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32 results on '"Barbara, Borroni"'

1. Derivation of cut‐offs for plasma neurofilament light in clinical routine using healthy subjects aged between 5‐90

Author

Joel Simrén, Johan Gobom, Ulf Andreasson, Marc Suárez‐Calvet, Herman Depypere, Lars Nyberg, Barbara Borroni, Henrik Zetterberg, and Kaj Blennow

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2022
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2. Protective association of HLA‐DRB1 *04 subtypes in neurodegenerative diseases implicates acetylated tau PHF6 sequences

Author

Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte, Iris E Jansen, Eric Yu, Aude Nicolas, Itziar de Rojas, Thiago Peixoto Leal, Akinori Miyashita, Céline Bellenguez, Michelle Mulan Lian, Kayenat Parveen, Takashi Morizono, Hyeonseul Park, Benjamin Grenier‐Boley, Tatsuhiko Naito, Fahri Küçükali, Seth D. Talyansky, Selina Marie Yogeshwar, Vicente Sempere, Wataru Satake, Victoria Álvarez‐Martínez, Beatrice Arosio, Michael E Belloy, Luisa Benussi, Anne Boland, Barbara Borroni, María J. Bullido, Paolo Caffarra, Jordi Clarimon, Antonio Daniele, Daniel Darling, Stéphanie Debette, Jean‐François Deleuze, Martin Dichgans, Carole Dufouil, Emmanuel During, Emrah Duzel, Daniela Galimberti, Guillermo García‐Ribas, Jose María García‐Alberca, Pablo García‐González, Vilmantas Giedraitis, Oliver Goldhardt, Caroline Graff, Edna Grunblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann‐Heimbach, Henne Holstege, Jakub Hort, Yoo Jin Jung, Deckert Jurgen, Silke Kern, Teemu Kuulasmaa, Kun Ho Lee, Ling Ling, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Alexandre de Mendonça, Mercè Boada, Pablo Mir, Susanne Moebus, Fermin Moreno, Benedetta Nacmias, Gaël Nicolas, Shumpei Niida, Børge G. Nordestgaard, Goran Papenberg, Janne M. Papma, Lucilla Parnetti, Florence Pasquier, Pau Pastor, Oliver Peters, Yolande A.L. Pijnenburg, Gerard Piñol‐Ripoll, Julius Popp, Laura Molina, Raquel Puerta, Jordi Pérez‐Tur, Innocenzo Rainero, Luis Miguel Real, Steffi G. Riedel‐Heller, Eloy Rodríguez Rodríguez, José Luís Royo, Dan Rujescu, Nikolaos Scarmeas, Philip Scheltens, Norbert Scherbaum, Anja Schneider, Davide Seripa, Ingmar Skoog, Vincenzo Solfrizzi, Gianfranco Spalletta, Alessio Squassina, John C van Swieten, Raquel Sanchez‐Valle, Eng‐King Tan, Thomas Tegos, Charlotte E. Teunissen, Jesper Qvist Thomassen, Lucio Tremolizzo, Martin Vyhnalek, Frans R.J. Verhey, Margda Waern, Jens Wiltfang, Jing Zhang, Henrik Zetterberg, Kaj Blennow, Julie Williams, Philippe Amouyel, Frank Jessen, Patrick G Kehoe, Ole Andreassen, Cornelia M van Duijn, Magda Tsolaki, Pascual Sanchez‐Juan, Ruth Frikke‐Schmidt, Kristel Sleegers, Tatsushi Toda, Anna Zettergren, Martin Ingelsson, Yukinori Okada, Giacomina Rossi, Mikko Hiltunen, Jungsoo Gim, Kouichi Ozaki, Rebecca Sims, Jia Nee Foo, Wiesje M. van der Flier, Takeshi Ikeuchi, Alfredo Ramirez, Ignacio Mata, Agustin Ruiz, Ziv Gan‐Or, Jean‐Charles Lambert, Michael D Greicius, and Emmanuel Mignot

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2022
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3. Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes

Author

Matthis Synofzik, Alexandre de Mendonça, Giovanni B. Frisoni, Maura Malpetti, Fermin Moreno, Christopher C Butler, Roberta Ghidoni, Daniela Galimberti, Rik Vandenberghe, Elizabeth Finger, Isabel Santana, Alexander Gerhard, Georgia Peakman, Emily Todd, Carolin Heller, Jonathan D. Rohrer, Katrina M. Moore, Kamen A. Tsvetanov, Rhian S Convery, P. Simon Jones, Johannes Levin, James B. Rowe, Caroline Graff, Markus Otto, Barbara Borroni, Raquel Sánchez-Valle, Sandro Sorbi, Fabrizio Tagliavini, John C. van Swieten, Maria Carmela Tartaglia, Rogier A. Kievit, Simon Ducharme, Robert Laforce, Mario Masellis, Timothy Rittman, Adrian Danek, David M. Cash, Martina Bocchetta, Apollo - University of Cambridge Repository, Repositório da Universidade de Lisboa, Neurology, Malpetti, Maura [0000-0001-8923-9656], Jones, Simon [0000-0001-9695-0702], Tsvetanov, Kamen A. [0000-0002-3178-6363], Rittman, Timothy [0000-0003-1063-6937], and Rowe, James [0000-0001-7216-8679]

