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52 results on '"Maritza Dowling"'

1. Waist‐hip ratio as a moderator of the effects of hormone therapy on cognitive function in recently menopausal women

Author

Taryn T. James, N. Maritza Dowling, Carola A. Ferrer Simó, Megan Zuelsdorff, Shenikqua Bouges, Nickolas H. Lambrou, Carol A Van Hulle, Adrienne L. Johnson, Mary F. Wyman, Hector Salazar, Emre Umucu, Firat Kara, JoAnn E. Manson, Eliot A Brinton, Marcelle I. Cedars, Rogerio A. Lobo, Genevieve Neal‐Perry, Nanette F Santoro, Frederick Naftolin, Sherman M. Harman, Lubna Pal, Virginia M. Miller, Kejal Kantarci, and Carey E. Gleason

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021

2. Higher systolic and diastolic blood pressures are associated with loss of white matter integrity in postmenopausal women of the KEEPS Continuation Study

Author

Firat Kara, Robert I. Reid, Christopher G. Schwarz, Nirubol Tosakulwong, Timothy G. Lesnick, Samantha M. Zuk, June Kendall‐Thomas, Kaely Thostenson, Denise A. Reyes, Julie A. Fields, Matthew L. Senjem, Hoon‐Ki Min, Val J. Lowe, Clifford R. Jack, Kent R. Bailey, Taryn T. James, Rogerio A. Lobo, JoAnn E. Manson, Lubna Pal, Dustin B. Hammers, Michael H. Malek‐Ahmadi, Marcelle I. Cedars, Frederick Naftolin, Virginia M. Miller, Sherman M. Harman, N. Maritza Dowling, Carey E. Gleason, and Kejal Kantarci

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021

3. Family history and TOMM40 '523 interactive associations with memory in middle‐aged and Alzheimer's disease cohorts

Author

Allen D. Roses, Auriel A. Willette, Sterling C. Johnson, Bruce P. Hermann, Alexandra M.V. Wennberg, Rebecca L. Koscik, Michael W. Lutz, N. Maritza Dowling, Joseph L. Webb, Jennifer M. Oh, Sanjay Asthana, and Barbara B. Bendlin

Subjects
0301 basic medicine, Gerontology, Epidemiology, Health Policy, Physiology, Cognition, Disease, Biology, medicine.disease, Outer mitochondrial membrane, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 030104 developmental biology, 0302 clinical medicine, Developmental Neuroscience, Global function, medicine, Biomarker (medicine), Neurology (clinical), Geriatrics and Gerontology, Alzheimer's disease, Family history, 030217 neurology & neurosurgery, Cohort study
Abstract

Introduction Family history (FH) of Alzheimer's disease (AD) affects mitochondrial function and may modulate effects of translocase of the outer mitochondrial membrane 40 kDa ( TOMM40 ) rs10524523 (‘523) poly-T length on memory decline. Methods For 912 nonapolipoprotein e4 middle-aged adults and 365 aged adults across the AD spectrum, linear mixed models gauged FH and TOMM40 ‘523 interactions on memory and global cognition between baseline and up to 10 years later. A cerebrospinal fluid mitochondrial function biomarker was also assessed. Results For FH negative participants, gene-dose preservation of memory and global cognition was seen for "very long" versus "short" carriers. For FH positive, an opposite gene-dose decline was seen for very long versus short carriers. Maternal FH was a stronger predictor in aged, but not middle-aged, participants. Similar gene-dose effects were seen for the mitochondrial biomarker aspartate aminotransferase. Discussion These results may clarify conflicting findings on TOMM40 poly-T length and AD-related decline.

Published
2017

4. F2‐01‐03: AN UPDATE ON MENOPAUSAL HORMONE THERAPY TRIALS

Author

Maritza Dowling, Kelly N. Morgan, and Carey E. Gleason

Subjects
Oncology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, medicine, Neurology (clinical), Menopausal hormone therapy, Geriatrics and Gerontology, business
Published
2018

5. P4‐305: IMPACT OF SIMVASTATIN ON CEREBRAL BLOOD FLOW, PULSATILITY INDEX, AND ALZHEIMER'S DISEASE BIOMARKERS: A CLINICAL TRIAL

Author

Sterling C. Johnson, Chuck Illingworth, Maritza Dowling, Carson Hoffman, Rick Chappell, Patrick A. Turski, Barbara B. Bendlin, Henrik Zettenberg, Natanya S. Russek, Sanjay Asthana, Cynthia M. Carlsson, Benjamin P. Austin, Yue Ma, Oliver Wieben, Jennifer M. Oh, Karen K. Lazar, Howard A. Rowley, Leonardo A. Rivera, Laura E. Jacobson, Carey E. Gleason, Kaj Blennow, Lindsay R. Clark, Sara E. Berman, and Hanna Blazel

