22 results on '"Rice, Treva K"'
Search Results
2. Resequencing Study Identifies Rare Renin–Angiotensin–Aldosterone System Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study
- Author
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Kelly, Tanika N., primary, Li, Changwei, additional, Hixson, James E., additional, Gu, Dongfeng, additional, Rao, Dabeeru C., additional, Huang, Jianfeng, additional, Rice, Treva K., additional, Chen, Jichun, additional, Cao, Jie, additional, Li, Jianxin, additional, Anderson, Christopher E., additional, and He, Jiang, additional
- Published
- 2017
- Full Text
- View/download PDF
3. Associations of the Serum/Glucocorticoid Regulated Kinase Genes With BP Changes and Hypertension Incidence: The Gensalt Study
- Author
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Zhang, Dingding, primary, Gu, Dongfeng, additional, He, Jiang, additional, Hixson, James E., additional, Rao, Dabeeru C., additional, Li, Changwei, additional, He, Hua, additional, Chen, Jichun, additional, Huang, Jianfeng, additional, Chen, Jing, additional, Rice, Treva K., additional, Chen, Shufeng, additional, and Kelly, Tanika N., additional
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- 2016
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- View/download PDF
4. Resequencing Epithelial Sodium Channel Genes Identifies Rare Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study.
- Author
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Xiaoying Gu, Dongfeng Gu, Jiang He, Rao, Dabeeru C., Hixson, James E., Jichun Chen, Jianxin Li, Jianfeng Huang, Xigui Wu, Rice, Treva K., Shimmin, Lawrence C., and Kelly, Tanika N.
- Subjects
SODIUM channels ,BLOOD pressure ,GENETIC epidemiology ,NUCLEOTIDE sequence ,THERAPEUTICS ,HYPERTENSION - Abstract
BACKGROUND A resequencing study of renal epithelial sodium channel (ENaC) genes was conducted to identify rare variants associated with blood pressure (BP) salt-sensitivity. METHODS The Genetic Epidemiology Network of Salt-Sensitivity (GenSalt) study was conducted among 1,906 participants who underwent a 7-day low-sodium followed by a 7-day high-sodium feeding-study. The 300 most salt-sensitive and 300 most salt-resistant GenSalt participants were selected for the resequencing study. Three ENaC genes (SCNN1A, SCNN1B, and SCNN1G) were resequenced using capillary-based sequencing methods. Traditional burden tests were utilized to examine association between rare variants and BP salt-sensitivity. Associations of low-frequency and common variants were tested using singlemarker analyses. RESULTS Carriers of SCNN1A rare variants had a 0.52 [95% confidence interval (CI): 0.32-0.85] decreased odds of BP salt-sensitivity compared with noncarriers. Neither SCNN1B nor SCNN1G associated with salt-sensitivity of BP in rare variant analyses (P = 0.65 and 0.48, respectively). In single-marker analyses, 3 independent common variants in SCNN1A, rs11614164, rs4764586, and rs3741914, associated with salt-sensitivity after Bonferroni correction (P = 4.4 × 10-4, 1.1 × 10-8, and 1.3 × 10-3). Each copy of the minor allele of rs4764586 was associated with a 1.36-fold (95% CI: 1.23-1.52) increased odds of salt-sensitivity, whereas each copy of the minor allele of rs11614164 and rs3741914 was associated with 0.68-fold (95% CI: 0.55-0.84) and 0.69-fold (95% CI: 0.54-0.86) decreased odds of salt-sensitivity, respectively. CONCLUSIONS This study demonstrated for the first time a relationship between rare variants in the ENaC pathway and BP salt-sensitivity. Future replication and functional studies are needed to confirm the findings in this study. [ABSTRACT FROM AUTHOR]
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- 2018
- Full Text
- View/download PDF
5. Associations Between Genetic Variants of the Natriuretic Peptide System and Blood Pressure Response to Dietary Sodium Intervention: The GenSalt Study
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Chen, Shufeng, primary, Huang, Jianfeng, additional, Zhao, Qi, additional, Chen, Jing, additional, Jaquish, Cashell E., additional, He, Jiang, additional, Lu, Xiangfeng, additional, Yang, Xueli, additional, Gu, Charles C., additional, Hixson, James E., additional, Liu, Fangchao, additional, Rice, Treva K., additional, Cao, Jie, additional, Chen, Jichun, additional, and Gu, Dongfeng, additional
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- 2015
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6. Blood Pressure Reactivity to the Cold Pressor Test Predicts Hypertension Among Chinese Adults: The GenSalt Study