Subjects
Male, longitudinal design, SYMPTOMS, pathology [Cognitive Dysfunction], Epidemiology, Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13], Medizin, apathy, DISEASE, 0302 clinical medicine, pathology [Brain], pathology [Gray Matter], C9orf72, presymptomatic carriers, cognitive decline, genetic frontotemporal dementia, MRI, Apathy, Gray Matter, Cognitive decline, genetics [Frontotemporal Dementia], pathology [Atrophy], 0303 health sciences, Health Policy, Brain, Cognition, IMPAIRMENT, Middle Aged, DEPRESSION, Magnetic Resonance Imaging, Psychiatry and Mental health, Frontotemporal Dementia, Female, IMPULSIVITY, medicine.symptom, Life Sciences & Biomedicine, Clinical psychology, Frontotemporal dementia, Clinical Neurology, FEATURED ARTICLE, Prodromal Symptoms, PHENOTYPES, genetics [Mutation], Impulsivity, 03 medical and health sciences, Cellular and Molecular Neuroscience, All institutes and research themes of the Radboud University Medical Center, Atrophy, SDG 3 - Good Health and Well-being, Developmental Neuroscience, mental disorders, medicine, Humans, Dementia, Cognitive Dysfunction, ddc:610, BEHAVIORAL-VARIANT, 030304 developmental biology, Science & Technology, EXECUTIVE FUNCTION, business.industry, DIGIT SYMBOL, 1103 Clinical Sciences, medicine.disease, DYSFUNCTION, Geriatrics, Mutation, FEATURED ARTICLES, Neurosciences & Neurology, Neurology (clinical), Geriatrics and Gerontology, 1109 Neurosciences, business, 030217 neurology & neurosurgery
Abstract

© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited., Introduction: Apathy adversely affects prognosis and survival of patients with frontotemporal dementia (FTD). We test whether apathy develops in presymptomatic genetic FTD, and is associated with cognitive decline and brain atrophy. Methods: Presymptomatic carriers of MAPT, GRN or C9orf72 mutations (N = 304), and relatives without mutations (N = 296) underwent clinical assessments and MRI at baseline, and annually for 2 years. Longitudinal changes in apathy, cognition, gray matter volumes, and their relationships were analyzed with latent growth curve modeling. Results: Apathy severity increased over time in presymptomatic carriers, but not in non-carriers. In presymptomatic carriers, baseline apathy predicted cognitive decline over two years, but not vice versa. Apathy progression was associated with baseline low gray matter volume in frontal and cingulate regions. Discussion: Apathy is an early marker of FTD-related changes and predicts a subsequent subclinical deterioration of cognition before dementia onset. Apathy may be a modifiable factor in those at risk of FTD., This work is co‐funded by the UK Medical Research Council (MR/M023664/1), the Italian Ministry of Health and the Canadian Institutes of Health Research as part of a Centres of Excellence in Neurodegeneration grant, a Canadian Institutes of Health Research operating grant and the Bluefield Project, as well as a JPND grant “GENFI‐prox” (by DLR/BMBF to MS, joined with JDR, JvS, MO, BB and CG). MM is supported by the Cambridge Trust & Sidney Sussex College Scholarship. PSJ is supported by the Cambridge Centre for Parkinson Plus. KAT is supported by the British Academy Postdoctoral Fellowship (KAT: PF160048) and Guarantors of Brain (KAT: 101149). TR is supported by the Cambridge Centre for Parkinson Plus and Cambridge Biomedical Resource Centre. RAK is supported by Medical Research Council (RAK: SUAG/047/G101400). JBR reports grants from the NIHR Cambridge Biomedical research centre, Wellcome Trust (103838), and Medical Research Council (SUAG051/G101400; MR/T033371/1); personal fees from Asceneuron, WAVE, Astex, and Biogen; and grants from Janssen, AZ Medimmune, and Eli Lilly, outside the submitted work. JDR is supported by an MRC Clinician Scientist Fellowship (MR/M008525/1) and has received funding from the NIHR Rare Disease Translational Research Collaboration (BRC149/NS/MH). MB is supported by a Fellowship award from the Alzheimer's Society, UK (AS‐JF‐19a‐004‐517), and by the UK Dementia Research Institute which receives its funding from DRI Ltd, funded by the UK Medical Research Council, Alzheimer's Society, and Alzheimer's Research UK.

