13 results on '"De Giorgio, F."'
Search Results
2. Cervical Spine Involvement in a Challenging Case of Accidental Strangulation.
- Author
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De-Giorgio F, Grassi S, Miscusi M, Ricciardi L, and Polli FM
- Subjects
- Humans, Male, Middle Aged, Neck Injuries diagnostic imaging, Neck Injuries pathology, Skull Fractures diagnostic imaging, Subarachnoid Hemorrhage, Traumatic pathology, Temporal Bone diagnostic imaging, Temporal Bone injuries, Tomography, X-Ray Computed, Accidents, Home, Asphyxia pathology, Cervical Vertebrae diagnostic imaging, Cervical Vertebrae injuries, Fracture Dislocation diagnostic imaging
- Abstract
Although strangulation is generally homicidal, the scientific literature reports several cases in which it is suicidal or even accidental. The former eventuality is particularly interesting because extremely atypical ligatures (such as locks of hair), complex dynamics, and uncommon findings can be involved. Only a meticulous evaluation of the body and of both direct and circumstantial evidence can help in the complex differential diagnosis that includes murder, suicide, and accident. In accidental strangulation, the number and severity of injuries depend on the magnitude of applied force. This implies that high-energy strangulation (in our case, caused by the entanglement of a scarf in an electrical generator) can produce a complex polytrauma. In this case, accidental self-strangulation caused widespread, posttraumatic subarachnoid hemorrhaging, laceration of the larynx, and fracture-dislocation of the C2/C3 vertebrae. We believe that all these events contributed to the death of the victim, but the complexity of the polytrauma and the lack of direct evidence did not allow us to determine a univocal cause-effect chain.
- Published
- 2019
- Full Text
- View/download PDF
3. Commentary on: Sudden Death in an Adult Due to Nontraumatic Diaphragmatic Hernia.
- Author
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De-Giorgio F, Grassi S, and Carbone A
- Subjects
- Female, Humans, Middle Aged, Obesity, Pneumonia, Aspiration pathology, Respiratory Aspiration pathology, Death, Sudden etiology, Esophageal Achalasia pathology
- Published
- 2019
- Full Text
- View/download PDF
4. An unusual suicide: asphyxia by methane gas.
- Author
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Rossi R, De-Giorgio F, Grassi VM, Pascali VL, and Lancia M
- Subjects
- Adult, Asphyxia pathology, Brain Edema pathology, Chromatography, Gas, Forensic Pathology, Forensic Toxicology, Gases, Humans, Male, Pericardium pathology, Pleura pathology, Pulmonary Edema pathology, Purpura pathology, Asphyxia etiology, Methane poisoning, Suicide
- Abstract
Asphyxia by suffocating gases, that is, methane or carbon dioxide, is characterized by the displacement of oxygen from inspired air. Thus, the cells are unable to receive oxygen and, as a consequence, are affected by acute hypoxemic hypoxia. The brain suffers because of the hypoxemic state, the subject become unconscious, and then, respiration arrest occurs, followed by cardiac arrest. This is the physiopathologic mechanism leading to death.We report a case of a 35-year-old man found dead at home with his mouth containing a tube linked to the domestic methane gas system originating from the wall, sealed with packing tape.
- Published
- 2013
- Full Text
- View/download PDF
5. Virtual autopsy in hanging.
- Author
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Polacco M, D'Alessio P, Ausania F, Zobel B, Pascali VL, d'Aloja E, Miscusi M, and De-Giorgio F
- Subjects
- Adult, Brain Edema pathology, Cervical Vertebrae injuries, Cervical Vertebrae pathology, Forensic Pathology, Fractures, Bone pathology, Hemorrhage pathology, Humans, Hyoid Bone injuries, Hyoid Bone pathology, Imaging, Three-Dimensional, Male, Neck Muscles pathology, Spinal Fractures pathology, Spondylolisthesis pathology, Tomography, X-Ray Computed, Asphyxia pathology, Autopsy methods, Neck Injuries pathology
- Abstract
The aim of the study was to compare postmortem computed tomographic (CT) imaging findings from a case of hanging with the autopsy findings. The CT showed a good match with autopsy findings especially for bone, soft tissue, and spinal injuries. The CT images of the injuries of the neck obtained by CT scan clearly showed the ligature mark, the hemorrhagic suffusion in the soft tissue (thickening of derma) and in the muscles (sternocleidomastoid) of the neck. Furthermore, CT 3-dimensional reconstruction showed brain edema, fracture of the left posterior horn of the hyoid bone, and a grade 1 retrolisthesis of C5 on C6. This last finding was not detected by autopsy because of the anterior approach that is frequently used in necropsy technique. Nevertheless, the CT virtual autopsy did not show vascular findings (like Amussat mark) because a barium mixture was not injected in the body.
