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18 results on '"Yadong Huang"'

1. Microglial activation: A process potentially related to Alzheimer's disease and late‐life major depression

Author

Martha S. Foiani, Nunzio Pomara, Berislav V. Zlokovic, Chelsea Reichert, Amanda Heslegrave, Yadong Huang, Davide Bruno, Kaj Blennow, and Henrik Zetterberg

Subjects
Oncology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Neuroimaging, Internal medicine, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Depression (differential diagnoses)
Published
2020

2. F2-02-03: ALZHEIMER'S DISEASE MODELING AND DRUG SCREENING USING PATIENT-DERIVED IPSCS WITH DIFFERENT APOE GENOTYPES

Author

Chengzhong Wang, Ramsey Najm, and Yadong Huang

Subjects
Drug, Apolipoprotein E, Epidemiology, business.industry, Health Policy, media_common.quotation_subject, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Genotype, Immunology, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Induced pluripotent stem cell, media_common
Published
2019

3. [P2–118]: FINE‐MAPPING OF THE HUMAN LEUKOCYTE ANTIGEN (HLA) LOCUS AS A RISK FACTOR FOR ALZHEIMER'S DISEASE

Author

John S. K. Kauwe, Jill A. Hollenbach, Kevin L. Boehme, Giovanni Coppola, Paul K. Crane, Bruce L. Miller, Shubhabrata Mukherjee, Zachary A. Miller, Rahul S. Desikan, Joel H. Kramer, Jessie S. Carr, Luke W. Bonham, Ethan G. Geier, Jennifer S. Yokoyama, Natasha Z.R. Steele, Vincent Damotte, and Yadong Huang

Subjects
Epidemiology, business.industry, Health Policy, Locus (genetics), Human leukocyte antigen, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Immunology, Medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2017

4. [P4–182]: A NEUROBIOLOGICAL MODEL OF MEMORY IMPAIRMENT IN LATE‐LIFE MAJOR DEPRESSIVE DISORDER

Author

Domenico Praticò, Nunzio Pomara, John G. Csernansky, Henry Sershen, Kenji Hashimoto, Michel J. Grothe, Kaj Blennow, Charles R. Marmar, Jay Nierenberg, Berislav V. Zlokovic, Henrik Zetterberg, Yadong Huang, Stefan J. Teipel, Davide Bruno, and Anilkumar Pillai

Subjects
Epidemiology, business.industry, Health Policy, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Endogenous depression, medicine, Memory impairment, Major depressive disorder, Neurology (clinical), Geriatrics and Gerontology, business, Clinical psychology
Published
2017

5. P4‐287: Eliminating TAU in Human Neurons is Neuroprotective

Author

David Walker, Lei Zhu, Chengzhong Wang, and Yadong Huang

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology, Neuroscience, Neuroprotection
Published
2016

6. P4–338: Hilar transplantation of MGE‐derived inhibitory interneuron progenitors restores normal learning and memory in Alzheimer's disease mouse models

Author

Leslie Tong, Yadong Huang, John L.R. Rubenstein, Christine M Arnold, Arturo Alvarez-Buylla, Seo Yeon Yoon, and Biljana Djukic

Subjects
Transplantation, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Inhibitory interneuron, Neurology (clinical), Disease, Geriatrics and Gerontology, Biology, Progenitor cell, Neuroscience
Published
2013

7. P2–037: Age‐dependent impairment of hilar GABAergic interneurons and cognitive function in Apolipoprotein E‐ε4 knock‐in mice is modified by sex

Author

David Walker, Sachi Jain, Max Mu Wang, Karen Ring, Yadong Huang, Leslie Tong, Jessica Dai, Seo Yeon Yoon, Yaisa Andrews-Zwilling, and Laura Leung

Subjects
Apolipoprotein E, medicine.medical_specialty, Epidemiology, Health Policy, Cognition, Age dependent, Biology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Endocrinology, Developmental Neuroscience, Gene knockin, Internal medicine, medicine, GABAergic, Neurology (clinical), Geriatrics and Gerontology
Published
2013

8. P4‐253: Hilar GABAergic interneuron activity controls spatial learning and memory retrieval

Author

Yaisa Andrews-Zwilling, Alexxai V. Kravitz, John L.R. Rubenstein, Karen Ring, Seo Yeon Yoon, Daniel Zwilling, Iris Lo, Nino Devidze, Anna K. Gillespie, Alexandra B. Nelson, Anatol C. Kreitzer, Gregory B. Potter, Nga Bien-Ly, and Yadong Huang

Subjects
Interneuron, Epidemiology, musculoskeletal, neural, and ocular physiology, Health Policy, Dentate gyrus, Morris water navigation task, Hippocampus, Amnesia, Optogenetics, Biology, Inhibitory postsynaptic potential, Psychiatry and Mental health, Cellular and Molecular Neuroscience, medicine.anatomical_structure, nervous system, Developmental Neuroscience, medicine, GABAergic, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, Neuroscience
Abstract