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Alzheimer's disease biomarkers, Pulsatility index, Clinical trial, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Cerebral blood flow, Simvastatin, Internal medicine, Cardiology, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, medicine.drug
Published
2018

6. O2‐03‐02: ASSOCIATION OF SLEEP QUALITY AND AMYLOID BURDEN WITH FUNCTIONAL ABILITY IN A SAMPLE OF VIETNAM VETERANS WITH PTSD AND TBI

Author

Robert T. Turner, Maritza Dowling, and Jeanne Geiger-Brown

Subjects
Sleep quality, Epidemiology, business.industry, Health Policy, Sample (statistics), Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, Amyloid burden, Neurology (clinical), Functional ability, Geriatrics and Gerontology, Association (psychology), business, Clinical psychology
Published
2018

7. [IC‐P‐066]: AD FAMILY HISTORY MODULATES EFFECTS OF TOMM40 ‘523’ POLY‐T ON MTL ATROPHY AND HYPOMETABOLISM IN PRECLINICAL AND AD COHORTS

Author

Barbara B. Bendlin, Maritza Dowling, Joseph L. Webb, Rebecca L. Koscik, Allen D. Roses, Michael W. Lutz, Jennifer M. Oh, Sanjay Asthana, Auriel A. Willette, Bruce P. Hermann, Sterling C. Johnson, and Alexandra M.V. Wennberg

Subjects
Oncology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Atrophy, Developmental Neuroscience, Internal medicine, medicine, Neurology (clinical), Geriatrics and Gerontology, Family history, business
Published
2017

8. [O2–07–06]: CHANGES IN BRAIN STRUCTURE THREE YEARS AFTER THE END OF MENOPAUSAL HORMONE THERAPIES IN A RANDOMIZED CONTROLLED TRIAL

Author

Kent R. Bailey, Jeffrey L. Gunter, Nirubol Tosakulwong, Megan L. Settell, Virginia M. Miller, Maritza Dowling, Lynne T. Shuster, Clifford R. Jack, Matthew L. Senjem, Timothy G. Lesnick, Kejal Kantarci, Samantha M. Zuk, Carey E. Gleason, and Walter A. Rocca

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, law.invention, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Randomized controlled trial, law, Internal medicine, Physical therapy, medicine, Neurology (clinical), Geriatrics and Gerontology, business, Hormone
Published
2017

9. [P3–021]: THE ROLE OF CARDIOVASCULAR HEALTH IN MODERATING THE EFFECTS OF POSTMENOPAUSAL HORMONE THERAPY ON NEUROIMAGING OUTCOMES

Author

Samantha M. Zuk, Carey E. Gleason, Lynne T. Shuster, Jeffrey L. Gunter, Kent R. Bailey, Virginia M. Miller, Clifford R. Jack, Maritza Dowling, and Kejal Kantarci

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Cardiovascular health, medicine.medical_treatment, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Neuroimaging, medicine, Neurology (clinical), Hormone therapy, Geriatrics and Gerontology, Intensive care medicine, business, Clinical psychology
Published
2017

10. P4‐037: Factors associated with the likelihood of providing cerebrospinal fluid for a medical research study in an ethnically diverse sample of adults

Author

N. Maritza Dowling, Dorothy F. Edwards, and Jennifer Dykema

Subjects
Gerontology, Epidemiology, business.industry, Health Policy, Sample (statistics), Ethnically diverse, Medical research, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2015

11. P3‐103: Assessing the significance of insulin resistance on cerebrospinal fluid Alzheimer's disease biomarkers and memory function in people at risk for Alzheimer's disease: Findings from the wisconsin adrc impact cohort

Author

Barbara B. Bendlin, Sterling C. Johnson, Ozioma C. Okonkwo, Carey E. Gleason, Howard A. Rowley, Kaj Blennow, Sanjay Asthana, Henrik Zetterberg, Jennifer M. Oh, Siobhan M. Hoscheidt, Cynthia M. Carlsson, Rachel A. Krause, and Maritza Dowling

Subjects
Oncology, medicine.medical_specialty, Pathology, Epidemiology, business.industry, Health Policy, Alzheimer's disease biomarkers, Disease, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Cerebrospinal fluid, Insulin resistance, Developmental Neuroscience, Internal medicine, Cohort, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2015

12. P1‐204: Insulin resistance is associated with altered microstructure in the medial temporal lobe and fornix of cognitively healthy ApoE ε4 carriers

Author

Erika Jane Starks, Joseph Patrick O'Grady, Siobhan M. Hoscheidt, Annie M. Racine, Ozioma C. Okonkwo, Henrik Zetterberg, Cynthia M. Carlsson, Howard A. Rowley, Kaj Blennow, Sanjay Asthana, Nagesh Adluru, Andrew L. Alexander, Carey E. Gleason, N. Maritza Dowling, LeAnn DeRungs, Nancy J. Davenport, Mark A. Sager, Sterling C. Johnson, and Barbara B. Bendlin

