1. Neuropathologic changes at age 90+ related to sleep duration 19 to 40 years earlier: The 90+ Study
- Author
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Melikyan, Zarui A, Kawas, Claudia H, Paganini‐Hill, Annlia, Jiang, Luohua, Bukhari, Syed, Montine, Thomas J, Mander, Bryce A, and Corrada, María M
- Subjects
Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Brain Disorders ,Dementia ,Neurodegenerative ,Behavioral and Social Science ,Alzheimer's Disease ,Acquired Cognitive Impairment ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Aging ,Basic Behavioral and Social Science ,Sleep Research ,Neurological ,Humans ,Aged ,80 and over ,Female ,Male ,Sleep ,Brain ,Aged ,Autopsy ,Self Report ,Amyloid beta-Peptides ,Sleep Duration ,age 90+ ,neuropathologic change ,oldest-old ,self-reported sleep ,sleep duration ,oldest‐old ,self‐reported sleep ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
IntroductionWe investigated the association between sleep duration and neuropathologic changes 19 to 40 years later in oldest-old (age 90+) participants of The 90+ Study.MethodsParticipants self-reported sleep duration and underwent neuropathologic evaluation. We categorized sleep duration as 8 hours and dichotomized neuropathologic changes as present/absent. We estimated odds ratio (OR) and 95% confidence intervals (CI) using logistic regression.ResultsIn 264 participants, mean age at sleep self-report was 69 years, mean age at autopsy was 98 years, and mean interval between sleep self-report and autopsy was 29 years (range: 19-40). Those reporting > 8 hours of sleep had lower likelihood of limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) inclusions (OR = 0.18; CI = 0.04-0.82) and amyloid beta deposits (OR = 0.34; 95% CI = 0.12-0.94).DiscussionLong self-reported sleep is associated with lower odds of neurodegenerative neuropathologic changes 19 to 40 years later in the oldest-old, suggesting a potential role of sleep in accumulation of dementia-related neuropathologies.HighlightsAssociation of self-reported sleep with non-Alzheimer's disease neuropathologic changes has not been explored. Whether sleep duration is related to dementia neuropathologic changes decades later is unclear. Long self-reported sleep is associated with lower odds of Alzheimer's disease neuropathologic change 19 to 40 years later in the oldest-old. Long self-reported sleep is associated with lower odds of limbic-predominant age-related TDP-43 encephalopathy neuropathologic change 19 to 40 years later in the oldest-old.
- Published
- 2024