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2. Health effects of exposure to chlorination by‐products in swimming pools

Author

Couto, Mariana, primary, Bernard, Alfred, additional, Delgado, Luís, additional, Drobnic, Franchek, additional, Kurowski, Marcin, additional, Moreira, André, additional, Rodrigues‐Alves, Rodrigo, additional, Rukhadze, Maia, additional, Seys, Sven, additional, Wiszniewska, Marta, additional, and Quirce, Santiago, additional

Published
2021
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3. Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study

Author

Lipp, Theresa, primary, Acar Şahin, Aydan, additional, Aggelidis, Xenophon, additional, Arasi, Stefania, additional, Barbalace, Andrea, additional, Bourgoin, Anne, additional, Bregu, Blerina, additional, Brighetti, Maria Antonia, additional, Caeiro, Elsa, additional, Caglayan Sozmen, Sule, additional, Caminiti, Lucia, additional, Charpin, Denis, additional, Couto, Mariana, additional, Delgado, Luís, additional, Di Rienzo Businco, Andrea, additional, Dimier, Claire, additional, Dimou, Maria V., additional, Fonseca, João A., additional, Goksel, Ozlem, additional, Guvensen, Aykut, additional, Hernandez, Dolores, additional, Hoffmann, Tara Maria, additional, Jang, Dah Tay, additional, Kalpaklioglu, Fusun, additional, Lame, Blerta, additional, Llusar, Ruth, additional, Makris, Michael P., additional, Mazon, Angel, additional, Mesonjesi, Eris, additional, Nieto, Antonio, additional, Öztürk, Ayse, additional, Pahus, Laurie, additional, Pajno, Giovanni Battista, additional, Panasiti, Ilenia, additional, Papadopoulos, Nikolaos G., additional, Pellegrini, Elisabetta, additional, Pelosi, Simone, additional, Pereira, Ana M., additional, Pereira, Mariana, additional, Pinar, Munevver, additional, Potapova, Ekaterina, additional, Priftanji, Alfred, additional, Psarros, Fotis, additional, Sackesen, Cansin, additional, Sfika, Ifigenia, additional, Suarez, Javier, additional, Thibaudon, Michel, additional, Travaglini, Alessandro, additional, Tripodi, Salvatore, additional, Verdier, Valentine, additional, Villella, Valeria, additional, Xepapadaki, Paraskevi, additional, Yazici, Duygu, additional, Matricardi, Paolo M., additional, and Dramburg, Stephanie, additional

Published
2021
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4. “Whole” vs. “fragmented” approach to EAACI pollen season definitions: A multicenter study in six Southern European cities

Author

Hoffmann, Tara Maria, primary, Acar Şahin, Aydan, additional, Aggelidis, Xenophon, additional, Arasi, Stefania, additional, Barbalace, Andrea, additional, Bourgoin, Anne, additional, Bregu, Blerina, additional, Brighetti, Maria Antonia, additional, Caeiro, Elsa, additional, Caglayan Sozmen, Sule, additional, Caminiti, Lucia, additional, Charpin, Denis, additional, Couto, Mariana, additional, Delgado, Luís, additional, Di Rienzo Businco, Andrea, additional, Dimier, Claire, additional, Dimou, Maria V., additional, Fonseca, João A., additional, Goksel, Ozlem, additional, Guvensen, Aykut, additional, Hernandez, Dolores, additional, Jang, Dah Tay, additional, Kalpaklioglu, Fusun, additional, Lame, Blerta, additional, Llusar, Ruth, additional, Makris, Michael P., additional, Mazon, Angel, additional, Mesonjesi, Eris, additional, Nieto, Antonio, additional, Öztürk, Ayse, additional, Pahus, Laurie, additional, Pajno, Giovanni Battista, additional, Panasiti, Ilenia, additional, Panetta, Valentina, additional, Papadopoulos, Nikolaos G., additional, Pellegrini, Elisabetta, additional, Pelosi, Simone, additional, Pereira, Ana Margarida, additional, Pereira, Mariana, additional, Pinar, Munevver, additional, Pfaar, Oliver, additional, Potapova, Ekaterina, additional, Priftanji, Alfred, additional, Psarros, Fotis, additional, Sackesen, Cansin, additional, Sfika, Ifigenia, additional, Suarez, Javier, additional, Thibaudon, Michel, additional, Travaglini, Alessandro, additional, Tripodi, Salvatore, additional, Verdier, Valentine, additional, Villella, Valeria, additional, Xepapadaki, Paraskevi, additional, Yazici, Duygu, additional, Matricardi, Paolo M., additional, and Dramburg, Stephanie, additional

