To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2004.08.029 Byline: Amy K. Ferketich (a), Jeanette Pohorence Ferguson (b), Philip F. Binkley (c) Abstract: Psychological depression has been linked to heart failure, both an antecedent to and as a risk factor for poor outcomes among patients with existing heart failure. Elevated levels of proinflammatory cytokines have been proposed as a possible physiological link between the 2 conditions. The objective of this study was to examine the proinflammatory cytokines interleukin (IL)-6, IL-1[beta], and tumor necrosis factor-alpha (TNF[alpha]) in heart failure patients with and without elevated symptoms of depression. Author Affiliation: (a) School of Public Health, Division of Epidemiology and Biostatistics, The Ohio State University College of Medicine and Public Health, Columbus, Ohio (b) Department of Pathology, The Ohio State University College of Medicine and Public Health, Columbus, Ohio (c) Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, Columbus, Ohio Article History: Received 14 May 2004; Accepted 24 August 2004 Article Note: (footnote) The study was supported by NHLBI/NIH K24-HL04208, 'Paradigm Shifts in Clinical Ischemia Detection.'