1. Dose‐response relationship between late‐life physical activity and incident dementia: A pooled analysis of 10 cohort studies of memory in an international consortium
- Author
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Wu, Wanqing, Ding, Ding, Zhao, Qianhua, Xiao, Zhenxu, Luo, Jianfeng, Ganguli, Mary, Hughes, Tiffany F, Jacobsen, Erin, Haan, Mary N, Dang, Kristine, Lima‐Costa, Maria Fernanda, Blay, Sergio Luis, Castro‐Costa, Erico, Ng, Tze Pin, Gwee, Xinyi, Gao, Qi, Gureje, Oye, Ojagbemi, Akin, Bello, Toyin, Shahar, Suzana, Ludin, Arimi Fitri Mat, Rivan, Nurul Fatin Malek, Scarmeas, Nikolaos, Anastasiou, Costas A, Yannakoulia, Mary, Brodaty, Henry, Crawford, John D, Lipton, Richard B, Derby, Carol A, Katz, Mindy J, Lipnicki, Darren M, Sachdev, Perminder S, and Consortium, for Cohort Studies of Memory in an International
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Acquired Cognitive Impairment ,Aging ,Rehabilitation ,Clinical Research ,Dementia ,Prevention ,Brain Disorders ,Neurological ,Humans ,Aged ,Cohort Studies ,Proportional Hazards Models ,Risk Factors ,cohort ,dementia ,dose-response ,physical activity ,pooled analysis ,population-based ,for Cohort Studies of Memory in an International Consortium ,Neurosciences ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
IntroductionThough consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear.MethodsWe harmonized longitudinal data of 11,988 participants from 10 cohorts in eight countries to examine the dose-response relationship between late-life physical activity and incident dementia among older adults.ResultsUsing no physical activity as a reference, dementia risk decreased with duration of physical activity up to 3.1 to 6.0 hours/week (hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.67 to 1.15 for 0.1 to 3.0 hours/week; HR 0.68, 95% CI 0.52 to 0.89 for 3.1 to 6.0 hours/week), but plateaued with higher duration. For the amount of physical activity, a similar pattern of dose-response curve was observed, with an inflection point of 9.1 to 18.0 metabolic equivalent value (MET)-hours/week (HR 0.92, 95% CI 0.70 to 1.22 for 0.1 to 9.0 MET-hours/week; HR 0.70, 95% CI 0.53 to 0.93 for 9.1 to 18.0 MET-hours/week).DiscussionThis cross-national analysis suggests that performing 3.1 to 6.0 hours of physical activity and expending 9.1 to 18.0/MET-hours of energy per week may reduce dementia risk.
- Published
- 2023