Published
2020
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6. Diagnostic testing for penicillin allergy: A survey of practices and cost perceptions

Author

Sousa‐Pinto, Bernardo, primary, Blumenthal, Kimberly G., additional, Macy, Eric, additional, Bavbek, Sevim, additional, Benić, Mirjana Stanić, additional, Alves‐Correia, Magna, additional, Dursun, Adile Berna, additional, Jerschow, Elina, additional, Kong‐Cardoso, Bárbara, additional, Kopač, Peter, additional, Lefèvre, Sébastien, additional, Lombardo, Carla, additional, Marraccini, Paolo, additional, Moral, Luis, additional, Norton, Allison Eaddy, additional, Petrişor, Cristina, additional, Poziomkowska‐Gęsicka, Iwona, additional, Regateiro, Frederico S., additional, Santos, Natacha, additional, Saretta, Francesca, additional, Turkalj, Mirjana, additional, Veličković, Jelena, additional, Wöhrl, Stefan, additional, Yazicioglu, Mehtap, additional, Zidarn, Mihaela, additional, Pereira, Mariana, additional, Rebelo‐Gomes, Eva, additional, Pereira, Ana Margarida, additional, Delgado, Luís, additional, and Almeida Fonseca, João, additional

Published
2019
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7. Exposure to indoor endocrine-disrupting chemicals and childhood asthma and obesity

Author

Paciência, Inês, primary, Cavaleiro Rufo, João, additional, Silva, Diana, additional, Martins, Carla, additional, Mendes, Francisca, additional, Farraia, Mariana, additional, Delgado, Luís, additional, de Oliveira Fernandes, Eduardo, additional, Padrão, Patrícia, additional, Moreira, Pedro, additional, Severo, Milton, additional, Barros, Henrique, additional, and Moreira, André, additional

Published
2019
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10. Disentangling the heterogeneity of allergic respiratory diseases by latent class analysis reveals novel phenotypes.

Author

Amaral, Rita, Bousquet, Jean, Pereira, Ana M., Araújo, Luís M., Sá‐Sousa, Ana, Jacinto, Tiago, Almeida, Rute, Delgado, Luís, and Fonseca, Joao A.

Subjects
RESPIRATORY diseases, ALLERGIES, REGRESSION trees, PHENOTYPES, BLOOD collection
Abstract

Background: Refined phenotyping of allergic diseases may unravel novel phenotypes. Conjunctivitis as an independent disorder has never been approached. Aim: To identify distinct classes of allergic respiratory diseases using latent class analysis (LCA) and distinguish each class using classification and regression tree (CART) analysis. Methods: Seven hundred and twenty‐eight adults from the Portuguese general population study ICAR had a structured medical interview combined with blood collection, skin prick tests, spirometry with bronchodilation, and exhaled nitric oxide. LCA was applied to 19 variables. The CART algorithm selected the most likely variables distinguishing LCA‐classes. Results: A six‐class model was obtained. Class 1 (25%): nonallergic participants without bronchial or ocular symptoms. Classes 2 (22%) and 3 (11%): nasal and ocular (low levels) symptoms without nasal impairment, monosensitized (Class 2) or polysensitized (Class 3). Class 4 (13%): polysensitized participants with high levels of nasal and ocular symptoms, and nasal impairment. Classes 5 (16%) and 6 (14%): high level of nasal, bronchial and ocular symptoms with nasal impairment (non‐allergic or polysensitized, respectively). Participants in classes 5 and 6 had more bronchial exacerbations and unscheduled medical visits (P < 0.001). Ocular symptoms were significantly higher in classes with nasal impairment, compared to those without impairment (P < 0.001) or no nasal symptom (P < 0.001). CART highlighted ocular symptoms as the most relevant variable in distinguishing LCA‐classes. Conclusion: Novel severe phenotypes of participants with co‐occurrence of ocular, nasal and bronchial symptoms, and exacerbation‐prone were identified. The tree algorithm showed the importance of the ocular symptoms in the expression of allergic diseases phenotypes. Novel phenotypes of allergic respiratory diseases were identified by latent class analysis, in adults from a general population sample. For the first time, ocular symptoms were used independently and ranked by classification and regression tree analysis as the most relevant variable to separate those phenotypes. [ABSTRACT FROM AUTHOR]