Published
2020
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4. A data‐driven disease progression model of fluid biomarkers in genetic FTD

Author

Emma van der Ende, Esther E. Bron, Jackie M. Poos, Lize C. Jiskoot, Jessica L. Panman, Janne M. Papma, Carlo Wilke, Matthis Synofzik, Carolin Heller, Imogen J. Swift, Aitana Sogorb Esteve, Arabella Bouzigues, Barbara Borroni, Raquel Sanchez‐Valle, Fermin Moreno, Caroline Graff, Robert Laforce, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, James B. Rowe, Alexandre Mendonca, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Christopher Butler, Alexander Gerhard, Johannes Levin, Adrian Danek, Markus Otto, Yolande A.L. Pijnenburg, Giovanni B. Frisoni, Sandro Sorbi, Roberta Ghidoni, Wiro J. Niessen, Jonathan D. Rohrer, Stefan Klein, John C van Swieten, Vikram Venkatraghavan, and Harro Seelaar

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021
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5. A cognitive composite for genetic frontotemporal dementia: GENFI‐cog

Author

Jackie M. Poos, Jennifer M Nicholas, Katrina M Moore, Lucy L Russell, Georgia Peakman, Lize C. Jiskoot, Esther van den Berg, Janne M. Papma, Harro Seelaar, Yolande A.L. Pijnenburg, Fermin Moreno, Raquel Sanchez‐Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Maria Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre Mendonca, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Christopher Butler, Alexander Gerhard, Johannes Levin, Adrian Danek, Markus Otto, John C van Swieten, and Jonathan D Rohrer

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021
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6. Trajectory of apathy, cognition and neural correlates in the decades before symptoms in frontotemporal dementia

Author

Roberta Ghidoni, Matthis Synofzik, Elizabeth Finger, Timothy Rittman, Kamen A. Tsvetanov, James B. Rowe, Caroline Graff, Georgia Peakman, Fabrizio Tagliavini, Johannes Levin, Alexandre de Mendonça, A. Danek, Giovanni B. Frisoni, Isabel Santana, Rhian S Convery, Carmela Tartaglia, Markus Otto, John C. van Swieten, Alexander Gerhard, Jonathan D. Rohrer, Simon Ducharme, P. Simon Jones, Maura Malpetti, Rogier A. Kievit, Fermin Moreno, Carolin Heller, Robert Laforce, Emily Todd, Daniela Galimberti, Raquel Sánchez-Valle, Rik Vandenberghe, Christopher C Butler, Barbara Borroni, Mario Masellis, Katrina M. Moore, and Martina Bocchetta

Subjects
Gerontology, Neural correlates of consciousness, Epidemiology, Health Policy, Cognition, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Ageing, medicine, Dementia, Apathy, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, Association (psychology), Psychology, Frontotemporal dementia
Published
2020
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7. The impact of culture on neuropsychological performance: A global social cognition study across 12 countries

Author

Anne Botzung, Sandra Baez, Ricardo F. Allegri, Begoña Indakoetxea, Catalina Trujillo, Lucia Crivelli, Fermin Moreno, Andrea Slachevsky, Sol Fittipaldi, Leonardo Cruz de Souza, Frédéric Blanc, François Quesque, Johan S. Grisales, Gada Musa, Alberto Benussi, Olga Iakovlena, Michael Hornberger, Maxime Bertoux, María Florencia Clarens, Antoine Coutrot, Antônio Lúcio Teixeira, Galina Prianishnikova, Junhua Liang, Thomas Duning, Ismael Calandri, David Huepe, Juan F. Cardona, Lina Zhao, Myriam Barandiaran, Luciana Cassimiro, Elena Lyashenko, Nahuel Magrath, Patricia Lillo, Paulo Caramelli, Thibaud Lebouvier, Anna Morozova, Nathalie Philippi, Carol Hudon, Florence Pasquier, Nadezda Veryugina, Adolfo M. García, Maura Cosseddu, Agustín Ibáñez, Fen Wang, Emma Flanagan, Hannah Mulet‐Perreault, Millena Vieira Brandão Moura, Carolina Delgado, Lucas Sedeño, Jennifer Kemp, Alejandra Neely-Prado, Sharon Cox, Mônica Sanches Yassuda, Andreas Johnen, and Barbara Borroni

Subjects
Epidemiology, Health Policy, media_common.quotation_subject, Neuropsychology, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Social cognition, Multiculturalism, medicine, Dementia, Neurology (clinical), Geriatrics and Gerontology, Psychology, media_common, Clinical psychology
Published
2020
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8. Serum NFL as a predictor of disease progression in dementia with Lewy bodies

Author

Maria Cristina Rizzetti, Alberto Imarisio, Rosanna Turrone, Sara Nocivelli, Emirena Garrafa, Alessandro Padovani, Henrik Zetterberg, Elisabetta Cottini, Andrea Pilotto, Roberto Grasso, Barbara Borroni, Stefano Gipponi, Nicholas J. Ashton, Arianna Bellucci, Francesca Conforti, Marina Pizzi, Laura Bonanni, Giuliana Giannì, Stefano Masciocchi, Alessandro Lupini, and Abdul Hye

Subjects
Oncology, medicine.medical_specialty, Epidemiology, Dementia with Lewy bodies, business.industry, Health Policy, Disease progression, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Neuroimaging, Internal medicine, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2020
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9. Subtype and stage inference identifies distinct atrophy patterns in genetic frontotemporal dementia that MAP onto specific MAPT mutations

