1. Changes in Epidemiology of Acetaminophen Overdoses in an Urban County Hospital After 20 Years.
- Author
-
Long A, Magrath M, Mihalopoulos M, Rule JA, Agrawal D, Haley R, Kleinschmidt K, and Lee WM
- Subjects
- Acetaminophen, Adult, Databases, Factual, Hospitals, County, Humans, United States epidemiology, Chemical and Drug Induced Liver Injury epidemiology, Chemical and Drug Induced Liver Injury etiology, Drug Overdose epidemiology, Liver Failure, Acute chemically induced, Liver Failure, Acute epidemiology
- Abstract
Introduction: Acetaminophen (APAP) toxicity is the main cause of acute liver failure in the United States. A prior series (1992-1995) identified 71 hospitalized adults with APAP toxicity through the International Statistical Classification of Disease and Related Health Problems, 9th revision (ICD-9) code at Parkland Hospital, Dallas, TX., Methods: We used a laboratory database search of serum APAP levels from 2011 to 2015 to identify patients with APAP toxicity in the same hospital., Results: We identified 140 patients hospitalized for APAP toxicity from 27,143 APAP levels obtained; 35 required Intensive Care Unit (ICU) admission, and there were no deaths. APAP toxicity/100,000 admissions was similar between eras., Discussion: APAP toxicity continues unabated after 20 years but with improved overall outcomes., (Copyright © 2022 by The American College of Gastroenterology.)
- Published
- 2022
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