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Zhao, Qi, primary, Gu, Dongfeng, additional, Lu, Fanghong, additional, Mu, Jianjun, additional, Wang, Xushan, additional, Ji, Xu, additional, Hu, Dongsheng, additional, Ma, Jixiang, additional, Huang, Jianfeng, additional, Li, Jianxin, additional, Chen, Jichun, additional, Cao, Jie, additional, Chen, Chung-Shiuan, additional, Chen, Jing, additional, Rice, Treva K., additional, and He, Jiang, additional
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- 2015
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7. Associations of Renin–Angiotensin–Aldosterone System Genes With Blood Pressure Changes and Hypertension Incidence
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He, William J., primary, Li, Changwei, additional, Rao, Dabeeru C., additional, Hixson, James E., additional, Huang, Jianfeng, additional, Cao, Jie, additional, Rice, Treva K., additional, Shimmin, Lawrence C., additional, Gu, Dongfeng, additional, and Kelly, Tanika N., additional
- Published
- 2015
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8. Associations of Endothelial System Genes With Blood Pressure Changes and Hypertension Incidence: The GenSalt Study
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Liu, Fangchao, primary, He, Jiang, additional, Gu, Dongfeng, additional, Rao, Dabeeru C., additional, Huang, Jianfeng, additional, Hixson, James E., additional, Jaquish, Cashell E., additional, Chen, Jichun, additional, Li, Changwei, additional, Yang, Xueli, additional, Li, Jianxin, additional, Rice, Treva K., additional, Shimmin, Lawrence C., additional, and Kelly, Tanika N., additional
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- 2014
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- View/download PDF
9. Associations of the Serum/Glucocorticoid Regulated Kinase Genes With BP Changes and Hypertension Incidence: The Gensalt Study.
- Author
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Dingding Zhang, Dongfeng Gu, Jiang He, Hixson, James E., Rao, Dabeeru C., Changwei Li, Hua He, Jichun Chen, Jianfeng Huang, Jing Chen, Rice, Treva K., Shufeng Chen, and Kelly, Tanika N.
- Subjects
GLUCOCORTICOIDS ,KINASE regulation ,GENETIC regulation ,BLOOD pressure ,HYPERTENSION - Abstract
BACKGROUND Single-marker and novel gene-based methods were employed to examine the associations of the serum/glucocorticoid regulated kinases (SGK) gene family with longitudinal blood pressure (BP) changes and hypertension incidence in a family-based cohort study. METHODS Totally, 1,768 Chinese participants from the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) follow-up study were included in the current analyses. Nine BP measures were obtained at each of 3 visits during the GenSalt follow-up study. Mixed-model and Gene-based analyses were used to examine the associations of the SGK gene family with longitudinal BP phenotypes. Bonferroni correction was applied to account for multiple testing. RESULTS After an average 7.2-year follow-up, 32.2% (513) of participants free of hypertension at baseline developed hypertension. Four novel SNPs in the SGK1 gene were predictive of the longitudinal BP phenotypes. The major alleles of SGK1 rs1763498 and rs114414980 conferred 2.9- and 2.5-fold increased risks of hypertension development, respectively (P = 1.0 × 10
-4 and 6.0 × 10-4, respectively). In addition, the major allele of SGK1 rs229133 was significantly associated with 0.4 mm Hg larger annual increases in systolic BP (P = 4.2 × 10-4 ), while the major allele of rs6924468 was significantly associated with 0.2 mm Hg smaller annual increases in diastolic BP (P = 4.2 × 10-4 ). Gene-based analyses revealed an association of the SGK1 gene with risk of hypertension development (P = 7.4 × 10-3 ). No evidence for the SGK2 and SGK3 genes was found. CONCLUSIONS The findings of the current study suggest that the SGK1 gene may play a role in long-term BP regulation and hypertension incidence. [ABSTRACT FROM AUTHOR]- Published
- 2017
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- View/download PDF
10. Associations of Epithelial Sodium Channel Genes With Blood Pressure Changes and Hypertension Incidence: The GenSalt Study
- Author
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Yang, Xueli, primary, He, Jiang, additional, Gu, Dongfeng, additional, Hixson, James E., additional, Huang, Jianfeng, additional, Rao, Dabeeru C., additional, Shimmin, Lawrence C., additional, Chen, Jichun, additional, Rice, Treva K., additional, Li, Jianxin, additional, Schwander, Karen, additional, and Kelly, Tanika N., additional
- Published
- 2014
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- View/download PDF
11. Associations Between Genetic Variants of the Natriuretic Peptide System and Blood Pressure Response to Dietary Sodium Intervention: The GenSalt Study.
