10 results on '"Varricchio M"'
Search Results
2. Plasma leptin concentration, insulin sensitivity, and 24-hour ambulatory blood pressure and left ventricular geometry
- Author
-
Arcangelo D'Errico, Maurizio Galderisi, Giuseppe Paolisso, Oreste de Divitiis, Raffaele Marfella, Maria Tagliamonte, Guido Antonio Zito, Carlo Carella, Michele Varricchio, Paolisso, Giuseppe, Tagliamonte, Mr, Galderisi, M, Zito, Ga, D'Errico, A, Marfella, Raffaele, Carella, Carlo, DE DIVITIIS, O, Varricchio, Michele, Paolisso, G, Tagliamonte, M. R, Galderisi, Maurizio, Zito, G. A, Marfella, R, Carella, C, de Divitiis, O, and Varricchio, M.
- Subjects
Adult ,Leptin ,Male ,medicine.medical_specialty ,Ambulatory blood pressure ,medicine.medical_treatment ,Diastole ,Hemodynamics ,Blood Pressure ,Left ventricular hypertrophy ,Internal medicine ,Blood plasma ,Internal Medicine ,medicine ,Humans ,Insulin ,business.industry ,Osmolar Concentration ,Blood Pressure Monitoring, Ambulatory ,Middle Aged ,medicine.disease ,Endocrinology ,Blood pressure ,Echocardiography ,Hypertension ,Hypertrophy, Left Ventricular ,business ,Human - Abstract
Left ventricular (LV) hypertrophy is an important predictor of cardiovascular morbidity and mortality. Hemodynamic factors, such as 24-h blood pressure (BP) values, are responsible for left ventricular hypertrophy in hypertensives. On the other hand, some metabolic factors have also been suggested to affect LV mass and geometry. In particular, plasma leptin concentrations have been found associated to LV myocardial growth. Because chronic leptin infusion stimulates sympathetic nervous system activity and increases BP levels, the role of 24-h BP values on leptin-related changes in myocardial wall geometry cannot be ruled out. Thus, the aim of our study was to evaluate whether the relationship between plasma leptin levels and LV wall thickness is mediated by 24-h BP values in hypertensive male patients. Thirty-six newly diagnosed hypertensive patients underwent Doppler echocardiographic examination, 24-h ambulatory BP recording, and metabolic (euglycemic hyperinsulinemic glucose clamp and fasting plasma leptin levels) measurements. Left ventricular mass correlated positively only with ambulatory diastolic BP (DBP) values, whereas the indices of myocardial wall growth such as interventricular septum thickness and sum of wall thickness (ie, septal + posterior wall thickness) correlated either with 24 h, daytime, or nighttime DBP, as well as with fasting plasma glucose, fasting plasma leptin, and insulin action after adjustment for age, body mass index (BMI), and waist/hip ratio (WHR). In contrast, plasma leptin concentration did not correlate with clinical and ambulatory BP values. A multiple linear regression analysis allowed to investigate the independent role of main anthropometric and cardiovascular covariates on the sum of wall thickness variability. A model that includes age, BMI, WHR, fasting plasma leptin concentration, plasma Na+ concentration, insulin action, and nighttime DBP explained 68% of the sum of wall thickness variability. In such a model, plasma leptin concentration (P < .001), insulin action (P < .029), and nighttime DBP (P < .002) were significantly and independently associated with myocardial wall thickness. In conclusion, our study demonstrates that in hypertensive men fasting plasma leptin levels are determinant of myocardial wall thickness independently of 24-h BP values.
- Published
- 2001
3. Effects of Magnesium and Nifedipine Infusions on Insulin Action, Substrate Oxidation, and Blood Pressure in Aged Hypertensive Patients
- Author
-
Felice D'Onofrio, Giuseppe Paolisso, Gambardella A, V. Balbi, M. Verza, Michele Varricchio, Domenico Galzerano, Paolisso, Giuseppe, Gambardella, Antonio, Balbi, V, Galzerano, D, Verza, M, Varricchio, M, and D'Onofrio, F.
