1. Sex-related differences in cognitive trajectories in older individuals with type 2 diabetes and overweight or obesity
- Author
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Mark A. Espeland, Hussein Yassine, Kathleen D. Hayden, Christina Hugenschmidt, Wendy L. Bennett, Ariana Chao, Rebecca Neiberg, Steven E. Kahn, José A. Luchsinger, and for the Action for Health in Diabetes (Look AHEAD) Research Group
- Subjects
0301 basic medicine ,obesity ,type 2 diabetes mellitus ,Type 2 diabetes ,Overweight ,Verbal learning ,03 medical and health sciences ,0302 clinical medicine ,Weight loss ,medicine ,sex ,Cognitive decline ,RC346-429 ,apoliprotein E ε4 ,Research Articles ,business.industry ,RC952-954.6 ,Type 2 Diabetes Mellitus ,Cognition ,medicine.disease ,cognitive decline ,Obesity ,Psychiatry and Mental health ,030104 developmental biology ,Geriatrics ,Neurology. Diseases of the nervous system ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Demography ,Research Article - Abstract
Introduction It is unknown whether rates of cognitive decline differ between older women and men with type 2 diabetes (T2D) and overweight or obesity. Methods Two to four cognitive assessments were obtained across up to 10 years from 2799 adults (mean age 68 years; 62% women) with T2D who had been enrolled in a clinical trial of weight loss intervention. Sex‐related differences in means and rates of decline of cognitive scores were assessed. Results Women outperformed men in verbal learning and processing speed (P
- Published
- 2020