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A commentary on the 2024 article "Reasons and Reproduction: Gene Editing and Genetic Selection," by J. McMahan and J. Savulescu is presented. Topics covered include the variations of the two-tier view of the authors, how the variations yield different ethical implications when causing a particular disability and a response to the objection that such a subject-dependent value profile would not work at the embryonic stage.

The article presents the discussion on HBOs lacking relevant sophisticated mental activities do not command the same moral significance as their human counterparts. Topics include Human brain organoids (HBOs), three-dimensional neural tissues derived from human pluripotent stem cells, are at the forefront of biomedical research, provoking intricate ethical quandaries; and HBOs transplanted into animal brains, and HBOs integrated into digital systems.