- Subjects
Blood Glucose ,Aging ,medicine.medical_specialty ,Erythrocytes ,Nifedipine ,medicine.medical_treatment ,chemistry.chemical_element ,Blood Pressure ,Calorimetry ,Calcium ,Calcium in biology ,Body Mass Index ,Internal medicine ,Blood plasma ,Internal Medicine ,medicine ,Humans ,Insulin ,Magnesium ,Infusions, Intravenous ,Aged ,business.industry ,Drug Synergism ,Glucose ,Endocrinology ,Blood pressure ,chemistry ,Hypertension ,Lean body mass ,business ,Oxidation-Reduction ,medicine.drug - Abstract
Eight aged (70.1 +/- 2.1 years), nonobese (body mass index [BMI] = 26.3 +/- 0.4), hypertensive (systolic blood pressure [SBP] = 184 +/- 4.1; diastolic blood pressure [DBP] = 105 +/- 2.4 mm Hg) subjects underwent a euglycemic hyperinsulinemic (7.1 pmol/kg x min during 240 min) glucose clamp with four different infusions: a) 0.9% NaCl; b) 1.0 micrograms/kg x min nifedipine; c) 100 mumol/min magnesium; d) 1.0 micrograms/kg x min nifedipine plus 100 mumol/min magnesium. All tests were performed in random order. Simultaneous D-3-H glucose infusion and indirect calorimetry allowed us to determine glucose turnover parameters and substrate oxidation. Insulin infusion per se stimulated erythrocyte magnesium (1.83 +/- 0.04 v 1.98 +/- 0.03 mmol/L, P < .03) and calcium (4.7 +/- 0.3 v 6.2 +/- 0.4 mumol/L, P < .02) accumulation, and enhanced total body glucose disposal oxidative and nonoxidative glucose metabolisms. Infusion of insulin and nifedipine v insulin alone reduced insulin-mediated increase in intracellular calcium (5.4 +/- 0.3 v 6.2 +/- 0.4 mumol/L, P < .02), but potentiated the insulin effect upon nonoxidative glucose (15.4 +/- 0.4 v 11.1 +/- 0.3 mumol/kg lean body mass [LBM] x min, P < .03) metabolism.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1993
4. Myocardial wall thickness and left ventricular geometry in hypertensives. Relationship with insulin
- Author
-
Giuseppe Paolisso, Maurizio Galderisi, Maria Tagliamonte, Oreste de Divitis, A. Petrocelli, Marcello de Divitis, Domenico Galzerano, Michele Varricchio, Pasquale Gualdiero, Paolisso, G, Galderisi, Maurizio, Tagliamonte, M. R, de Divitis, M, Galzerano, D, Petrocelli, A, Gualdiero, P, de Divitis, O, Varricchio, M., Paolisso, Giuseppe, Galderisi, M, Tagliamonte, Mr, DE DIVITIS, M, and DE DIVITIS, O
- Subjects
Adult ,Blood Glucose ,Male ,medicine.medical_specialty ,Blood Pressure ,Essential hypertension ,Left ventricular hypertrophy ,Insulin resistance ,Lipid oxidation ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Insulin ,Systole ,business.industry ,Glucose clamp technique ,Middle Aged ,medicine.disease ,Echocardiography, Doppler ,Endocrinology ,Blood pressure ,Hypertension ,Cardiology ,Glucose Clamp Technique ,Hypertrophy, Left Ventricular ,Insulin Resistance ,business ,Hyperinsulinism ,Human - Abstract
In hypertensive patients the presence of left ventricular (LV) hypertrophy has been associated with a more severe degree of insulin resistance. Whether myocardial wall thickness or LV geometry are associated with a different degree of insulin resistance is still unknown in essential hypertensives. For this reason 26 men with new diagnosed essential hypertension were enrolled. All patients underwent echocardiographic examination and euglycemic hyperinsulinemic glucose clamp combined with indirect calorimetry. According to LV mass and relative wall thickness data, all patients were categorized in four groups: 1) patients with a normal geometric LV pattern (n = 8) (PAT = 0); 2) patients with concentric remodeling LV mass (n = 8) (PAT = 1); 3) patients with eccentric LV hypertrophy (n = 3) (PAT = 2); and 4) patients with concentric LV hypertrophy (n = 7) (PAT = 3). All groups were similar for anthropometric characteristics. Patients with normal echocardiographic LV pattern (PAT = 0) had higher whole body glucose disposal (WBGD), oxidative and nonoxidative glucose metabolism, and lower lipid oxidation than patients with abnormal echocardiographic LV patterns (PAT = 1 to 3). Nevertheless, no significant differences among the groups with abnormal echocardiographic patterns were found. After controlling for age, body mass index (BMI), waist/hip ratio (WHR), and mean arterial blood pressure, only sum of the wall thickness was significantly correlated with fasting plasma insulin (r = -0.38, P < .05), WBGD (r = - 0.50, P < .009), and NOGM (r = - 0.48, P < .02). In multivariate analysis, a model made by age, BMI, WHR, systolic and diastolic blood pressure, and WBGD explained 38% of the echocardiographic pattern variability. In this model, WBGD (P < .02) was significantly and independently associated with echocardiographic patterns explaining 19% of the echocardiographic pattern variability. In conclusion, our data demonstrate that in arterial hypertension hyperinsulinemia/insulin resistance mainly affects myocardial wall thickness, whereas only a trivial association with LV geometry occurs.