Author

Sandro Sorbi, James B. Rowe, Matthis Synofzik, A. Danek, Martina Bocchetta, Johannes Levin, Markus Otto, Rhian S Convery, Fabrizio Tagliavini, Steven Williams, Daniel C. Alexander, Barbara Borroni, Mollie Neason, David L. Thomas, Jonathan D. Rohrer, Carmela Tartaglia, Alexandre de Mendonça, Giovanni B. Frisoni, David M. Cash, Katrina M. Moore, Roberta Ghidoni, Alexander Gerhard, Elizabeth Finger, Alexandra L. Young, Isabel Santana, Christopher C Butler, Fermin Moreno, Caroline Graff, John C. van Swieten, Mario Masellis, Raquel Sánchez-Valle, Robert Laforce, Simon Ducharme, Daniela Galimberti, and Rik Vandenberghe

Subjects
Epidemiology, Health Policy, Neurodegeneration, Inference, Biology, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Atrophy, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Stage (cooking), Neuroscience, Frontotemporal dementia
Published
2020
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10. The Free Cued Selective Reminding Test detects episodic memory impairment in the presymptomatic period of familial frontotemporal dementia within the GENFI cohort

Author

Alexandre de Mendonça, Esther van den Berg, Christopher C Butler, Fabrizio Tagliavini, Alexander Gerhard, Georgia Peakman, Janne M. Papma, Johannes Levin, James B. Rowe, Markus Otto, Katrina M. Moore, Elizabeth Finger, Jackie M. Poos, A. Danek, Simon Ducharme, Jonathan D. Rohrer, Daniela Galimberti, Carmela Tartaglia, Isabel Santana, Rik Vandenberghe, Caroline V. Greaves, Robert Laforce, Raquel Sánchez-Valle, Martina Bocchetta, Matthis Synofzik, Caroline Graff, Lize C. Jiskoot, John C. van Swieten, Mario Masellis, Lucy L. Russell, Fermin Moreno, and Barbara Borroni

Subjects
Cued speech, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Period (gene), Neuropsychology, Audiology, medicine.disease, Test (assessment), Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Cohort, medicine, Neurology (clinical), Geriatrics and Gerontology, Cognitive decline, business, Episodic memory, Frontotemporal dementia
Published
2020
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11. Modelling the cascade of biomarker changes in progranulin‐related frontotemporal dementia

Author

Meike W. Vernooij, Jessica L. Panman, Rebecca M. E. Steketee, Esther E. Bron, Laura Donker Kaat, Emma L. van der Ende, Stefan Klein, Anneke J.A. Kievit, Maura Cosseddu, Jackie M. Poos, Enrico Premi, Jonathan D. Rohrer, Lieke H.H. Meeter, Barbara Borroni, Serge A.R.B. Rombouts, Lize C. Jiskoot, John C. van Swieten, Janne M. Papma, Vikram Venkatraghavan, Jaume Olives, Elise G.P. Dopper, Elise Bonomi, and Raquel Sánchez-Valle

Subjects
Epidemiology, business.industry, Health Policy, Disease progression, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Neuroimaging, Biomarker (medicine), Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Neuroscience, Frontotemporal dementia
Published
2020
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12. O4-02-01: PHASE 2A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF THE HISTONE DEACETYLASE INHIBITOR (HDACI), FRM-0334, IN ASYMPTOMATIC CARRIERS OF, OR PATIENTS WITH FRONTOTEMPORAL LOBAR DEGENERATION (FTLD) DUE TO, PROGRANULIN GENE MUTATIONS

Author

Marco Onofrj, Holger Patzke, Murray Grossman, Rik Vandenberghe, Henry Riordan, Isabelle Le Ber, Sophie Auriacombe, Jacob Hesterman, Hans J Moebius, Gerhard Koenig, Giovanni B. Frisoni, Adam L. Boxer, Bradley F. Boeve, Gary Wisniewski, Ken Marek, Ira J. Goodman, Florence Pasquier, Didier Hannequin, Baruch Harris, Barbara Borroni, Scott M. McGinnis, Dana Hilt, John C. van Swieten, and Catherine J. Mummery

Subjects
medicine.medical_specialty, Epidemiology, medicine.drug_class, business.industry, Health Policy, Histone deacetylase inhibitor, Placebo-controlled study, Frontotemporal lobar degeneration, Gene mutation, medicine.disease, Gastroenterology, Double blind, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, medicine, Neurology (clinical), Geriatrics and Gerontology, business, Asymptomatic carrier
Published
2019
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13. P1-380: EARLY REGIONAL HYPOMETABOLISM IN PRE-SYMPTOMATIC CARRIERS OF MAPT : A GENFI SUB-STUDY

Author

John C. van Swieten, David M. Cash, Jason D. Warren, Frédéric St-Onge, Barbara Borroni, Giovanni B. Frisoni, Mirza Faisal Beg, Fabrizio Tagliavini, Daniela Galimberti, Sandro Sorbi, Carmela Tartaglia, Robert Laforce, Popuri Karteek, Caroline Graff, Mario Masellis, Martina Bocchetta, Alexandre de Mendonça, Katrina M. Dick, James B. Rowe, Jean-Mathieu Beauregard, Jonathan D. Rohrer, and Elizabeth Finger

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2019
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14. [IC‐P‐079]: MULTIPLE DISTINCT ATROPHY PATTERNS FOUND IN GENETIC FRONTOTEMPORAL DEMENTIA USING SUBTYPE AND STAGE INFERENCE (SUSTAIN)