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2015

13. IC‐P‐063: Alzheimer's disease biomarker‐based clusters predict amyloid accumulation and cognitive decline in a preclinical cohort: Findings from the wisconsin registry for Alzheimer's prevention (WRAP)

Author

Annie M. Racine, Christopher R. Nicholas, Lindsay R. Clark, Rebecca L. Koscik, Ozioma C. Okonkwo, Ansel T. Hillmer, Dhanabalan Murali, Todd E. Barnhart, Catherine L. Gallagher, Howard A. Rowley, N. Maritza Dowling, Sanjay Asthana, Barbara B. Bendlin, Kaj Blennow, Henrik Zetterberg, Cynthia M. Carlsson, Bradley T. Christian, and Sterling C. Johnson

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2015

14. P4‐274: Intra‐individual cognitive variability: An alternative to invasive Alzheimer's disease biomarkers?

Author

Sterling C. Johnson, Carey E. Gleason, Cynthia M. Carlsson, N. Maritza Dowling, Sanjay Asthana, Rebecca L. Koscik, Vikas Singh, Eric D. Anderson, Michelle L. Wahoske, and Derek Norton

Subjects
Oncology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Alzheimer's disease biomarkers, Cognition, Intra individual, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2015

15. P2‐210: Subjective memory complaints in middle‐aged adults with a family history of Alzheimer's disease

Author

N. Maritza Dowling, Chuck Illingworth, Barbara B. Bendlin, Rebecca L. Koscik, Christopher R. Nicholas, Lindsay R. Clark, Mark A. Sager, Sterling C. Johnson, Sanjay Asthana, Annie M. Racine, Bruce P. Hermann, and Jennifer M. Oh

Subjects
medicine.medical_specialty, Epidemiology, Health Policy, Disease, Subjective memory, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Family history, Psychology, Psychiatry
Published
2015

16. O1‐01‐03: Alzheimer's disease biomarker‐based clusters predict amyloid accumulation and cognitive decline in a preclinical cohort: Findings from the wisconsin registry for Alzheimer's prevention (WRAP)

Author

Christopher R. Nicholas, Kaj Blennow, Henrik Zetterberg, Sterling C. Johnson, Catherine L. Gallagher, Ozioma C. Okonkwo, Dhanabalan Murali, Todd E. Barnhart, Lindsay R. Clark, Rebecca L. Koscik, Ansel T. Hillmer, Sanjay Asthana, Howard A. Rowley, Cynthia M. Carlsson, Bradley T. Christian, Annie M. Racine, N. Maritza Dowling, and Barbara B. Bendlin

Subjects
Oncology, Gerontology, medicine.medical_specialty, Amyloid, Epidemiology, business.industry, Health Policy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, Cohort, medicine, Disease biomarker, Neurology (clinical), Geriatrics and Gerontology, Cognitive decline, business
Published
2015

17. O3‐01‐03: Effects of hormone therapy on brain structure in recently postmenopausal women: A randomized controlled trial

Author

Walter A. Rocca, Whitney Wharton, Samantha M. Zuk, Carey E. Gleason, Nirubol Tosakulwong, Jeffrey L. Gunter, N. Maritza Dowling, Timothy G. Lesnick, Sanjay Asthana, Virginia M. Miller, Lynne T. Shuster, Kent R. Bailey, Clifford R. Jack, Prashanthi Vemuri, Kejal Kantarci, and Matthew L. Senjem

Subjects
medicine.medical_specialty, Postmenopausal women, Epidemiology, business.industry, Health Policy, medicine.medical_treatment, law.invention, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Randomized controlled trial, law, Internal medicine, medicine, Neurology (clinical), Hormone therapy, Geriatrics and Gerontology, business
Published
2015

18. O4‐05‐01: INSULIN RESISTANCE AND CENTRAL OBESITY IN APOE4 CARRIERS ARE ASSOCIATED WITH INCREASES IN CEREBRAL SPINAL FLUID PHOSPHORYLATED TAU

Author

Carey E. Gleason, Erika J. Starks, Kaj Blennow, Joseph Patrick O'Grady, Annie M. Racine, Maritza Dowling, Mark A. Sager, Sterling C. Johnson, Ozioma C. Okonkwo, Barbara B. Bendlin, Henrik Zetterberg, Sanjay Asthana, LeAnn DeRungs, Cynthia M. Carlsson, Rozalyn M. Anderson, and Nancy J. Davenport

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Cerebral Spinal Fluid, Health Policy, medicine.disease, Obesity, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Insulin resistance, Endocrinology, Developmental Neuroscience, Internal medicine, Tau phosphorylation, Medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2014