- Published
- 1997
5. Chronic magnesium administration enhances oxidative glucose metabolism in thiazide treated hypertensive patients
- Author
-
Michele Varricchio, Domenico Cozzolino, Giosue Di Maro, Diana Lama, Teresa Salvatore, Felice D'Onofrio, Giuseppe Paolisso, A. D'Amore, Paolisso, Giuseppe, DI MARO, G, Cozzolino, Domenico, Salvatore, Teresa, D'Amore, A, Lama, Diana, Varricchio, M, and D'Onofrio, F.
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,Glucose uptake ,medicine.medical_treatment ,Metabolite ,Sodium Chloride Symporter Inhibitors ,Blood Pressure ,Carbohydrate metabolism ,Benzothiadiazines ,chemistry.chemical_compound ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Magnesium ,Diuretics ,Thiazide ,Aged ,business.industry ,Insulin ,Metabolism ,Middle Aged ,Endocrinology ,Glucose ,chemistry ,Hypertension ,Female ,Diuretic ,business ,Oxidation-Reduction ,medicine.drug ,Blood sampling - Abstract
In newly-diagnosed untreated (n = 24) and thiazide treated (n = 18) hypertensive patients erythrocyte ion content and plasma ion and metabolite levels were determined. Thiazide treated patients had lower arterial blood pressure, plasma ion levels, erythrocyte magnesium and potassium content but higher fasting plasma insulin (66 +/- 7 v 87 +/- 8 pmol/L P < .02), triglycerides (1.88 +/- 0.24 v 2.34 +/- 0.44 mmol/L P < .05), free fatty acids (0.68 +/- 0.11 v 0.81 +/- 0.18 mmol/L P < .05). Subsequently, in a double-blind fashion and in random order thiazide diuretic treated patients were assigned to two groups: the first (n = 9) taking magnesium (15.8 mmol/day) and the other (n = 9) a placebo. Each treatment period lasted 8 weeks. At the end of each treatment period, each patient underwent blood sampling for determination of erythrocyte ion content and plasma ion and metabolite levels and was submitted to an euglycemic hyperinsulinemic (1 mU/kg/min for 120 min) glucose clamp. In this latter test D-3-H glucose infusion and indirect calorimetry allowed determination of glucose turnover parameters and substrate oxidation respectively. Chronic magnesium administration (CMA) raised fasting plasma (0.79 +/- 0.03 v 0.83 +/- 0.02 mmol/L, P < .05) and erythrocyte (1.98 +/- 0.08 v 2.35 +/- 0.03 mmol/L, P < .01) magnesium content. Along with insulin infusion, CMA improved glucose uptake, glucose metabolic clearance rate, and oxidative glucose metabolism. In the multiple linear regression analysis of the pooled basal data (n = 42), erythrocyte magnesium content displayed an independent correlation with basal plasma insulin levels (t = -2.08, P < .05).(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1992
6. Impaired glucose metabolism and reduced insulin clearance in elderly hypertensives
- Author
-
Felice D'Onofrio, Michele Varricchio, R. Torella, G. Paolisso, Raffaello Buoninconti, Dario Giugliano, Teresa Salvatore, Giugliano, Dario, Salvatore, Teresa, Paolisso, Giuseppe, Buoninconti, R, Torella, R, Varricchio, M, and D'Onofrio, F.
