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2. Hypersensitivity reactions to proton pump inhibitors. An EAACI position paper

Author

Bavbek, Sevim, primary, Kepil Özdemir, Seçil, additional, Bonadonna, Patrizia, additional, Atanaskovic‐Markovic, Marina, additional, Barbaud, Annick, additional, Brockow, Knut, additional, Laguna Martinez, Jose, additional, Nakonechna, Alla, additional, Pagani, Mauro, additional, Arcolacı, Alessandra, additional, Lombardo, Carla, additional, and Torres, Maria J., additional

Published
2023
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3. EAACI/ENDA position paper on drug provocation testing.

Author

Barbaud, Annick, Garvey, Lene Heise, Torres, Maria, Laguna, Jose Julio, Arcolaci, Alessandra, Bonadonna, Patrizia, Scherer Hofmeier, Kathrin, Chiriac, Anca Mirela, Cernadas, Josefina, Caubet, Jean Christoph, and Brockow, Knut

Subjects
*BETA lactam antibiotics, *SKIN tests, *DRUG allergy, *CONTRAST media, *PROTON pump inhibitors
Abstract

In drug hypersensitivity, drug provocation testing (DPT), also called drug challenge, is the gold standard for investigation. In recent years, risk stratification has become an important tool for adjusting the diagnostic strategy to the perceived risk, whilst still maintaining a high level of safety for the patient. Skin tests are recommended before DPT but may be omitted in low‐risk patients. The task force suggests a strict definition of such low‐risk patients in children and adults. Based on experience and evidence from studies of allergy to beta‐lactam antibiotics, an algorithm on how to adjust DPT to the risk, and when to omit skin tests before DPT, is presented. For other antibiotics, non‐steroidal anti‐inflammatory drugs and other drugs, skin tests are poorly validated and DPT is frequently necessary. We recommend performing DPT with chemotherapeutics and biologicals to avoid unnecessary desensitization procedures and DPT with skin tests negative contrast media. We suggest DPT with anesthetics only in highly specialized centers. Specifics of DPT to proton pump inhibitors, anticonvulsants and corticosteroids are discussed. This position paper provides general recommendations and guidance on optimizing use of DPT, whilst balancing benefits with patient safety and optimizing the use of the limited available resources. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Hypersensitivity reactions to proton pump inhibitors. An EAACI position paper.

Author

Bavbek, Sevim, Kepil Özdemir, Seçil, Bonadonna, Patrizia, Atanaskovic‐Markovic, Marina, Barbaud, Annick, Brockow, Knut, Laguna Martinez, Jose, Nakonechna, Alla, Pagani, Mauro, Arcolacı, Alessandra, Lombardo, Carla, and Torres, Maria J.

Subjects
PROTON pump inhibitors, DELAYED hypersensitivity, FOOD allergy, ALLERGIES, MEDICAL personnel
Abstract

Proton pump inhibitors (PPIs) are invaluable therapeutic options in a variety of dyspeptic diseases. In addition to their well‐known risk profile, PPI consumption is related to food and environmental allergies, dysbiosis, osteoporosis, as well as immediate and delayed hypersensitivity reactions (HSRs). The latter, although a rare event, around 1%–3%, due to the extraordinarily high rate of prescription and consumption of PPIs are related to a substantial risk. In this Position Paper, we provide clinicians with practical evidence‐based recommendations for the diagnosis and management of HSRs to PPIs. Furthermore, the unmet needs proposed in the document aim to stimulate more in‐depth investigations in the topic. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Flow‐based basophil activation test in immediate drug hypersensitivity. An EAACI task force position paper.

Author

Mayorga, C., Çelik, G. E., Pascal, M., Hoffmann, H. J., Eberlein, B., Torres, M. J., Brockow, K., Garvey, L. H., Barbaud, A., Madrigal‐Burgaleta, R., Caubet, J. C., and Ebo, D. G.

Subjects
DRUG allergy, ALLERGIES, TASK forces, NEUROMUSCULAR blocking agents, BASOPHILS
Abstract

Diagnosing immediate drug hypersensitivity reactions (IDHRs) can pose a significant challenge and there is an urgent need for safe and reliable tests. Evidence has emerged that the basophil activation test (BAT), an in vitro assay that mirrors the in vivo response, can be a complementary test for many drugs. In this position paper, members of Task Force (TF) "Basophil activation test in the evaluation of Drug Hypersensitivity Reactions" from the European Academy of Allergy and Clinical Immunology (EAACI) present the data from a survey about the use and utility of BAT in IDHRs in Europe. The survey results indicate that there is a great interest for using BAT especially for diagnosing IDHRs. However, there are still main needs, mainly in the standardization of the protocols. Subsequently consensus‐based recommendations were formulated for: (i) Technical aspects of BAT in IDHRs including type of sample, management of drugs, flow cytometry protocols, interpretation of the results; and (ii) Drug‐specific aspects that should be taken into account when performing BAT in relation to betalactams, neuromuscular blocking agents, fluoroquinolones, chlorhexidine, opioids, radio contrast media, chemotherapeutics, biological agents, nonsteroidal anti‐inflammatory drugs, COVID vaccine, and excipients. Moreover, aspects in the evaluation of pediatric population have also been considered. All this indicates that BAT offers the clinician and laboratory a complementary tool for a safe diagnostic for IDHRs, although its place in the diagnostic algorithm depends on the drug class and patient population (phenotype, geography, and age). The standardization of BAT is important for generalizing this method beyond the individual laboratory. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Management of anaphylaxis due to COVID-19 vaccines in the elderly

