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This article discusses the importance of appropriate laboratory test orders in order to prevent misdiagnosis, incorrect treatment, and negative outcomes for patients. The authors highlight a study that introduced a decision support alert to improve compliance with clinical guidelines for ordering serum protein electrophoresis pattern (SPEP) testing with a concurrent serum free light chain (sFLC) measurement. The study found that the alert led to increased compliance and the identification of new diagnoses. However, the authors also acknowledge the potential for overordering if an order set defaults both SPEP and sFLC tests. The authors then present their own experience in verifying the appropriateness of sFLC orders in their academic institution, finding that 10-15% of orders were inappropriate. They suggest the need for specific interventions to reduce inappropriate orders, such as algorithmic approaches. [Extracted from the article]