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Shufeng Chen, Jianfeng Huang, Qi Zhao, Jing Chen, Jaquish, Cashell E., Jiang He, Xiangfeng Lu, Xueli Yang, Gu, Charles C., Hixson, James E., Fangchao Liu, Rice, Treva K., Jie Cao, Jichun Chen, and Dongfeng Gu
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HUMAN genetic variation ,BLOOD pressure ,NATRIURETIC peptides ,SINGLE nucleotide polymorphisms ,GENOTYPES - Abstract
BACKGROUND The aim of this study was to comprehensively test the association of genetic variants in the natriuretic peptide (NP) system with blood pressure (BP) response to dietary sodium intervention in a Chinese population. METHODS We conducted a 7-day low-sodium intervention followed by a 7-day high-sodium intervention among 1,906 participants in rural China. BP measurements were obtained at baseline and each dietary intervention using a random-zero sphygmomanometer. Linear mixed-effect models were used to assess the associations of 48 single-nucleotide polymorphisms (SNPs) in 6 genes of NP system with BP response to dietary sodium intervention. RESULTS SNP rs5063 in the NPPA gene and SNP rs2077386 in the NPPC gene exhibited significant associations with BP response to low-sodium dietary intervention under recessive genetic model. For rs5063, absolute mean arterial pressure responses (95% confidence interval) to the low-sodium intervention were 1.31 (-1.08, 3.70) mm Hg for TT genotype and -3.74 (-4.01, -3.46) mm Hg for CC or TC genotype, respectively (P = 4.1 x 10
-5 ). Individuals with at least one copy of the C allele of rs2077386 had significantly reduction in systolic BP during the low-sodium intervention compared to those with genotype GG with responses of-5.48 (-5.83, -5.14) vs. -2.76 (-3.52, -2.00) mm Hg, respectively (P = 1.9 x 10-13 ). CONCLUSIONS These novel findings suggested that genetic variants of NP system may contribute to the variation of BP response to sodium intervention in Chinese population. Certainly, replication of these results in other populations and further functional studies are warranted to clarify their role in the regulation of BP and hypertension. [ABSTRACT FROM AUTHOR]- Published
- 2016
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12. Blood Pressure Reactivity to the Cold Pressor Test Predicts Hypertension Among Chinese Adults: The GenSalt Study.
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Qi Zhao, Dongfeng Gu, Fanghong Lu, Jianjun Mu, Xushan Wang, Xu Ji, Dongsheng Hu, Jixiang Ma, Jianfeng Huang, Jianxin Li, Jichun Chen, Jie Cao, Chung-Shiuan Chen, Jing Chen, Rice, Treva K., and Jiang He
- Subjects
BLOOD pressure ,GENETIC epidemiology ,ANTIHYPERTENSIVE agents ,OLDER people ,SYMPATHETIC nervous system ,SURVIVAL analysis (Biometry) - Abstract
background Blood pressure (BP) hyper-reactivity to the cold pressor test (CPT) has been suggested as a predictor of hypertension. We examined whether BP reactivity to the CPT was associated with hypertension incidence among the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) study participants from China. methods A total of 1,961 GenSalt study participants without any antihypertensive treatment completed the CPT at the baseline examination. Hypertension status was assessed at baseline (2003–2005) and 2 follow- up visits (2008–2009 and 2011–2012). results After adjustment for multiple covariates, both systolic BP (SBP) and diastolic BP reactivity to the CPT were significantly associated with hypertension incidence. For example, the multivariable adjusted odds ratios (ORs, 95% CI) of developing hypertension were 0.92 (0.66, 1.29), 1.42 (1.03, 1.97), and 1.45 (1.05, 2.00) for participants with maximum SBP responses of 6.7–12.0, 12.1–19.2, and ≥19.3 mm Hg, respectively, compared to those with responses of <6.7 mm Hg (P for trend = 0.006). Likewise, the multivariable-adjusted ORs (95% CI) of hypertension were 1.12 (0.79, 1.57), 1.62 (1.15, 2.29), and 1.82 (1.30, 2.55) for participants with the area under the curve of SBP responses of 3.0–16.0, 16.1–29.9, and ≥ 30.0 mm Hg·min, respectively, compared to those with responses of < 3.0 mm Hg·min (P for trend = 0.0001). The associations between BP reactivity variables and the risk of hypertension were not different among subgroups of sex, age, and baseline BP levels. conclusions BP hyperreactivity to the cold stimulus may predict the risk of hypertension among Chinese adults. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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13. Novel Genetic Variants in the α-Adducin and Guanine Nucleotide Binding Protein β-Polypeptide 3 Genes and Salt Sensitivity of Blood Pressure
- Author
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Kelly, Tanika N., primary, Rice, Treva K., additional, Gu, Dongfeng, additional, Hixson, James E., additional, Chen, Jing, additional, Liu, Depei, additional, Jaquish, Cashell E., additional, Bazzano, Lydia A., additional, Hu, Dongsheng, additional, Ma, Jixiang, additional, Gu, C. Charles, additional, Huang, Jianfeng, additional, Hamm, L. Lee, additional, and He, Jiang, additional
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- 2009
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14. Common Genetic Variants in the Endothelial System Predict Blood Pressure Response to Sodium Intake: The GenSalt Study.