Author

Paulo Augusto Moreira Camargos, Radolslaw Gawlik, Mirko Petrovic, Gunter J. Sturm, Kristof Nekam, Sergio Bonini, Zhanat Ispayeva, Marilyn Urrutia Pereira, Jean Bousquet, Antti Lauerma, Menachem Rottem, Arzu Yorgancioglu, Hubert Blain, Antonio Cherubini, Mário Morais-Almeida, Nathalie Salles, Charlotte G. Mortz, Sylwia Smolinska, Davor Plavec, A. Bedbrook, Torsten Zuberbier, Helga Kraxner, M. Beatrice Bilò, Sinthia Bosnic-Anticevich, Gaëtan Gavazzi, Finbarr C. Martin, Alvaro A. Cruz, K. S. Bennoor, Isabella Annesi-Maesano, Mohamed H. Shamji, Karin Hoffmann-Sommergruber, Marina Atanaskovic-Markovic, Carsten Bindslev-Jensen, Lan Tt Le, Isabel Skypala, Ana Todo-Bom, Vincenzo Patella, Lorenzo Cecchi, Charlotte Suppli Ulrik, Oscar Palomares, Joaquin Sastre, Hans Jürgen Hoffmann, Knut Brockow, Eva Untersmayr, Martin Hrubisko, Bernadette Eberlein, Aziz Sheikh, Milan Sova, Osman M. Yusuf, Violeta Kvedariene, G. Walter Canonica, Dana Wallace, Ioana Agache, Milena Sokolowska, Jos M. G. A. Schols, Susan Waserman, Stéphanie Miot, Carla Irani, Regina E Roller-Winsberger, Michael Levin, Yves Rolland, Emma Montella, Bilun Gemicioglu, Bolesław Samoliński, Stefano Del Giacco, Madda lenaIllario, Yehia El-Gamal, Olga Lourenço, Jean-Christoph Roger J-P Caubet, Luisa Brussino, Marysia Recto, De Yun Wang, Igor Kaidashev, Renaud Louis, Antonino Romano, Mario E. Zernotti, Jacques Reynes, Pedro Carreiro-Martins, Alexandra F. Santos, Marek Niedoszytko, M. Gotua, Musa Khaitov, Thomas B. Casale, Andrea Matucci, Bernardo Sousa-Pinto, Rafael Stelmach, Dejan Dokic, Joana Vitte, Motohiro Ebisawa, Maria Teresa Ventura, Joaquim Mullol, Tomas Chivato, Petr Panzner, Oliver Pfaar, Sanna Toppila-Salmi, Ioanna Tsiligianni, Wytske Fokkens, Alessandra Vultaggio, H. Neffen, Juan Carlos Ivancevich, Ya-dong Gao, Anna Sediva, Maja Hofmann, Ana Maria Carriazo, João Fonseca, Marek Jutel, A. Benetos, Nhân Pham-Thi, Mona Al-Ahmad, Arunas Valiulis, Mihaela Zidarn, Elizabeth Angier, Yoshitaka Okamoto, Montserrat Fernandez-Rivas, Cezmi A. Akdis, Philip W. Rouadi, Olivier Guérin, John Farrell, Mikaela Odemyr, George Christoff, Vera Mahler, Claus Bachert, Edward F. Knol, Wienczyslawa Czarlewski, Robyn E O'Hehir, Victoria Cardona, Ludger Klimek, Tari Haahtela, Vincent Le Moing, Branislava Milenkovic, Carmen Rondon, Kaja Julge, Jolanta Walusiak-Skorupa, Nikolaos G. Papadopoulos, Aslı Gelincik, Markus Ollert, Piotr Kuna, Leyla Namazova-Baranova, Margitta Worm, Annick Barbaud, Elena Camelia Berghea, Todor A. Popov, Derek K. Chu, María José Torres, Faradiba Sarquis Serpa, Nicola Scichilone, Amir Hamzah Abdul Latiff, Frederico S. Regateiro, Gianni Passalacqua, Humboldt-Universität zu Berlin, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Center for Rhinology and Allergology Wiesbaden, University Hospital Mannheim, Humboldt University Of Berlin, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Transylvania University, Wrocław Medical University, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], University of Cagliari, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Università Politecnica delle Marche [Ancona] (UNIVPM), Medical Consulting Czarlewski, Universiti Putra Malaysia, University of Southampton, Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), University of Belgrade [Belgrade], Ghent University Hospital, CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Dhaka Shishu Hospital [Bangladesh], University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), Odense University Hospital (OUH), Italian National Research Council, National Research Council [Italy] (CNR), The University of Sydney, Technische Universität München = Technical University of Munich (TUM), Università degli studi di Torino = University of Turin (UNITO), Universidade Federal de Minas Gerais = Federal University of Minas Gerais [Belo Horizonte, Brazil] (UFMG), IRCCS Research Hospital, Milan, Vall d'Hebron University Hospital [Barcelona], Centro Hospitalar de Lisboa Central E.P.E, University of South Florida [Tampa] (USF), Geneva University Hospital (HUG), Azienda Usl Toscana centro [Firenze], Софийски университет = Sofia University, McMaster