19. P2‐118: CEREBROSPINAL FLUID MICROGLIAL MARKERS IN ALZHEIMER'S DISEASE, MCI, AND ASYMPTOMATIC ADULTS

Author

Kaj Blennow, Margarete A. Wichmann, Laura E. Jacobson, Hanna Blazel, Barbara B. Bendlin, Sterling C. Johnson, Sanjay Asthana, Benjamin P. Austin, Ozioma C. Okonkwo, N. Maritza Dowling, Henrik Zetterberg, Carey E. Gleason, Cynthia M. Carlsson, and Rick Chappell

Subjects
Pathology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, Asymptomatic, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Cerebrospinal fluid, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, business
Published
2014

20. P1‐011: SUBJECTIVE MEMORY COMPLAINTS, CORTICAL THINNING, AND COGNITIVE DYSFUNCTION IN MIDDLE‐AGED ADULTS AT RISK FOR AD: FINDINGS FROM THE WISCONSIN REGISTRY FOR ALZHEIMER'S PREVENTION

Author

Stephanie Schultz, Jennifer Oh, Rebecca L. Koscik, N. Maritza Dowling, Catherine Gallagher, Cynthia Carlsson, Barbara B. Bendlin, Asenath LaRue, Bruce Hermann, Howard Rowley, Sanjay Asthana, Mark A. Sager, Sterling Johnson, and Ozioma Okonkwo

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2014

21. IC‐P‐078: SUBJECTIVE MEMORY COMPLAINTS, CORTICAL THINNING, AND COGNITIVE DYSFUNCTION IN MIDDLE‐AGED ADULTS AT RISK FOR AD: FINDINGS FROM THE WISCONSIN REGISTRY FOR ALZHEIMER'S PREVENTION

Author

Barbara B. Bendlin, Stephanie A. Schultz, Bruce P. Hermann, Mark A. Sager, Sanjay Asthana, Howard A. Rowley, Catherine L. Gallagher, Jennifer M. Oh, Asenath LaRue, Rebecca L. Koscik, N. Maritza Dowling, Cynthia M. Carlsson, Sterling C. Johnson, and Ozioma C. Okonkwo

Subjects
medicine.medical_specialty, Epidemiology, Health Policy, Cortical thinning, Cognition, Subjective memory, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Psychiatry, Psychology
Published
2014

22. IC‐P‐118: AMYLOID BURDEN, CORTICAL THICKNESS, AND COGNITIVE FUNCTION IN THE WISCONSIN REGISTRY FOR ALZHEIMER'S PREVENTION

Author

Benjamin Matthew Doherty, Jennifer M. Oh, Stephanie A. Schultz, Rebecca L. Koscik, N. Maritza Dowling, Todd E. Barnhart, Dhanabalan E. Murali, Catherine L. Gallagher, Cynthia M. Carlsson, Barbara B. Bendlin, Asenath LaRue, Bruce P. Hermann, Howard A. Rowley, Sanjay Asthana, Mark A. Sager, Brad T. Christian, Sterling C. Johnson, and Ozioma C. Okonkwo

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2014

23. P2‐204: PARTICIPATION IN COGNITIVELY‐STIMULATING ACTIVITIES IS ASSOCIATED WITH BRAIN STRUCTURE AND COGNITIVE FUNCTION IN PRECLINICAL ALZHEIMER'S DISEASE

Author

Jordan Larson, Stephanie Schultz, Jennifer Oh, Rebecca L. Koscik, Maritza Dowling, Catherine Gallagher, Cynthia Carlsson, Howard Rowley, Barbara B. Bendlin, Sanjay Asthana, Bruce Hermann, Sterling Johnson, Mark A. Sager, Asenath LaRue, and Ozioma Okonkwo

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2014

24. IC‐01‐03: PARTICIPATION IN COGNITIVELY STIMULATING ACTIVITIES IS ASSOCIATED WITH BRAIN STRUCTURE AND COGNITIVE FUNCTION IN PRECLINICAL ALZHEIMER'S DISEASE

Author

Maritza Dowling, Catherine L. Gallagher, Bruce P. Hermann, Barbara B. Bendlin, Mark A. Sager, Howard A. Rowley, Jordan Larson, Rebecca L. Koscik, Jennifer M. Oh, Cynthia M. Carlsson, Asenath LaRue, Sanjay Asthana, Sterling C. Johnson, and Ozioma C. Okonkwo

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Cognition, Neurology (clinical), Disease, Geriatrics and Gerontology, Psychology, Neuroscience
Published
2014

25. P3‐344: PHYSICAL ACTIVITY MODIFIES ALZHEIMER BIOMARKERS IN PRECLINICAL AD: EVIDENCE FROM THE WISCONSIN REGISTRY FOR ALZHEIMER'S PREVENTION

