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548 results on '"O'Connor, Christopher"'

3. Prevalent digoxin use and subsequent risk of death or hospitalization in ambulatory heart failure patients with a reduced ejection fraction—Findings from the Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) randomized controlled trial

Author

Ambrosy, Andrew P., Bhatt, Ankeet S., Stebbins, Amanda L., Wruck, Lisa M., Fudim, Marat, Greene, Stephen J., Kraus, William E., O'Connor, Christopher M., Piña, Ileana L., Whellan, David J., and Mentz, Robert J.

Published
2018
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4. Relationship of technetium-99m tetrofosmin-gated rest single-photon emission computed tomography myocardial perfusion imaging to death and hospitalization in heart failure patients: results from the nuclear ancillary study of the HF-ACTION trial

Author

Atchley, Allen E., Iskandrian, Ami E., Bensimhon, Dan, Ellis, Stephen J., Kitzman, Dalane W., Shaw, Linda K., Pagnanelli, Robert A., Whellan, David J., Gardin, Julius M., Kao, Andrew, Abdul-Nour, Khaled, Ewald, Greg, Walsh, Mary Norine, Kraus, William E., O'Connor, Christopher M., and Borges-Neto, Salvador

Published
2011
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6. Causes of death and rehospitalization in patients hospitalized with worsening heart failure and reduced left ventricular ejection fraction: Results from efficacy of vasopressin antagonism in heart failure outcome study with tolvaptan (EVEREST) program

Author

O'Connor, Christopher M., Miller, Alan B., Blair, John E.A., Konstam, Marvin A., Wedge, Patricia, Bahit, Maria C., Carson, Peter, Haass, Markus, Hauptman, Paul J., Metra, Marco, Oren, Ron M., Patten, Richard, Piña, Ileana, Roth, Sherryn, Sackner-Bernstein, Jonathan D., Traver, Brian, Cook, Thomas, and Gheorghiade, Mihai

Published
2010
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7. Influence of dedicated heart failure clinics on delivery of recommended therapies in outpatient cardiology practices: Findings from the Registry to Improve the Use of Evidence-Based Heart Failure Therapies in the Outpatient Setting (IMPROVE HF)

Author

Albert, Nancy M., Fonarow, Gregg C., Yancy, Clyde W., Curtis, Anne B., Stough, Wendy Gattis, Gheorghiade, Mihai, Heywood, J. Thomas, McBride, Mark, Mehra, Mandeep R., O'Connor, Christopher M., Reynolds, Dwight, and Walsh, Mary Norine

Published
2010
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8. Does aspirin use adversely influence intermediate-term postdischarge outcomes for hospitalized patients who are treated with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers? Findings from Organized Program to Facilitate Life-Saving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF)

Author

Levy, Phillip D., Nandyal, Deepa, Welch, Robert D., Sun, Jie Lena, Pieper, Karen, Ghali, Jalal K., Fonarow, Gregg C., Gheorgiade, Mihai, and O'Connor, Christopher M.

Published
2010
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13. Myocardial perfusion, function, and dyssynchrony in patients with heart failure: Baseline results from the single-photon emission computed tomography imaging ancillary study of the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION) Trial

Author

Atchley, Allen E., Kitzman, Dalane W., Whellan, David J., Iskandrian, Ami E., Ellis, Stephen J., Pagnanelli, Robert A., Kao, Andrew, Abdul-Nour, Khaled, O'Connor, Christopher M., Ewald, Greg, Kraus, William E., and Borges-Neto, Salvador

Published
2009
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16. Phase III clinical trial end points in acute heart failure syndromes: A virtual roundtable with the acute heart failure syndromes international working group