University [Hamilton, Ontario], State University of Bahia, Institute of Public Health of Republic of North Macedonia [Skopje], Ain Shams University (ASU), Sagamihara National Hospital [Kanagawa, Japan], Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] (IdISSC), Amsterdam UMC - Amsterdam University Medical Center, Universidade do Porto = University of Porto, Wuhan University [China], CHU Grenoble, Silesian University of Medicine, Istanbul Faculty of Medicine, Cerrahpasa Faculty of Medicine, Istanbul University, Centre Hospitalier Universitaire de Nice (CHU Nice), Helsinki University Hospital [Helsinki, Finlande], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Medizinische Universität Wien = Medical University of Vienna, Aarhus University [Aarhus], Oncology Institute of St Elisabeth, University of Naples Federico II = Università degli studi di Napoli Federico II, St Joseph University, Hôtel-Dieu de France (HDF), Université Saint-Joseph de Beyrouth (USJ), Kazakh National Medical University, Servicio de Alergia e ImmunologiaBuenos Aires (Clinica Santa Isabel), Tartu University Institute of Clinical Medicine, Ukrainina Medical Stomatological Academy [Poltava, Ukraine], Federal Medicobiological Agency [Moscow, Russian Federation], University Medical Center [Utrecht], Semmelweis University [Budapest], Medical University of Łódź (MUL), Vilnius University [Vilnius], University of Medicine and Pharmacy (VIETNAM), University of Cape Town, CHU Sart Tilman, Université de Liège, University of Beira Interior [Portugal] (UBI), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), uBibliorum, Ear, Nose and Throat, AII - Inflammatory diseases, CHU Montpellier, Wroclaw Medical University [Wrocław, Pologne], University of Bari Aldo Moro (UNIBA), Service de Médecine Interne = Hôpital de jour de médecine [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sagamihara National Hospital, Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), CHU Toulouse [Toulouse], RS: CAPHRI - R1 - Ageing and Long-Term Care, Health Services Research, Bousquet J., Agache I., Blain H., Jutel M., Ventura M.T., Worm M., Del Giacco S., Benetos A., Bilo B.M., Czarlewski W., Abdul Latiff A.H., Al-Ahmad M., Angier E., Annesi-Maesano I., Atanaskovic-Markovic M., Bachert C., Barbaud A., Bedbrook A., Bennoor K.S., Berghea E.C., Bindslev-Jensen C., Bonini S., Bosnic-Anticevich S., Brockow K., Brussino L., Camargos P., Canonica G.W., Cardona V., Carreiro-Martins P., Carriazo A., Casale T., Caubet J.-C., Cecchi L., Cherubini A., Christoff G., Chu D.K., Cruz A.A., Dokic D., El-Gamal Y., Ebisawa M., Eberlein B., Farrell J., Fernandez-Rivas M., Fokkens W.J., Fonseca J.A., Gao Y., Gavazzi G., Gawlik R., Gelincik A., Gemicioglu B., Gotua M., Guerin O., Haahtela T., Hoffmann-Sommergruber K., Hoffmann H.J., Hofmann M., Hrubisko M., Illario M., Irani C., Ispayeva Z., Ivancevich J.C., Julge K., Kaidashev I., Khaitov M., Knol E., Kraxner H., Kuna P., Kvedariene V., Lauerma A., Le L.T.T., Le Moing V., Levin M., Louis R., Lourenco O., Mahler V., Martin F.C., Matucci A., Milenkovic B., Miot S., Montella E., Morais-Almeida M., Mortz C.G., Mullol J., Namazova-Baranova L., Neffen H., Nekam K., Niedoszytko M., Odemyr M., O'Hehir R.E., Okamoto Y., Ollert M., Palomares O., Papadopoulos N.G., Panzner P., Passalacqua G., Patella V., Petrovic M., Pfaar O., Pham-Thi N., Plavec D., Popov T.A., Recto M.T., Regateiro F.S., Reynes J., Roller-Winsberger R.E., Rolland Y., Romano A., Rondon C., Rottem M., Rouadi P.W., Salles N., Samolinski B., Santos A.F., S Sarquis F., Sastre J., M. G. A. Schols J., Scichilone N., Sediva A., Shamji M.H., Sheikh A., Skypala I., Smolinska S., Sokolowska M., Sousa-Pinto B., Sova M., Stelmach R., Sturm G., Suppli Ulrik C., Todo-Bom A.M., Toppila-Salmi S., Tsiligianni I., Torres M., Untersmayr E., Urrutia Pereira M., Valiulis A., Vitte J., Vultaggio A., Wallace D., Walusiak-Skorupa J., Wang D.-Y., Waserman S., Yorgancioglu A., Yusuf O.M., Zernotti M., Zidarn M., Chivato T., Akdis C.A., Zuberbier T., Klimek L., HUS Inflammation Center, University of Helsinki, and Department of Dermatology, Allergology and Venereology

