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Your search keyword '"Mitchel A. Kling"' showing total 16 results
Start Over Author "Mitchel A. Kling" Journal alzheimer's & dementia
16 results on '"Mitchel A. Kling"'

2. F3‐02‐04: SERUM INDICES OF ETHANOLAMINE PLASMALOGENS AND PHOSPHATIDE METABOLISM IN THE COMBINED ADNI‐1/GO/2 COHORT: DOES THE LIVER CONTRIBUTE TO AD RISK BY FAILING TO SUPPLY KEY LIPIDS TO THE BRAIN?

Author

Rebecca Baillie, Rima Kaddurah-Daouk, Mitchel A. Kling, Siamak Mahmoudiandehkordi, Alexandra Kueider-Paisley, Xianlin Han, Dayan B. Goodenowe, and Vijitha Senanayake

Subjects
0301 basic medicine, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Metabolism, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 030104 developmental biology, Endocrinology, Developmental Neuroscience, Internal medicine, Cohort, medicine, Neurology (clinical), Ethanolamine plasmalogen, Geriatrics and Gerontology, business
Published
2018

3. P2‐261: APOLIPOPROTEIN J/CLUSTERIN IS THE PRIMARY DETERMINANT OF THE CHOLESTEROL EFFLUX CAPACITY OF CEREBROSPINAL FLUID

Author

Rima Kaddurah-Daouk, Nicholas N. Lyssenko, Antonino Picataggi, Leslie M. Shaw, Daniel J. Rader, Hannah J Szapary, Eleonora Cipollari, Jeffrey T. Billheimer, and Mitchel A. Kling

Subjects
medicine.medical_specialty, Clusterin, biology, Epidemiology, Chemistry, Cholesterol, Health Policy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Cerebrospinal fluid, Endocrinology, Developmental Neuroscience, Internal medicine, medicine, biology.protein, Neurology (clinical), Efflux, Geriatrics and Gerontology, Apolipoprotein J
Published
2018

4. P3‐069: CHOLESTEROL EFFLUX CAPACITY (CEC) IN PLASMA AND CEREBROSPINAL FLUID (CSF) OF PATIENTS WITH ALZHEIMER'S DISEASE (AD) AND MILD COGNITIVE IMPAIRMENT (MCI) AND COMPARISON SUBJECTS: EFFECTS OF GENDER AND DIAGNOSIS

Author

Daniel J. Rader, Leslie M. Shaw, Nicholas N. Lyssenko, Mitchel A. Kling, Jeffrey T. Billheimer, and Rima Kaddurah-Daouk

Subjects
0301 basic medicine, medicine.medical_specialty, Epidemiology, Disease, Gastroenterology, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Cerebrospinal fluid, Developmental Neuroscience, Internal medicine, medicine, Mild cognitive impairment (MCI), business.industry, Cholesterol, Health Policy, medicine.disease, Psychiatry and Mental health, 030104 developmental biology, chemistry, Neurology (clinical), Efflux, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery
Published
2018

5. F3‐02‐01: ALTERED BILE ACID METABOLITES IN MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE: RELATION TO NEUROIMAGING AND CSF BIOMARKERS

Author

Mitchel A. Kling, Rima Kaddurah-Daouk, Rebecca Baillie, Matthias Arnold, Colette Blach, Leslie M. Shaw, Alexandra Kueider-Paisley, Kwangsik Nho, Michael W. Weiner, P. Murali Doraiswamy, Siamak Mahmoudiandehkordi, Gabi Kastenmüller, Andrew J. Saykin, Xianlin Han, Gregory Louie, John Q. Trojanowski, and Shannon L. Risacher

Subjects
Bile acid, Epidemiology, medicine.drug_class, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Neuroimaging, Csf biomarkers, Immunology, medicine, Neurology (clinical), Geriatrics and Gerontology, Cognitive impairment, business
Published
2018

6. P1-386: ASSOCIATION OF SERUM-BASED PLASMALOGENS WITH NEUROIMAGING AND GENETIC VARIATION IN ALZHEIMER'S DISEASE

Author

Vijitha Senanayake, P. Murali Doraiswamy, Gregory Louie, Matthias Arnold, Siamak MahmoudianDehkordi, Rima Kaddurah-Daouk, Xianlin Han, Gabi Kastenmüller, Dayan B. Goodenowe, Mitchel A. Kling, Rebecca Baillie, Andrew J. Saykin, Kwangsik Nho, Alexandra Kueider-Paisley, and Shannon L. Risacher