Author

Robert Laforce, John C. van Swieten, Alexandre de Mendonça, Katrina M. Dick, Razvan V. Marinescu, Daniela Galimberti, Daniel C. Alexander, Fabrizio Tagliavini, Mario Masellis, Barbara Borroni, Sandro Sorbi, Neil P. Oxtoby, James B. Rowe, Maria Carmela Tartaglia, Jonathan M. Schott, Nick C. Fox, David L. Thomas, Jonathan D. Rohrer, Giovanni B. Frisoni, Elizabeth Finger, Sebastien Ourselin, Alexandra L. Young, David M. Cash, Martina Bocchetta, Caroline Graff, and M. Jorge Cardoso

Subjects
Epidemiology, Health Policy, Inference, Biology, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Atrophy, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Stage (cooking), Neuroscience, Frontotemporal dementia
Published
2017
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15. [IC‐03–04]: WHITE MATTER HYPERINTENSITIES IN GENETIC FRONTOTEMPORAL DEMENTIA: A GENFI STUDY

Author

Carole H. Sudre, Elizabeth Finger, David L. Thomas, Sebastien Ourselin, Jonathan D. Rohrer, Daniela Galimberti, Barbara Borroni, M. Jorge Cardoso, Martina Bocchetta, Robert Laforce, Fabrizio Tagliavini, Alexandre de Mendonça, Ione O.C. Woollacott, David M. Cash, Maria Carmela Tartaglia, James B. Rowe, Sandro Sorbi, Katrina M. Dick, Caroline Graff, Giovanni B. Frisoni, Mario Masellis, and John C. van Swieten

Subjects
medicine.medical_specialty, Epidemiology, Health Policy, medicine.disease, Hyperintensity, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Psychiatry, Psychology, Frontotemporal dementia
Published
2017
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16. [P1–029]: IN GENETIC FRONTOTEMPORAL DEMENTIA, FUNCTIONAL NETWORK EFFICIENCY IS MAINTAINED UNTIL THE ONSET OF SYMPTOMS: EVIDENCE FOR FUNCTIONAL RESILIENCE TO STRUCTURAL CHANGE

Author

Alexandre de Mendonça, Robin J Borchert, Sandro Sorbi, Jonathan D. Rohrer, James B. Rowe, P. Simon Jones, Robert Laforce, Fabrizio Tagliavini, Barbara Borroni, Elizabeth Finger, Daniela Galimberti, Giovanni B. Frisoni, Caroline Graff, Timothy Rittman, John C. van Swieten, and Mario Masellis

Subjects
Epidemiology, Health Policy, medicine.disease, Developmental psychology, Functional networks, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Psychology, Resilience (network), Frontotemporal dementia
Published
2017
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17. [P2–222]: SENSITIVITY AND SPECIFICITY OF TRANSCRANIAL MAGNETIC STIMULATION FOR DIFFERENTIAL DIAGNOSIS OF ALZHEIMER's DISEASE AND FRONTOTEMPORAL DEMENTIA

Author

Alessandro Padovani, Carlo Caltagirone, Valentina Dell'Era, Giacomo Koch, Alberto Benussi, Barbara Borroni, and Francesco Di Lorenzo

Subjects
0301 basic medicine, Epidemiology, business.industry, Health Policy, medicine.medical_treatment, Disease, medicine.disease, Transcranial magnetic stimulation, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 030104 developmental biology, 0302 clinical medicine, Developmental Neuroscience, Medicine, Neurology (clinical), Sensitivity (control systems), Geriatrics and Gerontology, Differential diagnosis, business, Neuroscience, 030217 neurology & neurosurgery, Frontotemporal dementia
Published
2017
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18. [P4–189]: SYMPTOM ONSET IN GENETIC FRONTOTEMPORAL DEMENTIA

Author

Alexandre de Mendonça, Maria Carmela Tartaglia, Edward D. Huey, Matthis Synofzik, Isabelle Le Ber, John C. van Swieten, Jennifer M. Nicholas, Johannes Levin, Ian R. A. Mackenzie, Erik D. Roberson, Robert Laforce, Florence Pasquier, Markus Otto, Philippe Couratier, Nupur Ghoshal, Sokratis G. Papageorgiou, Jonathan D. Rohrer, Mario Masellis, Caroline Graff, Raquel Sánchez-Valle, Christopher C Butler, Adam L. Boxer, Giovanni B. Frisoni, Adeline Su Lyn Ng, Katrina M. Dick, Bradley F. Boeve, Sandro Sorbi, John R. Hodges, Howard J. Rosen, Simon Ducharme, Emily Rogalski, Fabrizio Tagliavini, Barbara Borroni, Isabel Santana, Daniela Galimberti, Chiadi U. Onyike, Rik Vandenberghe, Amy Brodtmann, Elizabeth Finger, Fermin Moreno, Olivier Martinaud, Alexander Gerhard, James B. Rowe, Bradford C. Dickerson, and Murray Grossman