Subjects
Male, Allergy, Pediatrics, Eaaci Position Paper, COVID-19 vaccines, older (adults, GUIDELINES, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Medicine and Health Sciences, Immunology and Allergy, Medicine, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Geriatrics, MESH: Aged, RISK, Vaccines, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, people), EPINEPHRINE, Epinephrine, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, COVID -19 vaccines, Anaphylaxis, medicine.drug, older (adults/people), medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), MESH: Covid-19, MESH: Epinephrine, Immunology, adrenaline, anaphylaxis, Aged, COVID-19 Vaccines, Humans, SARS-CoV-2, COVID-19, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Diabetes mellitus, Anaphylaxis/etiology, MESH: SARS-CoV-2, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, COVID‐19 vaccines, Older - Adults/people, Asthma, MESH: Humans, business.industry, adrenaline, anaphylaxis, COVID-19 vaccines, older (adults/people), medicine.disease, Obesity, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, MESH: Male, MESH: Anaphylaxis, Older, 3121 General medicine, internal medicine and other clinical medicine, business, MESH: Covid-19 vaccines, 030215 immunology
Abstract

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Published
2021

7. Risk stratification through extensive allergy work‐up in COVID‐19‐mRNA vaccine allergic reactions

Author

Soria, Angèle, primary, Labella, Marina, additional, Doña, Inmaculada, additional, Nicaise‐Roland, Pascale, additional, Chollet‐Martin, Sylvie, additional, Autegarden, Jean‐Eric, additional, Castagna, Julie, additional, Le Thai, Claire, additional, de Chaisemartin, Luc, additional, Torres, Maria José, additional, and Barbaud, Annick, additional

Published
2023
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9. Clinical approach on challenge and desensitization procedures with aspirin in patients with ischemic heart disease and nonsteroidal anti‐inflammatory drug hypersensitivity

Author

Cortellini, G., Romano, A., Santucci, A., Barbaud, A., Bavbek, S., Bignardi, D., Blanca, M., Bonadonna, P., Costantino, M. T., Laguna, J. J., Lombardo, C., Losappio, L.M., Makowska, J., Nakonechna, A., Quercia, O., Pastorello, E. A., Patella, V., Terreehorst, I., Testi, S., Cernadas, J. R., Dionicio Elera, J., Lippolis, D., Voltolini, S., and Grosseto, D.

Published
2017
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10. Allergies and COVID‐19 vaccines: An ENDA/EAACI Position paper

Author

Barbaud, Annick, primary, Garvey, Lene Heise, additional, Arcolaci, Alessandra, additional, Brockow, Knut, additional, Mori, Francesca, additional, Mayorga, Cristobalina, additional, Bonadonna, Patrizia, additional, Atanaskovic‐Markovic, Marina, additional, Moral, Luis, additional, Zanoni, Giovanna, additional, Pagani, Mauro, additional, Soria, Angèle, additional, Jošt, Maja, additional, Caubet, Jean‐Christoph, additional, Carmo, Abreu, additional, Mona, Al‐Ahmad, additional, Alvarez‐Perea, Alberto, additional, Bavbek, Sevim, additional, Benedetta, Biagioni, additional, Bilo, M.Beatrice, additional, Blanca‐López, Natalia, additional, Bogas, Herrera Gádor, additional, Buonomo, Alessandro, additional, Calogiuri, Gianfranco, additional, Carli, Giulia, additional, Cernadas, Josefina, additional, Cortellini, Gabriele, additional, Celik, Gülfem, additional, Demir, Semra, additional, Doña, Inmaculada, additional, Dursun, Adile Berna, additional, Eberlein, Bernadette, additional, Faria, Emilia, additional, Fernandes, Bryan, additional, Garcez, Tomaz, additional, Garcia‐Nunez, Ignacio, additional, Gawlik, Radoslaw, additional, Gelincik, Asli, additional, Gomes, Eva, additional, Gooi, Jimmy H. C., additional, Grosber, Martine, additional, Gülen, Theo, additional, Hacard, Florence, additional, Hoarau, Cyrille, additional, Janson, Christer, additional, Johnston, Sebastian L., additional, Joerg, Lukas, additional, Kepil Özdemir, Seçil, additional, Klimek, Ludger, additional, Košnik, Mitja, additional, Kowalski, Marek L., additional, Kuyucu, Semanur, additional, Kvedariene, Violeta, additional, Laguna, Jose Julio, additional, Lombardo, Carla, additional, Marinho, Susana, additional, Merk, Hans, additional, Meucci, Elisa, additional, Morisset, Martine, additional, Munoz‐Cano, Rosa, additional, Murzilli, Francesco, additional, Nakonechna, Alla, additional, Popescu, Florin‐Dan, additional, Porebski, Grzegorz, additional, Radice, Anna, additional, Regateiro, Frederico S., additional, Röckmann, Heike, additional, Romano, Antonino, additional, Sargur, Ravishankar, additional, Sastre, Joaquin, additional, Scherer Hofmeier, Kathrin, additional, Sedláčková, Lenka, additional, Sobotkova, Marta, additional, Terreehorst, Ingrid, additional, Treudler, Regina, additional, Walusiak‐Skorupa, Jolanta, additional, Wedi, Bettina, additional, Wöhrl, Stefan, additional, Zidarn, Mihael, additional, Zuberbier, Torsten, additional, Agache, Ioana, additional, and Torres, Maria J., additional

Published
2022
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11. Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19: An EAACI Position Paper

Author

Antonino Romano, Knut Brockow, Cristobalina Mayorga, María José Torres, Gülfem Çelik, Aslı Gelincik, Marina Atanaskovic-Markovic, Annick Barbaud, Ozge Soyer, and Inmaculada Doña

Subjects
Drug, medicine.medical_specialty, SARS‐CoV2, medicine.medical_treatment, media_common.quotation_subject, Immunology, desensitization, Review Article, Disease, medicine.disease_cause, Asymptomatic, Drug Hypersensitivity, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, COVID‐19, Pandemic, medicine, Humans, Immunology and Allergy, drug hypersensitivity reactions, Intensive care medicine, Pandemics, Review Articles, Coronavirus, Desensitization (medicine), media_common, SARS-CoV-2, business.industry, Academies and Institutes, COVID-19, 3. Good health, Europe, 030228 respiratory system, Position paper, Differential diagnosis, medicine.symptom, business
Abstract

