1. Long-term Outcomes With Ifosfamide-based Hypofractionated Preoperative Chemoradiotherapy for Extremity Soft Tissue Sarcomas
- Author
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Pennington, Joseph Daniel, Eilber, Fritz C, Eilber, Frederick R, Singh, Arun S, Reed, Jarred P, Chmielowski, Bartosz, Eckardt, Jeffrey J, Bukata, Susan V, Bernthal, Nicholas M, Federman, Noah, Nelson, Scott D, Dry, Sarah M, Wang, Pin-Chieh, Luu, Michael, Selch, Michael T, Steinberg, Michael L, Kalbasi, Anusha, and Kamrava, Mitchell
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Patient Safety ,6.5 Radiotherapy and other non-invasive therapies ,Evaluation of treatments and therapeutic interventions ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Antineoplastic Combined Chemotherapy Protocols ,Chemoradiotherapy ,Adjuvant ,Doxorubicin ,Extremities ,Female ,Follow-Up Studies ,Humans ,Ifosfamide ,Male ,Middle Aged ,Neoadjuvant Therapy ,Preoperative Care ,Prognosis ,Radiation Dose Hypofractionation ,Retrospective Studies ,Sarcoma ,Survival Rate ,Young Adult ,extremity sarcoma ,hypofractionated radiotherapy ,neoadjuvant chemotherapy ,limb-sparing surgery ,pathologic necrosis score ,Dentistry ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
ObjectivesThe objective of this study was to analyze outcomes for patients with soft tissue sarcoma of the extremities using neoadjuvant ifosfamide-based chemotherapy and hypofractionated reduced dose radiotherapy, followed by limb-sparing surgery.Materials and methodsAn Institutional Review Board (IRB)-approved retrospective review of patients treated at a single institution between 1990 and 2013 was performed. In total, 116 patients were identified who received neoadjuvant ifosfamide-based chemotherapy and 28 Gy in 8 fractions of preoperative radiation (equivalent dose in 2 Gray fractions, 31.5 Gy [α/β 10] 36.4 Gy [α/β 3]) followed by limb-sparing surgery. Local recurrence (LR), distant failure (DF), and overall survival (OS) were calculated. Univariate and multivariate analysis for LR, DF, and OS were performed using Cox analysis. Statistical significance was set at a P
- Published
- 2018