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Background: The objective was to investigate the local side-effects of inhaled corticosteroids (ICS) in daily life in asthmatic children, particularly the younger ones, by an observational prospective cross-sectional cohort study. Methods: Asthmatic children (n =639, 75.9±48.9 months, 61.3% boys), treated with beclomethasone dipropionate (BDP) (721.0±287.3 µg per day) or budesonide (BUD) (835.5±684.9 µg per day) for at least 1 month, were recruited at the time of a scheduled visit. Local side-effects were researched by questionnaire (cough during inhalation, hoarseness, dysphonia, and thirsty feeling) and clinical examination (perioral dermatitis, oral candidiasis, and tongue hypertrophy). Results: Exactly 63.3% of the children aged under 6 years and 59.5% of the older ones reported one local side-effect. Cough (39.7%) was dependent on young age, use of BDP, and mainly use of spacer device, with an OR of 4.7 (95% CI: 2.7–8.2). Thirsty feeling (21.9%) and hoarseness (14.1%) occurred in children using ICS and long-acting β2 -agonists. Dysphonia (11.1%) was favored by high doses of BDP and BUD, and by inhalation from spacer devices or nebulizers. No factor favored oral candidiasis (10.7%). Perioral dermatitis (2.9%) and tongue hypertrophy (0.1%) were associated with nebulization. Conclusions: Local side-effects of ICS are common in asthmatic children of all_ ages, and the device used constitutes the most influential factor. [ABSTRACT FROM AUTHOR]