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1. A theoretical explanation for the epinephrine-fast state as a manifestation of imbalance in the histamine-sympathin see-saw is presented (“epinephrine-histamine toxicity”). The experimental observations described lead us to conclude that repeated administrations of epinephrine to such individuals produce an increase in plasma histamine overcoming the effects of the epinephrine. It is theoretically plausible that suitably administered antihistaminic agents might return the see-saw to its normal balance. 2. In eight of a group of ten patients displaying epinephrine-fastness significant improvement followed the use of intravenous tripelennamine hydrochloride or diphenhydramine hydrochloride. Epinephrine, administered subcutaneously or by the aerosol route, appeared to bring relief from acute paroxysmal bronchospasm, whereas previously only the side effects of epinephrine had been observed following its use.