Author

Gheorghiade, Mihai, Adams, Kirkwood F., Cleland, John G.F., Cotter, Gad, Felker, G. Michael, Filippatos, Gerasimos S., Fonarow, Gregg C., Greenberg, Barry H., Hernandez, Adrian F., Khan, Sadiya, Komajda, Michel, Konstam, Marvin A., Liu, Peter P., Maggioni, Aldo P., Massie, Barry M., McMurray, John J., Mehra, Mandeep, Metra, Marco, O'Connell, John, O'Connor, Christopher M., Pang, Peter S., Piña, Ileana L., Sabbah, Hani N., Teerlink, John R., Udelson, James E., Yancy, Clyde W., Zannad, Faiez, and Stockbridge, Norman

Published
2009
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17. Influence of coronary angiography on the utilization of therapies in patients with acute heart failure syndromes: Findings from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF)

Author

Flaherty, James D., Rossi, Joseph S., Fonarow, Gregg C., Nunez, Eduardo, Stough, Wendy Gattis, Abraham, William T., Albert, Nancy M., Greenberg, Barry H., O'Connor, Christopher M., Yancy, Clyde W., Young, James B., Davidson, Charles J., and Gheorghiade, Mihai

Published
2009
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20. Standardizing care for acute decompensated heart failure in a large megatrial: The approach for the Acute Studies of Clinical Effectiveness of Nesiritide in Subjects with Decompensated Heart Failure (ASCEND-HF)

Author

Ezekowitz, Justin A., Hernandez, Adrian F., Starling, Randall C., Yancy, Clyde W., Massie, Barry, Hill, James A., Krum, Henry, Diaz, Rafael, Ponikowski, Piotr, Metra, Marco, Howlett, Jonathon G., Gennevois, Daniel, O'Connor, Christopher M., Califf, Robert M., and Fonarow, Gregg C.

Published
2009
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21. Does study subject diversity influence cardiology research site performance?: Insights from 2 U.S. National Coronary Stent Registries

Author

Batchelor, Wayne B., primary, Damluji, Abdulla A., additional, Yong, Celina, additional, Fiuzat, Mona, additional, Barnett, Scott D., additional, Kandzari, David E., additional, Sherwood, Matthew W., additional, Epps, Kelly C., additional, Tehrani, Behnam N., additional, Allocco, Dominic J., additional, Meredith, Ian T., additional, Lindenfeld, JoAnn, additional, O'Connor, Christopher M., additional, and Mehran, Roxana, additional

Published
2021
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25. Revascularization for heart failure

Author

Phillips, Harry R., O'Connor, Christopher M., and Rogers, Joseph

Subjects
Coronary artery bypass, Heart failure, Health
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2007.01.026 Byline: Harry R. Phillips, Christopher M. O'Connor, Joseph Rogers Abstract: Coronary artery disease is the most common underlying cause of heart failure, yet there is little consensus on the role of revascularization in the management of patients with ischemic cardiomyopathy. The concept of recovery of dysfunctional but viable myocardium forms the pathophysiologic basis for the benefit of revascularization. Data from observational studies suggest that patients with coronary disease and left ventricular dysfunction may have improved outcomes after surgical revascularization or percutaneous coronary intervention (PCI) compared to medical treatment. Viability testing may be useful in selecting a population of patients who will receive differential benefit. In the clinical management of patients with heart failure, clinicians face challenging decisions about whether to recommend revascularization especially in patients who do not have angina. As data from randomized trials are awaited, PCI and coronary artery bypass grafting may be considered as complimentary revascularization approaches. Registry data suggest a benefit of coronary artery bypass grafting over PCI in patients with reduced ejection fraction; however, in patients with focal disease and comorbidities including previous surgery, PCI is reasonable, especially if complete revascularization is possible. Author Affiliation: Duke University Medical Center, Durham, NC

Published
2007

26. The new heart failure guidelines: Strategies for implementation

Author

O'Connor, Christopher M.