Subjects
Pediatrics, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, 030204 cardiovascular system & hematology, medicine.disease, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 0302 clinical medicine, Developmental Neuroscience, medicine, Neurology (clinical), Symptom onset, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Frontotemporal dementia
Published
2017
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19. [O4–02–02]: POLY‐GP DIPEPTIDE REPEATS AND NEUROFILAMENT LIGHT CHAIN AS BIOMARKERS IN PRESYMPTOMATIC AND SYMPTOMATIC FRONTOTEMPORAL DEMENTIA CAUSED BY C9ORF72 REPEAT EXPANSIONS

Author

Yolande A.L. Pijnenburg, Jonathan D. Rohrer, Tania F. Gendron, Lieke H.H. Meeter, Suzee E. Lee, Leonard Petrucelli, John C. van Swieten, Caroline Graff, Barbara Borroni, Adam L. Boxer, Roberta Ghidoni, Ana C. Sias, Lize C. Jiskoot, Sebastien Ourselin, David M. Cash, Martina Bocchetta, Raquel Sánchez-Valle, M. Jorge Cardoso, Luisa Benussi, and Robert Laforce

Subjects
Dipeptide, Epidemiology, business.industry, Health Policy, Neurofilament light, medicine.disease, Molecular biology, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Developmental Neuroscience, Biochemistry, chemistry, C9orf72, Medicine, 030212 general & internal medicine, Neurology (clinical), Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Frontotemporal dementia
Published
2017
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20. [P1–437]: PRESYMPTOMATIC WHITE MATTER INTEGRITY LOSS IN FAMILIAL FRONTOTEMPORAL DEMENTIA IN THE GENETIC FRONTOTEMPORAL DEMENTIA INITIATIVE (GENFI) COHORT: A MULTI‐CENTRE, CROSS‐SECTIONAL, DIFFUSION TENSOR IMAGING STUDY

Author

Alexandre de Mendonça, Robert Laforce, Caroline Graff, Giovanni B. Frisoni, Lize C. Jiskoot, James B. Rowe, Barbara Borroni, Fabrizio Tagliavini, Jennifer M. Nicholas, Maria Carmela Tartaglia, Daniela Galimberti, Jonathan D. Rohrer, Martina Bocchetta, John C. van Swieten, David M. Cash, Mario Masellis, Sandro Sorbi, Janne M. Papma, Elizabeth Finger, and Marc Modat

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, medicine.disease, White matter, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Physical medicine and rehabilitation, medicine.anatomical_structure, Developmental Neuroscience, Cohort, medicine, Neurology (clinical), Geriatrics and Gerontology, Multi centre, business, Diffusion MRI, Frontotemporal dementia
Published
2017
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21. O4-03-06: LONGITUDINAL ASSOCIATION BETWEEN APATHY AND COGNITIVE DECLINE IN PRE- AND POST-SYMPTOMATIC GENETIC FRONTOTEMPORAL DEMENTIA

Author

Johannes Levin, Matthis Synofzik, Rhian S Convery, Markus Otto, Alexandre de Mendonça, John C. van Swieten, Maura Malpetti, Fermin Moreno, Raquel Sánchez-Valle, Rogier A. Kievit, P. Simon Jones, Carolin Heller, Kamen A. Tsvetanov, Isabel Santana, Robert Laforce, Adrian Danek, Mario Masellis, Simon Ducharme, Elizabeth Finger, Jonathon D. Rohrer, Timothy Rittman, Christopher C Butler, Daniela Galimberti, Stefano F. Cappa, Rik Vandenberghe, Carmela Tartaglia, Fabrizio Tagliavini, James B. Rowe, Barbara Borroni, Alexander Gerhard, Katrina M. Dick, Caroline Graff, and Giovanni B. Frisoni

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Apathy, Neurology (clinical), Geriatrics and Gerontology, Cognitive decline, medicine.symptom, Psychiatry, business, Association (psychology), Pre and post, Frontotemporal dementia
Published
2019
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22. IC‐P‐054: Grey matter differences in genetic frontotemporal dementia: Results from the genfi study

Author

Giovanni B. Frisoni, Martin N. Rossor, James B. Rowe, Caroline Graff, Mario Masellis, Miklos Espak, Alexander D. Fellows, David M. Cash, Sandro Sorbi, Katrina M. Dick, Barbara Borroni, John C. van Swieten, Daniela Galimberti, Robert Laforce, Alexandre de Mendonça, Fabrizio Tagliavini, Jonathan D. Rohrer, Elizabeth Finger, and Sebastien Ourselin

Subjects
Epidemiology, Health Policy, Grey matter, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, medicine.anatomical_structure, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Psychology, Clinical psychology, Frontotemporal dementia
Published
2015
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23. O2‐01‐01: Grey matter differences in genetic frontotemporal dementia: Results from the genfi study

Author

James B. Rowe, Sandro Sorbi, Elizabeth Finger, Martin N. Rossor, Alexandre de Mendonça, David M. Cash, Katrina M. Dick, John C. van Swieten, Robert Laforce, Mario Masellis, Giovanni B. Frisoni, Sebastien Ourselin, Miklos Espak, Daniela Galimberti, Alexander D. Fellows, Caroline Graff, Barbara Borroni, Jonathan D. Rohrer, and Fabrizio Tagliavini

