Jonathan J., additional, Seliger, Stephen L., additional, Appel, Lawrence J., additional, Feldman, Harold I., additional, Lash, James P., additional, Nelson, Robert G., additional, Rao, Panduranga S., additional, Rahman, Mahboob, additional, Shah, Vallabh O., additional, Townsend, Raymond R., additional, and Unruh, Mark L., additional
- Published
- 2022
- Full Text
- View/download PDF
44. Time-Updated Changes in Estimated GFR and Proteinuria and Major Adverse Cardiac Events: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study
- Author
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Cohen, Jordana B., primary, Yang, Wei, additional, Li, Liang, additional, Zhang, Xiaoming, additional, Zheng, Zihe, additional, Orlandi, Paula, additional, Bansal, Nisha, additional, Deo, Rajat, additional, Lash, James P., additional, Rahman, Mahboob, additional, He, Jiang, additional, Shafi, Tariq, additional, Chen, Jing, additional, Cohen, Debbie L., additional, Matsushita, Kunihiro, additional, Shlipak, Michael G., additional, Wolf, Myles, additional, Go, Alan S., additional, Feldman, Harold I., additional, Appel, Lawrence J., additional, Nelson, Robert G., additional, Rao, Panduranga S., additional, Shah, Vallabh O., additional, Townsend, Raymond R., additional, and Unruh, Mark L., additional
- Published
- 2022
- Full Text
- View/download PDF
45. Heart Failure–Type Symptom Score Trajectories in CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
- Author
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Walther, Carl P., Benoit, Julia S., Bansal, Nisha, Nambi, Vijay, Navaneethan, Sankar D., Feldman, Harold I., Appel, Lawrence J., Chen, Jing, Cohen, Debbie L., Go, Alan S., Lash, James P., Nelson, Robert G., Rahman, Mahboob, Rao, Panduranga S., Shah, Vallabh O., and Unruh, Mark L.
- Abstract
Quality of life in chronic kidney disease (CKD) is impaired by a large burden of symptoms including some that overlap with the symptoms of heart failure (HF). We studied a group of individuals with CKD to understand the patterns and trajectories of HF-type symptoms in this setting.
- Published
- 2023
- Full Text
- View/download PDF
46. Risk of Potentially Inappropriate Medications in Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
- Author
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Hall, Rasheeda K., primary, Blumenthal, Jacob B., additional, Doerfler, Rebecca M., additional, Chen, Jing, additional, Diamantidis, Clarissa J., additional, Jaar, Bernard G., additional, Kusek, John W., additional, Kallem, Krishna, additional, Leonard, Mary B., additional, Navaneethan, Sankar D., additional, Sha, Daohang, additional, Sondheimer, James H., additional, Wagner, Lee-Ann, additional, Yang, Wei, additional, Zhan, Min, additional, Fink, Jeffrey C., additional, Appel, Lawrence J., additional, Feldman, Harold I., additional, Go, Alan S., additional, Rahman, Mahboob, additional, Rao, Panduranga S., additional, Shah, Vallabh O., additional, Townsend, Raymond R., additional, and Unruh, Mark L., additional
- Published
- 2021
- Full Text
- View/download PDF
47. Sex Differences in Cardiovascular Outcomes in CKD: Findings From the CRIC Study
- Author
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Toth-Manikowski, Stephanie M., primary, Yang, Wei, additional, Appel, Lawrence, additional, Chen, Jing, additional, Deo, Rajat, additional, Frydrych, Anne, additional, Krousel-Wood, Marie, additional, Rahman, Mahboob, additional, Rosas, Sylvia E., additional, Sha, Daohang, additional, Wright, Jackson, additional, Daviglus, Martha L., additional, Go, Alan S., additional, Lash, James P., additional, Ricardo, Ana C., additional, Feldman, Harold I., additional, He, Jiang, additional, Nelson, Robert G., additional, Rao, Panduranga S., additional, Shah, Vallabh O., additional, Townsend, Raymond R., additional, and Unruh, Mark L., additional
- Published
- 2021
- Full Text
- View/download PDF
48. Mobile Health (mHealth) Technology: Assessment of Availability, Acceptability, and Use in CKD
- Author
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Schrauben, Sarah J., primary, Appel, Lawrence, additional, Rivera, Eleanor, additional, Lora, Claudia M., additional, Lash, James P., additional, Chen, Jing, additional, Hamm, L. Lee, additional, Fink, Jeffrey C., additional, Go, Alan S., additional, Townsend, Raymond R., additional, Deo, Rajat, additional, Dember, Laura M., additional, Feldman, Harold I., additional, Diamantidis, Clarissa J., additional, He, Jiang, additional, Nelson, Robert G, additional, Rao, Panduranga S, additional, Rahman, Mahboob, additional, Shah, Vallabh O, additional, and Unruh, Mark L, additional
- Published
- 2021
- Full Text
- View/download PDF
49. Change in Cardiac Biomarkers and Risk of Incident Heart Failure and Atrial Fibrillation in CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study
- Author
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Bansal, Nisha, primary, Zelnick, Leila R., additional, Soliman, Elsayed Z., additional, Anderson, Amanda, additional, Christenson, Robert, additional, DeFilippi, Christopher, additional, Deo, Rajat, additional, Feldman, Harold I., additional, He, Jiang, additional, Ky, Bonnie, additional, Kusek, John, additional, Lash, James, additional, Seliger, Stephen, additional, Shafi, Tariq, additional, Wolf, Myles, additional, Go, Alan S., additional, Shlipak, Michael G., additional, Appel, Lawrence J., additional, Rao, Panduranga S., additional, Rahman, Mahboob, additional, and Townsend, Raymond R., additional
- Published
- 2021
- Full Text
- View/download PDF
50. Adherence to Healthy Dietary Patterns and Risk of CKD Progression and All-Cause Mortality: Findings From the CRIC (Chronic Renal Insufficiency Cohort) Study
- Author
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Hu, Emily A., primary, Coresh, Josef, additional, Anderson, Cheryl A.M., additional, Appel, Lawrence J., additional, Grams, Morgan E., additional, Crews, Deidra C., additional, Mills, Katherine T., additional, He, Jiang, additional, Scialla, Julia, additional, Rahman, Mahboob, additional, Navaneethan, Sankar D., additional, Lash, James P., additional, Ricardo, Ana C., additional, Feldman, Harold I., additional, Weir, Matthew R., additional, Shou, Haochang, additional, Rebholz, Casey M., additional, Go, Alan S., additional, Rao, Panduranga S., additional, and Townsend, Raymond R., additional
- Published
- 2021
- Full Text
- View/download PDF
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