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The occurrence of lobomycosis outside central and South America is extremely rare. Herein we report 2 extraordinary cases of lobomycosis in 2 South African patients seeking medical attention at the Liverpool School of Hygiene and Tropical Medicine. The first patient presented with a 32-year history of a lesion on his left foot, with a further lesion subsequently developing on the right foot within the year. Six years ago he developed nontender keloid-like lesions on his left arm and on the face. The second patient is a 16-year-old black South African man who presented with a 2-year history of an ulcerating fungating tumor on his back. Microscopically, biopsies from both patients consisted of a diffuse granulomatous dermal inflammatory cell infiltrate composed of numerous multinucleate giant cells, and histiocytes, which contained rounded organisms with refractile walls, imparting a characteristic sievelike morphology; there were admixed acute and chronic inflammatory cells. Grocott's methenamine silver stain, and periodic acid Schiff (positive), demonstrated many uniform spherical to oval yeastlike organisms arranged singly or in small chains connected by thin tubular connections. In conclusion, we report 2 unique and exceedingly rare cases of cutaneous lobomycosis.

We report a fatal case of disseminated amebiasis in a young African woman, which initially presented with an ulcerated cutaneous lesion on the left flank. The causative organism was confirmed by examination of a wet drop preparation from the ulcer discharge and by skin biopsy. The patient was not immunosuppressed and was treated unsuccessfully with metronidazole. Postmortem examination revealed the presence of intestinal amebiasis complicated by a liver abscess.