1. Small-quantity, lipid-based nutrient supplements provided to women during pregnancy and 6 mo postpartum and to their infants from 6 mo of age increase the mean attained length of 18-mo-old children in semi-urban Ghana: a randomized controlled trial 1 , 2
- Author
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Adu-Afarwuah, Seth, Lartey, Anna, Okronipa, Harriet, Ashorn, Per, Peerson, Janet M, Arimond, Mary, Ashorn, Ulla, Zeilani, Mamane, Vosti, Stephen, and Dewey, Kathryn G
- Subjects
Reproductive Medicine ,Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Pediatric Research Initiative ,Pediatric ,Clinical Research ,Nutrition ,Clinical Trials and Supportive Activities ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Reproductive health and childbirth ,Zero Hunger ,Adult ,Body Height ,Child Development ,Dietary Fats ,Dietary Supplements ,Double-Blind Method ,Female ,Fetal Development ,Fetal Growth Retardation ,Ghana ,Growth Disorders ,Humans ,Infant Nutrition Disorders ,Infant Nutritional Physiological Phenomena ,Infant ,Newborn ,Lactation ,Male ,Maternal Nutritional Physiological Phenomena ,Micronutrients ,Pregnancy ,Pregnancy Trimester ,First ,Prevalence ,Risk ,Suburban Health ,lipid-based nutrient supplements ,child growth ,home fortification ,multiple micronutrients ,supplementation ,Engineering ,Medical and Health Sciences ,Nutrition & Dietetics ,Clinical sciences ,Nutrition and dietetics - Abstract
BackgroundChildhood stunting usually begins in utero and continues after birth; therefore, its reduction must involve actions across different stages of early life.ObjectiveWe evaluated the efficacy of small-quantity, lipid-based nutrient supplements (SQ-LNSs) provided during pregnancy, lactation, and infancy on attained size by 18 mo of age.DesignIn this partially double-blind, individually randomized trial, 1320 women at ≤20 wk of gestation received standard iron and folic acid (IFA group), multiple micronutrients (MMN group), or SQ-LNS (LNS group) daily until delivery, and then placebo, MMNs, or SQ-LNS, respectively, for 6 mo postpartum; infants in the LNS group received SQ-LNS formulated for infants from 6 to 18 mo of age (endline). The primary outcome was child length by 18 mo of age.ResultsAt endline, data were available for 85% of 1228 infants enrolled; overall mean length and length-for-age z score (LAZ) were 79.3 cm and -0.83, respectively, and 12% of the children were stunted (LAZ
- Published
- 2016