Subjects
Pediatrics, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Neuroimaging, medicine, Neurology (clinical), Geriatrics and Gerontology, business, Frontotemporal dementia
Published
2015
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24. O3‐13‐06: Targeted re‐sequencing of sorl1 in early‐onset Alzheimer's dementia: The european early onset dementia consortium

Author

Julie van der Zee, Christine Van Broeckhoven, Caroline Graff, Kristel Sleegers, Peter Paul De Deyn, Sebastiaan Engelborghs, Karolien Bettens, Rik Vandenberghe, Pau Pastor, Alexandre de Mendonça, Barbara Borroni, Raquel Sánchez-Valle, Jan Verheijen, Mathieu Vandenbulcke, and Luisa Benussi

Subjects
Pediatrics, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, SORL1, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Re sequencing, medicine, Alzheimer s dementia, Neurology (clinical), Geriatrics and Gerontology, Alzheimer's disease, business, Early onset dementia, Early onset
Published
2015
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25. P4‐074: ITALIAN NETWORK FOR AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE AND FRONTOTEMPORAL LOBAR DEGENERATION (ITALIANDIAFN)

Author

Alessandro Padovani, Giuseppe Di Fede, Elio Scarpini, Martina Bocchetta, Emilio Di Maria, Giacomina Rossi, Silvia Suardi, Giuliano Binetti, Massimo Gennarelli, Daniela Galimberti, Livia Bernardi, Fabrizio Vecchio, Barbara Borroni, Benedetta Nacmias, Luisa Benussi, Anna Mega, Claudio Babiloni, Fabrizio Tagliavini, Amalia C. Bruni, Irene Piaceri, Corinna Porteri, Michela Pievani, Giovanni B. Frisoni, Roberta Ghidoni, Sandro Sorbi, Nicola Marzano, and Silvia Fostinelli

Subjects
Epidemiology, Health Policy, media_common.quotation_subject, Frontotemporal lobar degeneration, Art, medicine.disease, Associative learning, Right frontal lobe, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Right hemisphere, Humanities, media_common
Abstract

Diffusion datasets were corrected for motion and eddy current distortions (Smith et al., 2004) and then processed with a Spherical Deconvolution algorithm based on a damped version of the Richardson-Lucy algorithm (Dell’acqua et al., 2010, Dell’Acqua et al., 2013). Tractography was performed following the method described in (Catani et al., 2012). We dissected fiftyfive frontal tracts including U-shaped fibers. For each dissection FA (Basser and Pierpaoli, 1996) and hindrance modulated oriented anisotropy (HMOA) (Dell’Acqua et al., 2013) were extracted as an indirect measure of the tract integrity and correlated with the age of the participants regressing out the level of education. P values are presented after false discovery rate (FDR) correction for multiple comparisons (* p < 0.05 ; ** p < 0.01 ; *** p < 0.001). Results: Aging was significantly associated with a decrease of FA (r1⁄4 0.501*) and OA (r1⁄4 0.508**) in the frontal projections of the corpus callosum. Aging was also associated with a decrease of OA in the right frontal lobe including the SLF I (r 1⁄4 0.401**) and SLF III (r 1⁄4 0.576***) branches of the superior longitudinal fasciculus, inferior fronto-occipital fasciculus (r 1⁄4 0.331*), fronto-thalamic projections (r 1⁄4 0.515***). In the left hemisphere, OA measure also decreased with aging for the frontal inferior longitudinal fasciculus (r1⁄4 0.542***) and the frontal orbito-polar tract (r 1⁄4 0.542***). Results are summarized in Figure 1. Conclusions: We confirmed preliminary evidences reporting reduced integrity in the frontal portion of the corpus callosum associated with aging (Lebel et al., 2010). This commissural decline may explain the increased reaction times associated with aging reported in tasks requiring interhemispheric transfer (Reuter-Lorenz and Stanczak, 2000). Our results also suggest for the first time that aging alters significantly other tracts in the right hemisphere which brings up interesting pathophysiological hypotheses for ageing decline in visuospatial and verbal working memory, memory encoding and retrieval, reward-based associative learning that can be tested in the elderly (Cabeza and Dennis, 2012). IC-P-069 ITALIAN NETWORK FOR AUTOSOMAL DOMINANTALZHEIMER’S DISEASE AND FRONTOTEMPORAL LOBAR DEGENERATION (ITALIANDIAFN) Martina Bocchetta, Michela Pievani, Claudio Babiloni, Amalia C. Bruni, Elio Scarpini, Sandro Sorbi, Fabrizio Tagliavini, Alessandro Padovani, Luisa Benussi, Livia Bernardi, Giuliano Binetti, Barbara Borroni, Giuseppe Di Fede, Emilio Di Maria, Silvia Fostinelli, Daniela Galimberti, Massimo Gennarelli, Roberta Ghidoni, Nicola Marzano, Anna Mega, Benedetta Nacmias, Irene Piaceri, Corinna Porteri, Giacomina Rossi, Silvia Suardi, Fabrizio Vecchio, Giovanni B. Frisoni, IRCCS Centro S. Giovanni di Dio, Fatebenefratelli, Brescia, Italy; IRCCS Fatebenefratelli, Brescia, Italy; 3 University of Rome "La Sapienza", Rome, Italy; 4 Centro Regionale di Neurogenetica, Lamezia Terme (CZ), Italy; 5 Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; University of Florence, Florence, Italy; IRCCS Foundation "Carlo Besta" Neurological Institute, Milano, Italy; 8 University of Brescia, Brescia, Italy; 9 IRCCS Instituto Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy; 10 Centro Regionale di Neurogenetica, Lamezia Terme, Italy; IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy; University of Genova, Genova, Italy; 13 IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; University of Milan, Ospedale Policlinico, Milan, Italy; IRCCS Centro San Giovanni di Dio, Fatebenefratelli, Brescia, Italy; 16 University of Florence, Florence, Italy; 17 IRCCS Fondazione Instituto Neurologico Carlo Besta, Milano, Italy; 18 IRCCS Fondazione Instituto Neurologico Carlo Besta, Milan, Italy; IRCCS Instituto San Giovanni di Dio Fatebenefratelli, Brecia, Italy. Contact e-mail: mbocchetta@ fatebenefratelli.it