Coronavirus disease 2019 (COVID‐19), a respiratory tract infection caused by a novel human coronavirus, the severe acute respiratory syndrome coronavirus 2, leads to a wide spectrum of clinical manifestations ranging from asymptomatic cases to patients with mild and severe symptoms, with or without pneumonia. Given the huge influence caused by the overwhelming COVID‐19 pandemic affecting over three million people worldwide, a wide spectrum of drugs is considered for the treatment in the concept of repurposing and off‐label use. There is no knowledge about the diagnosis and clinical management of the drug hypersensitivity reactions that can potentially occur during the disease. This review brings togetherall the published information about the diagnosis and management of drug hypersensitivity reactions due to current and candidate off‐label drugs andhighlights relevant recommendations. Furthermore, it gathers all the dermatologic manifestations reported during the disease for guiding the clinicians to establish a better differential diagnosis of drug hypersensitivity reactionsin the course of the disease.

Published
2020

12. Management of anaphylaxis due to COVID‐19 vaccines in the elderly

Author

Bousquet, Jean, primary, Agache, Ioana, additional, Blain, Hubert, additional, Jutel, Marek, additional, Ventura, Maria Teresa, additional, Worm, Margitta, additional, Del Giacco, Stefano, additional, Benetos, Athanasios, additional, Bilo, Beatrice Maria, additional, Czarlewski, Wienczyslawa, additional, Abdul Latiff, Amir Hamzah, additional, Al‐Ahmad, Mona, additional, Angier, Elizabeth, additional, Annesi‐Maesano, Isabella, additional, Atanaskovic‐Markovic, Marina, additional, Bachert, Claus, additional, Barbaud, Annick, additional, Bedbrook, Anna, additional, Bennoor, Kazi S., additional, Berghea, Elena Camelia, additional, Bindslev‐Jensen, Carsten, additional, Bonini, Sergio, additional, Bosnic‐Anticevich, Sinthia, additional, Brockow, Knut, additional, Brussino, Luisa, additional, Camargos, Paulo, additional, Canonica, G. Walter, additional, Cardona, Victoria, additional, Carreiro‐Martins, Pedro, additional, Carriazo, Ana, additional, Casale, Thomas, additional, Caubet, Jean‐Christoph, additional, Cecchi, Lorenzo, additional, Cherubini, Antonio, additional, Christoff, George, additional, Chu, Derek K., additional, Cruz, Alvaro A., additional, Dokic, Dejan, additional, El‐Gamal†, Yehia, additional, Ebisawa, Motohiro, additional, Eberlein, Bernadette, additional, Farrell, John, additional, Fernandez‐Rivas, Montserrat, additional, Fokkens, Wytske J., additional, Fonseca, Joao A., additional, Gao, Yadong, additional, Gavazzi, Gaëtan, additional, Gawlik, Radoslaw, additional, Gelincik, Asli, additional, Gemicioğlu, Bilun, additional, Gotua, Maia, additional, Guérin, Olivier, additional, Haahtela, Tari, additional, Hoffmann‐Sommergruber, Karin, additional, Hoffmann, Hans Jürgen, additional, Hofmann, Maja, additional, Hrubisko, Martin, additional, Illario, Maddalena, additional, Irani, Carla, additional, Ispayeva, Zhanat, additional, Ivancevich, Juan Carlos, additional, Julge, Kaja, additional, Kaidashev, Igor, additional, Khaitov, Musa, additional, Knol, Edward, additional, Kraxner, Helga, additional, Kuna, Piotr, additional, Kvedariene, Violeta, additional, Lauerma, Antti, additional, Le, Lan T. T., additional, Le Moing, Vincent, additional, Levin, Michael, additional, Louis, Renaud, additional, Lourenco, Olga, additional, Mahler, Vera, additional, Martin, Finbarr C., additional, Matucci, Andrea, additional, Milenkovic, Branislava, additional, Miot, Stéphanie, additional, Montella, Emma, additional, Morais‐Almeida, Mario, additional, Mortz, Charlotte G., additional, Mullol, Joaquim, additional, Namazova‐Baranova, Leyla, additional, Neffen, Hugo, additional, Nekam, Kristof, additional, Niedoszytko, Marek, additional, Odemyr, Mikaëla, additional, O’Hehir, Robyn E., additional, Okamoto, Yoshitaka, additional, Ollert, Markus, additional, Palomares, Oscar, additional, Papadopoulos, Nikolaos G., additional, Panzner, Petr, additional, Passalacqua, Giovanni, additional, Patella, Vincenzo, additional, Petrovic, Mirko, additional, Pfaar, Oliver, additional, Pham‐Thi, Nhân, additional, Plavec, Davor, additional, Popov, Todor A., additional, Recto, Marysia T., additional, Regateiro, Frederico S., additional, Reynes, Jacques, additional, Roller‐Winsberger, Regina E., additional, Rolland, Yves, additional, Romano, Antonino, additional, Rondon, Carmen, additional, Rottem, Menachem, additional, Rouadi, Philip W., additional, Salles, Nathalie, additional, Samolinski, Boleslaw, additional, Santos, Alexandra F., additional, S Sarquis, Faradiba, additional, Sastre, Joaquin, additional, M. G. A. Schols, Jos, additional, Scichilone, Nicola, additional, Sediva, Anna, additional, Shamji, Mohamed H., additional, Sheikh, Aziz, additional, Skypala, Isabel, additional, Smolinska, Sylwia, additional, Sokolowska, Milena, additional, Sousa‐Pinto, Bernardo, additional, Sova, Milan, additional, Stelmach, Rafael, additional, Sturm, Gunter, additional, Suppli Ulrik, Charlotte, additional, Todo‐Bom, Ana Maria, additional, Toppila‐Salmi, Sanna, additional, Tsiligianni, Ioanna, additional, Torres, Maria, additional, Untersmayr, Eva, additional, Urrutia Pereira, Marilyn, additional, Valiulis, Arunas, additional, Vitte, Joana, additional, Vultaggio, Alessandra, additional, Wallace, Dana, additional, Walusiak‐Skorupa, Jolanta, additional, Wang, De‐Yun, additional, Waserman, Susan, additional, Yorgancioglu, Arzu, additional, Yusuf, Osman M., additional, Zernotti, Mario, additional, Zidarn, Mihaela, additional, Chivato, Tomas, additional, Akdis, Cezmi A., additional, Zuberbier, Torsten, additional, and Klimek, Ludger, additional