Author

Stephanie A. Schultz, Bruce P. Hermann, Sterling C. Johnson, Catherine L. Gallagher, Rebecca L. Koscik, Howard A. Rowley, Sanjay Asthana, Ozioma C. Okonkwo, Dane B. Cook, Maritza Dowling, Cynthia M. Carlsson, Jennifer M. Oh, Barbara B. Bendlin, Brad T. Christian, Mark A. Sager, Asenath LaRue, Jordan Larson, and Dorothy F. Edwards

Subjects
Gerontology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Physical activity, Neurology (clinical), Geriatrics and Gerontology, Psychology
Published
2014

26. O1‐12‐02: AMYLOID BURDEN, CORTICAL THICKNESS, AND COGNITIVE FUNCTION IN THE WISCONSIN REGISTRY FOR ALZHEIMER'S PREVENTION

Author

Mark A. Sager, Sterling C. Johnson, Asenath LaRue, Benjamin M. Doherty, Ozioma C. Okonkwo, N. Maritza Dowling, Catherine L. Gallagher, Todd E. Barnhart, Brad T. Christian, Cynthia M. Carlsson, Rebecca L. Koscik, Sanjay Asthana, Dhanabalan Murali, Stephanie A. Schultz, Howard A. Rowley, Jennifer M. Oh, Bruce P. Hermann, and Barbara B. Bendlin

Subjects
medicine.diagnostic_test, Amyloid, Epidemiology, Health Policy, Magnetic resonance imaging, Cognition, Disease, Entorhinal cortex, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, medicine.anatomical_structure, Developmental Neuroscience, chemistry, medicine, Neurology (clinical), Geriatrics and Gerontology, Cognitive decline, Pittsburgh compound B, Psychology, Neuroscience, Parahippocampal gyrus
Abstract

There is a growing interest in understanding how amyloid b (Ab) accumulation in preclinical Alzheimer’s disease relates to brain morphometric measures and cognition. Existing investigations in this area have been primarily conducted in older cognitively normal (CN) individuals. Therefore, not much is known about the associations between Ab burden, cortical thickness, and cognition in midlife. We examined this question in 109, CN, late to middle-aged adults (mean age5 60.72 65.65 years) from the Wisconsin Registry for Alzheimer’s Prevention. They underwent Pittsburgh Compound B (PiB) and anatomical magnetic resonance (MR) imaging, and a comprehensivecognitiveexamination.BlindedvisualratingofthePiBscanswasusedtoclassifytheparticipants as Ab1 or Ab2. Cortical thickness measurements were derived from the MR images. The Ab1 group exhibited significant thinning of the entorhinal cortex and accelerated age-associated thinning of the parahippocampal gyrus compared with the Ab2 group. The Ab1 group also had numerically lower, butnonsignificant,testscores onallcognitivemeasures, and significantlyfasterage-associated cognitive decline on measures of Speed & Flexibility, Verbal Ability, and Visuospatial Ability. Our findings suggest that early Ab aggregation is associated with deleterious changes in brain structure and cognitive function, even in midlife, and that the temporal lag between Ab deposition and the inception of neurodegenerative/cognitive changes might be narrower than currently thought. 2015 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/ 4.0/).

Published
2014

27. IC‐01‐01: IMAGING OF TAU PATHOLOGY IN PATIENTS WITH NON‐ALZHEIMER'S DISEASE TAUOPATHIES BY [11C]PBB3‐PET

Author

Rebecca L. Koscik, Howard A. Rowley, Dorothy F. Edwards, Maritza Dowling, Barbara B. Bendlin, Asenath LaRue, Mark A. Sager, Jordan Larson, Sanjay Asthana, Brad T. Christian, Catherine L. Gallagher, Dane B. Cook, Jennifer M. Oh, Sterling C. Johnson, Ozioma C. Okonkwo, Stephanie A. Schultz, Bruce P. Hermann, and Cynthia M. Carlsson

Subjects
Pathology, medicine.medical_specialty, Tau pathology, Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, In patient, Neurology (clinical), Geriatrics and Gerontology, business
Published
2014

28. IC‐P‐121: CARDIORESPIRATORY FITNESS IS ASSOCIATED WITH BRAIN STRUCTURE, COGNITION, AND MOOD IN A MIDDLE‐AGED COHORT AT RISK FOR ALZHEIMER'S DISEASE

Author

Elizabeth Anne Boots, Jennifer Oh, Stephanie Schultz, Jordan Larson, Dorothy Farrar Edwards, Dane Cook, Rebecca Koscik, Maritza Dowling, Catherine Gallagher, Cynthia Carlsson, Howard Rowley, Barbara B. Bendlin, Asenath LaRue, Sanjay Asthana, Bruce Hermann, Sterling Johnson, Mark A. Sager, and Ozioma Okonkwo

