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Your search keyword '"Pinto VM"' showing total 9 results
Start Over Author "Pinto VM" Journal american journal of hematology
9 results on '"Pinto VM"'

1. Reduction of extramedullary erythropoiesis and amelioration of anemia in a β-thalassemia patient treated with thalidomide.

Author

Pinto VM, Romano N, Balocco M, Carrara P, Lamagna M, Quintino S, Castaldi A, and Forni GL

Subjects
Humans, Thalidomide therapeutic use, Erythropoiesis, beta-Thalassemia complications, beta-Thalassemia drug therapy, Hematopoiesis, Extramedullary, Hematologic Diseases, alpha-Thalassemia
Abstract

β-thalassemia patient treated with thalidomide: dimensional reduction of EMH foci (MRI evaluation) and reduction of hematological responce at follow-up., (© 2023 Wiley Periodicals LLC.)

Published
2024
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2. Coinheritance of PIEZO1 variants and multi-locus red blood cell defects account for the symptomatic phenotype in beta-thalassemia carriers.

Author

Pinto VM, Russo R, Quintino S, Rosato BE, Marra R, Del Giudice F, Mogni M, Maffei M, Iolascon A, Forni GL, and Andolfo I

Subjects
Humans, Erythrocytes, Heterozygote, Phenotype, Ion Channels genetics, beta-Thalassemia genetics
Abstract

Workflow of the study with some examples of the achieved results., (© 2023 Wiley Periodicals LLC.)

Published
2023
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3. Inflammatory and senescence-associated mediators affect the persistence of humoral response to COVID-19 mRNA vaccination in transfusion-dependent beta-thalassemic patients.

Author

Bordoni V, Casale M, Pinto VM, Carsetti R, Gianesin B, Gamberini MR, Mazdai L, Barella S, Denotti AR, Colavita F, Perrotta S, Maggio A, Pitrolo L, Quintino S, Caminati M, Mazzi F, Ceolan J, De Franceschi L, Forni GL, Locatelli F, and Agrati C

Subjects
Humans, Blood Transfusion, RNA, Messenger, Vaccination, Antibodies, Viral, Immunity, Humoral, COVID-19 prevention & control, beta-Thalassemia genetics, beta-Thalassemia therapy
Published
2023
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4. Overall and complication-free survival in a large cohort of patients with β-thalassemia major followed over 50 years.

Author

Forni GL, Gianesin B, Musallam KM, Longo F, Rosso R, Lisi R, Gamberini MR, Pinto VM, Graziadei G, Vitucci A, Bonetti F, Musto P, Piga A, Cappellini MD, and Borgna-Pignatti C

Subjects
Female, Humans, Male, Young Adult, Adult, Bone Marrow Transplantation, Risk Factors, beta-Thalassemia complications, beta-Thalassemia therapy, Heart Diseases, Thromboembolism complications
Abstract

We report data on survival and complications for a longitudinal cohort of 709 transfusion-dependent β-thalassemia major patients (51.1% males) born between 1970 and 1997 and followed through 2020 at seven major centers in Italy. Overall survival probability at 30 years was 83.6% (95%CI: 78.5-89.1) in the oldest birth cohort (1970-1974) compared with 93.3% (95%CI: 88.6-98.3) in the youngest birth cohort (1985-1997) (p = 0.073). Females showed better survival than males (p = 0.022). There were a total of 93 deaths at a median age of 23.2 years with the most frequent disease-related causes being heart disease (n = 53), bone marrow transplant (BMT) complication (n = 10), infection (n = 8), liver disease (n = 4), cancer (n = 3), thromboembolism (n = 2) and severe anemia (n = 1). There was a steady decline in the number of deaths due to heart disease from the year 2000 onwards and no death from BMT was observed after the year 2010. A progressive decrease in the median age of BMT was observed in younger birth cohorts (p < 0.001). A total of 480 (67.7%) patients developed ≥1 complication. Patients in younger birth cohorts demonstrated better complication-free survival (p < 0.001) which was comparable between sexes (p = 0.230). Independent risk factors for death in multivariate analysis included heart disease (HR: 4.63, 95%CI: 1.78-12.1, p = 0.002), serum ferritin >1000 ng/mL (HR: 15.5, 95%CI: 3.52-68.2, p < 0.001), male sex (HR: 2.75, 95%CI: 0.89-8.45, p = 0.078), and splenectomy (HR: 6.97, 95%CI: 0.90-54.0, p < 0.063). Survival in patients with β-thalassemia major continues to improve with adequate access to care, best practice sharing, continued research, and collaboration between centers., (© 2023 Wiley Periodicals LLC.)

Published
2023
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5. Italian patients with hemoglobinopathies exhibit a 5-fold increase in age-standardized lethality due to SARS-CoV-2 infection.