Published
2021
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13. Allergological workup with half-dose challenge in iodinated contrast media hypersensitivity

Author

J.E. Autegarden, Amandine Vial-Dupuy, Angèle Soria, H. Gaouar, Sylvie Chollet-Martin, Annick Barbaud, Pascale Nicaise-Roland, Nathalie Masson, and Emmanuelle Amsler

Subjects
0301 basic medicine, medicine.medical_specialty, business.industry, Immunology, Iodine Compounds, Contrast Media, Disease Management, Allergens, Dermatology, Drug Hypersensitivity, Iodinated contrast media, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030228 respiratory system, Humans, Immunology and Allergy, Medicine, Disease management (health), business, Skin Tests
Published
2018

14. Practice parameters for diagnosing and managing iodinated contrast media hypersensitivity

Author

Torres, María José, primary, Trautmann, Axel, additional, Böhm, Ingrid, additional, Scherer, Kathrin, additional, Barbaud, Annick, additional, Bavbek, Sevim, additional, Bonadonna, Patrizia, additional, Cernadas, Josefina Rodrigues, additional, Chiriac, Anca Mirela, additional, Gaeta, Francesco, additional, Gimenez‐Arnau, Ana M., additional, Kang, Hye‐Ryun, additional, Moreno, Esther, additional, and Brockow, Knut, additional

Published
2021
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16. Towards a more precise diagnosis of hypersensitivity to beta‐lactams — an EAACI position paper

Author

Romano, Antonino, primary, Atanaskovic‐Markovic, Marina, additional, Barbaud, Annick, additional, Bircher, Andreas J., additional, Brockow, Knut, additional, Caubet, Jean‐Christoph, additional, Celik, Gulfem, additional, Cernadas, Josefina, additional, Chiriac, Anca‐Mirela, additional, Demoly, Pascal, additional, Garvey, Lene H., additional, Mayorga, Cristobalina, additional, Nakonechna, Alla, additional, Whitaker, Paul, additional, and Torres, María José, additional

Published
2020
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17. First evidence of occupational asthma to argan powder in a cosmetic factory

Author

Isabelle Thaon, Fabrice Herin, Mathias Poussel, Emmanuelle Penven, Christelle Richard, Christophe Paris, S Jacquenet, A. Barbaud, Centre de consultations de pathologies professionnelles [CHRU Nancy] (CCPP), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Interactions Gènes-Risques environnementaux et Effets sur la Santé (INGRES), Université de Lorraine (UL), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de consultations de pathologies professionnelles [CHU Toulouse], CHU Toulouse [Toulouse], Université Fédérale Toulouse Midi-Pyrénées, Genclis SAS, Service de Dermatologie et Allergologie [CHRU Nancy], Développement, Adaptation et Handicap. Régulations cardio-respiratoires et de la motricité (DevAH), and Service des examens de la Fonction respiratoire et de l’aptitude à l’exercice [CHRU Nancy]

Subjects
Adult, Male, Allergy, medicine.medical_specialty, Probable Case, media_common.quotation_subject, Immunology, Occupational disease, Cosmetics, Bronchial Provocation Tests, 03 medical and health sciences, Specific inhalation challenge, 0302 clinical medicine, Risk Factors, Occupational Exposure, medicine, Humans, Immunology and Allergy, Asthma, Occupational, Skin Tests, media_common, Sapotaceae, 030201 allergy, Traditional medicine, business.industry, Allergens, Antigens, Plant, Immunoglobulin E, Middle Aged, medicine.disease, 11s globulin, Elisa inhibition, 3. Good health, Surgery, 030228 respiratory system, Female, business, Occupational asthma, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; BackgroundArgan is used worldwide in numerous cosmetic products, as this fruit is supposed to have many beneficial properties on health. New cases of allergy can be expected with the growing use of argan. We investigated all workers (9) employed by a cosmetic factory and exposed to argan powder to identify possible allergies related to exposure to argan powder.MethodsPatients were investigated in the occupational disease department and, according to their symptoms, underwent pulmonary function testing, methacholine challenge, specific inhalation challenge to argan powder, skin prick tests, and immunoblotting analysis.ResultsWe report three cases of occupational asthma to argan powder and a probable case of rhinitis. Fifteen argan proteins were recognized by the patients' IgE. Identification of proteins, cross-reactions to nuts, and ELISA inhibition tests suggested that some argan allergens can cross-react in vitro with hazelnut allergens, including 11S globulin and vicilin.ConclusionHigh-level exposure to argan powder should be considered to be a potential cause of IgE-mediated allergy, and workers handling argan powder should be carefully investigated.