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Defagó, Maria Daniela, Gu, Dongfeng, Hixson, James E., Shimmin, Lawrence C., Rice, Treva K., Gu, Charles C., Jaquish, Cashell E., Liu, De-Pei, He, Jiang, and Kelly, Tanika N.
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BLOOD pressure ,GENETIC polymorphisms ,SPHYGMOMANOMETERS ,ENDOTHELIAL cells ,AMPLIFIED fragment length polymorphism - Abstract
BACKGROUND We examined the association between 14 endothelial system genes and salt-sensitivity of blood pressure (BP). METHODS After a 3-day baseline examination, during which time the usual diet was consumed, 1,906 Chinese participants received a 7-day low-sodium diet (51.3 mmol of sodium/day) followed by a 7-day high-sodium diet (307.8 mmol of sodium/day). BP measurements were obtained at baseline and at the end of each intervention using a random-zero sphygmomanometer. RESULTS The DDAH1 rs11161637 variant was associated with reduced BP salt sensitivity, conferring attenuated systolic BP (SBP) and mean arterial pressure (MAP) decreases from baseline to the low-sodium intervention (both P = 2×10−4). Examination of genotype–sex interactions revealed that this relation was driven by the strong associations observed in men (P for interactions = 1.10×10−4 and 0.008, respectively). When switching from the low- to high-sodium intervention, increases in diastolic BP (DBP) and MAP were attenuated by the COL18A1 rs2838944 minor A allele (P = 1.41×10−4 and 1.55×10−4, respectively). Conversely, the VWF rs2239153 C variant was associated with increased salt sensitivity, conferring larger DBP and MAP reductions during low-sodium intervention (P = 1.22×10−4 and 4.44×10−5, respectively). Ten variants from 3 independent SELE loci displayed significant genotype–sex interactions on DBP and MAP responses to low-sodium (P for interaction = 1.56×10−3 to 1.00×10−4). Among men, minor alleles of 4 correlated markers attenuated BP responses to low-sodium intake, whereas minor alleles of another 4 correlated markers increased BP responses. No associations were observed in women for these variants. Further, qualitative interactions were shown for 2 correlated SELE markers. CONCLUSIONS These data support a role for the endothelial system genes in salt sensitivity. [ABSTRACT FROM AUTHOR]
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- 2013
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15. Analysis of Sex Hormone Genes Reveals Gender Differences in the Genetic Etiology of Blood Pressure Salt Sensitivity: The GenSalt Study.
