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Your search keyword '"Javier Sáez-Valero"' showing total 10 results
Start Over Author "Javier Sáez-Valero" Journal alzheimer's & dementia
10 results on '"Javier Sáez-Valero"'

1. Measurement of CSF α‐synuclein improves early differential diagnosis of mild cognitive impairment due to Alzheimer’s disease

Author

Javier Sáez-Valero, María-Salud García-Ayllón, Jose Antonio Monge-Argilés, Victoria Monge García, Ruth Gasparini-Berenguer, Jorge Manzanares Robles, C. Leiva-Santana, and Francisco Navarrete Rueda

Subjects
Epidemiology, business.industry, Health Policy, Alzheimer's disease biomarkers, Bioinformatics, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Neuroimaging, Medicine, α synuclein, Neurology (clinical), Geriatrics and Gerontology, Differential diagnosis, business, Cognitive impairment
Published
2020
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2. Relation between alpha‐synuclein and core CSF biomarkers in Alzheimer's disease

Author

María-Salud García-Ayllón, Raquel Romero-Lorenzo, Jorge Manzanares Robles, C. Leiva-Santana, Victoria Monge García, Javier Sáez-Valero, Francisco Navarrete Rueda, Ruth Gasparini-Berenguer, and Jose Antonio Monge-Argilés

Subjects
Alpha-synuclein, Epidemiology, business.industry, Health Policy, Alzheimer's disease biomarkers, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Developmental Neuroscience, Neuroimaging, chemistry, Csf biomarkers, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Neuroscience
Published
2020
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3. CSF Biomarkers profile in siblings with Alzheimer’s disease carrying the ADAM10 nonsense mutation p.Tyr167*

Author

Adriano Jimenez-Escrig, María José Sainz, María-Salud García-Ayllón, Juilán Pérez Pérez, Javier Sáez-Valero, Estrella Gómez-Tortosa, Pablo Agüero, Rosa Guerrero-López, and Raquel Téllez

Subjects
Epidemiology, business.industry, Health Policy, ADAM10, Nonsense mutation, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Immunology, Csf biomarkers, Medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2020
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4. P2‐228: PRE‐ANALYTICAL STABILITY OF NOVEL CEREBROSPINAL FLUID BIOMARKERS FOR DEMENTIA

Author

Vera M. Mendes, Wiesje M. Flier, Yannick Vermeiren, Naomi De Roeck, Peter Paul De Deyn, Javier Sáez-Valero, Charlotte E. Teunissen, Eduard A. Struys, Ulf Andreasson, Erwin Janssen, Eugeen Vanmechelen, María-Salud García-Ayllón, Kees Wj. Uffelen, Bruno Manadas, Eline A.J. Willemse, Claire Bridel, Sebastiaan Engelborghs, and Inmaculada Lopes Font

Subjects
Oncology, medicine.medical_specialty, Epidemiology, Pre analytical, business.industry, Health Policy, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Cerebrospinal fluid, Developmental Neuroscience, Internal medicine, medicine, Dementia, Neurology (clinical), Geriatrics and Gerontology, business
Published
2018
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5. P2‐115: CEREBROSPINAL FLUID PRESENILIN‐1 COMPLEXES: A POTENTIAL BIOMARKER FOR ALZHEIMER'S DISEASE

Author

Maria-Letizia Campanari, Niels Andreasen, Carlos A. Saura, María-Salud García-Ayllón, Javier Sáez-Valero, Jordi Alom, Gunnar Brinkmalm, Kaj Blennow, and Alberto Rábano-Gutierrez

Subjects
Pathology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, Presenilin, law.invention, Blot, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Cerebrospinal fluid, Developmental Neuroscience, Confocal microscopy, law, Potential biomarkers, Medicine, Neurology (clinical), Senile plaques, Geriatrics and Gerontology, Cognitive decline, business
Abstract

control brains, JNKs levels were assessed by western blots and Ab42 was evaluated by ELISA. In 8 AD and 9 control brains JNKs immunostainings were also carried out. CSF analysis included Ab42, tau and ptau by ELISA and JNK3 by immunoblot in 30 AD patients and 26 neurological disease controls. AD patients were followed from two to three years using MMSE scores. Results: Biochemical and histological results revealed significant increased JNK3 and phosphorylated JNK levels in AD brains and JNK3 levels correlated with Ab42 levels. Confocal microscopy showed that JNK3 was associated with Ab in senile plaques. CSF JNK3 levels were significantly enhanced in AD patients and were statistically correlated with the rate of cognitive decline. A mild enhancement of CSF JNK3 level was linked to a more accentuated slope of cognitive impairment.Conclusions:All together, brain and CSF JNK3 levels are increased in AD and CSF levels could reflect the rate of cognitive in AD patients.

Published
2014
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6. P3‐037: THE B‐AMYLOID PEPTIDE COMPROMISES REELIN SIGNALING IN ALZHEIMER'S DISEASE

Author

Valeria Balmaceda, Javier Sáez-Valero, Trinidad Mata, and Inmaculada Cuchillo-Ibañez

Subjects
chemistry.chemical_classification, biology, Amyloid, Epidemiology, business.industry, Health Policy, Peptide, Disease, DAB1, Cell biology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, chemistry, biology.protein, Medicine, Neurology (clinical), Reelin, Geriatrics and Gerontology, business
Published
2014
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7. P3‐067: ELEVATED ACETYLCHOLINESTERASE LEVELS BY HYPERPHOSPHORYLATED TAU OVEREXPRESSION

Author

Jordi Alom, Esther Llorens, Jesús Avila, Javier Sáez-Valero, and María-Salud García-Ayllón

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Acetylcholinesterase, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Endocrinology, Developmental Neuroscience, chemistry, Internal medicine, Medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2014
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8. P2‐311: Acetylcholinesterase expression levels modulates Presenilin‐1

Author

María-Salud García-Ayllón, María-Ximena Silveyra, Javier Sáez-Valero, Maria-Letizia Campanari, and Carol Serra-Basante

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Developmental Neuroscience, chemistry, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology, Acetylcholinesterase, Presenilin, Cell biology
Published
2011
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9. P3‐345: Presenilin‐1 interacts with acetylcholinesterase

Author

Javier Sáez-Valero, Cecilo J. Vidal, Janetta G. Culvenor, María-Fernanda Montenegro, Salvador Martinez, Genevieve Evin, and María-Ximena Silveyra

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Developmental Neuroscience, Epidemiology, Chemistry, Health Policy, Neurology (clinical), Geriatrics and Gerontology, Acetylcholinesterase, Presenilin, Cell biology
Published
2008
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10. P1–148: Altered Reelin expression in Alzheimer's disease brain and cerebrospinal fluid

Author

María Salud García-Ayllón, Jordi Peña-Casanova, Arancha Botella-López, José Antonio del Río, Rosalina Gavín, Ferran Burgaya, Eduardo Soriano, Javier Sáez-Valero, Rafael Blesa, Estrella Gómez-Tortosa, and María Ximena Silveyra

Subjects
Pathology, medicine.medical_specialty, biology, Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Cerebrospinal fluid, Developmental Neuroscience, biology.protein, medicine, Neurology (clinical), Reelin, Geriatrics and Gerontology, business
Published
2006
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