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2014

29. P2‐106: CSF BIOMARKER PROFILES IN MIDDLE‐AGED ADULTS WITH PARENTAL HISTORY OF AD: THE WISCONSIN ADRC COHORTS

Author

Laura E. Jacobson, Cynthia M. Carlsson, Hanna Blazel, Mark A. Sager, Sterling C. Johnson, Benjamin P. Austin, Sanjay Asthana, Rick Chappell, Barbara B. Bendlin, Ozioma C. Okonkwo, Kaj Blennow, Henrik Zetterberg, Margarete A. Wichmann, Maritza Dowling, and Carey E. Gleason

Subjects
Oncology, Gerontology, medicine.medical_specialty, Epidemiology, Health Policy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, Csf biomarkers, medicine, Neurology (clinical), Geriatrics and Gerontology, Psychology
Published
2014

30. IC‐P‐102: THE RELATIONSHIP BETWEEN CEREBRAL PERFUSION, AGE, AND APOE4 IN MIDDLE‐AGED ADULTS AT RISK FOR ALZHEIMER'S DISEASE

Author

Rick Chappell, Mark A. Sager, Benjamin P. Austin, Sterling C. Johnson, Laura E. Jacobson, Cynthia M. Carlsson, Ozioma C. Okonkwo, N. Maritza Dowling, Carey E. Gleason, Jennifer M. Oh, Howard A. Rowley, Sanjay Asthana, Barbara B. Bendlin, and Hanna Blazel

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, Cardiology, Medicine, Neurology (clinical), Geriatrics and Gerontology, Cerebral perfusion pressure, business
Published
2014

31. P1‐229: THE RELATIONSHIP BETWEEN CEREBRAL PERFUSION, AGE, AND APOE4 IN MIDDLE‐AGED ADULTS AT RISK FOR ALZHEIMER'S DISEASE

Author

Benjamin Piya Austin, Sterling Johnson, Jennifer Oh, Barbara B. Bendlin, Carey Elizabeth Gleason, Ozioma Okonkwo, Laura E. Jacobson, Hanna Blazel, Rick Chappell, N. Maritza Dowling, Howard Rowley, Mark A. Sager, Sanjay Asthana, and Cynthia M. Carlsson

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2014

32. O2‐02‐03: CARDIORESPIRATORY FITNESS IS ASSOCIATED WITH BRAIN STRUCTURE, COGNITION, AND MOOD IN A MIDDLE‐AGED COHORT AT RISK FOR ALZHEIMER'S DISEASE

Author

Stephanie A. Schultz, Dorothy F. Edwards, Asenath LaRue, Howard A. Rowley, Maritza Dowling, Bruce P. Hermann, Catherine L. Gallagher, Barbara B. Bendlin, Jennifer M. Oh, Sanjay Asthana, Jordan Larson, Rebecca L. Koscik, Cynthia M. Carlsson, Sterling C. Johnson, Ozioma C. Okonkwo, Dane B. Cook, Elizabeth A. Boots, and Mark A. Sager

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Cardiorespiratory fitness, Cognition, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Mood, Developmental Neuroscience, Cohort, medicine, Neurology (clinical), Geriatrics and Gerontology, Psychiatry, business, Clinical psychology
Published
2014

34. P1–186: The relationship of cerebral perfusion with age and CSF measures in middle‐aged adults at risk for Alzheimer's disease

Author

Benjamin Austin, Barbara Bendlin, Sterling Johnson, Henrik Zetterberg, Kaj Blennow, Hanna Blazel, Jodi Barnet, Maritza Dowling, Luigi Puglielli, Carey Gleason, Mark Sager, Sanjay Asthana, and Cynthia Carlsson

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2013

35. IC‐P‐095: The relationship of cerebral perfusion with age and CSF measures in middle‐aged adults at risk for Alzheimer's disease

Author

Kaj Blennow, Barbara B. Bendlin, Jodi H. Barnet, Carey E. Gleason, Mark A. Sager, Sanjay Asthana, Cynthia M. Carlsson, Henrik Zetterberg, Maritza Dowling, Benjamin P. Austin, Hanna Blazel, Luigi Puglielli, and Sterling C. Johnson

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, Cardiology, medicine, Neurology (clinical), Geriatrics and Gerontology, Cerebral perfusion pressure, business
Published
2013

36. P3–311: Baseline lipid levels predict cerebral blood flow response to statin therapy in middle‐aged adults at risk for Alzheimer's disease

Author

Jodi H. Barnet, Carey E. Gleason, Mark A. Sager, Barbara B. Bendlin, N. Maritza Dowling, Sanjay Asthana, Hanna Blazel, Sterling C. Johnson, Benjamin P. Austin, and Cynthia M. Carlsson

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Cerebral blood flow, Internal medicine, medicine, Cardiology, Physical therapy, Neurology (clinical), Statin therapy, Geriatrics and Gerontology, Baseline (configuration management), business
Published
2013