Published
2016

18. Genetic variants associated with drugs-induced immediate hypersensitivity reactions: a PRISMA-compliant systematic review

Author

Ingrid Terreehorst, Jean-Christoph Roger J-P Caubet, Luciana Kase Tanno, Josefina Cernadas, M. Gotua, M. Atanaskovic, Pascal Demoly, M. Blanca, Abderrahim Oussalah, Alla Nakonechna, Andreas J. Bircher, A. Barbaud, Antonino Romano, Jose Julio Laguna, Knut Brockow, Cristobalina Mayorga, Jean-Louis Guéant, Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service de Biochimie et Biologie Moléculaire, Nutrition et Métabolisme [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Biomedical Research Institute of Málaga (IBIMA), Service de Dermatologie et Allergologie [CHRU Nancy], Allergy and Immunology Clinic [Royal Liverpool and Broadgreen University Hospital], Royal Liverpool and Broadgreen University Hospital NHS Trust, Immunoallergy Department [Porto], Centro Hospitalar São João EPE, Center for Allergy and Immunology Research [Tbilisi], Department of Dermatology and Allergy Biederstein, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Division of Paediatrics [Geneva], University Hospital of Geneva, University Hospital Basel [Basel], Department of Allergology and Pulmonology [Belgrade], University Children's Hospital [Belgrade], Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Hospital Sírio-Libanês [São Paulo, Brazil], Academisch Medisch Centrum bij, Universiteit van Amsterdam (UvA), Allergy Unit [Cruz Roja-Madrid], Hospital Central de la Cruz Roja San Jose y Santa Adela, and Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)

Subjects
Hypersensitivity, Immediate, Candidate gene, [SDV]Life Sciences [q-bio], Immunology, Human leukocyte antigen, Drug Hypersensitivity, Atopy, 03 medical and health sciences, 0302 clinical medicine, Genetic variation, Genetic predisposition, medicine, Humans, Immunology and Allergy, Genetic Predisposition to Disease, 030212 general & internal medicine, Allele frequency, Aspirin, ddc:618, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Nonsteroidal anti-inflammatory drugs, Genetic Variation, Environmental exposure, Immunoglobulin E, medicine.disease, Anti-Bacterial Agents, 3. Good health, Beta-lactam antibiotics, 030228 respiratory system, Genetic predictors, IgE-mediated drug allergy, business, medicine.drug
Abstract

International audience; Drug hypersensitivity includes allergic (AR) and nonallergic reactions (NARs) influenced by genetic predisposition. We performed a systematic review of genetic predictors of IgE-mediated AR and NAR with MEDLINE and PubMed search engine between January 1966 and December 2014. Among 3110 citations, the search selected 53 studies, 42 of which remained eligible. These eligible studies have evaluated genetic determinants of immediate reactions (IR) to beta-lactams (n = 19), NAR against aspirin (n = 12) and other nonsteroidal anti-inflammatory drugs (NSAIDs) (n = 8), and IR to biologics (n = 3). We reported two genomewide association studies and four case–control studies on candidate genes validated by replication. Genes involved in IR to beta-lactams belonged to HLA type 2 antigen processing, IgE production, atopy, and inflammation, including 4 genes validated by replications, HLA-DRA, ILR4, NOD2, and LGALS3. Genes involved in NAR to aspirin belonged to arachidonic acid pathway, membrane-spanning 4A gene family, histamine production pathway, and pro-inflammatory cytokines, while those involved in NAR to all NSAIDs belonged to arachidonic acid pathway and HLA antigen processing pathway. ALOX5 was a common predictor of studies on NAR to both aspirin and NSAIDs. Although these first conclusions could be drawn, this review highlights also the lack of reliable data and the need for replicating studies in contrasted populations, taking into account worldwide allele frequencies, gene–gene interactions, and contrasted situations of environmental exposure.

Published
2016

19. A EAACI drug allergy interest group survey on how European allergy specialists deal with β-lactam allergy

Author

Torres, Maria Jose, primary, Celik, Gulfem Elif, additional, Whitaker, Paul, additional, Atanaskovic-Markovic, Marina, additional, Barbaud, Annick, additional, Bircher, Andreas, additional, Blanca, Miguel, additional, Brockow, Knut, additional, Caubet, Jean-Christoph, additional, Cernadas, Josefina Rodrigues, additional, Chiriac, Anca, additional, Demoly, Pascal, additional, Garvey, Lene Heise, additional, Merk, Hans F., additional, Mosbech, Holger, additional, Nakonechna, Alla, additional, and Romano, Antonino, additional

Published
2019
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22. Genetic variants associated with T cell–mediated cutaneous adverse drug reactions: A PRISMA‐compliant systematic review—An EAACI position paper.

