1. A comparison of measurement methods of hippocampal atrophy rate for predicting Alzheimer's dementia in the Aberdeen Birth Cohort of 1936
- Author
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Christopher J. McNeil, Arnab Rana, Roger T. Staff, Anca-Larisa Sandu, Alison D. Murray, Kenna Louise Robertson, and Lawrence J. Whalley
- Subjects
Gerontology ,Measurement method ,Hippocampal atrophy rate ,Alzheimer's disease ,medicine.disease ,Hippocampal volume ,Hippocampal atrophy ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Automated volumetry ,mental disorders ,medicine ,Dementia ,Alzheimer s dementia ,Neurology (clinical) ,PART II. State of the Field: Advances in Neuroimaging from the 2016 Alzheimer's Imaging Consortium ,Psychology ,Birth cohort ,Neuroscience ,030217 neurology & neurosurgery ,Scheltens' score ,Rounding ratio - Abstract
Introduction Various methods are available to measure hippocampal atrophy rate. We compared methods to predict Alzheimer's dementia. Methods Participants with brain imaging at ages 69 and 73 years were identified from a previous study. Simple manual measures and computationally automated volumetry were performed. Receiver operating characteristics assessed the predictive ability of each method at baseline and on logit regression analysis of two serial scans. Results Ten of 149 participants developed Alzheimer's dementia and had lower baseline volumes (3647 vs. 4194 mm3P = .002), rates of volume loss (−126 vs. −36 mm3/y; P = .001), and rates of loss in hippocampal fraction (−8.55 vs. −2.35 x 10−5/y; P = .001). Baseline volume with a rate of change gave the highest area under the curve value of 0.96. Discussion Automated volumetry measuring hippocampal size at age 69 years and subsequent rate of change predicts Alzheimer's dementia development.
- Published
- 2016
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