- Published
- 2013
- Full Text
- View/download PDF
6. Acute Ibuprofen intoxication: report on a case and review of the literature.
- Author
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Lodise M, De-Giorgio F, Rossi R, d'Aloja E, and Fucci N
- Subjects
- Anti-Inflammatory Agents, Non-Steroidal analysis, Brain Edema pathology, Forensic Pathology, Forensic Toxicology, Gas Chromatography-Mass Spectrometry, Gastrointestinal Contents chemistry, Humans, Ibuprofen analysis, Kidney pathology, Liver pathology, Lung pathology, Male, Middle Aged, Myocardium pathology, Pulmonary Edema pathology, Anti-Inflammatory Agents, Non-Steroidal poisoning, Ibuprofen poisoning, Suicide
- Abstract
A fatality following the ingestion of ibuprofen is reported. Ibuprofen is a prototypical nonsteroidal anti-inflammatory drug widely prescribed as an analgesic, anti-inflammatory, and antipyretic agent. To date, there are few case reports of fatal overdose with ibuprofen, following ibuprofen self-poisoning or accidental overdose. We report the case of a 51-year-old man with medical history of psychiatric disease, who was brought to the emergency department by ambulance with a chief complaint of having taken large amounts of drugs in a suicide attempt.Multiple empty containers of medications (ibuprofen, meloxicam, celecoxib, risperidone, citalopram, ketorolac, bromazepam) were found at the scene. He died 4 hours after admission to the emergency department, despite vigorous supportive care. Toxicological analyses were performed using a gas chromatography/mass spectrometry technique. The estimated ibuprofen concentration in the plasma was 600 μg/mL; gastric content was 200 μg/mL for this compound. Our report describes results of the forensic investigation and discuss the review of the literature.
- Published
- 2012
- Full Text
- View/download PDF
7. Subarachnoid hemorrhage during sexual activity after sildenafil intake: an accidental association?
- Author
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De-Giorgio F, Arena V, Arena E, Lodise M, Valerio L, d'Aloja E, and Chiarotti M
- Subjects
- Anterior Cerebral Artery pathology, Coitus, Forensic Pathology, Humans, Male, Middle Aged, Phosphodiesterase 5 Inhibitors administration & dosage, Piperazines administration & dosage, Purines administration & dosage, Purines adverse effects, Rupture, Spontaneous, Sildenafil Citrate, Sulfones administration & dosage, Intracranial Aneurysm pathology, Phosphodiesterase 5 Inhibitors adverse effects, Piperazines adverse effects, Subarachnoid Hemorrhage pathology, Sulfones adverse effects
- Abstract
We report and describe an autopsy case of a man dead for rupture of cerebral artery aneurysm with subsequent subarachnoid hemorrhage after sexual intercourse. Toxicologic analysis demonstrated that he had consumed sildenafil (Viagra). Although subarachnoid hemorrhage has been reported to be associated with sexual intercourse, it is not among the known adverse effects of sildenafil. However, sildenafil has been found to interact with vascular physiology via multiple mechanisms and in most of the vascular districts of the human body. This case provides an example of a very rare association between this drug and a fatal pathologic event and deserves to be added to the existing clinical knowledge about sildenafil and the pathophysiology of the events involved. This knowledge may be helpful in orienting further investigation into the mechanisms of action of sildenafil and their clinical implications.
- Published
- 2011
- Full Text
- View/download PDF
8. Death secondary to a donkey's bites.
- Author
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d'Aloja E, Grimaldi L, Cascini F, De Mercurio D, and De-Giorgio F
- Subjects
- Aged, Animals, Asphyxia pathology, Bites and Stings pathology, Exsanguination pathology, Forensic Pathology, Humans, Male, Neck Injuries pathology, Respiratory Aspiration etiology, Respiratory Aspiration pathology, Trachea injuries, Trachea pathology, Asphyxia etiology, Bites and Stings complications, Equidae, Exsanguination etiology, Neck Injuries etiology
- Abstract
We present a unique case of death due to the assault and bites of a donkey on a 65-year-old man. The farmer, found dead in his farmyard, had a very deep wound in the anterior region of the neck, with a sharp transection of the trachea and severe bleeding by several minor vessels wall disruptions. The cause of death was established to be massive bleeding combined with asphyxia due to aspiration of the blood. Moreover, multiple contusions with associated skin abrasions and perforations were present. The general impression of the injuries was consistent with an animal's bite marks. Herbivorous or omnivorous bite attacks on humans are rare; instead, these animals attack by kicking, trampling, and kneeling, resulting in secondary blunt injuries. The donkey is usually a docile animal, but its behavior can be aggressive during the mating season, and the possibility of biting should not be underestimated, as illustrated by the 2 cases published previously as well as by the case presented here.