Background: Although extensive research has demonstrated the importance of excitatory granule neurons in the dentate gyrus of the hippocampus in normal learning and memory and in the pathogenesis of amnesia in Alzheimer’s disease (AD), the role of hilar GABAergic inhibitory interneurons, which control the granule neuron activity, remains unclear. Methodology and Principal Findings: We explored the function of hilar GABAergic interneurons in spatial learning and memory by inhibiting their activity through Cre-dependent viral expression of enhanced halorhodopsin (eNpHR3.0)—a light-driven chloride pump. Hilar GABAergic interneuron-specific expression of eNpHR3.0 was achieved by bilaterally injecting adeno-associated virus containing a double-floxed inverted open-reading frame encoding eNpHR3.0 into the hilus of the dentate gyrus of mice expressing Cre recombinase under the control of an enhancer specific for GABAergic interneurons. In vitro and in vivo illumination with a yellow laser elicited inhibition of hilar GABAergic interneurons and consequent activation of dentate granule neurons, without affecting pyramidal neurons in the CA3 and CA1 regions of the hippocampus. We found that optogenetic inhibition of hilar GABAergic interneuron activity impaired spatial learning and memory retrieval, without affecting memory retention, as determined in the Morris water maze test. Importantly, optogenetic inhibition of hilar GABAergic interneuron activity did not alter short-term working memory, motor coordination, or exploratory activity. Conclusions and Significance: Our findings establish a critical role for hilar GABAergic interneuron activity in controlling spatial learning and memory retrieval and provide evidence for the potential contribution of GABAergic interneuron impairment to the pathogenesis of amnesia in AD.

Published
2012

9. O4‐02‐02: Apolipoprotein E4 causes tau‐dependent hilar GABAergic interneuron impairment, leading to learning and memory deficits in mice

Author

Tonya Xue Yan, Daniel Zwilling, Nga Bien-Ly, Gang Li, Seo Yeon Yoon, Yaisa Andrews-Zwilling, Ligong Chen, Aubrey Bernardo, Qin Xu, and Yadong Huang

Subjects
Interneuron, Epidemiology, Health Policy, Biology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, medicine.anatomical_structure, Developmental Neuroscience, medicine, GABAergic, Neurology (clinical), Apolipoprotein e4, Geriatrics and Gerontology, Neuroscience
Published
2010

10. P3‐432: An inhibitor of kynurenine 3‐monooxygenase is neuroprotective in a mouse model of Alzheimer's disease

Author

Yadong Huang, Daniel Zwilling, Robert Schwarcz, Yaisa Andrews-Zwilling, Eliezer Masliah, Joseph M. Muchowski, Paul J. Muchowski, Jamie Louie, Eric Hsieh, and Jennifer Truong

Subjects
Epidemiology, business.industry, Health Policy, Disease, Pharmacology, Neuroprotection, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Kynurenine 3-Monooxygenase
Published
2010

11. P2‐248: Arf4 regulates dendritic spine development in mouse primary neurons

Author

Yadong Huang, Jens Brodbeck, David Walker, Sachi Jain, and Aubrey Bernardo

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Dendritic spine, Primary (chemistry), Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology, Biology, Neuroscience, Dendritic filopodia
Published
2010

12. P1‐281: C‐terminal‐truncated apoE4 inefficiently clears amyloid‐beta peptides and synergizes with Abeta to elicit Alzheimer‐like deficits in mice

Author

Qin Xu, Aubrey Bernardo, Yaisa Andrews-Zwilling, Nga Bien-Ly, and Yadong Huang

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, biology, Terminal (electronics), Epidemiology, Amyloid beta, Chemistry, Health Policy, biology.protein, Neurology (clinical), Geriatrics and Gerontology, Cell biology
Published
2010

13. P2‐156: Apolipoprotein E4‐induced mitochondrial dysfunction depends on its structure and can be rescued by a structure corrector

Author

R. Dennis Miranda, Charles Rosenblum, Aurawan Vongs, Zhong-Sheng Ji, Guy R. Seabrook, Ian J. Reynolds, Hung-Kai Chen, Yadong Huang, Jinny Wong, Karl H. Weisgraber, Robert W. Mahley, Stephen B. Freedman, and James G. McGuire

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Chemistry, Health Policy, Neurology (clinical), Apolipoprotein e4, Geriatrics and Gerontology, Cell biology
Published
2009

14. P2‐158: Apolipoprotein E fragmentation in human brain and CSF samples is isoform and Alzheimer's disease dependent

Author

Qin Xu, A. David Smith, Mary J. Savage, C Joachim, Mei Xiu Steele, Sidney H.-K. Hsieh, Stephen B. Freedman, Robert W. Mahley, Mary Jeong, Guoxin Wu, Yadong Huang, Karl H. Weisgraber, and Walter J. Brecht

Subjects
Apolipoprotein E, Gene isoform, Epidemiology, Chemistry, Health Policy, Human brain, Molecular biology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, medicine.anatomical_structure, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Fragmentation (cell biology)
Published
2009

15. P2‐157: Apolipoprotein E4 impairs mitochondrial function and increases reactive oxygen species in neuronal cells

Author

Jens Brodbeck, R. Dennis Miranda, Stephen B. Freedman, Karl H. Weisgraber, Yadong Huang, and Robert W. Mahley

Subjects
chemistry.chemical_classification, Reactive oxygen species, Epidemiology, Health Policy, Cell biology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Biochemistry, chemistry, Neurology (clinical), Apolipoprotein e4, Geriatrics and Gerontology, Function (biology)
Published
2009

17. O3‐03–03: Apolipoprotein E4 and its fragment impair mitochondrial dynamics in neuronal cultures

Author

Maureen E. Balestra, Robert W. Mahley, Jens Brodbeck, Stephen B. Freedman, Yadong Huang, and Karl H. Weisgraber

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Fragment (logic), Epidemiology, Health Policy, Dynamics (mechanics), Neurology (clinical), Apolipoprotein e4, Geriatrics and Gerontology, Biology, Cell biology
Published
2008

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