Subjects
Heart failure, Health
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2007.01.010 Byline: Christopher M. O'Connor Abstract: Several life-prolonging therapies are available for the treatment of heart failure, yet they are underutilized in many patients. A treatment gap exists between patients who are eligible for a therapy and the number of patients who actually receive them. Suboptimal prescribing rates for angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, [beta]-blockers, and aldosterone antagonists have been reported. Strategies are needed to increase the proportion of patients who are receiving evidence-based therapies. Predischarge initiation of evidence-based therapies has effectively increased utilization in the acute coronary syndrome population. Predischarge initiation of [beta]-blockade in patients hospitalized for heart failure has also been shown to be safe and effective for improving [beta]-blocker use at 60 days. Larger registry initiatives have demonstrated improved use of evidence-based therapies associated with implementation of a performance improvement process system. The mortality and morbidity associated with heart failure is strikingly high, and it is critical that proven therapies are prescribed to all eligible patients so that clinical outcomes can be improved. Systematic processes are effective approaches to ensuring appropriate evidence-based therapies are prescribed in most patients. Author Affiliation: Division of Clinical Pharmacology, Duke University Medical Center, Durham, NC

Published
2007

27. Heart Failure and A Controlled Trial Investigating Outcomes of Exercise traiNing (HF-ACTION): design and rationale

Author

Whellan, David J., O'Connor, Christopher M., Lee, Kerry L., Keteyian, Steven J., Cooper, Lawton S., Ellis, Stephen J., Leifer, Eric S., Kraus, William E., Kitzman, Dalane W., Blumenthal, James A., Rendall, David S., Houston-Miller, Nancy, Fleg, Jerome L., Schulman, Kevin A., and Pina, Ileana L.

Subjects
Experimental design -- Evaluation, Heart failure -- Research, Cardiovascular research -- Evaluation, Health
Published
2007

28. Carvedilol use at discharge in patients hospitalized for heart failure is associated with improved survival: an analysis from organized program to initiate lifesaving treatment in hospitalized patients with heart failure (OPTIMIZE-HF)

Author

Fonarow, Gregg C., Abraham, William T., Albert, Nancy M., Stough, Wendy Gattis, Gheorghiade, Mihai, Greenberg, Barry H., O'Connor, Christopher M., Sun, Jie Lena, Yancy, Clyde, and Young, James B.

Subjects
Hospital patients -- Drug therapy, Hospital patients -- Prognosis, Hospital patients -- Research, Heart failure -- Care and treatment, Heart failure -- Patient outcomes, Heart failure -- Research, Hospitals -- Admission and discharge, Hospitals -- Research, Health
Published
2007

31. Predicting significant coronary artery disease in patients with left ventricular dysfunction

Author

Whellan, David J., Tuttle, Robert H., Velazquez, Eric J., Shaw, Linda K., Jollis, James G., Ellis, Wendell, O'Connor, Christopher M., Califf, Robert M., and Borges-Neto, Salvador

Subjects
Coronary heart disease -- Risk factors, Coronary heart disease -- Diagnosis, Coronary heart disease -- Research, Heart ventricle, Left -- Physiological aspects, Cardiac catheterization -- Research, Health
Published
2006

33. Prediction of medical morbidity and mortality after acute myocardial infarction in patients at increased psychosocial risk in the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) study

Author

Jaffe, Allan S., Krumholz, Harlan M., Catellier, Diane J., Freedland, Kenneth E., Bittner, Vera, Blumenthal, James A., Calvin, James E., Norman, James, Sequeira, Rafael, O'Connor, Christopher, Rich, Michael W., Sheps, David, and Wu, Colin

Subjects
Heart attack -- Care and treatment, Cardiac patients -- Psychological aspects, Cardiac patients -- Care and treatment, Cardiac patients -- Research, Morbidity -- Evaluation, Mortality -- Evaluation, Depression, Mental -- Causes of, Health
Published
2006

34. Anemia in patients with heart failure and preserved systolic function

Author

Felker, G. Michael, Shaw, Linda K., Stough, Wendy Gattis, and O'Connor, Christopher M.