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Kelly, Tanika N., Rebholz, Casey M., Gu, Dongfeng, Hixson, James E., Rice, Treva K., Cao, Jie, Chen, Jichun, Li, Jianxin, Lu, Fanghong, Ma, Jixiang, Mu, Jianjun, Whelton, Paul K., and He, Jiang
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SINGLE nucleotide polymorphisms ,SEX hormones ,SODIUM ,SPHYGMOMANOMETERS ,BLOOD pressure - Abstract
BACKGROUND We examined the association between 799 single-nucleotide polymorphisms in 39 sex hormone genes and blood pressure (BP) responses to a dietary-sodium intervention. METHODS A 7-day low-sodium feeding study (51.3 mmol sodium/day) followed by a 7-day high-sodium feeding study (307.8 mmol sodium/day) was conducted among 1,906 Han Chinese participants. Nine BP measurements were obtained at baseline and the end of each intervention period using a random-zero sphygmomanometer. RESULTS Among men, absolute BP responses to sodium interventions decreased with the number of minor alleles of estrogen receptor 1 (ESR1) markers rs9340844, rs9397453, rs9371562, rs9397459, and rs9383951. For example, mean diastolic blood pressure (DBP) responses to low-sodium intervention (95% confidence interval) were –2.67 (–3.13, –2.22) mm Hg among those with the rs9397453 C/C genotype, –1.23 (–1.98, –0.48) mm Hg among those with the C/T genotype, and 0.08 (–2.31, 2.47) mm Hg among those with the T/T genotype (P = 1×10–4; false discovery rate (FDR)-q = 0.04). Mean DBP responses to high sodium according to the rs9397453 genotypes were 1.46 (1.03, 1.89) mm Hg among those with C/C, 0.19 (–0.54, 0.91) mm Hg among those with C/T, and –1.10 (–2.82, 0.61) mm Hg among those with T/T (P = 2×10–4; FDR-q = 0.04). Similar trends were noted for the association between these ESR1 variants and SBP responses to the dietary intervention. There were no significant associations between sex hormone gene variants and salt sensitivity in women, with genotype-gender interactions noted for the ESR1 markers that achieved significance in men. CONCLUSIONS We identified strong, consistent associations between ESR1 gene variants and salt sensitivity in men. Our results support a gender-specific role for ESR1 in the etiology of this complex trait. [ABSTRACT FROM PUBLISHER]
- Published
- 2013
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16. Heritability of Blood Pressure Responses to Cold Pressor Test in a Chinese Population.
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Hao Mei, Dongfeng Gu, Rice, Treva K., Hixson, James E., Jing Chen, Jaquish, Cashell E., Qi Zhao, Chung-Shiuan Chen, Ji-Chun Chen, Gu, C. Charles, Kelly, Tanika N., and Jiang He
- Subjects
CARDIOVASCULAR diseases ,BLOOD pressure ,PHENOTYPES ,GENES - Abstract
BackgroundGenetic determinants of blood pressure (BP) responses to the cold pressor test (CPT), a phenotype associated with risk of hypertension and cardiovascular disease has not been well studied.MethodsWe examined the heritability of BP response to CPT in 1,994 subjects from 627 families in rural north China. BP was measured before and at 0, 1, 2, and 4 min after the participants immersed their hand in ice water for 1 min. Heritabilities of baseline BP and responses at 0 min, maximum response, and area-under-the-curve (AUC) during CPT were computed using a variance components method. Additionally, bivariate heritabilities were calculated to test the existence of shared genetic determinants between baseline BP and responses to CPT.ResultsHeritabilities of baseline BP and responses to CPT were estimated from 14 to 35%, which all significantly differed from 0 (P ≤ 0.002). Genetic correlations (s.e.) due to the same genes between baseline BP and responses to CPT ranged from −0.07 (0.14) to 0.21 (0.15), which were not significantly different from 0. Genetic correlations between reactivity and recovery were 0.67 (0.10) and 0.59 (0.10) for systolic (SBP) and diastolic BP (DBP), respectively, which were significantly different from 0.ConclusionsWe concluded that (i) baseline BP and BP responses to CPT had strong genetic determinants; (ii) baseline BP and BP response to CPT did not share the same genetic components; and (iii) BP reactivity and recovery shared the same genetic components. These findings may lead to a better understanding of the genetic mechanism of BP responses to CPT.American Journal of Hypertension 2009; doi:10.1038/ajh.2009.139 [ABSTRACT FROM AUTHOR]
- Published
- 2009
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17. Resequencing Epithelial Sodium Channel Genes Identifies Rare Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study.
