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Your search keyword '"Hernández, Isabel"' showing total 9 results
Start Over Author "Hernández, Isabel" Journal alzheimer's research & therapy
9 results on '"Hernández, Isabel"'

1. Association of oxidative stress and inflammatory metabolites with Alzheimer’s disease cerebrospinal fluid biomarkers in mild cognitive impairment

Author

Ahmad, Shahzad, Yang, Wei, Orellana, Adelina, Frölich, Lutz, de Rojas, Itziar, Cano, Amanda, Boada, Mercè, Hernández, Isabel, Hausner, Lucrezia, Harms, Amy C., Bakker, Margot H. M., Cabrera-Socorro, Alfredo, Amin, Najaf, Ramírez, Alfredo, Ruiz, Agustín, Van Duijn, Cornelia M., and Hankemeier, Thomas

Published
2024
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2. Automatized FACEmemory® scoring is related to Alzheimer’s disease phenotype and biomarkers in early-onset mild cognitive impairment: the BIOFACE cohort

Author

Alegret, Montserrat, Sotolongo-Grau, Oscar, de Antonio, Ester Esteban, Pérez-Cordón, Alba, Orellana, Adelina, Espinosa, Ana, Gil, Silvia, Jiménez, Daniel, Ortega, Gemma, Sanabria, Angela, Roberto, Natalia, Hernández, Isabel, Rosende-Roca, Maitee, Tartari, Juan Pablo, Alarcon-Martin, Emilio, de Rojas, Itziar, Montrreal, Laura, Morató, Xavier, Cano, Amanda, Rentz, Dorene M., Tárraga, Lluís, Ruiz, Agustín, Valero, Sergi, Marquié, Marta, and Boada, Mercè

Published
2022
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4. The role of sex and gender in the selection of Alzheimer patients for clinical trial pre-screening

Author

Rosende-Roca, Maitee, Abdelnour, Carla, Esteban, Ester, Tartari, Juan Pablo, Alarcon, Emilio, Martínez-Atienza, Juliana, González-Pérez, Antonio, Sáez, María E., Lafuente, Asunción, Buendía, Mar, Pancho, Ana, Aguilera, Nuria, Ibarria, Marta, Diego, Susana, Jofresa, Sara, Hernández, Isabel, López, Rogelio, Gurruchaga, Miren Jone, Tárraga, Lluís, Valero, Sergi, Ruiz, Agustín, Marquié, Marta, and Boada, Mercè

Published
2021
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6. A computerized version of the Short Form of the Face-Name Associative Memory Exam (FACEmemory®) for the early detection of Alzheimer’s disease

Author

Alegret, Montserrat, Muñoz, Nathalia, Roberto, Natalia, Rentz, Dorene M., Valero, Sergi, Gil, Silvia, Marquié, Marta, Hernández, Isabel, Riveros, Catalina, Sanabria, Angela, Perez-Cordon, Alba, Espinosa, Ana, Ortega, Gemma, Mauleón, Ana, Abdelnour, Carla, Rosende-Roca, Maitee, Papp, Kathryn V., Orellana, Adela, Benaque, Alba, Tarraga, Lluís, Ruiz, Agustín, and Boada, Mercè

Published
2020
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8. Association between retinal thickness and β-amyloid brain accumulation in individuals with subjective cognitive decline: Fundació ACE Healthy Brain Initiative.

Author

Marquié, Marta, Valero, Sergi, Castilla-Marti, Miguel, Martínez, Joan, Rodríguez-Gómez, Octavio, Sanabria, Ángela, Tartari, Juan Pablo, Monté-Rubio, Gemma C., Sotolongo-Grau, Oscar, Alegret, Montserrat, Pérez-Cordón, Alba, Roberto, Natalia, de Rojas, Itziar, Moreno-Grau, Sonia, Montrreal, Laura, Hernández, Isabel, Rosende-Roca, Maitee, Mauleón, Ana, Vargas, Liliana, and Abdelnour, Carla

Subjects
VISUAL fields, POSITRON emission tomography, OPTICAL coherence tomography, MILD cognitive impairment, ALZHEIMER'S patients, THICKNESS measurement
Abstract

Background: Optical coherence tomography (OCT) of the retina is a fast and easily accessible tool for the quantification of retinal structural measurements. Multiple studies show that patients with Alzheimer's disease (AD) exhibit thinning in several retinal layers compared to age-matched controls. Subjective cognitive decline (SCD) has been proposed as a risk factor for progression to AD. There is little data about retinal changes in preclinical AD and their correlation with amyloid-β (Aβ) uptake. Aims: We investigated the association of retinal thickness quantified by OCT with Aβ accumulation and conversion to mild cognitive impairment (MCI) over 24 months in individuals with SCD. Methods: One hundred twenty-nine individuals with SCD enrolled in Fundació ACE Healthy Brain Initiative underwent comprehensive neuropsychological testing, OCT scan of the retina and florbetaben (FBB) positron emission tomography (PET) at baseline (v0) and after 24 months (v2). We assessed the association of sixteen retinal thickness measurements at baseline with FBB-PET status (+/−) and global standardize uptake value ratio (SUVR) as a continuous measure at v0 and v2 and their predictive value on clinical status change (conversion to mild cognitive impairment (MCI)) at v2. Results: Mean age of the sample was 64.72 ± 7.27 years; 62.8% were females. Fifteen participants were classified as FBB-PET+ at baseline and 22 at v2. Every 1 μm of increased thickness in the inner nasal macular region conferred 8% and 6% higher probability of presenting a FBB-PET+ status at v0 (OR = 1.08, 95% CI = 1.02–1.14, p = 0.007) and v2 (OR = 1.06, 95% CI = 1.02–1.11, p = 0.004), respectively. Inner nasal macular thickness also positively correlated with global SUVR (at v0: β = 0.23, p = 0.004; at v2: β = 0.26, p = 0.001). No retinal measurements were associated to conversion to MCI over 24 months. Conclusions: Subtle retinal thickness changes in the macular region are already present in SCD and correlate with Aβ uptake. [ABSTRACT FROM AUTHOR]

Published
2020
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9. Association between cell-bound blood amyloid-β(1 - 40) levels and hippocampus volume

Author

Sotolongo-Grau, Oscar, primary, Pesini, Pedro, additional, Valero, Sergi, additional, Lafuente, Asunción, additional, Buendía, Mar, additional, Pérez-Grijalba, Virginia, additional, Josè, Itziar San, additional, Ibarria, Marta, additional, Tejero, Miguel A, additional, Giménez, Joan, additional, Hernández, Isabel, additional, Tárraga, Lluís, additional, Ruiz, Agustín, additional, Boada, Mercè, additional, and Sarasa, Manuel, additional

Published
2014
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