Published
2014
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26. P3‐036: SAP97 DRIVES ADAM10 FROM GOLGI OUTPOSTS TO THE SYNAPSE THROUGH A PKC‐DEPENDENT PHOSPHORYLATION PROCESS

Author

Alessandro Padovani, Elena Marcello, Stefano Musardo, Silvia Pelucchi, Monica Di Luca, Barbara Borroni, Anna Tramontano, Daniele Di Marino, Claudia Saraceno, and Fabrizio Gardoni

Subjects
Epidemiology, Chemistry, Health Policy, ADAM10, Golgi apparatus, Cell biology, Synapse, Phosphorylation Process, Psychiatry and Mental health, Cellular and Molecular Neuroscience, symbols.namesake, Developmental Neuroscience, symbols, Neurology (clinical), Geriatrics and Gerontology, Protein kinase C
Published
2014
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27. P2‐099: CSF P‐TAU181/TAU RATIO TO DISTINGUISH FTLD‐TDP FROM FTLD‐TAU

Author

Alessandro Padovani, Silvana Archetti, Barbara Borroni, and Alberto Benussi

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Pathology, medicine.medical_specialty, Developmental Neuroscience, Epidemiology, business.industry, Health Policy, Ftld tdp, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2014
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28. IC‐P‐002: DEMENTIA EXPERTS' PERCEIVED DIAGNOSTIC VALUE OF PET AMYLOID IMAGING

Author

Michela Pievani, Cristina Muscio, Giovanni B. Frisoni, Patrizio Pasqualetti, Alessandro Padovani, Samantha Galluzzi, Marina Boccardi, and Barbara Borroni

Subjects
Oncology, medicine.medical_specialty, Amyloid, Epidemiology, business.industry, Health Policy, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, medicine, Dementia, Neurology (clinical), Geriatrics and Gerontology, Psychiatry, business, Value (mathematics)
Published
2014
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29. IC‐P‐069: ITALIAN NETWORK FOR AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE AND FRONTOTEMPORAL LOBAR DEGENERATION (ITALIANDIAFN)

Author

Martina Bocchetta, Michela Pievani, Claudio Babiloni, Amalia C. Bruni, Elio Scarpini, Sandro Sorbi, Fabrizio Tagliavini, Alessandro Padovani, Luisa Benussi, Livia Bernardi, Giuliano Binetti, Barbara Borroni, Giuseppe Di Fede, Emilio Di Maria, Silvia Fostinelli, Daniela Galimberti, Massimo Gennarelli, Roberta Ghidoni, Nicola Marzano, Anna Mega, Benedetta Nacmias, Irene Piaceri, Corinna Porteri, Giacomina Rossi, Silvia Suardi, Fabrizio Vecchio, and Giovanni B. Frisoni

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2014
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31. P4‐148: Merging amyloid‐beta cascade and activity‐dependent plasticity in hippocampus: A possible role for ADAM10

Author

Alessandro Padovani, Hugo Vara-Rivera, Flaminio Cattabeni, Barbara Borroni, Maurizio Giustetto, Isabel Pérez-Otaño, Monica Di Luca, Fabrizio Gardoni, Elena Marcello, and Roberta Epis

Subjects
biology, Epidemiology, Chemistry, Amyloid beta, Health Policy, ADAM10, Hippocampus, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Cascade, Activity-dependent plasticity, biology.protein, Neurology (clinical), Geriatrics and Gerontology, Neuroscience
Published
2009
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32. P3–254: SAP97 scaffolding protein mediates alpha–secretase ADAM10 trafficking and directly promotes its activity both in vitro and in vivo

Author

Alessandro Padovani, Elena Marcello, Monica Di Luca, Daniela Mauceri, Barbara Borroni, and Fabrizio Gardoni

Subjects
Scaffold protein, Epidemiology, Chemistry, Health Policy, ADAM10, media_common.quotation_subject, In vitro, Cell biology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Presentation, Developmental Neuroscience, Alpha secretase, In vivo, Neurology (clinical), Geriatrics and Gerontology, media_common
Published
2006
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