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Your search keyword '"Letizia Polito"' showing total 10 results
Start Over Author "Letizia Polito" Journal alzheimer's & dementia
10 results on '"Letizia Polito"'

1. P4-551: VALIDATION OF A NEW ANTIBODY THAT RECOGNIZES A CONFORMATIONAL VARIANT OF P53 SPECIFIC FOR ALZHEIMER'S AT THE PRE-CLINICAL AND PRODROMAL STAGES OF THE DISEASE

Author

Marika Vezzoli, Christopher Fowler, Maurizio Memo, Letizia Polito, Jeffrey L. Cummings, Giulia Abate, Antonio Guaita, and Daniela Uberti

Subjects
biology, Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Immunology, biology.protein, Medicine, Neurology (clinical), Geriatrics and Gerontology, Antibody, business
Published
2019
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2. [P3–227]: A NEW PUTATIVE EARLY BIOMARKER FOR A BLOOD‐BASED TIMELY DIAGNOSIS FOR ALZHEIMER's DISEASE

Author

Fernando Cueto, Antonello Novelli, Wiramon Rungratanawanich, Letizia Polito, Carmen Martínez, Antonio Guaita, Noemí Arce Varas, Maria Teresa Fernández-Sánchez, Daniela Uberti, Giulia Abate, Marika Vezzoli, Mariagrazia Marziano, and Maurizio Memo

Subjects
Oncology, medicine.medical_specialty, Pathology, Epidemiology, business.industry, Health Policy, Disease, Timely diagnosis, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, Medicine, Biomarker (medicine), Neurology (clinical), Geriatrics and Gerontology, business
Published
2017
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3. [P3–221]: A BLOOD‐BASED REDOX PROFILE AS A FINGERPRINT FOR ALZHEIMER PATHOLOGY

Author

Daniela Uberti, Giulia Abate, Marika Vezzoli, Mariagrazia Marziano, Noemí Arce Varas, Wiramon Rungratanawanich, Carmen Martinez, Fernando Cueto, Antonello Novelli, Letizia Polito, Antonio Guaita, and Maurizio Memo

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Chemistry, Health Policy, Fingerprint (computing), Neurology (clinical), Computational biology, Geriatrics and Gerontology, Redox
Published
2017
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4. A novel PSENEN mutation in a patient with complaints of memory loss and a family history of dementia

Author

Letizia Polito, Marzia Pesaresi, Francesca Prato, Gianluigi Forloni, Diego Albani, Roberta Pantieri, and Sara Batelli

Subjects
Genetics, Daughter, Epidemiology, Health Policy, media_common.quotation_subject, Neurogenetics, Disease, Biology, medicine.disease, Bioinformatics, Presenilin, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Polymorphism (computer science), Mutation (genetic algorithm), medicine, Dementia, Neurology (clinical), Geriatrics and Gerontology, Family history, media_common
Abstract

Presenilin enhancer-2 (PSENEN) is a fundamental component of the gamma-secretase protein complex involved in beta-amyloid precursor protein (beta APP) processing, a key event in Alzheimer's disease (AD) etiopathogenesis. In a mild cognitive impairment (MCI)-diagnosed woman, belonging to a family with a positive history for AD, we found that a novel PSENEN mutation (S73F) was the only genetic alteration of relevance. The mutation was absent in 253 age-matched controls. In an attempt to learn the biochemical effects of this mutation, we cultured skin primary fibroblasts from the patient and her daughter, and we assessed A beta(1-40) and Abeta(1-42) production. We did not find any relevant differences in comparison to age-matched, normal subjects. Although our data do not definitively support a pathogenetic role for this mutation, it does not appear to be a common polymorphism. Further follow-up is warranted in this family.

Published
2007
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5. P3‐135: Cognitive stimulation and APOE genotype in non‐demented elderly subjects from the InveCe.Ab population study

Author

Letizia Polito, Eleonora Valle, Roberta Vaccaro, Gianluigi Forloni, Simona Abbondanza, and Antonio Guaita

Subjects
Apolipoprotein E, medicine.medical_specialty, Cognitive stimulation, Epidemiology, business.industry, Health Policy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Endocrinology, Developmental Neuroscience, Internal medicine, Genotype, medicine, Population study, Neurology (clinical), Geriatrics and Gerontology, business
Published
2012
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6. P1‐254: Denaturing High Performance Liquid Chromatography (dHPLC) Screening to Find Out Genetic Polymorphisms in the Sirtuin Gene Family Relevant for Alzheimer's Disease Susceptibility

Author

Diego Albani, Gianluigi Forloni, and Letizia Polito

Subjects
Genetics, Epidemiology, Health Policy, Biology, Denaturing high performance liquid chromatography, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Disease susceptibility, Developmental Neuroscience, Sirtuin, biology.protein, Gene family, Neurology (clinical), Geriatrics and Gerontology
Published
2011
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7. P3‐034: Environmental enrichment paradigm in APP23

Author

Letizia Polito, Gianluigi Forloni, and Diego Albani

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Environmental enrichment, Developmental Neuroscience, Epidemiology, Health Policy, Environmental chemistry, Environmental science, Neurology (clinical), Geriatrics and Gerontology
Published
2011
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8. P2‐182: Opposite role of SIRT1 and SIRT2 in neurodegeneration

Author

Mario Negri, Mario Salmona, Gianluigi Forloni, Letizia Polito, Diego Albani, and Laura Colombo

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurodegeneration, medicine, Neurology (clinical), Geriatrics and Gerontology, Biology, SIRT2, medicine.disease, Neuroscience
Published
2009
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9. P4‐106: Association study about genetic variants of inflammation‐linked genes and dementia in the very old: The Monzino 80‐plus Study

Author

Gianluigi Forloni, Mario Negri, Mauro Tettamanti, Sabrina Dusi, Diego Albani, Sara Batelli, Ugo Lucca, and Letizia Polito

Subjects
Genetics, Epidemiology, Health Policy, Genetic variants, Inflammation, Biology, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Genetic linkage, medicine, Dementia, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, Association (psychology)
Published
2009
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10. P4‐180: The sirtuins activator resveratrol protects SK‐N‐BE cells from oxidative stress and toxicity arising from protein aggregation

Author

Alessandro Negro, Letizia Polito, Diego Albani, and Gianluigi Forloni

Subjects
Epidemiology, Chemistry, Activator (genetics), Health Policy, Protein aggregation, Resveratrol, medicine.disease_cause, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Developmental Neuroscience, Biochemistry, Toxicity, medicine, Neurology (clinical), Geriatrics and Gerontology, Oxidative stress
Published
2008
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