1. Maternal Concentrations of Perfluoroalkyl Substances and Fetal Markers of Metabolic Function and Birth Weight.
- Author
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Ashley-Martin, Jillian, Dodds, Linda, Arbuckle, Tye E., Bouchard, Maryse F., Fisher, Mandy, Morriset, Anne-Sophie, Monnier, Patricia, Shapiro, Gabriel D., Ettinger, Adrienne S., Dallaire, Renee, Taback, Shayne, Fraser, William, and Platt, Robert W.
- Subjects
FETAL abnormalities -- Risk factors ,AGE distribution ,ANALYSIS of covariance ,BIOMARKERS ,BIRTH weight ,CONFIDENCE intervals ,STATISTICAL correlation ,GESTATIONAL age ,HIGH performance liquid chromatography ,LONGITUDINAL method ,FIRST trimester of pregnancy ,PROBABILITY theory ,REGRESSION analysis ,RESEARCH funding ,SEX distribution ,SMOKING ,LEPTIN ,ENVIRONMENTAL exposure ,BODY mass index ,FETAL development ,DATA analysis software ,ADIPONECTIN ,DESCRIPTIVE statistics ,PREGNANCY - Abstract
Perfluoroalkyl substances (PFAS) are ubiquitous, persistent chemicals that have been widely used in the production of common household and consumer goods for their nonflammable, lipophobic, and hydrophobic properties. Inverse associations between maternal or umbilical cord blood concentrations of perfluorooctanoic acid and perfluorooctanesulfonate and birth weight have been identified. This literature has primarily examined each PFAS individually without consideration of the potential influence of correlated exposures. Further, the association between PFAS exposures and indicators of metabolic function (i.e., leptin and adiponectin) has received limited attention. We examined associations between first-trimester maternal plasma PFAS concentrations and birth weight and cord blood concentrations of leptin and adiponectin using data on 1,705 mother-infant pairs from the Maternal Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada birth cohort study that recruited women between 2008 and 2011. Bayesian hierarchical models were used to quantify associations and calculate credible intervals. Maternal perfluorooctanoic acid concentrations were inversely associated with birth weight z score, though the null value was included in all credible intervals (log
10 β = -0.10, 95% credible interval: -0.34, 0.13). All associations between maternal PFAS concentrations and cord blood adipocy-tokine concentrations were of small magnitude and centered around the null value. Follow-up in a cohort of children is required to determine how the observed associations manifest in childhood. [ABSTRACT FROM AUTHOR]- Published
- 2017
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