- Subjects
Blood Glucose ,medicine.medical_specialty ,Aging ,medicine.medical_treatment ,Glucose uptake ,Carbohydrate metabolism ,Essential hypertension ,chemistry.chemical_compound ,Internal medicine ,Diabetes mellitus ,Insulin Secretion ,Internal Medicine ,medicine ,Homeostasis ,Humans ,Insulin ,Glycemic ,Aged ,C-Peptide ,C-peptide ,business.industry ,Osmolar Concentration ,Fasting ,medicine.disease ,Endocrinology ,Glucose ,chemistry ,Basal (medicine) ,Hypertension ,business - Abstract
Diabetes mellitus and essential hypertension are characterized by a continuous rise of prevalence with aging and this association may not be casual. Thirty nonobese nondiabetic elderly patients with primary hypertension and 28 healthy normotensives matched for age, sex, and body weight were evaluated for insulin secretion (oral glucose tolerance test, day-long glycemic and insulinemic profiles), action (euglycemic moderately hyperinsulinemic glucose clamp associated with 3H-3-glucose dilution technique), and clearance (120 min insulin/glucose infusion at two prefixed doses). Compared with normotensives, hypertensive elderly patients were characterized by the following: 1) plasma insulin and C-peptide were similar in basal conditions but significantly enhanced in response to both oral glucose and a mixed meal; 2) insulin-stimulated glucose uptake was significantly impaired with a similar rate of hepatic glucose production; 3) exogenous insulin metabolic clearance rate was significantly lower at both insulin infusion rates. The multiple alterations of insulin secretion, action and metabolism found in nonobese nondiabetic elderly hypertensives seem to support a role for this hormone in the regulation of arterial blood pressure.
- Published
- 1992
7. Plasma leptin concentration, insulin sensitivity, and 24-hour ambulatory blood pressure and left ventricular geometry.
- Author
-
Paolisso G, Tagliamonte MR, Galderisi M, Zito GA, D'Errico A, Marfella R, Carella C, de Divitiis O, and Varricchio M
- Subjects
- Adult, Humans, Hypertension diagnostic imaging, Male, Middle Aged, Osmolar Concentration, Blood Pressure, Blood Pressure Monitoring, Ambulatory, Echocardiography, Hypertension physiopathology, Hypertrophy, Left Ventricular diagnostic imaging, Insulin physiology, Leptin blood
- Abstract
Left ventricular (LV) hypertrophy is an important predictor of cardiovascular morbidity and mortality. Hemodynamic factors, such as 24-h blood pressure (BP) values, are responsible for left ventricular hypertrophy in hypertensives. On the other hand, some metabolic factors have also been suggested to affect LV mass and geometry. In particular, plasma leptin concentrations have been found associated to LV myocardial growth. Because chronic leptin infusion stimulates sympathetic nervous system activity and increases BP levels, the role of 24-h BP values on leptin-related changes in myocardial wall geometry cannot be ruled out. Thus, the aim of our study was to evaluate whether the relationship between plasma leptin levels and LV wall thickness is mediated by 24-h BP values in hypertensive male patients. Thirty-six newly diagnosed hypertensive patients underwent Doppler echocardiographic examination, 24-h ambulatory BP recording, and metabolic (euglycemic hyperinsulinemic glucose clamp and fasting plasma leptin levels) measurements. Left ventricular mass correlated positively only with ambulatory diastolic BP (DBP) values, whereas the indices of myocardial wall growth such as interventricular septum thickness and sum of wall thickness (ie, septal + posterior wall thickness) correlated either with 24 h, daytime, or nighttime DBP, as well as with fasting plasma glucose, fasting plasma leptin, and insulin action after adjustment for age, body mass index (BMI), and waist/hip ratio (WHR). In contrast, plasma leptin concentration did not correlate with clinical and ambulatory BP values. A multiple linear regression analysis allowed to investigate the independent role of main anthropometric and cardiovascular covariates on the sum of wall thickness variability. A model that includes age, BMI, WHR, fasting plasma leptin concentration, plasma Na+ concentration, insulin action, and nighttime DBP explained 68% of the sum of wall thickness variability. In such a model, plasma leptin concentration (P < .001), insulin action (P < .029), and nighttime DBP (P < .002) were significantly and independently associated with myocardial wall thickness. In conclusion, our study demonstrates that in hypertensive men fasting plasma leptin levels are determinant of myocardial wall thickness independently of 24-h BP values.