Subjects
Epidemiology, business.industry, Health Policy, Disease, Bioinformatics, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Neuroimaging, Genetic variation, Medicine, Neurology (clinical), Geriatrics and Gerontology, Association (psychology), business
Published
2019

7. P3‐157: Indices of Plasmalogen Biosynthesis in ADNI‐1 Baseline Serum Samples: Association with Progression to Dementia in Subjects with Mild Cognitive Impairment

Author

Rima Kaddurah-Daouk, Xianlin Han, Rebecca Baillie, Dayan B. Goodenowe, Mitchel A. Kling, Jessica D. Tenenbaum, Vijitha Senanayake, Alison A. Motsinger-Reif, Joseph E. Lucas, and Jon B. Toledo

Subjects
0301 basic medicine, medicine.medical_specialty, Plasmalogen, Epidemiology, business.industry, Health Policy, medicine.disease, Serum samples, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 030104 developmental biology, Endocrinology, Developmental Neuroscience, Internal medicine, medicine, Dementia, Neurology (clinical), Geriatrics and Gerontology, business, Cognitive impairment, Association (psychology)
Published
2016

8. Vascular disease and dementias: Paradigm shifts to drive research in new directions

Author

David A. Wolk, Mitchel A. Kling, Steven E. Arnold, John Q. Trojanowski, and Virginia M.-Y. Lee

Subjects
Network medicine, Epidemiology, business.industry, Vascular disease, Health Policy, Disease, medicine.disease, Article, Cerebrovascular Disorders, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Humans, Dementia, Neurology (clinical), Senile plaques, Geriatrics and Gerontology, Cognitive decline, business, Vascular dementia, Neurocognitive, Neuroscience
Abstract

Vascular disease was once considered the principal cause of aging-related dementia. More recently, however, research emphasis has shifted to studies of progressive neurodegenerative disease processes, such as those giving rise to neuritic plaques, neurofibrillary tangles, and Lewy bodies. Although these studies have led to critical insights and potential therapeutic strategies, interest in the role of systemic and cerebrovascular disease mechanisms waned and has received relatively less attention and research support. Recent studies suggest that vascular disease mechanisms play an important role in the risk for aging-related cognitive decline and disorders. Vascular disease frequently coexists with cognitive decline in aging individuals, shares many risk factors with dementias considered to be of the "Alzheimer type," and is observed more frequently than expected in postmortem material from individuals manifesting "specific" disease stigmata, such as abundant plaques and tangles. Considerable difficulties have emerged in attempting to classify dementias as being related to vascular versus neurodegenerative causes, and several systems of criteria have been used. Despite multiple attempts, a lack of consensus remains regarding the optimal means of incorporating vascular disease into clinical diagnostic, neurocognitive, or neuropathologic classification schemes for dementias. We propose here an integrative, rather than a strictly taxonomic, approach to the study and elucidation of how vascular disease mechanisms contribute to the development of dementias. We argue that, instead of discriminating between, for example, "Alzheimer's disease," "vascular dementia," and other diseases, there is a greater need to focus clinical and research efforts on elucidating specific pathophysiologic mechanisms that contribute to dementia phenotypes and neuropathologic outcomes. We outline a multitiered strategy, beginning with clinical and public health interventions that can be implemented immediately, enhancements to ongoing longitudinal studies to increase their informative value, and new initiatives to capitalize on recent advances in systems biology and network medicine. This strategy will require funding from multiple public and private sources to support collaborative and interdisciplinary research efforts to take full advantage of these opportunities and realize their societal benefits.