- Author
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Gu X, Gu D, He J, Rao DC, Hixson JE, Chen J, Li J, Huang J, Wu X, Rice TK, Shimmin LC, and Kelly TN
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- Adult, Blood Pressure Determination, Female, Genetic Predisposition to Disease, Humans, Male, Polymorphism, Single Nucleotide, Blood Pressure genetics, Epithelial Sodium Channels genetics, Hypertension metabolism, Hypertension physiopathology, Sodium Chloride, Dietary metabolism
- Abstract
Background: A resequencing study of renal epithelial sodium channel (ENaC) genes was conducted to identify rare variants associated with blood pressure (BP) salt-sensitivity., Methods: The Genetic Epidemiology Network of Salt-Sensitivity (GenSalt) study was conducted among 1,906 participants who underwent a 7-day low-sodium followed by a 7-day high-sodium feeding-study. The 300 most salt-sensitive and 300 most salt-resistant GenSalt participants were selected for the resequencing study. Three ENaC genes (SCNN1A, SCNN1B, and SCNN1G) were resequenced using capillary-based sequencing methods. Traditional burden tests were utilized to examine association between rare variants and BP salt-sensitivity. Associations of low-frequency and common variants were tested using single-marker analyses., Results: Carriers of SCNN1A rare variants had a 0.52 [95% confidence interval (CI): 0.32-0.85] decreased odds of BP salt-sensitivity compared with noncarriers. Neither SCNN1B nor SCNN1G associated with salt-sensitivity of BP in rare variant analyses (P = 0.65 and 0.48, respectively). In single-marker analyses, 3 independent common variants in SCNN1A, rs11614164, rs4764586, and rs3741914, associated with salt-sensitivity after Bonferroni correction (P = 4.4 × 10-4, 1.1 × 10-8, and 1.3 × 10-3). Each copy of the minor allele of rs4764586 was associated with a 1.36-fold (95% CI: 1.23-1.52) increased odds of salt-sensitivity, whereas each copy of the minor allele of rs11614164 and rs3741914 was associated with 0.68-fold (95% CI: 0.55-0.84) and 0.69-fold (95% CI: 0.54-0.86) decreased odds of salt-sensitivity, respectively., Conclusions: This study demonstrated for the first time a relationship between rare variants in the ENaC pathway and BP salt-sensitivity. Future replication and functional studies are needed to confirm the findings in this study., Clinical Trial Registry: Trial Number NCT00721721., (© American Journal of Hypertension, Ltd 2017. All rights reserved. For Permissions, please email: journals.permissions@oup.com)
- Published
- 2018
- Full Text
- View/download PDF
18. Associations of the Serum/Glucocorticoid Regulated Kinase Genes With BP Changes and Hypertension Incidence: The Gensalt Study.
- Author
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Zhang D, Gu D, He J, Hixson JE, Rao DC, Li C, He H, Chen J, Huang J, Chen J, Rice TK, Chen S, and Kelly TN
- Subjects
- Adult, China epidemiology, Cohort Studies, Female, Humans, Hypertension epidemiology, Incidence, Male, Middle Aged, Multigene Family, Blood Pressure genetics, Hypertension genetics, Immediate-Early Proteins genetics, Protein Serine-Threonine Kinases genetics
- Abstract
Background: Single-marker and novel gene-based methods were employed to examine the associations of the serum/glucocorticoid regulated kinases (SGK) gene family with longitudinal blood pressure (BP) changes and hypertension incidence in a family-based cohort study., Methods: Totally, 1,768 Chinese participants from the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) follow-up study were included in the current analyses. Nine BP measures were obtained at each of 3 visits during the GenSalt follow-up study. Mixed-model and Gene-based analyses were used to examine the associations of the SGK gene family with longitudinal BP phenotypes. Bonferroni correction was applied to account for multiple testing., Results: After an average 7.2-year follow-up, 32.2% (513) of participants free of hypertension at baseline developed hypertension. Four novel SNPs in the SGK1 gene were predictive of the longitudinal BP phenotypes. The major alleles of SGK1 rs1763498 and rs114414980 conferred 2.9- and 2.5-fold increased risks of hypertension development, respectively (P = 1.0×10
-4 and 6.0×10-4 , respectively). In addition, the major allele of SGK1 rs229133 was significantly associated with 0.4mm Hg larger annual increases in systolic BP (P = 4.2×10-4 ), while the major allele of rs6924468 was significantly associated with 0.2mm Hg smaller annual increases in diastolic BP (P = 4.2×10-4 ). Gene-based analyses revealed an association of the SGK1 gene with risk of hypertension development (P = 7.4×10-3 ). No evidence for the SGK2 and SGK3 genes was found., Conclusions: The findings of the current study suggest that the SGK1 gene may play a role in long-term BP regulation and hypertension incidence., (© American Journal of Hypertension, Ltd 2016. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)- Published
- 2017
- Full Text
- View/download PDF
19. Associations Between Genetic Variants of the Natriuretic Peptide System and Blood Pressure Response to Dietary Sodium Intervention: The GenSalt Study.
