1. Effects on virological and immunological parameters during CD34 mobilization in HIV patients with lymphoma
- Author
-
Chiara Pratesi, Rosamaria Tedeschi, Massimiliano Berretta, Maurizio Rupolo, Stefania Zanussi, Maria Teresa Bortolin, Ettore Bidoli, Paolo De Paoli, and Cecilia Simonelli
- Subjects
Adult ,medicine.medical_specialty ,Lymphoma ,medicine.medical_treatment ,CD4-CD8 Ratio ,Antigens, CD34 ,HIV Infections ,G-CSF ,Virus Replication ,Proviruses ,Recurrence ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,Granulocyte Colony-Stimulating Factor ,medicine ,Humans ,HIV load ,ASCT ,Hematopoietic Stem Cell Mobilization ,Aged ,Lymphoma, AIDS-Related ,Chemotherapy ,Mobilization ,Hematology ,business.industry ,virus diseases ,CD8 ,CD4 ,Middle Aged ,medicine.disease ,Granulocyte colony-stimulating factor ,Blood Cell Count ,Treatment Outcome ,Immunology ,RNA, Viral ,business ,Viral load - Abstract
The effects of CD34 mobilization with chemotherapy and G-CSF administration were evaluated in 13 HIV-positive patients with relapsed lymphomas and low CD4 counts. After mobilization, CD4+ cells increased significantly while HIV-RNA and integrated HIV-DNA showed no increases. G-CSF led to an increase of CD4+ cells with limited effects on HIV replication.
- Published
- 2006