1. Hepatic Steatosis in Genotype 4 Chronic Hepatitis C Is Mainly Because of Metabolic Factors.
- Author
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Tsochatzis, Emmanuel, Papatheodoridis, George V., Manesis, Emanuel K., Chrysanthos, Nikolaos, Kafiri, Georgia, Petraki, Kalliopi, Hadziyannis, Emilia, Pandelidaki, Helen, Zafiropoulou, Rodessa, Savvas, Savvas, Koskinas, John, and Archimandritis, Athanasios J.
- Subjects
HEPATITIS C ,GENETIC polymorphisms ,LIVER diseases ,ISOPENTENOIDS ,LOW-cholesterol diet ,BODY weight - Abstract
BACKGROUND/AIM: Hepatic steatosis is considered to be mostly associated with viral factors in genotype 3 and metabolic factors in genotype 1 chronic hepatitis C, while there are rather few data for genotype 4. We determined the parameters associated with steatosis in 350 chronic hepatitis C patients, focusing on genotype 4. METHODS: Histological lesions were evaluated according to Ishak's classification and steatosis was semiquantitatively graded. Several patient characteristics on the biopsy day were also evaluated. RESULTS: Steatosis was present in 73% of patients without significant differences among genotypes. Moderate/severe steatosis was more frequent in genotype 3 than 4 (44% vs 26%, P= 0.025) and similar between genotype 4 and 1 patients. Moderate/severe steatosis was associated with body mass index (BMI) in genotype 4 ( P= 0.023) and gamma-glutamyl-transpeptidase in genotype 3 patients ( P= 0.044). In 150 nondiabetic patients with BMI ≤25 kg/m
2 , moderate/severe steatosis was present in 15, 40, and 11% of genotype 1, 3, and 4 patients, respectively, ( P= 0.005) and was independently associated only with genotype 3. In multivariate analysis, steatosis grade or moderate/severe steatosis was independently associated with higher BMI, genotype 3, and lower cholesterol. CONCLUSIONS: Moderate or severe steatosis is significantly less frequent in genotype 4 than 3 chronic hepatitis C patients and similar between genotype 4 and 1. In nondiabetic, nonoverweight patients, moderate or severe steatosis is present in only 10–15% of genotype 4 or 1 compared with 40% of genotype 3 patients. Thus, hepatic steatosis in genotype 4 is mostly associated with metabolic factors, similar to those in genotype 1. [ABSTRACT FROM AUTHOR]- Published
- 2007
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