Search

Your search keyword '"Jeremy H. Herskowitz"' showing total 7 results
Start Over Author "Jeremy H. Herskowitz" Journal alzheimer's & dementia
7 results on '"Jeremy H. Herskowitz"'

2. P3‐168: DENDRITIC SPINES PROVIDE COGNITIVE RESILIENCE AGAINST ALZHEIMER'S DISEASE

Author

Benjamin D. Boros, Kelsey M. Greathouse, Kendall A. Curtis, Jeremy H. Herskowitz, and Marla Gearing

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Dendritic spine, Developmental Neuroscience, Epidemiology, Health Policy, Cognition, Neurology (clinical), Disease, Geriatrics and Gerontology, Psychology, Resilience (network), Neuroscience
Published
2018
Full Text
View/download PDF

3. P3-211: PHARMACOLOGIC INHIBITION OF LIM KINASE PROVIDES DENDRITIC SPINE RESILIENCE AGAINST AMYLOID-β

Author

Svitlana V. Bach, Nicholas T. Seyfried, Jeremy H. Herskowitz, Jeremy J. Day, Courtney K. Walker, Benjamin W. Henderson, and Kelsey M. Greathouse

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Dendritic spine, Developmental Neuroscience, Amyloid β, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology, Biology, Resilience (network), Neuroscience, Lim kinase
Published
2019
Full Text
View/download PDF

4. [P3–177]: STRUCTURAL REMODELING OF DENDRITIC SPINES PROVIDES COGNITIVE RESILIENCE AGAINST ALZHEIMER's DISEASE PATHOLOGY

Author

Erik G. Gentry, Jeremy H. Herskowitz, Elizabeth L. Birchall, Benjamin D. Boros, and Marla Gearing

Subjects
Pathology, medicine.medical_specialty, Dendritic spine, Epidemiology, Health Policy, Cognition, Disease, Structural remodeling, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Resilience (network), Psychology, Neuroscience
Published
2017
Full Text
View/download PDF

5. P4‐080: Pharmacologic Inhibition of Rock1 and Rock2 Reverses Dendritic Spine Morphology Abnormalities Associated with Age‐Related Memory Loss and Alzheimer’s Disease

Author

Erik G. Gentry, Travis Rush, Benjamin W. Henderson, and Jeremy H. Herskowitz

Subjects
Pathology, medicine.medical_specialty, Dendritic spine, Epidemiology, business.industry, Health Policy, Morphology (biology), Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Age related, Medicine, ROCK1, Neurology (clinical), ROCK2, Geriatrics and Gerontology, business, Neuroscience
Published
2016
Full Text
View/download PDF

7. O1–11–06: Selective drug inhibition of rho kinase II (ROCK2) reduces beta‐amyloid production in the brain

Author

Allan I. Levey, Yangbo Feng, Lenora Higginbotham, Nicholas T. Seyfried, James J. Lah, and Jeremy H. Herskowitz

Subjects
Apolipoprotein E, Neocortex, Amyloid, Epidemiology, Chemistry, Health Policy, Molecular biology, nervous system diseases, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, medicine.anatomical_structure, nervous system, Developmental Neuroscience, mental disorders, medicine, Hippocampus (mythology), lipids (amino acids, peptides, and proteins), Thioflavin, Neurology (clinical), ROCK2, Geriatrics and Gerontology, Beta (finance), human activities, Rho-associated protein kinase
Abstract

worse than apoE4-TR mice. Ab12-28P treatment of APP SW/PS1 dE9/ apoE4-TR mice normalized OR behavior and improved RAM performance to the level of apoE4-TR mice. Levels of soluble and insoluble Ab x-40 and Ab x-42 measured by ELISA in the whole brain extract and the burden of Thioflavin-S positive plaques were significantly higher in APP SW/PS1 dE9/apoE4-TR than in APP SW/PS1 dE9/apoE2-TR mice. Ab12-28P treatment was associated with significant reduction in soluble and insoluble Ab x-40 and Ab x-42 levels and lower Thioflavin-S plaque burden in the neocortex and in the hippocampus in both APP SW/PS1 dE9/apoE2-TR and APP SW/PS1 dE9/apoE4-TR lines. Conclusions: Our results indicate that future therapies targeting the apoE/Ab interaction could produce favorable outcome in both APOE2 and APOE4 carriers.

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results