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Your search keyword '"Nakajima, Toshiaki"' showing total 4 results
Start Over Author "Nakajima, Toshiaki" Journal american journal of human genetics
4 results on '"Nakajima, Toshiaki"'

1. Natural selection and population history in the human angiotensinogen gene (AGT): 736 complete AGT sequences in chromosomes from around the world

Author

Nakajima, Toshiaki, Wooding, Stephen, Sakagami, Takuro, Emi, Mitsuru, Tokunaga, Katsushi, Tamiya, Gen, Ishigami, Tomoaki, Umemura, Satoshi, Munkhbat, Batmunkh, Jin, Feng, Guan-jun, Jia, Hayasaka, Ikuo, Ishida, Takafumi, Saitou, Naruya, Pavelka, Karel, Lalouel, Jean-Marc, Jorde, Lynn B., and Inoue, Ituro

Subjects
Human genetics -- Research, Biological sciences
Published
2004

2. Genomewide linkage and linkage disequilibrium analyses identify COL6A1, on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine

Author

Tanaka, Toshihiro, Ikari, Katsunori, Furushima, Kozo, Okada, Akihiro, Tanaka, Hiroshi, Furukawa, Ken-Ichi, Yoshida, Kenichi, Ikeda, Toshiyuki, Ikegawa, Shiro, Hunt, Steven C., Takeda, Jun, Toh, Satoshi, Harata, Seiko, Nakajima, Toshiaki, and Inoue, Ituro

Subjects
Central nervous system diseases -- Genetic aspects, Human genetics -- Research, Aged -- Health aspects, Bone diseases -- Genetic aspects, Biological sciences
Published
2003

4. Genomewide-Linkage and Haplotype-Association Studies Map Intracranial Aneurysm to Chromosome 7q11.

Author

Onda, Hideaki, Kasuya, Hidetoshi, Yoneyama, Taku, Takakura, Kintomo, Hori, Tomokatsu, Takeda, Jun, Nakajima, Toshiaki, and Inoue, Ituro

Subjects
*INTRACRANIAL aneurysms, *ANEURYSMS, *GENETICS
Abstract

Rupture of intracranial aneurysms (IAs) causes subarachnoid hemorrhage, a devastating condition with high mor-bidity and mortality. Angiographic and autopsy studies show that IA is a common disorder, with a prevalence of 3%--6%. Although IA has a substantial genetic component, little attention has been given to the genetic determinants. We report here a genomewide linkage study of IA in 104 Japanese affected sib pairs in which positive evidence of linkage on chromosomes 5q22-31 (maximum LOD score [MLS] 2.24), 7q11 (MLS 3.22), and 14q22 (MLS 2.31) were found. The best evidence of linkage is detected at D7S2472, in the vicinity of the elastin gene (ELN), a candidate gene for IA. Fourteen distinct single-nucleotide polymorphisms (SNPs) were identified in ELN, and no obvious allelic association between IA and each SNP was observed. The haplotype between the intron-20/intron-23 polymorphism of ELN is strongly associated with IA ( ), and homozygous patients are at high 5 6 P p 3.81 #10 risk ( ), with an odds ratio of 4.39. These findings suggest that a genetic locus for IA lies within or close P p .002 to the ELN locus on chromosome 7. [ABSTRACT FROM AUTHOR]

Published
2001
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