Published
2019
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11. Exhaled breath condensate volatilome allows sensitive diagnosis of persistent asthma.

Author

Cavaleiro Rufo, João, Paciência, Inês, Mendes, Francisca Castro, Farraia, Mariana, Rodolfo, Ana, Silva, Diana, de Oliveira Fernandes, Eduardo, Delgado, Luís, and Moreira, André

Subjects
ELECTRONIC noses, ASTHMA diagnosis, FOOTBALL training, DIAGNOSIS, VOLATILE organic compounds, RESPIRATORY organs
Abstract

Background: The diagnosis and phenotyping of paediatric asthma are particularly complex due to the lack of currently available sensitive diagnostic tools. This often results in uncertainties associated with inhaled steroid therapy prescription. Therefore, this study aimed to investigate whether volatile organic compounds measured in exhaled breath condensate can be used as biomarkers for asthma diagnosis in the paediatric population. Methods: A total of 64 participants, aged 6‐18 years, were recruited on a random basis during visits to an outpatient allergy clinic and to a juvenile football team training session. Lung function, airway reversibility and skin prick tests were performed. Exhaled breath condensate samples were collected, and breathprints were assessed using an electronic nose. Information on medical diagnosis of asthma, rhinitis and atopic dermatitis was retrieved for each participant. A hierarchical cluster model based on the volatilome profiles was then created. Results: A two‐cluster exhaled volatile organic compound‐based hierarchical model was able to significantly discriminate individuals with asthma from those without the disease (AUC = 0.81 [0.69‐0.93], P < 0.001). Individuals who had persistent asthma and were prescribed corticosteroid therapy by the physician were also significantly distinguished in the model (AUC = 0.81 [0.70‐0.92], P < 0.001). Despite being less specific, the method showed higher overall accuracy, sensitivity and AUC values when compared to spirometry with bronchodilation. Conclusions: Analysis of the exhaled breath condensate volatilome allowed the distinction of paediatric individuals with a medical diagnosis of asthma, identifying those in need of corticosteroid therapy. The developed breathomics model was able to identify individuals with asthma and with persistent asthma with improved performance over spirometry with bronchodilation. The study shows that a breathomics model was able to identify individuals with a medical diagnosis of asthma with high accuracy. Individuals with asthma in need of inhaled corticosteroid therapy were significantly clustered in the model. Breathomics has the potential to assist the physician in the diagnosis of asthma and/or administration of corticosteroid therapy for paediatric patients with asthma. [ABSTRACT FROM AUTHOR]

Published
2019
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12. Diagnostic testing for penicillin allergy: A survey of practices and cost perceptions.

Author

Sousa-Pinto B, Blumenthal KG, Macy E, Bavbek S, Benić MS, Alves-Correia M, Dursun AB, Jerschow E, Kong-Cardoso B, Kopač P, Lefèvre S, Lombardo C, Marraccini P, Moral L, Norton AE, Petrişor C, Poziomkowska-Gęsicka I, Regateiro FS, Santos N, Saretta F, Turkalj M, Veličković J, Wöhrl S, Yazicioglu M, Zidarn M, Pereira M, Rebelo-Gomes E, Pereira AM, Delgado L, and Almeida Fonseca J

Subjects
Adult, Drug Hypersensitivity epidemiology, Europe epidemiology, Female, Humans, Male, Middle Aged, North America epidemiology, Surveys and Questionnaires, Allergists psychology, Anti-Bacterial Agents adverse effects, Diagnostic Tests, Routine economics, Drug Hypersensitivity diagnosis, Drug Hypersensitivity etiology, Penicillins adverse effects
Published
2020
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