Subjects
Anemia -- Care and treatment, Heart failure -- Care and treatment, Cardiac patients -- Care and treatment, Health
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2005.03.056 Byline: G. Michael Felker, Linda K. Shaw, Wendy Gattis Stough, Christopher M. O'Connor Abstract: Anemia has been shown to be a predictor of mortality in patients with heart failure and impaired left ventricular systolic function (ISF). Although heart failure in the setting of preserved systolic function (PSF) is an important clinical problem, the relationship between anemia and outcomes in patients with PSF has not been carefully evaluated. Author Affiliation: Duke Clinical Research Institute, Durham, NC Article History: Received 12 November 2004; Accepted 30 March 2005 Article Note: (footnote) Dr Felker is supported in part by NIH K23 HL72357-01A1. This research was funded independently by the Duke Clinical Research Institute.

Published
2006

35. Anemia in patients with heart failure and preserved systolic function

Author

Fleker, G. Michael, Shaw, Linda K., Stough, Wendy Gattis, and O'Connor, Christopher M.

Subjects
Anemia -- Research, Heart failure -- Patient outcomes, Heart failure -- Research, Heart ventricle, Left -- Physiological aspects, Heart ventricle, Left -- Research, Health
Published
2006

36. A cooperative network of trained sites for the conduct of a complex clinical trial: a new concept in multicenter clinical research

Author

Davidson, Robert M., McNeer, J. Frederick, Logan, Leanne, Higginbotham, Michael B., Anderson, Jerome, Blackshear, Joseph, Chu, Alan, Hettleman, Bruce, McGrew, Frank, Meesse, Roderick, O'Connor, Christopher, Schneider, Ricky, and Wagner, Galen S.

Subjects
Cardiologists -- Influence, Clinical trials -- Management, Cardiovascular research -- Management, Company business management, Health
Published
2006

37. Valsartan inhibits platelet activity at different doses in mild to moderate hypertensives: Valsartan Inhibits Platelets (VIP) trial

Author

Serebruany, Victor L., Pokov, Alex N., Malinin, Alex I., O'Connor, Christopher, Bhatt, Deepak L., Tanguay, Jean-Francois, Sane, David C., and Hennekens, Charles H.

Subjects
Angiotensin II receptor blockers -- Dosage and administration, Angiotensin II receptor blockers -- Research, Hypertension -- Drug therapy, Blood platelets -- Physiological aspects, Blood platelets -- Aggregation, Blood platelets -- Research, Health
Published
2006

38. Testing new targets of therapy in advanced heart failure: the design and rationale of the Strategies for Tailoring Advanced heart failure Regimens in the outpatient setting: BRain natrIuretic peptide versus the clinical congesTion scorE (STARBRITE) trial

Author

Shah, Monica R., Claise, Karen A., Bowers, Margaret T., Bhapkar, Manjushri, Little, Julie, Nohria, Anju, Gaulden, Laura H., McKee, Vickie K., Cozart, Kara L., Mancinelli, Karen L., Daniels, Helen, Kinard, Tesca, Stevenson, Lynne W., Mancini, Donna M., O'Connor, Christopher M., and Califf, Robert M.

Subjects
Congestive heart failure -- Care and treatment, Diuretics -- Research, Ambulatory medical care -- Research, Natriuretic peptides -- Evaluation, Health
Published
2005

40. Depression and ischemic heart disease: What have we learned so far and what must we do in the future?

Author

Jiang, Wei, Glassman, Alexander, Krishnan, Ranga, O'Connor, Christopher M., and Califf, Robert M.

Subjects
Heart diseases, Depression, Mental, Ischemia, Health
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2005.04.012 Byline: Wei Jiang (a), Alexander Glassman (b), Ranga Krishnan (c), Christopher M. O'Connor (d), Robert M. Califf (e) Author Affiliation: (a) Department of Internal Medicine and Psychiatry and Behavioral Sciences, Duke University, Medical Center, Durham, NC (b) Department of Clinical Psychopharmacology, New York State Psychiatric Institute, New York, NY (c) Division of Biological Psychiatry, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC (d) Department of Medicine, Duke University Medical Center, Durham, NC (e) Duke Clinical Research Institute, Durham, NC Article History: Received 18 April 2005; Accepted 18 April 2005 Article Note: (footnote) Sponsors: Aventis Pharmaceuticals, Inc; Forest Laboratories, Inc; GlaxoSmithKline; Pfizer, Inc; and Wyeth-Ayerst Pharmaceuticals.

