1. Clinical and Prognostic Significance of Coagulation Assays in Pancreatic Cancer Patients With Absence of Venous Thromboembolism
- Author
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Yan Liu, Wei Sun, Wei Dong Ma, Lin Luo, Ji Hui Hao, Chun Tao Gao, He Ren, and Peng Jin
- Subjects
Adult ,Male ,Oncology ,Cancer Research ,medicine.medical_specialty ,Antithrombin III ,Fibrinogen ,Gastroenterology ,Cohort Studies ,Fibrin Fibrinogen Degradation Products ,Internal medicine ,D-dimer ,medicine ,Coagulation testing ,Humans ,International Normalized Ratio ,Neoplasm Metastasis ,Coagulation Disorder ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Blood coagulation test ,Aged, 80 and over ,Prothrombin time ,Factor VIII ,medicine.diagnostic_test ,business.industry ,Venous Thromboembolism ,Middle Aged ,Prognosis ,Pancreatic Neoplasms ,Case-Control Studies ,Hemostasis ,Disease Progression ,Prothrombin Time ,Female ,Partial Thromboplastin Time ,Blood Coagulation Tests ,business ,Carcinoma, Pancreatic Ductal ,Follow-Up Studies ,Protein C ,Partial thromboplastin time ,medicine.drug - Abstract
OBJECTIVES Activation of coagulation and fibrinolysis is frequently observed in patients with cancer, even with absence of thrombosis. Furthermore, plasma coagulation parameters were associated with tumor progression, metastasis, and prognosis. Few studies have investigated these associations in pancreatic cancer (PA). This study aimed to investigate the clinical and prognostic significance of various plasma coagulation tests in PA patients with absence of venous thromboembolism (VTE). MATERIALS AND METHODS A total of 139 PA patients with the absence of VTE were included in the analysis. Patients were followed up for at least 12 months until death. Pretreatment coagulation parameters including prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT), fibrinogen (F), antithrombin-III (AT-III), protein C (PC), factor-VIII (F-VIII), and D-dimer (DD) were evaluated. A total of 40 age-matched and sex-matched healthy individuals without coagulation disorder were enrolled as the control group. RESULTS Patients were inclined to have higher levels of PT, INR, APTT, F, F-VIII, and DD and lower levels of AT-III and PC than the control group (P
- Published
- 2015