1. Rates of longitudinal change in
- Author
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Jeffrey S, Phillips, Frederick J, Nitchie, Fulvio, Da Re, Christopher A, Olm, Philip A, Cook, Corey T, McMillan, David J, Irwin, James C, Gee, Jacob G, Dubroff, Murray, Grossman, and Ilya M, Nasrallah
- Subjects
Amyloid beta-Peptides ,Alzheimer Disease ,Positron-Emission Tomography ,Brain ,Humans ,Cognitive Dysfunction ,tau Proteins ,Carbolines - Abstract
Longitudinal positron emission tomography (PET) studies of tau accumulation in Alzheimer's disease (AD) have noted reduced increases or frank decreases in tau signal. We investigated how such reductions related to analytical confounds and disease progression markers in atypical AD.We assessed regional and interindividual variation in longitudinal change onIn atypical AD,Results suggested radioligand uptake plateaus or declines in advanced neurodegeneration. Further research should investigate whether results generalize to other radioligands and whether they relate to changes of the radioligand binding site structure or accessibility.
- Published
- 2021