1. Successive B-cell lymphomas mostly reflect recurrences rather than unrelated primary lymphomas
- Author
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Willemina R. R. Geurts-Giele, King H. Lam, Anton W. Langerak, Ingrid L. M. Wolvers-Tettero, Winand N.M. Dinjens, Pathology, and Immunology
- Subjects
Pathology ,medicine.medical_specialty ,Lymphoma, B-Cell ,Chronic lymphocytic leukemia ,Biology ,Somatic evolution in cancer ,Cohort Studies ,Immunoglobulin kappa-Chains ,immune system diseases ,hemic and lymphatic diseases ,medicine ,Humans ,B-cell lymphoma ,Gene Rearrangement, B-Lymphocyte ,B cell ,Netherlands ,Incidence ,Neoplasms, Second Primary ,General Medicine ,Gene rearrangement ,DNA, Neoplasm ,Sequence Analysis, DNA ,medicine.disease ,Primary tumor ,Lymphoma ,Clone Cells ,medicine.anatomical_structure ,Lymphoma, Large B-Cell, Diffuse ,Neoplasm Recurrence, Local ,Immunoglobulin Heavy Chains ,Diffuse large B-cell lymphoma ,Multiplex Polymerase Chain Reaction - Abstract
Objectives: To address whether successive B-cell lymphomas, diagnosed within a 5- to 15-year interval, are recurrences or unrelated primary lymphomas. Methods: Immunoglobulin heavy and κ light chain gene rearrangements were studied using multiplex polymerase chain reaction fragment assays and sequence analysis in 61 patients. Results: Clonal patterns of the multiple lymphomas from 36 patients were determined and classified accordingly: 30 recurrences, 2 possible recurrences, 2 different clones with a common origin, and 2 unrelated primary lymphomas. Conclusions: Regardless of subtype, 89% to 94% of late B-cell lymphoma relapses were recurrences of the primary tumor. Therefore, routinely investigating the possible clonal relationship between successive lymphomas may not be warranted except for specific lymphoma subtypes such as diffuse large B-cell lymphomas.
- Published
- 2013