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Your search keyword '"Martin Kroll"' showing total 2 results
Start Over Author "Martin Kroll" Journal american journal of clinical pathology
2 results on '"Martin Kroll"'

1. Renal Dysfunction, Hemodialysis, and the NT-proBNP/BNP RatioThe Authors’ Reply

Author

Pornpen Srisawasdi, Leo H. Jacobs, Alma M. Mingels, Will K. Wodzig, Marja P. van Dieijen-Visser, Jeroen P. Kooman, Somlak Vanavanan, Charaslak Charoenpanichkit, and Martin Kroll

Subjects
medicine.medical_specialty, education.field_of_study, medicine.drug_class, business.industry, medicine.medical_treatment, Population, Renal function, General Medicine, Disease, medicine.disease, Endocrinology, Internal medicine, cardiovascular system, Natriuretic peptide, medicine, Cardiology, Biomarker (medicine), Myocardial infarction complications, cardiovascular diseases, Hemodialysis, business, education, hormones, hormone substitutes, and hormone antagonists, Linear trend
Abstract

With great interest we read the article by Srisawasdi et al.1 They found that the ratio between N-terminal (NT)-pro-B-natriuretic peptide (BNP) and BNP increases exponentially with the stage of renal disease. van Kimmenade et al,2 however, suggested the NT-proBNP/BNP ratio increases only slightly and shows a linear trend. Their findings are used to support the hypothesis that BNP and NT-proBNP concentrations rely equally on the glomerular filtration rate and predominantly on cardiac diseases, rather than on renal clearance.2,3 The findings by Srisawasdi et al1 suggest otherwise, and they rightly advocate that renal dysfunction should be taken into account when interpreting the diagnostic and prognostic potential of NT-proBNP and BNP. Missing in the data from Srisawasdi et al1 are the ratios in the patients with end-stage renal disease who were treated with hemodialysis. On reading the article by Srisawasdi et al,1 we decided to take a look at the NT-proBNP/BNP ratios in a population of patients receiving long-term hemodialysis for whom we recently described cardiac biomarker concentrations4 and their relationship …

Published
2010

2. Advantages and Disadvantages of Serum Cholesterol Determination by the Kinetic vs the End Point Method.

Author

Pornpen Srisawasdi, Martin Kroll, and Porntip Lolekha

Subjects
*CHOLESTEROL, *STREPTOMYCES, *BIOLOGICAL reagents, *ENZYMES, *STEROLS
Abstract

Enzymatic assays for cholesterol determination can use an end point or a kinetic method. We evaluated and compared the performance of these methods. We constructed user-defined methods on 3 automated analyzers using Streptomyces cholesterol reagents to evaluate the analytic performance of both methods. Linearity (700-900 mg/dL) and stability of reagents (5-11 weeks) depended on the analyzers. The coefficients of variation for imprecision were 2.41% to 2.99% and 3.78% to 5.52% for the end point and kinetic methods, respectively. The end point method showed less bias at decision cut points (-0.8% to 1.3%) than did the kinetic method (-1.1% to 3.6%) but was more affected by interfering substances.The advantages of the end point over the kinetic method are better precision and lower reagent cost. The end point imprecision fell within National Cholesterol Education Program guidelines (⩽3%), but the kinetic did not. The kinetic method showed less interference and required shorter analysis time. [ABSTRACT FROM AUTHOR]

Published
2007
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