Published
2012

9. O4–01–06: Targeted lipidomic pathway‐guided genetic association with Alzheimer's disease–relevant endophenotypes

Author

Rima Kaddurah-Daouk, Mitchel A. Kling, Kwangsik Nho, Vijay K. Ramanan, P. Murali Doraiswamy, John Q. Trojanowski, Xianlin Han, Patrick Sullivan, Shannon L. Risacher, Sungeun Kim, Hongjie Zhu, Li Shen, Andrew J. Saykin, and Steven E. Arnold

Subjects
Epidemiology, business.industry, Health Policy, Computational biology, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Endophenotype, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Genetic association
Published
2013

10. P3–056: Alterations in metabolic pathways and networks in mild cognitive impairment and early Alzheimer's disease

Author

Xianlin Han, Sungeun Kim, Swati Sharma, P. Murali Doraiswamy, Li Shen, John Q. Trojanowski, Andrew J. Saykin, Mitchel A. Kling, Wayne R. Matson, Kwangsik Nho, Rima Kaddurah-Daouk, Steven E. Arnold, and Hongjie Zhu

Subjects
Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Metabolic pathway, Developmental Neuroscience, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Cognitive impairment, Neuroscience
Published
2013

11. O1–02–05: Identifying multi‐analyte CSF biomarkers for Alzheimer's disease in a multi‐cohort study

Author

David M. Holtzman, Sharon X. Xie, Victor S. Lobanov, Tim Schultz, Yuk Yee Leung, Alexey Nefedov, Gayle M. Wittenberg, Juan Toledo, William T. Hu, Richard J. Perrin, Leslie M. Shaw, David Baker, Li-San Wang, Michael A Farnum, Allitia DiBernardo, Holly Soares, Matthew D. Mailman, Steven E. Arnold, Nandini Raghavan, Young Min Baek, Vaibhav A. Narayan, Vivianna M. Van Deerlin, Murray Grossman, Mitchel A. Kling, Anne M. Fagan, Virginia M.-Y. Lee, Alice Chen-Plotkin, John Q. Trojanowski, Robi Polikar, and John C. Morris

Subjects
Oncology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, Csf biomarkers, medicine, Neurology (clinical), Geriatrics and Gerontology, business, Multi analyte, Cohort study
Published
2013

12. S5‐02‐04: Relationships of cerebrovascular atherosclerosis with amyloid, tau, α‐synuclein and TDP‐43 pathologies in neurodegenerative disease dementias

Author

Edward B. Lee, Vivianna M. Van Deerlin, M.-Y. Lee Virginia, Sharon X. Xie, Mark Yarchoan, Juan Toledo, David A. Wolk, John Q. Trojanowski, Steven E. Arnold, and Mitchel A. Kling

Subjects
Pathology, medicine.medical_specialty, Amyloid, Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, α synuclein, Neurology (clinical), Geriatrics and Gerontology, business
Published
2012

13. P1‐128: Factors associated with cognitive resilience in late life: A three‐sample comparison

Author

Mitchel A. Kling, Susanne Steinberg, Mary D. Sammel, Steven E. Arnold, Melissa Livney, Hannah McCoubrey, and Stephanie Yuen

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Cognition, Sample (statistics), Neurology (clinical), Geriatrics and Gerontology, Psychology, Resilience (network), Developmental psychology
Published
2012

14. P2‐049: Cerebrospinal fluid biochemical biomarkers of depressive symptoms in older adults

Author

Li-San Wang, William T. Hu, Mitchel A. Kling, Virginia M.-Y. Lee, John Q. Trojanowski, Leslie M. Shaw, Steven E. Arnold, David A. Wolk, and Yuk Yee Leung

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Biochemical biomarkers, Gastroenterology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Cerebrospinal fluid, Developmental Neuroscience, Internal medicine, medicine, Neurology (clinical), Geriatrics and Gerontology, business, Depressive symptoms
Published
2012

15. P2‐017: Biochemical Biomarkers of Depressive Symptoms in ADNI

Author

Eun Ji Kim, Leslie M. Shaw, Yuk Yee Leung, David A. Wolk, John Q. Trojanowski, Mitchel A. Kling, Sharon X. Xie, David A. Bennett, Virginia M.-Y. Lee, Alice Chen-Plotkin, Steven E. Arnold, Robert S. Wilson, Murray Grossman, Scott Mackin, and William T. Hu

Subjects
Oncology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Biochemical biomarkers, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, medicine, Neurology (clinical), Geriatrics and Gerontology, business, Depressive symptoms
Published
2011

16. P3‐279: Predictors of resilient cognitive aging: Baseline characteristics

Author

Hannah McCoubrey, Stephanie Yuen, Melissa Livney, Carol Edwards, Steven E. Arnold, Mitchel A. Kling, Sharon X. Xie, and Susanne Steinberg

Subjects
Gerontology, Cognitive aging, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, business.industry, Health Policy, Baseline characteristics, Medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2011

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