Published
2005

41. Tezosentan in patients with acute heart failure: design of the value of endothelin receptor inhibition with tezosentan in acute heart failure study (VERITAS)

Author

Teerlink, John R., McMurray, John J.V., Bourge, Robert C., Cleland, John G.F., Cotter, Gadi, Jondeau, Guillaume, Krum, Henry, Metra, Marco, O'Connor, Christopher M., Parker, John D., Torre-Amione, Guillermo, Van Veldhuisen, Dirk J., Frey, Aline, Rainisio, Maurizio, and Kobrin, Isaac

Subjects
Tezosentan -- Research, Heart failure -- Patient outcomes, Endothelin -- Research, Health
Published
2005

42. Geographical affiliation with top 10 NIH-funded academic medical centers and differences between mortality from cardiovascular disease and cancer

Author

Angraal, Suveen, primary, Caraballo, César, additional, Kahn, Peter, additional, Bhatnagar, Ambika, additional, Singh, Bikramjot, additional, Wilson, F Perry, additional, Fiuzat, Mona, additional, O’Connor, Christopher M, additional, Allen, Larry A., additional, Desai, Nihar R, additional, Mamtani, Ronac, additional, and Ahmad, Tariq, additional

Published
2020
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46. Training trials in heart failure: Time to exercise restraint?

Author

Whellan, David J., O'Connor, Christopher M., and Pina, Ilena

Subjects
Physiological research -- Analysis, Walking -- Research, Walking -- Physiological aspects, Physical fitness -- Physiological aspects, Physical fitness -- Research, Cardiac patients -- Behavior, Cardiac patients -- Health aspects, Heart diseases -- Care and treatment, Health
Published
2004

47. Relationship between heart failure treatment and development of worsening renal function among hospitalized patients

Author

Butler, Jeved, Forman, Daniel E., Abraham, William T., Gottlieb, Stephen S., Loh, Evan, Massie, Barry M., O'Connor, Christopher M., Rich, Michael W., Stevenson, Lynne Warner, Wang, Yonfei, Young, James B., and Krumholz, Harlan M.

Subjects
Diuretics -- Dosage and administration, Kidney failure -- Risk factors, Hospital care -- Complications and side effects, Heart failure -- Complications and side effects, Health
Published
2004

48. Importance of echocardiography in patients with severe nonischemic heart failure: The second prospective randomized amlodipine survival evaluation(PRAISE-2) echocardiographic study

Author

Cabell, Christopher H., Trichon, Benjamin H., Velazquez, Eric J., Dumesnil, Jean G., Anstrom, Kevin J., Ryan, Thomas, Miller, Alan B., Belkin, Robert N., Cropp, Anne B., O'Connor, Christopher M., and Jollis, James G.

Subjects
Cardiac patients -- Research, Heart failure -- Research, Heart failure -- Care and treatment, Echocardiography -- Research, Health
Published
2004

49. Effects of clopidogrel and aspirin combination versus aspirin alone on platelet aggregation and major receptor expression in patients with heart failure: The Plavix use for treatment of congestive heart failure (PLUTO-CHF) trial

Author

Serebruany, Victor L., Malinin, Alex I., Jerome, Scott D., Lowry, David R., Morgan, Athol W., Sane, David C., Tanguay, Jean-Francois, Steinhubl, Steven, and O'Connor, Christopher M.

Subjects
Cardiac patients -- Research, Cardiac patients -- Health aspects, Aspirin -- Usage, Congestive heart failure -- Diagnosis, Congestive heart failure -- Research, Health
Published
2003

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