- Author
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Chen S, Huang J, Zhao Q, Chen J, Jaquish CE, He J, Lu X, Yang X, Gu CC, Hixson JE, Liu F, Rice TK, Cao J, Chen J, and Gu D
- Subjects
- Adult, Alleles, Asian People genetics, Atrial Natriuretic Factor genetics, Blood Pressure drug effects, Female, Genetic Variation, Genotype, Humans, Male, Middle Aged, Natriuretic Peptide, Brain genetics, Natriuretic Peptide, C-Type genetics, Polymorphism, Single Nucleotide, Blood Pressure genetics, Diet, Sodium-Restricted, Natriuretic Peptides genetics, Receptors, Atrial Natriuretic Factor genetics, Sodium, Dietary pharmacology
- Abstract
Background: The aim of this study was to comprehensively test the association of genetic variants in the natriuretic peptide (NP) system with blood pressure (BP) response to dietary sodium intervention in a Chinese population., Methods: We conducted a 7-day low-sodium intervention followed by a 7-day high-sodium intervention among 1,906 participants in rural China. BP measurements were obtained at baseline and each dietary intervention using a random-zero sphygmomanometer. Linear mixed-effect models were used to assess the associations of 48 single-nucleotide polymorphisms (SNPs) in 6 genes of NP system with BP response to dietary sodium intervention., Results: SNP rs5063 in the NPPA gene and SNP rs2077386 in the NPPC gene exhibited significant associations with BP response to low-sodium dietary intervention under recessive genetic model. For rs5063, absolute mean arterial pressure responses (95% confidence interval) to the low-sodium intervention were 1.31 (-1.08, 3.70) mm Hg for TT genotype and -3.74 (-4.01, -3.46) mm Hg for CC or TC genotype, respectively (P = 4.1 × 10(-5)). Individuals with at least one copy of the C allele of rs2077386 had significantly reduction in systolic BP during the low-sodium intervention compared to those with genotype GG with responses of -5.48 (-5.83, -5.14) vs. -2.76 (-3.52, -2.00) mm Hg, respectively (P = 1.9 × 10(-13))., Conclusions: These novel findings suggested that genetic variants of NP system may contribute to the variation of BP response to sodium intervention in Chinese population. Certainly, replication of these results in other populations and further functional studies are warranted to clarify their role in the regulation of BP and hypertension., (© American Journal of Hypertension, Ltd 2015. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Published
- 2016
- Full Text
- View/download PDF
20. Associations of Endothelial System Genes With Blood Pressure Changes and Hypertension Incidence: The GenSalt Study.
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Liu F, He J, Gu D, Rao DC, Huang J, Hixson JE, Jaquish CE, Chen J, Li C, Yang X, Li J, Rice TK, Shimmin LC, and Kelly TN
- Subjects
- Adult, Blood Pressure drug effects, China epidemiology, Endothelial Cells metabolism, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Polymorphism, Single Nucleotide, Sodium, Dietary metabolism, Amidohydrolases genetics, Blood Pressure genetics, Collagen Type XVIII genetics, E-Selectin genetics, Hypertension epidemiology, Hypertension genetics, Receptor, Endothelin A genetics
- Abstract
Background: We used single-marker and novel gene-based methods to examine the associations of endothelial system genes with blood pressure (BP) changes and hypertension in a longitudinal family study., Methods: The Genetic Epidemiology Network of Salt Sensitivity follow-up study was conducted among 1,768 Chinese participants from 633 families. Nine BP measurements were obtained at baseline and at 2 follow-up visits using a random-zero sphygmomanometer. Mixed-effect models were used to assess the additive associations of 206 single-nucleotide polymorphisms (SNPs) in 15 endothelial system genes with longitudinal BP changes and hypertension incidence. Gene-based analyses were conducted using the truncated product method. The Bonferroni method was used to adjust for multiple testing in all analyses., Results: Among those free from hypertension at baseline, 512 (32.1%) developed hypertension during the average 7.2 years of follow-up. In single-marker analyses, each copy of the minor alleles of correlated SELE markers rs4656704, rs6427212, and rs5368 were associated with increased risk of developing hypertension (P for trend = 1.48 × 10(-4), 6.69 × 10(-5), and 7.64 × 10(-5), respectively). In addition, the minor allele of SELE marker rs3917436 was associated with smaller diastolic BP (DBP) increases over time. Results of gene-based analyses confirmed associations of the SELE gene with the longitudinal BP phenotypes (P values < 1.00 × 10(-6) for DBP change and hypertension incidence). Furthermore, the DDAH1 and COL18A1 genes were associated with systolic BP change (P < 1.00 × 10(-6) and P = 4.00 × 10(-6), respectively), while EDNRA was associated with hypertension incidence (P = 2.39 × 10(-4))., Conclusions: The current study provides strong evidence of a role of endothelial system genes in BP progression and hypertension incidence., (© American Journal of Hypertension, Ltd 2014. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Published