37. P1‐405: Empirically derived mild cognitive impairment subtypes based on performance on memory tests predict conversion to Alzheimer's disease

Author

Maritza Dowling, Shubhabrata Mukherjee, Cathy LaBrish, and Jodi M. Casabianca

Subjects
Oncology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, medicine, Neurology (clinical), Geriatrics and Gerontology, Cognitive decline, Cognitive impairment, business
Abstract

(SD4.80), (CDR3) M 1⁄4 3.57 (SD3.56). Results: Subjects cognitively healthy (N 1⁄4 40; 35.40%) met the inclusion criteria for the ControlGroup. However patients with (AD) showed a tendency to cognitive decline [(MMSE), (CDR 0)M 1⁄4 28.57 (SD1.46); (CDR 1) M 1⁄4 22.65 (SD4.91); (CDR 2) M13.62 (SD7,24); (CDR 3) M 1⁄4 5.85 (SD4.32)], dependency in activities of daily live [(Katz) (CDR 0) M 1⁄4 .05 (SD.22); (CDR 1) M 1⁄4 10.05 (SD8.64); M 1⁄4 27.25 (SD7.91); M 1⁄4 37.21 (SD4.20)], decrease of functional stage [(FAST) (CDR 0) M 1⁄4 .07 (SD .26); (CDR 1) M 1⁄4 4.4 (SD1.41); (CDR2)M 1⁄4 5.5 (SD1,31); (CDR3) M 1⁄4 6.71 (SD .46)] and evidence of non-Piagetian conservation, so match the severity of the disease in three stages (CDR). Conclusions: This study confirms previous findings that in AD, cognitive decline has characteristics similar to the Piaget theoretical model, but in a reverse development pattern (retrogenesis).

Published
2011

38. P3‐298: Hippocampal volumes are associated with cognitive performance in recently menopausal APOE ∊4 carriers

Author

Glenn E. Smith, Carey E. Gleason, Heather J. Wiste, Virginia M. Miller, Clifford R. Jack, Kejal Kantarci, Samantha Wille, Chad Ward, Whitney Wharton, Teresa Zais, Stephen D. Weigand, Maritza Dowling, Nirubol Tosakulwong, and Sanjay Asthana

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, business.industry, Health Policy, Medicine, Neurology (clinical), Effects of sleep deprivation on cognitive performance, Geriatrics and Gerontology, Hippocampal formation, business, Neuroscience
Published
2011

39. P4‐416: Findings from a randomized, placebo‐control, clinical trial examining the potential cognitive effects of soy isoflavones in patients with Alzheimer's disease

Author

Jodi H. Barnet, Craig S. Atwood, Carey E. Gleason, Sterling C. Johnson, Cynthia M. Carlsson, N. Maritza Dowling, Kenneth D. R. Setchell, and Sanjay Asthana

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Cognition, Disease, Placebo, Clinical trial, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, medicine, In patient, Neurology (clinical), Geriatrics and Gerontology, business, SOY ISOFLAVONES
Published
2011

40. P4‐012: The Influence of Metabolic Syndrome on Simvastatin Therapy In Asymptomatic Adults at Risk for Alzheimer's Disease: The ESPRIT Study

Author

Jodi H. Barnet, Sterling C. Johnson, Sanjay Asthana, Henrik Zetterberg, Laura L. Miller, Bruce P. Hermann, Mark A. Sager, Luigi Puglielli, N. Maritza Dowling, Kaj Blennow, Cynthia M. Carlsson, Carey E. Gleason, Alyce J. Marsh, Craig S. Atwood, and Hanna Blazel

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, medicine.disease, Asymptomatic, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Endocrinology, Developmental Neuroscience, Simvastatin, Internal medicine, medicine, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, Metabolic syndrome, business, medicine.drug
Published
2010

41. O4‐01‐06: A randomized, double‐blind placebo‐controlled trial of simvastatin on CSF, MRI, and cognitive biomarkers in middle‐aged adults at risk for Alzheimer's disease: The ESPRIT Study

Author

Carey E. Gleason, Mark A. Sager, Guofan Xu, Sean B. Fain, Sterling C. Johnson, Sanjay Asthana, Henrik Zetterberg, Jodi H. Barnet, Howard A. Rowley, Luigi Puglielli, Cynthia M. Carlsson, Craig S. Atwood, Hanna Blazel, George C. Newman, Bruce P. Hermann, Kaj Blennow, Yin Huang, and N. Maritza Dowling

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Placebo-controlled study, Cognition, Disease, Double blind, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Simvastatin, Internal medicine, medicine, Physical therapy, Neurology (clinical), Geriatrics and Gerontology, business, medicine.drug
Published
2010

42. P1‐451: Mid‐life dementia risk scores as a predictor of CSF biomarker response to simvastatin therapy in asymptomatic adults at risk for Alzheimer's disease: The ESPRIT study