Author

Oussalah, Abderrahim, Yip, Vincent, Mayorga, Cristobalina, Blanca, Miguel, Barbaud, Annick, Nakonechna, Alla, Cernadas, Josefina, Gotua, Maia, Brockow, Knut, Caubet, Jean‐Christoph, Bircher, Andreas, Atanaskovic‐Markovic, Marina, Demoly, Pascal, Kase‐Tanno, Luciana, Terreehorst, Ingrid, Laguna, José Julio, Romano, Antonino, Guéant, Jean‐Louis, and Pirmohamed, Munir

Subjects
TOXIC epidermal necrolysis, DRUG side effects, HLA histocompatibility antigens, META-analysis, PATHOLOGY, DRUG metabolism, SIDE effects of anticonvulsants, STEVENS-Johnson Syndrome
Abstract

Drug hypersensitivity reactions (DHRs) are associated with high global morbidity and mortality. Cutaneous T cell–mediated reactions classically occur more than 6 hours after drug administration and include life‐threatening conditions such as toxic epidermal necrolysis, Stevens‐Johnson syndrome, and hypersensitivity syndrome. Over the last 20 years, significant advances have been made in our understanding of the pathogenesis of DHRs with the identification of human leukocyte antigens as predisposing factors. This has led to the development of pharmacogenetic screening tests, such as HLA‐B*57:01 in abacavir therapy, which has successfully reduced the incidence of abacavir hypersensitivity reactions. We have completed a PRISMA‐compliant systematic review to identify genetic associations that have been reported in DHRs. In total, 105 studies (5554 cases and 123 548 controls) have been included in the review reporting genetic associations with carbamazepine (n = 31), other aromatic antiepileptic drugs (n = 24), abacavir (n = 11), nevirapine (n = 14), trimethoprim‐sulfamethoxazole (n = 11), dapsone (n = 4), allopurinol (n = 10), and other drugs (n = 5). The most commonly reported genetic variants associated with DHRs are located in human leukocyte antigen genes and genes involved in drug metabolism pathways. Increasing our understanding of genetic variants that contribute to DHRs will allow us to improve diagnosis, develop new treatments, and predict and prevent DHRs in the future. [ABSTRACT FROM AUTHOR]

Published
2020
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23. Allergological workup with half‐dose challenge in iodinated contrast media hypersensitivity.

Author

Soria, Angèle, Masson, Nathalie, Vial‐Dupuy, Amandine, Gaouar, Hafida, Amsler, Emmanuelle, Chollet‐Martin, Sylvie, Nicaise‐Roland, Pascale, Autegarden, Jean‐Eric, and Barbaud, Annick

Subjects
RADIOGRAPHIC contrast media, ALLERGIES, ANTIALLERGIC agents
Abstract

The article offers information on the diagnosis of hypersensitivity reaction (HSR) to iodinated contrast media (ICM) is challenging when based on clinical history and skin tests. It mentions the objective of this study was to determine the negative predictive value (NPV) for skin tests as compared with the intravenous provocation tests (IPT) 50 mL; and also mentions the IPT was reduced to 10 mL with glomerular filtration rate (GFR).

Published
2019
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24. EAACI position paper on how to classify cutaneous manifestations of drug hypersensitivity.

Author

Brockow, Knut, Ardern‐Jones, Michael R., Mockenhaupt, Maja, Aberer, Werner, Barbaud, Annick, Caubet, Jean‐Christoph, Spiewak, Radoslaw, Torres, María José, and Mortz, Charlotte G.

Subjects
SKIN inflammation, SKIN disease treatment, TRANSDERMAL medication, ALLERGIES, IMMUNOLOGIC diseases
Abstract

Drug hypersensitivity reactions (DHRs) are common, and the skin is by far the most frequently involved organ with a broad spectrum of reaction types. The diagnosis of cutaneous DHRs (CDHR) may be difficult because of multiple differential diagnoses. A correct classification is important for the correct diagnosis and management. With these guidelines, we aim to give precise definitions and provide the background needed for doctors to correctly classify CDHR. [ABSTRACT FROM AUTHOR]

Published
2019
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26. Genetic variants associated with drugs-induced immediate hypersensitivity reactions: a PRISMA-compliant systematic review.

Author

Oussalah, A., Mayorga, C., Blanca, M., Barbaud, A., Nakonechna, A., Cernadas, J., Gotua, M., Brockow, K., Caubet, J.‐C., Bircher, A., Atanaskovic, M., Demoly, P., K. Tanno, L., Terreehorst, I., Laguna, J. J., Romano, A., and Guéant, J.‐L.

Subjects
DRUG allergy, IMMUNOGLOBULIN E, BETA lactam antibiotics, NONSTEROIDAL anti-inflammatory agents, ASPIRIN, GENETICS
Abstract

Drug hypersensitivity includes allergic ( AR) and nonallergic reactions ( NARs) influenced by genetic predisposition. We performed a systematic review of genetic predictors of IgE-mediated AR and NAR with MEDLINE and PubMed search engine between January 1966 and December 2014. Among 3110 citations, the search selected 53 studies, 42 of which remained eligible. These eligible studies have evaluated genetic determinants of immediate reactions ( IR) to beta-lactams ( n = 19), NAR against aspirin ( n = 12) and other nonsteroidal anti-inflammatory drugs ( NSAIDs) ( n = 8), and IR to biologics ( n = 3). We reported two genomewide association studies and four case-control studies on candidate genes validated by replication. Genes involved in IR to beta-lactams belonged to HLA type 2 antigen processing, IgE production, atopy, and inflammation, including 4 genes validated by replications, HLA- DRA, ILR4, NOD2, and LGALS3. Genes involved in NAR to aspirin belonged to arachidonic acid pathway, membrane-spanning 4A gene family, histamine production pathway, and pro-inflammatory cytokines, while those involved in NAR to all NSAIDs belonged to arachidonic acid pathway and HLA antigen processing pathway. ALOX5 was a common predictor of studies on NAR to both aspirin and NSAIDs. Although these first conclusions could be drawn, this review highlights also the lack of reliable data and the need for replicating studies in contrasted populations, taking into account worldwide allele frequencies, gene-gene interactions, and contrasted situations of environmental exposure. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

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