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4 results on '"Wilson, Nicholas J."'

1. Anti‐β c mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model

Author

Yip, Kwok Ho, primary, Wilson, Nicholas J., additional, Pant, Harshita, additional, Brown, Christopher L., additional, Busfield, Samantha, additional, Ng, Milica, additional, Alhamdoosh, Monther, additional, Woodman, Naomi, additional, Schembri, Mark, additional, Tumes, Damon J., additional, Vairo, Gino, additional, Lopez, Angel F., additional, Nash, Andrew D., additional, Wilson, Michael J., additional, Grimbaldeston, Michele A., additional, and Owczarek, Catherine M., additional

Published
2019
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2. Anti‐βc mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model.

Author

Yip, Kwok Ho, Wilson, Nicholas J., Pant, Harshita, Brown, Christopher L., Busfield, Samantha, Ng, Milica, Alhamdoosh, Monther, Woodman, Naomi, Schembri, Mark, Tumes, Damon J., Vairo, Gino, Lopez, Angel F., Nash, Andrew D., Wilson, Michael J., Grimbaldeston, Michele A., and Owczarek, Catherine M.

Subjects
*NASAL polyps, *PATHOLOGICAL physiology, *GRANULOCYTE-macrophage colony-stimulating factor, *PATHOLOGY, *MICE, *MEDICAL research
Abstract

Anti- c mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model We found that treatment with CSL311 for 1 week resulted in an immediate reduction in NP volume measured externally, which was not observed with positive control prednisolone treatment. CSL311 mAb treatment reduces (A) volume of nasal polyp measured externally every week, (B) granulocytes and plasma B-cell populations, (C) mast cell numbers, (D) mucous gland numbers and mucus production and (E) fibroblast numbers in xenografted nasal polyps compared with isotype control mAb treatment. To understand how CSL311 treatment inhibited NP growth, we examined the immune cell profiles in the xenografted NPs collected at the end of the 5-week engraftment. [Extracted from the article]

Published
2020
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3. Anti‐β c mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model

Author

Gino Vairo, Naomi Woodman, Kwok Ho Yip, Christopher Brown, Catherine M. Owczarek, Harshita Pant, Michael J. Wilson, Mark Schembri, Damon J. Tumes, Monther Alhamdoosh, Nicholas J. Wilson, Andrew D. Nash, Michele A. Grimbaldeston, Milica Ng, Samantha J. Busfield, Angel F. Lopez, Yip, Kwok Ho, Wilson, Nicholas J, Pant, Harshita, Brown, Christopher L, Busfield, Samantha, Ng, Milica, Alhamdoosh, Monther, Woodman, Naomi, Schembri, Mark, Tumes, Damon J, Vairo, Gino, Lopez, Angel F, Nash, Andrew D, Wilson, Michael J, Grimbaldeston, Michele A, and Owczarek, Catherine M

Subjects
nasal polyps, biology, medicine.drug_class, business.industry, medicine.medical_treatment, Immunology, medicine.disease, Monoclonal antibody, Pathophysiology, Cytokine, Humanized mouse, Monoclonal, Cancer research, medicine, biology.protein, Immunology and Allergy, Nasal polyps, Antibody, Receptor, business, rhinosinusitis
Abstract

Refereed/Peer-reviewed

Published
2019

4. Anti-β c mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model.

Author

Yip KH, Wilson NJ, Pant H, Brown CL, Busfield S, Ng M, Alhamdoosh M, Woodman N, Schembri M, Tumes DJ, Vairo G, Lopez AF, Nash AD, Wilson MJ, Grimbaldeston MA, and Owczarek CM

Subjects
Animals, Cytokines metabolism, Disease Models, Animal, Humans, Mice, Mice, Transgenic, Nasal Polyps pathology, Th2 Cells immunology, Transcriptome, Treatment Outcome, Antibodies, Monoclonal immunology, Antibodies, Monoclonal therapeutic use, Heterografts, Nasal Polyps complications, Nasal Polyps drug therapy, Receptors, Cytokine immunology, Rhinitis complications, Rhinitis drug therapy, Sinusitis complications, Sinusitis drug therapy
Published
2020
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