1. Dementia in Latin America: Paving the way toward a regional action plan
- Author
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Parra, Mario Alfredo, Baez, Sandra, Sedeño, Lucas, Campo, Cecilia Gonzalez, Santamaría‐García, Hernando, Aprahamian, Ivan, Bertolucci, Paulo HF, Bustin, Julian, Bicalho, Maria Aparecida Camargos, Cano‐Gutierrez, Carlos, Caramelli, Paulo, Chaves, Marcia LF, Cogram, Patricia, Beber, Bárbara Costa, Court, Felipe A, Souza, Leonardo Cruz, Custodio, Nilton, Damian, Andres, de la Cruz, Myriam, Rodriguez, Roberta Diehl, Brucki, Sonia Maria Dozzi, Fajersztajn, Lais, Farías, Gonzalo A, De Felice, Fernanda G, Ferrari, Raffaele, de Oliveira, Fabricio Ferreira, Ferreira, Sergio T, Ferretti, Ceres, Balthazar, Marcio Luiz Figueredo, Frota, Norberto Anizio Ferreira, Fuentes, Patricio, García, Adolfo M, Garcia, Patricia J, de Gobbi Porto, Fábio Henrique, Peñailillo, Lissette Duque, Engler, Henry Willy, Maier, Irene, Mata, Ignacio F, Gonzalez‐Billault, Christian, Lopez, Oscar L, Morelli, Laura, Nitrini, Ricardo, Quiroz, Yakeel T, Barragan, Alejandra Guerrero, Huepe, David, Pio, Fabricio Joao, Suemoto, Claudia Kimie, Kochhann, Renata, Kochen, Silvia, Kumfor, Fiona, Lanata, Serggio, Miller, Bruce, Mansur, Leticia Lessa, Hosogi, Mirna Lie, Lillo, Patricia, Guerra, Jorge Llibre, Lira, David, Lopera, Francisco, Comas, Adelina, Avila‐Funes, José Alberto, Sosa, Ana Luisa, Ramos, Claudia, de Paula França Resende, Elisa, Snyder, Heather M, Tarnanas, Ioannis, Yokoyama, Jenifer, Llibre, Juan, Cardona, Juan Felipe, Possin, Kate, Kosik, Kenneth S, Montesinos, Rosa, Moguilner, Sebastian, Solis, Patricia Cristina Lourdes, de Lucena Ferretti‐Rebustini, Renata Eloah, Ramirez, Jeronimo Martin, Matallana, Diana, Mbakile‐Mahlanza, Lingani, Ton, Alyne Mendonça Marques, Tavares, Ronnielly Melo, Miotto, Eliane C, Muniz‐Terrera, Graciela, Muñoz‐Nevárez, Luis Arnoldo, Orozco, David, de Oliveira, Maira Okada, Piguet, Olivier, Caipa, Maritza Pintado, Escudero, Stefanie Danielle Piña, Schilling, Lucas Porcello, Palmeira, André Luiz Rodrigues, Yassuda, Mônica Sanches, Santacruz‐Escudero, Jose Manuel, Serafim, Rodrigo Bernardo, Smid, Jerusa, Slachevsky, Andrea, Serrano, Cecilia, Soto‐Añari, Marcio, Takada, Leonel Tadao, Grinberg, Lea Tenenholz, Teixeira, Antonio Lucio, and Barbosa, Maira Tonidandel
- Subjects
Aging ,Brain Disorders ,Dementia ,Acquired Cognitive Impairment ,Clinical Research ,Prevention ,Neurological ,Biomarkers ,Evidence-Based Practice ,Humans ,Latin America ,Socioeconomic Factors ,biomarkers ,clinical trials ,dementia ,epidemiology ,evidence-based recommendations ,genetics ,knowledge to action framework ,networking and translational research ,nonpharmacological interventions ,Clinical Sciences ,Neurosciences ,Geriatrics - Abstract
Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.
- Published
- 2021