- Published
- 2001
- Full Text
- View/download PDF
8. Myocardial wall thickness and left ventricular geometry in hypertensives. Relationship with insulin.
- Author
-
Paolisso G, Galderisi M, Tagliamonte MR, de Divitis M, Galzerano D, Petrocelli A, Gualdiero P, de Divitis O, and Varricchio M
- Subjects
- Adult, Blood Glucose metabolism, Blood Pressure physiology, Echocardiography, Doppler, Glucose Clamp Technique, Humans, Hypertension physiopathology, Insulin Resistance, Male, Middle Aged, Hypertension blood, Hypertension diagnostic imaging, Hypertrophy, Left Ventricular blood, Hypertrophy, Left Ventricular diagnostic imaging, Insulin blood
- Abstract
In hypertensive patients the presence of left ventricular (LV) hypertrophy has been associated with a more severe degree of insulin resistance. Whether myocardial wall thickness or LV geometry are associated with a different degree of insulin resistance is still unknown in essential hypertensives. For this reason 26 men with new diagnosed essential hypertension were enrolled. All patients underwent echocardiographic examination and euglycemic hyperinsulinemic glucose clamp combined with indirect calorimetry. According to LV mass and relative wall thickness data, all patients were categorized in four groups: 1) patients with a normal geometric LV pattern (n = 8) (PAT = 0); 2) patients with concentric remodeling LV mass (n = 8) (PAT = 1); 3) patients with eccentric LV hypertrophy (n = 3) (PAT = 2); and 4) patients with concentric LV hypertrophy (n = 7) (PAT = 3). All groups were similar for anthropometric characteristics. Patients with normal echocardiographic LV pattern (PAT = 0) had higher whole body glucose disposal (WBGD), oxidative and nonoxidative glucose metabolism, and lower lipid oxidation than patients with abnormal echocardiographic LV patterns (PAT = 1 to 3). Nevertheless, no significant differences among the groups with abnormal echocardiographic patterns were found. After controlling for age, body mass index (BMI), waist/hip ratio (WHR), and mean arterial blood pressure, only sum of the wall thickness was significantly correlated with fasting plasma insulin (r = -0.38, P < .05), WBGD (r = - 0.50, P < .009), and NOGM (r = - 0.48, P < .02). In multivariate analysis, a model made by age, BMI, WHR, systolic and diastolic blood pressure, and WBGD explained 38% of the echocardiographic pattern variability. In this model, WBGD (P < .02) was significantly and independently associated with echocardiographic patterns explaining 19% of the echocardiographic pattern variability. In conclusion, our data demonstrate that in arterial hypertension hyperinsulinemia/insulin resistance mainly affects myocardial wall thickness, whereas only a trivial association with LV geometry occurs.
- Published
- 1997
- Full Text
- View/download PDF
9. Effects of magnesium and nifedipine infusions on insulin action, substrate oxidation, and blood pressure in aged hypertensive patients.