Author

Longo F, Gianesin B, Voi V, Motta I, Pinto VM, Piolatto A, Spasiano A, Ruffo GB, Gamberini MR, Barella S, Mariani R, Fidone C, Rosso R, Casale M, Roberti D, Dal Zotto C, Vitucci A, Bonetti F, Pitrolo L, Quaresima M, Ribersani M, Quota A, Arcioni F, Campisi S, Massa A, De Michele E, Lisi R, Miano M, Bagnato S, Gentile M, Carrai V, Putti MC, Serra M, Gaglioti C, Migone De Amicis M, Graziadei G, De Giovanni A, Ricchi P, Balocco M, Quintino S, Borsellino Z, Fortini M, Denotti AR, Tartaglione I, Beccaria A, Marziali M, Maggio A, Perrotta S, Piperno A, Filosa A, Cappellini MD, De Franceschi L, Piga A, and Forni GL

Subjects
Adult, Age Factors, Aged, Aged, 80 and over, COVID-19 epidemiology, COVID-19 mortality, Female, Hemoglobinopathies epidemiology, Hemoglobinopathies mortality, Humans, Italy epidemiology, Male, Middle Aged, Prevalence, Risk Factors, SARS-CoV-2 isolation & purification, Thalassemia complications, Thalassemia epidemiology, Thalassemia mortality, Young Adult, COVID-19 complications, Hemoglobinopathies complications
Published
2022
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6. SARS-CoV-2 infection in beta thalassemia: Preliminary data from the Italian experience.

Author

Motta I, Migone De Amicis M, Pinto VM, Balocco M, Longo F, Bonetti F, Gianesin B, Graziadei G, Cappellini MD, De Franceschi L, Piga A, and Forni GL

Subjects
Adult, COVID-19, Comorbidity, Female, Humans, Italy epidemiology, Male, Middle Aged, Pandemics, Preliminary Data, SARS-CoV-2, Betacoronavirus, Coronavirus Infections epidemiology, Pneumonia, Viral epidemiology, beta-Thalassemia epidemiology
Published
2020
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7. Daily alternating deferasirox and deferiprone therapy successfully controls iron accumulation in untreatable transfusion-dependent thalassemia patients.

Author

Pinto VM, Balocco M, Quintino S, Bacigalupo L, Gianesin B, Rizzi M, Malagò R, De Franceschi L, and Forni GL

Subjects
Adolescent, Adult, Deferasirox therapeutic use, Deferiprone therapeutic use, Drug Administration Schedule, Drug Synergism, Female, Follow-Up Studies, Humans, Iron Chelating Agents therapeutic use, Iron Overload etiology, Iron Overload prevention & control, Male, Thalassemia complications, Young Adult, Blood Transfusion, Chelation Therapy methods, Deferasirox administration & dosage, Deferiprone administration & dosage, Iron metabolism, Iron Chelating Agents administration & dosage, Iron Overload drug therapy, Thalassemia therapy
Published
2018
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8. Lack of correlation between heart, liver and pancreas MRI-R2*: Results from long-term follow-up in a cohort of adult β-thalassemia major patients.

Author

Pinto VM, Bacigalupo L, Gianesin B, Balocco M, De Franceschi L, Malagò R, Wood J, and Forni GL

Subjects
Adult, Chelation Therapy, Combined Modality Therapy, Endocrine System Diseases etiology, Erythrocyte Transfusion adverse effects, Female, Follow-Up Studies, Glucose Metabolism Disorders epidemiology, Glucose Metabolism Disorders etiology, Heart Diseases etiology, Humans, Incidence, Iron Chelating Agents therapeutic use, Iron Overload drug therapy, Iron Overload etiology, Iron Overload pathology, Liver pathology, Liver Cirrhosis etiology, Magnetic Resonance Imaging methods, Male, Organ Specificity, Pancreas pathology, Splenectomy, beta-Thalassemia complications, beta-Thalassemia therapy, Heart diagnostic imaging, Iron Overload diagnostic imaging, Liver diagnostic imaging, Myocardium pathology, Pancreas diagnostic imaging, beta-Thalassemia pathology
Published
2018
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9. Noninvasive monitoring of liver fibrosis in sickle cell disease: Longitudinal observation of a cohort of adult patients.

Author

Pinto VM, Gianesin B, Balocco M, Bacigalupo L, and Forni GL

Subjects
Adolescent, Adult, Aged, Anemia, Sickle Cell complications, Anemia, Sickle Cell physiopathology, Female, Humans, Liver Cirrhosis etiology, Liver Cirrhosis physiopathology, Longitudinal Studies, Male, Middle Aged, Anemia, Sickle Cell diagnostic imaging, Elasticity Imaging Techniques, Liver Cirrhosis diagnostic imaging
Published
2017
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