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Your search keyword '"Maricarmen Pachicano"' showing total 3 results
Start Over Author "Maricarmen Pachicano" Journal alzheimer's & dementia
3 results on '"Maricarmen Pachicano"'

1. Combined segmentation and classification of Alzheimer’s disease pathology distribution within human hippocampal subregions

Author

Terri‐Leigh Stephen, Laura Korobkova, Kymry T Jones, Ryan P Cabeen, Maricarmen Pachicano, Debra Hawes, Carol A Miller, and Michael S Bienkowski

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2022
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2. A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid

Author

Daniel A. Nation, Helena C. Chui, Axel Montagne, Lon S. Schneider, Maricarmen Pachicano, Arthur W. Toga, Melanie D. Sweeney, Abhay P. Sagare, Anne M. Fagan, Elizabeth Joe, Berislav V. Zlokovic, Michael G. Harrington, Judy Pa, John C. Morris, and John M. Ringman

Subjects
0301 basic medicine, Pathology, Epidemiology, Angiogenesis, 0302 clinical medicine, Cerebrospinal fluid, vascular, medicine.diagnostic_test, Health Policy, Platelet-Derived Growth Factor beta, Psychiatry and Mental health, medicine.anatomical_structure, Blood-Brain Barrier, Neurological, biomarker, Biomarker (medicine), Pericyte, Receptor, Blood vessel, medicine.medical_specialty, Physical Injury - Accidents and Adverse Effects, Clinical Sciences, Blood–brain barrier, Sensitivity and Specificity, cerebrospinal fluid, pericytes, Article, Receptor, Platelet-Derived Growth Factor beta, 03 medical and health sciences, Cellular and Molecular Neuroscience, Developmental Neuroscience, Growth factor receptor, Acquired Cognitive Impairment, medicine, Humans, Cognitive Dysfunction, cognitive impairment, business.industry, Neurosciences, blood-brain barrier, Brain Disorders, 030104 developmental biology, Geriatrics, Immunoassay, Neurology (clinical), Geriatrics and Gerontology, Pericytes, business, Biomarkers, 030217 neurology & neurosurgery
Abstract

Introduction Blood-brain barrier (BBB) breakdown and loss of brain capillary pericytes contributes to cognitive impairment. Pericytes express platelet-derived growth factor receptor-β (PDGFRβ) that regulates brain angiogenesis and blood vessel stability. Elevated soluble PDGFRβ (sPDGFRβ) levels in cerebrospinal fluid (CSF) indicate pericyte injury and BBB breakdown, which is an early biomarker of human cognitive dysfunction. Methods A combination of reagents and conditions were tested, optimized, and validated on the Meso Scale Discovery electrochemiluminescence platform to develop a new sPDGFRβ immunoassay that was used to measure sPDGFRβ in human CSF from 147 individuals. Results We developed standard operating procedures for a highly sensitive and reproducible sPDGFRβ immunoassay with a dynamic range from 100 to 26,000 pg/mL, and confirmed elevated CSF sPDGFRβ levels in individuals with cognitive dysfunction. Discussion This assay could be applied at different laboratories to study brain pericytes and microvascular damage in relation to cognition in disorders associated with neurovascular and cognitive dysfunction.

Published
2020
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3. Relationships between cerebrovascular health and tau PET uptake are associated with global cognition

Author

Judy Pa, Lisette Isenberg, Lon S. Schneider, Joy Stradford, Teresa Monreal, Peter S. Conti, Daniel S. Albrecht, Helena C. Chui, Elizabeth Joe, Arthur W. Toga, Kay Jann, Maricarmen Pachicano, Berislav V. Zlokovic, and Abhay P. Sagare

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Modal, Developmental Neuroscience, Neuroimaging, Epidemiology, Health Policy, Cognition, Neurology (clinical), Geriatrics and Gerontology, Psychology, Neuroscience
Published
2020
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