- Published
- 2011
- Full Text
- View/download PDF
9. Does the principle of cost/benefit analysis apply to forensic pathology?
- Author
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De-Giorgio F and Vetrugno G
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- Autopsy legislation & jurisprudence, Cost-Benefit Analysis, Forensic Pathology legislation & jurisprudence, Humans, Autopsy economics, Forensic Pathology economics
- Published
- 2010
- Full Text
- View/download PDF
10. Death from renal cyst: spontaneous or traumatic rupture?
- Author
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Rainio J, De Giorgio F, and Carbone A
- Subjects
- Forensic Pathology, Hematoma pathology, Hemorrhage pathology, Humans, Male, Middle Aged, Rib Fractures pathology, Rupture pathology, Cysts pathology, Kidney Diseases pathology
- Abstract
We report an unusual death of an apparently healthy 56-year-old male due to massive hemorrhage caused by rupture of an artery in the wall of a solitary renal cyst, possibly after a relatively minor trauma. Fatalities due to spontaneous or posttraumatic rupture of renal cysts are extremely rare but can represent a potential danger for people with acquired cystic kidney disease. Our report describes results of the forensic investigation and discusses possible mechanisms of the rupture.
- Published
- 2006
- Full Text
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11. Acute flurazepam intoxication: a case report.
- Author
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Martello S, Oliva A, De Giorgio F, and Chiarotti M
- Subjects
- Aged, Bile chemistry, Female, Forensic Medicine, Gas Chromatography-Mass Spectrometry, Gastrointestinal Contents chemistry, Humans, Hypnotics and Sedatives analysis, Molecular Structure, Suicide, Flurazepam analysis, Flurazepam poisoning, Hypnotics and Sedatives poisoning
- Abstract
A fatality due to ingestion of flurazepam is reported. Flurazepam is a benzodiazepine, a widely prescribed hypnotic drug for use in sleep disorders. There are only few documented reports of the disposition of flurazepam in deaths due to overdose. A 68-year-old woman was found deceased at home with no evidence of trauma or asphyxia. Toxicologic analyses were performed and drug levels measured by means of gas chromatography coupled to mass spectrometry. The flurazepam concentration in each specimen was as follows: heart blood 2.8 microg/mL, bile 323 microg/mL, and urine 172 microg/mL. Presence of flurazepam into gastric content was observed too. Based on the autopsy findings, patient history, and toxicologic results, the cause of death was determined to be acute intoxication of flurazepam and the manner, suicide.
- Published
- 2006
- Full Text
- View/download PDF
12. Medicolegal aspects of an unusual uterine perforation with multiload-Cu 375R.
- Author
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Grimaldi L, De Giorgio F, Andreotta P, D'Alessio MC, Piscicelli C, and Pascali VL
- Subjects
- Device Removal, Female, Humans, Laparoscopy, Middle Aged, Time Factors, Ultrasonography, Uterus diagnostic imaging, Foreign-Body Migration diagnostic imaging, Intrauterine Devices adverse effects, Uterine Perforation etiology
- Abstract
Perforation of the uterus is one of the most serious complications associated with insertion of intrauterine contraceptive devices (IUD). According to recent studies, this lesion occurs in 0.87 per 1000 cases, but statistics generally fluctuate between 0.05 and 13 per 1000 insertions. "Primary" perforations occur at the time of IUD insertion, and "secondary," or delayed, perforations are usually assumed to be caused by reactive uterine contractions. We report an unusual case of uterine perforation, which occurred 9 days after the insertion of a Multiload-Cu 375 IUD. The criteria for differential diagnosis between primary and secondary complications are discussed, particularly from the perspective of medical malpractice cases.
- Published
- 2005
- Full Text
- View/download PDF
13. Spontaneous rupture of coronary artery in human immunodeficiency virus-positive patient treated with highly active anti-retroviral therapy (HAART).
- Author
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De Giorgio F, Abbate A, Capelli A, and Arena V
- Subjects
- Adult, Coronary Aneurysm complications, Coronary Thrombosis etiology, Coronary Thrombosis pathology, Humans, Male, Myocardial Infarction etiology, Myocardial Infarction pathology, Myocardium pathology, Rupture, Spontaneous, Antiretroviral Therapy, Highly Active, Coronary Aneurysm pathology, Death, Sudden, Cardiac etiology, HIV Infections drug therapy
- Published
- 2005
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