- Author
-
Paolisso G, Gambardella A, Balbi V, Galzerano D, Verza M, Varricchio M, and D'Onofrio F
- Subjects
- Aged, Aging metabolism, Blood Glucose analysis, Blood Pressure drug effects, Body Mass Index, Calcium analysis, Calcium blood, Calorimetry, Drug Synergism, Erythrocytes chemistry, Glucose metabolism, Humans, Hypertension metabolism, Infusions, Intravenous, Magnesium administration & dosage, Magnesium blood, Nifedipine administration & dosage, Oxidation-Reduction, Aging physiology, Blood Pressure physiology, Hypertension physiopathology, Insulin pharmacology, Magnesium pharmacology, Nifedipine pharmacology
- Abstract
Eight aged (70.1 +/- 2.1 years), nonobese (body mass index [BMI] = 26.3 +/- 0.4), hypertensive (systolic blood pressure [SBP] = 184 +/- 4.1; diastolic blood pressure [DBP] = 105 +/- 2.4 mm Hg) subjects underwent a euglycemic hyperinsulinemic (7.1 pmol/kg x min during 240 min) glucose clamp with four different infusions: a) 0.9% NaCl; b) 1.0 micrograms/kg x min nifedipine; c) 100 mumol/min magnesium; d) 1.0 micrograms/kg x min nifedipine plus 100 mumol/min magnesium. All tests were performed in random order. Simultaneous D-3-H glucose infusion and indirect calorimetry allowed us to determine glucose turnover parameters and substrate oxidation. Insulin infusion per se stimulated erythrocyte magnesium (1.83 +/- 0.04 v 1.98 +/- 0.03 mmol/L, P < .03) and calcium (4.7 +/- 0.3 v 6.2 +/- 0.4 mumol/L, P < .02) accumulation, and enhanced total body glucose disposal oxidative and nonoxidative glucose metabolisms. Infusion of insulin and nifedipine v insulin alone reduced insulin-mediated increase in intracellular calcium (5.4 +/- 0.3 v 6.2 +/- 0.4 mumol/L, P < .02), but potentiated the insulin effect upon nonoxidative glucose (15.4 +/- 0.4 v 11.1 +/- 0.3 mumol/kg lean body mass [LBM] x min, P < .03) metabolism.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1993
- Full Text
- View/download PDF
10. Chronic magnesium administration enhances oxidative glucose metabolism in thiazide treated hypertensive patients.
- Author
-
Paolisso G, Di Maro G, Cozzolino D, Salvatore T, D'Amore A, Lama D, Varricchio M, and D'Onofrio F
- Subjects
- Aged, Blood Pressure drug effects, Diuretics, Female, Humans, Hypertension metabolism, Male, Middle Aged, Oxidation-Reduction drug effects, Time Factors, Benzothiadiazines, Glucose metabolism, Hypertension drug therapy, Magnesium therapeutic use, Sodium Chloride Symporter Inhibitors therapeutic use
- Abstract
In newly-diagnosed untreated (n = 24) and thiazide treated (n = 18) hypertensive patients erythrocyte ion content and plasma ion and metabolite levels were determined. Thiazide treated patients had lower arterial blood pressure, plasma ion levels, erythrocyte magnesium and potassium content but higher fasting plasma insulin (66 +/- 7 v 87 +/- 8 pmol/L P < .02), triglycerides (1.88 +/- 0.24 v 2.34 +/- 0.44 mmol/L P < .05), free fatty acids (0.68 +/- 0.11 v 0.81 +/- 0.18 mmol/L P < .05). Subsequently, in a double-blind fashion and in random order thiazide diuretic treated patients were assigned to two groups: the first (n = 9) taking magnesium (15.8 mmol/day) and the other (n = 9) a placebo. Each treatment period lasted 8 weeks. At the end of each treatment period, each patient underwent blood sampling for determination of erythrocyte ion content and plasma ion and metabolite levels and was submitted to an euglycemic hyperinsulinemic (1 mU/kg/min for 120 min) glucose clamp. In this latter test D-3-H glucose infusion and indirect calorimetry allowed determination of glucose turnover parameters and substrate oxidation respectively. Chronic magnesium administration (CMA) raised fasting plasma (0.79 +/- 0.03 v 0.83 +/- 0.02 mmol/L, P < .05) and erythrocyte (1.98 +/- 0.08 v 2.35 +/- 0.03 mmol/L, P < .01) magnesium content. Along with insulin infusion, CMA improved glucose uptake, glucose metabolic clearance rate, and oxidative glucose metabolism. In the multiple linear regression analysis of the pooled basal data (n = 42), erythrocyte magnesium content displayed an independent correlation with basal plasma insulin levels (t = -2.08, P < .05).(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1992
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.