- 2015
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- View/download PDF
21. Heritability of blood pressure responses to cold pressor test in a Chinese population.
- Author
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Mei H, Gu D, Rice TK, Hixson JE, Chen J, Jaquish CE, Zhao Q, Chen CS, Chen JC, Gu CC, Kelly TN, and He J
- Subjects
- Adult, Blood Pressure Determination, China epidemiology, Cold Temperature, Female, Genetic Predisposition to Disease, Humans, Hypertension epidemiology, Hypertension genetics, Immersion, Male, Middle Aged, Risk Factors, Young Adult, Blood Pressure genetics
- Abstract
Background: Genetic determinants of blood pressure (BP) responses to the cold pressor test (CPT), a phenotype associated with risk of hypertension and cardiovascular disease has not been well studied., Methods: We examined the heritability of BP response to CPT in 1,994 subjects from 627 families in rural north China. BP was measured before and at 0, 1, 2, and 4 min after the participants immersed their hand in ice water for 1 min. Heritabilities of baseline BP and responses at 0 min, maximum response, and area-under-the-curve (AUC) during CPT were computed using a variance components method. Additionally, bivariate heritabilities were calculated to test the existence of shared genetic determinants between baseline BP and responses to CPT., Results: Heritabilities of baseline BP and responses to CPT were estimated from 14 to 35%, which all significantly differed from 0 (P < or = 0.002). Genetic correlations (s.e.) due to the same genes between baseline BP and responses to CPT ranged from -0.07 (0.14) to 0.21 (0.15), which were not significantly different from 0. Genetic correlations between reactivity and recovery were 0.67 (0.10) and 0.59 (0.10) for systolic (SBP) and diastolic BP (DBP), respectively, which were significantly different from 0., Conclusions: We concluded that (i) baseline BP and BP responses to CPT had strong genetic determinants; (ii) baseline BP and BP response to CPT did not share the same genetic components; and (iii) BP reactivity and recovery shared the same genetic components. These findings may lead to a better understanding of the genetic mechanism of BP responses to CPT.
- Published
- 2009
- Full Text
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22. Novel genetic variants in the alpha-adducin and guanine nucleotide binding protein beta-polypeptide 3 genes and salt sensitivity of blood pressure.
- Author
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Kelly TN, Rice TK, Gu D, Hixson JE, Chen J, Liu D, Jaquish CE, Bazzano LA, Hu D, Ma J, Gu CC, Huang J, Hamm LL, and He J
- Subjects
- Adolescent, Adult, China, Diet, Sodium-Restricted, Ethnicity, Female, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Blood Pressure genetics, Calmodulin-Binding Proteins genetics, Heterotrimeric GTP-Binding Proteins genetics, Sodium Chloride, Dietary adverse effects
- Abstract
Background: We examined the association between 12 single-nucleotide polymorphisms (SNPs) in the alpha-adducin (ADD1) and guanine nucleotide binding protein (G protein) beta-polypeptide 3 (GNB3) genes and systolic (SBP), diastolic (DBP), and mean arterial (MAP) pressure responses to salt intake., Methods: A 7-day low-sodium (51.3 mmol sodium/day) followed by a 7-day high-sodium intervention (307.8 mmol sodium/day) was conducted among 1,906 Han participants from rural North China. Blood pressure (BP) measurements were obtained at baseline and at the end of each intervention period using a random-zero sphygmomanometer., Results: We identified a significant association between a rare ADD1 variant rs17833172 and SBP, DBP, and MAP responses to high sodium (P values <0.0001) and DBP response to low sodium (P value = 0.002). Participants homozygous for the variant A allele of this marker had SBP, DBP, and MAP responses (95% confidence interval) to high salt of 1.6 (-1.8, 4.9), -0.8 (-5.6, 4.0), and -0.1 (-4.0, 3.9) mm Hg, respectively, vs. corresponding responses of 4.6 (2.5, 6.6), 1.7 (-0.2, 3.6), and 2.7 (0.9, 4.4) mm Hg, respectively, for those who were heterozygous or homozygous for the G allele. In addition, participants with at least one copy of the A allele of SNP rs1129649 of the GNB3 gene had significantly decreased MAP response to low salt compared to homozygotes for the C allele (P value = 0.004) with responses of -3.4 (-3.8, -3.0) vs. -4.2 (-4.6, -3.8) mm Hg, respectively., Conclusions: These data support a role for the ADD1 and GNB3 genes in BP salt sensitivity. Future studies aimed at replicating these novel findings are warranted.
- Published
- 2009
- Full Text
- View/download PDF
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