Author

Sanjay Asthana, Bruce P. Hermann, N. Maritza Dowling, Henrik Zetterberg, Craig S. Atwood, Carey E. Gleason, Jodi H. Barnet, Sterling C. Johnson, Cynthia M. Carlsson, Alyce J. Marsh, Luigi Puglielli, Mark A. Sager, Hanna Blazel, and Kaj Blennow

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, medicine.disease, Asymptomatic, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Simvastatin, Internal medicine, Csf biomarkers, medicine, Physical therapy, Dementia, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, business, medicine.drug
Published
2010

43. P3‐199: Relationship between CSF biomarkers and language fluency in asymptomatic middle‐aged adults at increased risk for Alzheimer's disease: The ESPRIT study

Author

Cynthia M. Carlsson, Alyce J. Marsh, Jodi H. Barnet, Sanjay Asthana, Henrik Zetterberg, Carey E. Gleason, Bruce P. Hermann, Mark A. Sager, Kaj Blennow, N. Maritza Dowling, Sterling C. Johnson, Craig S. Atwood, Hanna Blazel, and Luigi Puglielli

Subjects
Pediatrics, medicine.medical_specialty, Epidemiology, Health Policy, Disease, Asymptomatic, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Increased risk, Developmental Neuroscience, Language fluency, Csf biomarkers, medicine, Physical therapy, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, Psychology
Published
2010

44. P3‐386: Relation between blood pressure and cognition in a randomized, placebo‐controlled, double‐blind pilot study with soy isoflavones: Examination of the healthy user bias

Author

Maritza Dowling, Carey E. Gleason, C. M. Carlsson, Christine Khosropore, Sanjay Asthana, and Whitney Wharton

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Cognition, Placebo, Double blind, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Blood pressure, Developmental Neuroscience, Internal medicine, medicine, Neurology (clinical), Geriatrics and Gerontology, business, SOY ISOFLAVONES
Published
2010

45. P2‐059: Using regression and classification trees to examine dementia risk as a predictor of cognitive function in healthy middle‐aged adults with a family history of Alzheimer's disease

Author

Maritza Dowling, Mark A. Sager, Cynthia M. Carlsson, Bruce P. Hermann, and Asenath La Rue

Subjects
Epidemiology, Health Policy, Cognition, Disease, medicine.disease, Regression, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Dementia, Neurology (clinical), Geriatrics and Gerontology, Family history, Psychology, Clinical psychology
Published
2009

46. P4‐268: Impact Of Statin Blood‐brain Barrier Permeability On Test Performance In Asymptomatic Middle‐aged Adults At Risk For AD: The WRAP Cohort

Author

Asenath La Rue, Bruce P. Hermann, Sanjay Asthana, Carey E. Gleason, Sterling C. Johnson, Mark A. Sager, N. Maritza Dowling, and Cynthia M. Carlsson

Subjects
medicine.medical_specialty, Statin, Epidemiology, business.industry, medicine.drug_class, Health Policy, Asymptomatic, Surgery, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, Cohort, medicine, Test performance, Neurology (clinical), Blood brain barrier permeability, Geriatrics and Gerontology, medicine.symptom, business
Published
2009

47. P4‐084: Interactive effects of family history of Alzheimer's disease and childhood learning problems on midlife memory performance

Author

Asenath LaRue, Maritza Dowling, Bruce P. Hermann, Mark A. Sager, and Nicole Wright

Subjects
Epidemiology, Health Policy, Disease, Memory performance, Developmental psychology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Interactive effects, Neurology (clinical), Childhood memory, Geriatrics and Gerontology, Family history, Psychology, Cognitive psychology
Published
2008

48. P2‐115: Influence of vascular risk factors on cognitive performance in community‐dwelling African Americans

Author

Sanjay Asthana, Carey E. Gleason, Whitney Wharton, Dorothy F. Edwards, Christine M. Khosropour, Cynthia M. Carlsson, and N. Maritza Dowling

Subjects
Gerontology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, business.industry, Health Policy, Medicine, Neurology (clinical), Effects of sleep deprivation on cognitive performance, Geriatrics and Gerontology, Vascular risk, business
Published
2008

50. P4‐012: Increased duration of statin use is associated with better cognitive performance in middle‐aged adults: The Wisconsin Registry for Alzheimer's Prevention (WRAP)

Author

Carey E. Gleason, Cynthia M. Carlsson, N. Maritza Dowling, Sanjay Asthana, Mark A. Sager, Asenath LaRue, Bruce P. Hermann, and Sterling C. Johnson

Subjects
Gerontology, medicine.medical_specialty, Epidemiology, Health Policy, Statin treatment, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Physical therapy, medicine, Neurology (clinical), Effects of sleep deprivation on cognitive performance, Geriatrics and Gerontology, Duration (project management), Psychology
Published
2008

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